| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Kishibayashi, A Karasaw. Stimulating effects of KW-5092, a novel gastroprokinetic agent, on the gastric emptying, small intestinal propulsion and colonic propulsion in rats. Japanese journal of pharmacology. vol 67. issue 1. 1995-06-14. PMID:7745844. |
kw-5092 ((1-[2-[[[5-(piperidinomethyl)-2-furanyl]methyl]amino]ethyl]- 2-imidazolidinylidene) propanedinitrile fumarate) is a novel gastroprokinetic agent with acetylcholinesterase (ache) inhibitory activity and acetylcholine (ach) release facilitatory activity. |
1995-06-14 |
2023-08-12 |
rat |
| A Klegeris, L G Korkina, S A Greenfiel. A possible interaction between acetylcholinesterase and dopamine molecules during autoxidation of the amine. Free radical biology & medicine. vol 18. issue 2. 1995-06-12. PMID:7744305. |
acetylcholinesterase has an action in the central nervous system, independent of hydrolysis of acetylcholine. |
1995-06-12 |
2023-08-12 |
Not clear |
| N Kishibayashi, A Ishii, A Karasaw. Inhibitory effects of KW-5092, a novel gastroprokinetic agent, on the activity of acetylcholinesterase in guinea pig ileum. Japanese journal of pharmacology. vol 66. issue 4. 1995-05-23. PMID:7723214. |
kw-5092 ([1-[2-[[[5-(piperidinomethyl)-2- furanyl]methyl]amino]ethyl]-2-imidazolidinylidene] propanedinitrile fumarate) is a novel gastroprokinetic agent with acetylcholinesterase (ache) inhibitory activity and acetylcholine release facilitatory activity. |
1995-05-23 |
2023-08-12 |
Not clear |
| J Antosiewicz, M K Gilson, I H Lee, J A McCammo. Acetylcholinesterase: diffusional encounter rate constants for dumbbell models of ligand. Biophysical journal. vol 68. issue 1. 1995-05-18. PMID:7711269. |
interestingly, the asymmetric charge distribution of acetylcholinesterase, apparent from the crystallographic structure, suggests that its electrostatic field accelerates the encounter of its cationic substrate, acetylcholine, with the entrance to the active site. |
1995-05-18 |
2023-08-12 |
Not clear |
| J P Sie. [Congenital diseases of neuromuscular transmission: congenital myasthenia syndromes]. Der Nervenarzt. vol 66. issue 2. 1995-05-18. PMID:7715748. |
these genetic disorders include defects of acetylcholine release, absence of the endplate-specific form of acetylcholinesterase, and kinetic abnormalities of the acetylcholine receptor. |
1995-05-18 |
2023-08-12 |
Not clear |
| P J Chowienczyk, J R Cockcroft, J M Ritte. Inhibition of acetylcholinesterase selectively potentiates NG-monomethyl-L-arginine-resistant actions of acetylcholine in human forearm vasculature. Clinical science (London, England : 1979). vol 88. issue 1. 1995-05-11. PMID:7704991. |
inhibition of acetylcholinesterase selectively potentiates ng-monomethyl-l-arginine-resistant actions of acetylcholine in human forearm vasculature. |
1995-05-11 |
2023-08-12 |
human |
| P J Chowienczyk, J R Cockcroft, J M Ritte. Inhibition of acetylcholinesterase selectively potentiates NG-monomethyl-L-arginine-resistant actions of acetylcholine in human forearm vasculature. Clinical science (London, England : 1979). vol 88. issue 1. 1995-05-11. PMID:7704991. |
to investigate whether this difference results from the relative susceptibility of these agonists to hydrolysis by acetylcholinesterase, we studied vasodilator responses to brachial artery administration of acetylcholine alone and in the presence of the acetylcholinesterase inhibitor edrophonium. |
1995-05-11 |
2023-08-12 |
human |
| H Namba, T Irie, K Fukushi, M Iy. In vivo measurement of acetylcholinesterase activity in the brain with a radioactive acetylcholine analog. Brain research. vol 667. issue 2. 1995-05-03. PMID:7697367. |
in vivo measurement of acetylcholinesterase activity in the brain with a radioactive acetylcholine analog. |
1995-05-03 |
2023-08-12 |
human |
| X C Tang, G H Kindel, A P Kozikowski, I Hani. Comparison of the effects of natural and synthetic huperzine-A on rat brain cholinergic function in vitro and in vivo. Journal of ethnopharmacology. vol 44. issue 3. 1995-04-27. PMID:7898122. |
this inhibition of acetylcholinesterase activity was inversely related to levels of acetylcholine measured in the hippocampus and followed the same time course of effect. |
1995-04-27 |
2023-08-12 |
rat |
| H L Fernandez, C A Hodges-Savol. Axoplasmic transport of calcitonin gene-related peptide in rat peripheral nerve as a function of age. Neurochemical research. vol 19. issue 11. 1995-04-26. PMID:7534874. |
these data are consistent with the notion that changes in cgrp delivery may contribute to age-related changes in junctional acetylcholine receptors and acetylcholinesterase. |
1995-04-26 |
2023-08-12 |
rat |
| G Lawrance, R J Rylett, P M Richardson, R J Dunn, K E Dow, R J Riopell. Differentiation effects of ciliary neurotrophic factor on human neuroblastoma cells. Journal of neurochemistry. vol 64. issue 4. 1995-04-18. PMID:7891074. |
cntf markedly stimulated choline acetyltransferase activity and acetylcholine synthesis, whereas high-affinity choline transport was only slightly enhanced and acetylcholinesterase activity was unchanged. |
1995-04-18 |
2023-08-12 |
human |
| V L Arvanov, H H Liou, Y C Chang, R C Chen, F C Peng, K H Ling, M C Tsa. Interactions of anticholinesterases with Achatina fulica acetylcholine responses and electrogenic sodium pump. Neuroscience. vol 62. issue 2. 1995-02-17. PMID:7830898. |
the dose-dependent effects of the anticholinesterases, neostigmine and mycotoxin territrem-b, were determined on: (i) cl(-)-responses of voltage clamped achatina fulica neurons to microperfused acetylcholine; (ii) the 4 k(+)-induced outward currents evoked by an electrogenic sodium pump in the same neuron; and (iii) acetylcholinesterase activity of achatina fulica ganglionic homogenates. |
1995-02-17 |
2023-08-12 |
Not clear |
| V L Arvanov, H H Liou, Y C Chang, R C Chen, F C Peng, K H Ling, M C Tsa. Interactions of anticholinesterases with Achatina fulica acetylcholine responses and electrogenic sodium pump. Neuroscience. vol 62. issue 2. 1995-02-17. PMID:7830898. |
thus, territrem-b may be a useful tool for studying the interaction between acetylcholinesterase and acetylcholine receptors. |
1995-02-17 |
2023-08-12 |
Not clear |
| M Koutsoviti-Papadopoulou, G Kounenis, V Elezoglo. Ketamine protects acetylcholinesterase against inhibition by propoxur and phoxim. Pharmacological research. vol 30. issue 2. 1995-02-09. PMID:7816740. |
propoxur and phoxim augmented the contractile responses induced by acetylcholine in the presence of acetylcholinesterase. |
1995-02-09 |
2023-08-12 |
Not clear |
| N Konno, N Suzuki, H Horiguchi, M Fukushim. Characterization of high-affinity binding sites for diisopropylfluorophosphate (DFP) from chicken spinal cord membranes. Biochemical pharmacology. vol 48. issue 11. 1995-01-23. PMID:7802697. |
concentration-dependent curves suggested that the [3h]dfp binding sites differ from the active sites of acetylcholinesterase, butyrylcholinesterase, and neuropathy target esterase, as well as from muscarinic acetylcholine receptors. |
1995-01-23 |
2023-08-12 |
chicken |
| E Kosenko, Y Kaminsky, M D Miñana, S Grisolia, V Felip. High ammonia levels decrease brain acetylcholinesterase activity both in vivo and in vitro. Molecular and chemical neuropathology. vol 22. issue 3. 1995-01-19. PMID:7993526. |
these results suggest that at least part of the neurologic effects of ammonia could be mediated by an increase of acetylcholine as a consequence of the inhibition of acetylcholinesterase. |
1995-01-19 |
2023-08-12 |
mouse |
| J K Liu, T Kat. Effect of physostigmine on relative acetylcholine output induced by systemic treatment with scopolamine in in vivo microdialysis of rat frontal cortex. Neurochemistry international. vol 24. issue 6. 1995-01-03. PMID:7981642. |
from these results, it appears that perfusion of physostigmine at a variety of concentrations, changes not only the basal level of acetylcholine induced by the inhibition of acetylcholinesterase but also the relative acetylcholine output induced by systemic treatment with scopolamine. |
1995-01-03 |
2023-08-12 |
rat |
| N Kishibayashi, A Tomaru, S Ichikawa, T Kitazawa, K Shuto, A Ishii, A Karasaw. Enhancement by KW-5092, a novel gastroprokinetic agent, of the gastrointestinal motor activity in dogs. Japanese journal of pharmacology. vol 65. issue 2. 1994-12-28. PMID:7967226. |
kw-5092 ([1-[2-[[[5-(piperidinomethyl)-2- furanyl]methyl]amino]ethyl]-2-imidazolidinylidene) propanedinitrile fumarate) is a novel gastroprokinetic agent with acetylcholinesterase (ache) inhibitory activity and acetylcholine (ach) release facilitatory activity. |
1994-12-28 |
2023-08-12 |
Not clear |
| E P Hornstein, D L Sambursky, S C Chamberlai. Histochemical localization of acetylcholinesterase in the lateral eye and brain of Limulus polyphemus: might acetylcholine be a neurotransmitter for lateral inhibition in the lateral eye? Visual neuroscience. vol 11. issue 5. 1994-12-12. PMID:7947410. |
histochemical localization of acetylcholinesterase in the lateral eye and brain of limulus polyphemus: might acetylcholine be a neurotransmitter for lateral inhibition in the lateral eye? |
1994-12-12 |
2023-08-12 |
horseshoe_crab |
| G Kounenis, M Koutsoviti-Papadopoulou, V Elezoglo. Ketamine inhibits the anticholinesterase activity of ranitidine and physostigmine. General pharmacology. vol 25. issue 4. 1994-12-08. PMID:7958721. |
the contractile responses induced by acetylcholine were inhibited by exogenous acetylcholinesterase. |
1994-12-08 |
2023-08-12 |
Not clear |