| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J L Sussman, M Harel, I Silma. Three-dimensional structure of acetylcholinesterase and of its complexes with anticholinesterase drugs. Chemico-biological interactions. vol 87. issue 1-3. 1993-09-03. PMID:8343975. |
based on our recent x-ray crystallographic determination of the structure of acetylcholinesterase (ache) from torpedo californica, we can see for the first time, at atomic resolution, a protein binding pocket for the neurotransmitter, acetylcholine. |
1993-09-03 |
2023-08-12 |
Not clear |
| b' P Taylor, Y Li, S Camp, T L Rachinsky, T Ekstr\\xc3\\xb6m, D Getman, M E Fuentes, D C Vellom, Z Radi\\xc4\\x8. Structure and regulation of expression of the acetylcholinesterase gene. Chemico-biological interactions. vol 87. issue 1-3. 1993-09-03. PMID:8343976.' |
acetylcholinesterase, an enzyme essential for the termination of the action of acetylcholine, is encoded by a single gene. |
1993-09-03 |
2023-08-12 |
Not clear |
| M Morales, C Sierra, A Vidal, J del Castillo, D S Smit. Pharmacological sensitivity of the articular capsule of the primary spines of Eucidaris tribuloides. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology. vol 105. issue 1. 1993-09-02. PMID:8101790. |
eserine and neostigmine potentiate the responses to acetylcholine, indicating the presence of acetylcholinesterase in the ligament. |
1993-09-02 |
2023-08-12 |
Not clear |
| W B Farms, D A Godfrey, A Askar. Effect of copper-deficient diet on metabolism in rat auditory structures. Hearing research. vol 67. issue 1-2. 1993-09-01. PMID:8101836. |
homogenates of cochlea, cochlear nucleus and inferior colliculus of rats, as well as whole brain, were assayed for activities of enzymes of oxidative and glycolytic energy metabolism--malate and lactate dehydrogenase, enzymes of acetylcholine metabolism--choline acetyltransferase and acetylcholinesterase, and concentrations of amino acids. |
1993-09-01 |
2023-08-12 |
rat |
| S A Grando, D A Kist, M Qi, M V Dah. Human keratinocytes synthesize, secrete, and degrade acetylcholine. The Journal of investigative dermatology. vol 101. issue 1. 1993-08-19. PMID:8331294. |
thus, we have demonstrated that normal human keratinocytes possess choline acetyltransferase and acetylcholinesterase, and synthesize, store, release, and degrade acetylcholine. |
1993-08-19 |
2023-08-12 |
human |
| J Hashiguchi, M Ito, I Sekin. The effect of the autonomic nervous system on cell proliferation of the gastric mucosa in stress ulcer formation. Journal of the autonomic nervous system. vol 43. issue 2. 1993-08-10. PMID:8326098. |
the acetylcholine content in the mucosa significantly decreased and the density of acetylcholinesterase (ach-e) containing fiber of mucosa remarkably increased in only wky after two hours stress exposure. |
1993-08-10 |
2023-08-12 |
rat |
| S Itabashi, T Ohrui, K Sekizawa, Y Matsuzaki, H Sasak. Peripheral airway hyperresponsiveness in the choline-deficiently fed rat. Respiration physiology. vol 92. issue 2. 1993-08-06. PMID:8327793. |
rats fed with choline-deficient diets are known as a model of aging and learning impairments due to acetylcholine (ach) deficiency in the brain which may be associated with a decrease in acetylcholinesterase (ache; ec 3.1.1.7). |
1993-08-06 |
2023-08-12 |
rat |
| Y Kawato, M Sekiguchi, K Akahane, Y Tsutomi, Y Hirota, H Kuga, W Suzuki, H Hakusui, K Sat. Inhibitory activity of camptothecin derivatives against acetylcholinesterase in dogs and their binding activity to acetylcholine receptors in rats. The Journal of pharmacy and pharmacology. vol 45. issue 5. 1993-07-22. PMID:8099964. |
inhibitory activity of camptothecin derivatives against acetylcholinesterase in dogs and their binding activity to acetylcholine receptors in rats. |
1993-07-22 |
2023-08-12 |
rat |
| Y Kawato, M Sekiguchi, K Akahane, Y Tsutomi, Y Hirota, H Kuga, W Suzuki, H Hakusui, K Sat. Inhibitory activity of camptothecin derivatives against acetylcholinesterase in dogs and their binding activity to acetylcholine receptors in rats. The Journal of pharmacy and pharmacology. vol 45. issue 5. 1993-07-22. PMID:8099964. |
in the present study, we investigated the activities of camptothecin derivatives in inhibiting acetylcholinesterase (ache) and in binding to muscarinic acetylcholine receptors (achr). |
1993-07-22 |
2023-08-12 |
rat |
| J C López-García, J Fernández-Ruiz, M L Escobar, F Bermúdez-Rattoni, R Tapi. Effects of excitotoxic lesions of the nucleus basalis magnocellularis on conditioned taste aversion and inhibitory avoidance in the rat. Pharmacology, biochemistry, and behavior. vol 45. issue 1. 1993-07-19. PMID:8100072. |
postlesion reductions of choline acetyltransferase and acetylcholinesterase activities and of k(+)-stimulated [3h]acetylcholine release were found in the insular cortex. |
1993-07-19 |
2023-08-12 |
rat |
| V Tõugu, T Kesvatera, A Lääne, A Aaviksa. Acetylcholinesterase as polyelectrolyte: interaction with multivalent cationic inhibitors. Biochimica et biophysica acta. vol 1157. issue 2. 1993-07-09. PMID:8099499. |
the zl psi+z values for the complex formation between native acetylcholinesterase and hexamethonium (zl = +2) or gallamine (zl = +3) were in quantitative agreement with those predicted by the theory making use of psi+1 = 0.50 found earlier from the influence of salts upon the hydrolysis of acetylcholine by the enzyme. |
1993-07-09 |
2023-08-12 |
Not clear |
| D R Ripoll, C H Faerman, P H Axelsen, I Silman, J L Sussma. An electrostatic mechanism for substrate guidance down the aromatic gorge of acetylcholinesterase. Proceedings of the National Academy of Sciences of the United States of America. vol 90. issue 11. 1993-07-07. PMID:8506359. |
electrostatic calculations based on the recently solved crystal structure of acetylcholinesterase (acetylcholine acetylhydrolase, ec 3.1.1.7) indicate that this enzyme has a strong electrostatic dipole. |
1993-07-07 |
2023-08-12 |
Not clear |
| A Friboulet, D Thoma. Reaction-diffusion coupling in a structured system: application to the quantitative simulation of endplate currents. Journal of theoretical biology. vol 160. issue 4. 1993-06-29. PMID:8501917. |
the transmitter acetylcholine (ach) is released at the presynaptic membrane, diffuses through the cleft where acetylcholinesterase is homogeneously distributed and then reaches the postsynaptic surface where the receptor is located. |
1993-06-29 |
2023-08-12 |
Not clear |
| L J Fuortes, A D Ayebo, B C Kros. Cholinesterase-inhibiting insecticide toxicity. American family physician. vol 47. issue 7. 1993-06-29. PMID:8503347. |
the inhibition of acetylcholinesterase causes accumulation of acetylcholine at nerve endings, resulting in a cholinergic or hypersecretory syndrome. |
1993-06-29 |
2023-08-12 |
Not clear |
| L L Butcher, J D Oh, N J Woolf, R H Edwards, A Roghan. Organization of central cholinergic neurons revealed by combined in situ hybridization histochemistry and choline-O-acetyltransferase immunocytochemistry. Neurochemistry international. vol 21. issue 3. 1993-06-24. PMID:1303168. |
it is concluded that hybridocytochemistry with digoxigenin-labeled riboprobes confirms the existence of cholinergic neurons in most of the neural regions believed to contain them on the basis of acetylcholinesterase pharmacohistochemistry and choline-o-acetyltransferase immunocytochemistry, with the prominent exceptions of the cerebral cortex, hippocampus, olfactory bulb, anterior olfactory nucleus, and caudal raphe nuclei, which apparently do not possess neurons expressing detectable levels of the mrna for the synthetic enzyme of acetylcholine. |
1993-06-24 |
2023-08-11 |
rat |
| M M el-Etri, M Ennis, M Jiang, M T Shiple. Pilocarpine-induced convulsions in rats: evidence for muscarinic receptor-mediated activation of locus coeruleus and norepinephrine release in cholinolytic seizure development. Experimental neurology. vol 121. issue 1. 1993-06-24. PMID:7684335. |
this activation was thought to be due to inhibition of acetylcholinesterase by soman, leading to rapid, sustained accumulation of acetylcholine in lc, causing these cells to fire at a high sustained rate. |
1993-06-24 |
2023-08-12 |
rat |
| S Sasho, H Obase, S Ichikawa, T Kitazawa, H Nonaka, R Yoshizaki, A Ishii, K Shut. Synthesis of 2-imidazolidinylidenepropanedinitrile derivatives as stimulators of gastrointestinal motility. Journal of medicinal chemistry. vol 36. issue 5. 1993-06-24. PMID:8496937. |
ranitidine (1), the histamine h2-receptor antagonist, has been previously reported to increase gastric emptying and gastric motility by inhibition of acetylcholinesterase (ache) and enhancement of acetylcholine (ach) release. |
1993-06-24 |
2023-08-12 |
Not clear |
| N O Sjöstrand, S D Beckett, E Kling. Nervous regulation of the tone of the retractor penis muscle in the goat. Acta physiologica Scandinavica. vol 147. issue 4. 1993-06-17. PMID:8388153. |
the noradrenaline (na) and acetylcholine (ach) content of the rp was determined, and histochemistry for adrenergic and acetylcholinesterase (ache) positive nerves was performed. |
1993-06-17 |
2023-08-12 |
Not clear |
| J R Wolff, F Joó, P Kás. Modulation by GABA of neuroplasticity in the central and peripheral nervous system. Neurochemical research. vol 18. issue 4. 1993-05-19. PMID:8474568. |
apart from postsynaptic effects, gaba inhibits acetylcholine release from preganglionic nerve terminals and changes, at least transiently, the neurochemical markers of cholinergic innervation (acetylcholinesterase and nicotinic receptors). |
1993-05-19 |
2023-08-12 |
rat |
| J Salamoun, J Remie. Indirect detection of anti-acetylcholinesterase compounds in microcolumn liquid chromatography using packed bed reactor with immobilized human red blood cell acetylcholinesterase and choline oxidase. Journal of pharmaceutical and biomedical analysis. vol 10. issue 10-12. 1993-05-07. PMID:1298399. |
a home-made packed bed microbioreactor system containing immobilized enzyme acetylcholinesterase (ache) in human red blood cell membrane and choline oxidase (cho) from alcaligenes was used for the post-column conversion of acetylcholine to hydrogen peroxide which was detected by an electrochemical detector. |
1993-05-07 |
2023-08-11 |
human |