| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F M Cowan, T M Shih, D E Lenz, J M Madsen, C A Broomfiel. Hypothesis for synergistic toxicity of organophosphorus poisoning-induced cholinergic crisis and anaphylactoid reactions. Journal of applied toxicology : JAT. vol 16. issue 1. 1997-01-17. PMID:8821672. |
the neurotoxicity of organophosphorus (op) compounds involves the inhibition of acetylcholinesterase (ache), causing accumulation of acetylcholine (ach) at synapses. |
1997-01-17 |
2023-08-12 |
Not clear |
| J Strupi Suput, T Turk, P Macek, D Supu. Pseudozoanthoxantin-like compound from Parazoanthus axinellae Adriaticus inhibits acetylcholinesterase. Pflugers Archiv : European journal of physiology. vol 431. issue 6 Suppl 2. 1997-01-16. PMID:8739391. |
acetylcholinesterase is an enzyme responsible for the timely termination of acetylcholine action at muscarinic and nicotinic receptors, so it is essential for the normal function of cholinergic synapses. |
1997-01-16 |
2023-08-12 |
Not clear |
| A Nery da Matta, C B Silva, A Hassón-Voloc. Effect of Mg(2+)-ATP on acetylcholinesterase of Electrophorus electricus (L.). Zeitschrift fur Naturforschung. C, Journal of biosciences. vol 51. issue 1-2. 1997-01-15. PMID:8721214. |
it was shown that acetylcholinesterase presents an apparent activation at high concentration of substrates and an inhibition in the presence of mg(2+)-atp at low concentration of acetylcholine and acetylthiocholine. |
1997-01-15 |
2023-08-12 |
Not clear |
| V Tõugu, T Kesvater. Role of ionic interactions in cholinesterase catalysis. Biochimica et biophysica acta. vol 1298. issue 1. 1997-01-06. PMID:8948485. |
acetylcholinesterase (ache, ec 3.1.1.7) is an enzyme terminating the transmission of nerve impulse in synapses by rapid and selective hydrolysis of the neurotransmitter acetylcholine. |
1997-01-06 |
2023-08-12 |
Not clear |
| D H Small, S Michaelson, G Sbern. Non-classical actions of cholinesterases: role in cellular differentiation, tumorigenesis and Alzheimer's disease. Neurochemistry international. vol 28. issue 5-6. 1996-12-30. PMID:8792327. |
acetylcholinesterase (ache) is distinguished from butyrylcholinesterase (bche) by its greater specificity for hydrolysing acetylcholine. |
1996-12-30 |
2023-08-12 |
Not clear |
| J G van Dijk, G J Lammers, A R Wintzen, P C Molenaa. Repetitive CMAPs: mechanisms of neural and synaptic genesis. Muscle & nerve. vol 19. issue 9. 1996-12-18. PMID:8761268. |
"synaptic" r-cmaps, due to excess acetylcholine in the neuromuscular synapse, can occur in congenital myasthenia, the slow-channel syndrome, and acetylcholinesterase inhibition. |
1996-12-18 |
2023-08-12 |
human |
| S Hirokawa, M Nose, A Ishige, S Amagaya, T Oyama, Y Ogihar. Effect of Hachimi-jio-gan on scopolamine-induced memory impairment and on acetylcholine content in rat brain. Journal of ethnopharmacology. vol 50. issue 2. 1996-12-13. PMID:8866727. |
the effect of hachimi-jio-gan (hj) on scopolamine induced memory impairment was studied using a radial maze performance, the effect of hj on the central cholinergic system as measured by acetylcholine (ach) content, choline acetyltransferase (cat) and acetylcholinesterase (ache) activities was also examined. |
1996-12-13 |
2023-08-12 |
rat |
| J E McKenzie, D M Scandling, N W Ahle, H J Bryant, R R Kyle, P H Abbrech. Effects of soman (pinacolyl methylphosphonofluoridate) on coronary blood flow and cardiac function in swine. Fundamental and applied toxicology : official journal of the Society of Toxicology. vol 29. issue 1. 1996-12-11. PMID:8838649. |
the increase in coronary sinus acetylcholine concentration was significantly correlated with a 10-fold fall in coronary sinus acetylcholinesterase levels from a control of 2.47 +/- 0.97 mol acetylcholine hydrolyzed/ml blood/min and was consistent with the time course for the reduced hemodynamic measurements. |
1996-12-11 |
2023-08-12 |
Not clear |
| A Inoue, T Kawai, M Wakita, Y Iimura, H Sugimoto, Y Kawakam. The simulated binding of (+/-)-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]meth yl] -1H-inden-1-one hydrochloride (E2020) and related inhibitors to free and acylated acetylcholinesterases and corresponding structure-activity analyses. Journal of medicinal chemistry. vol 39. issue 22. 1996-12-10. PMID:8893840. |
the simulated binding profiles of acetylcholine, ach, and the inhibitor (+/-)-2,3-dihydro-5,6- dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1h-inden-1-on e hydrochloride (e2020), 1, and some of its analogs to acetylcholinesterase, ache, were determined using full force field energetics and allowing complete conformational flexibility in both the ligand and receptor. |
1996-12-10 |
2023-08-12 |
Not clear |
| P T Carrol. Evidence to suggest that cytosolic acetylcholine in rat hippocampal nerve terminals is not directly transferred into synaptic vesicles for release. Brain research. vol 725. issue 1. 1996-12-06. PMID:8828580. |
rat hippocampal minces were loaded with [acetyl 1-14c]acetylcholine ([14c]ach) in the presence of the "poorly penetrating" acetylcholinesterase (ec 3.1.1.7; ache) inhibitor echothiophate and the effect of high k+ depolarization determined on the subcellular storage and release of [14c]ach and its metabolites. |
1996-12-06 |
2023-08-12 |
rat |
| K Hiramoto, T Okada, M It. Abnormalities in behavior, learning ability, and the cholinergic system induced by long-term ultraviolet A irradiation of mice. Neuropsychobiology. vol 33. issue 4. 1996-12-06. PMID:8840340. |
acetylcholine levels, acetylcholinesterase and choline acetyltransferase activities in the whole brains were decreased in both of 6- and 12-month irradiated mice. |
1996-12-06 |
2023-08-12 |
mouse |
| P Kasa, S Karcsu, I Kovacs, J R Wolf. Cholinoceptive neurons without acetylcholinesterase activity and enzyme-positive neurons without cholinergic synaptic innervation are present in the main olfactory bulb of adult rat. Neuroscience. vol 73. issue 3. 1996-12-04. PMID:8809802. |
in the main olfactory bulb, the acetylcholinesterase present in the relay cells therefore appears to have functions other than the hydrolysis of acetylcholine. |
1996-12-04 |
2023-08-12 |
rat |
| R B BARLOW, A ZOLLE. SOME EFFECTS OF LONG CHAIN POLYMETHYLENE BISONIUM SALTS ON JUNCTIONAL TRANSMISSION IN THE PERIPHERAL NERVOUS SYSTEM. British journal of pharmacology and chemotherapy. vol 23. 1996-12-01. PMID:14208190. |
they were also tested for their ability to block transmission in the cat superior cervical ganglion, to block the actions of acetylcholine on the guinea-pig isolated ileum, and for ability to inhibit the hydrolysis of acetylcholine by acetylcholinesterase. |
1996-12-01 |
2023-08-12 |
rat |
| J J Hutsler, M S Gazzanig. Acetylcholinesterase staining in human auditory and language cortices: regional variation of structural features. Cerebral cortex (New York, N.Y. : 1991). vol 6. issue 2. 1996-11-27. PMID:8670655. |
acetylcholinesterase (ache), the enzyme responsible for deactivating acetylcholine, is found within both cholinergic axons arising from the basal forebrain and a subgroup of pyramidal cells in layers iii and v of the cerebral cortex. |
1996-11-27 |
2023-08-12 |
human |
| M Guenneugues, M Verdière-Sahuqué, R Amouri, D Goudou, F Riege. Mouse G2-GPI AChE is processed as a membrane-bound ectoenzyme in transfected mouse sarcoma cells but is not a homophilic adhesion molecule. Neuroscience letters. vol 210. issue 1. 1996-10-31. PMID:8762181. |
acetylcholinesterase (ache) is mainly involved in synaptic transmission by hydrolyzing acetylcholine in the synaptic cleft. |
1996-10-31 |
2023-08-12 |
mouse |
| V B Prozorovskiĭ, V I Rozengart, T V Ardab'eva, L I Kugusheva, I M Suslov. [Biochemical characteristics of aminostigmine--a new anticholinesterase agent]. Biokhimiia (Moscow, Russia). vol 61. issue 4. 1996-10-28. PMID:8724787. |
the rate of decarbamylation of acetylcholinesterase inhibited by aminostigmine measured by the dilution method, by creating excessive acetylcholine and by dialysis is characterized by k2c constants equal to (1.1-1.6).10(-2), (2.5-2.8).10(-2) and 0.025.10(-2) min-1, respectively. |
1996-10-28 |
2023-08-12 |
Not clear |
| T R Ward, W R Mund. Organophosphorus compounds preferentially affect second messenger systems coupled to M2/M4 receptors in rat frontal cortex. Brain research bulletin. vol 39. issue 1. 1996-10-24. PMID:8846108. |
the differential activity on these two second messenger systems make it unlikely that the observed effects on camp formation are due to increases in endogenous acetylcholine resulting from inhibition of acetylcholinesterase. |
1996-10-24 |
2023-08-12 |
rat |
| M Weinstoc. The pharmacotherapy of Alzheimer's disease based on the cholinergic hypothesis: an update. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. vol 4. issue 4. 1996-10-24. PMID:8846227. |
current pharmacological strategies, aimed at increasing cholinergic activity include acetylcholinesterase (ache) inhibitors, cholinergic agonists, acetylcholine (ach) releasers and stimulants of nerve growth factors (ngf). |
1996-10-24 |
2023-08-12 |
Not clear |
| N Kishibayashi, A Karasaw. Effects of KW-5092, a novel gastroprokinetic agent, on intestinal water and electrolyte transport in rats. Biological & pharmaceutical bulletin. vol 18. issue 12. 1996-10-23. PMID:8787786. |
kw-5092 ([1-[2-[[[5-(piperidinomethyl)- 2-furanyl]methyl]amino]ethyl]-2-imidazolidinylidene]propanedini trile fumarate) enhances acetylcholine release from enteric neurons and inhibits acetylcholinesterase (ache), resulting in the enhancement of a wide range of gastrointestinal motilities. |
1996-10-23 |
2023-08-12 |
rat |
| L Peng, I Silman, J Sussman, M Goeldne. Biochemical evaluation of photolabile precursors of choline and of carbamylcholine for potential time-resolved crystallographic studies on cholinesterases. Biochemistry. vol 35. issue 33. 1996-09-30. PMID:8718877. |
acetylcholinesterase and butyrylcholinesterase both rapidly hydrolyze the neurotransmitter acetylcholine. |
1996-09-30 |
2023-08-12 |
Not clear |