| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M J Kubek, T M Shih, J L Meyerhof. Thyrotropin-releasing hormone (TRH) is markedly increased in the rat brain following soman-induced convulsions. Brain research. vol 747. issue 2. 1997-05-27. PMID:9046010. |
soman is an organophosphorus (op) compound which irreversibly inhibits acetylcholinesterase (ache), the primary synaptic inactivator of acetylcholine. |
1997-05-27 |
2023-08-12 |
rat |
| H M Bryson, P Benfiel. Donepezil. Drugs & aging. vol 10. issue 3. 1997-05-15. PMID:9108896. |
in vivo, donepezil inhibited acetylcholinesterase activity in human erythrocytes and increased extracellular acetylcholine levels in the cerebral cortex and hippocampus of the rat. |
1997-05-15 |
2023-08-12 |
human |
| R S Broide, M Grifman, M Shapira, D Ginzberg, H Sore. Genetic manipulations of cholinergic communication reveal trans-acting control mechanisms over acetylcholine receptors. Journal of receptor and signal transduction research. vol 17. issue 1-3. 1997-05-06. PMID:9029496. |
for example, acetylcholinesterase (ache) overexpression in microinjected xenopus tadpoles has been shown to upregulate alpha-bungarotoxin binding levels, indicating trans-acting control conferring overproduction of muscle nicotinic acetylcholine receptors. |
1997-05-06 |
2023-08-12 |
mouse |
| R S Jope, L Song, R E Power. Cholinergic activation of phosphoinositide signaling is impaired in Alzheimer's disease brain. Neurobiology of aging. vol 18. issue 1. 1997-04-03. PMID:8983039. |
similar deficits were observed in ad in the responses to five additional cholinergic agonists, including acetylcholine with three different acetylcholinesterase inhibitors. |
1997-04-03 |
2023-08-12 |
Not clear |
| P DeBoer, M J Heeringa, E D Abercrombi. Spontaneous release of acetylcholine in striatum is preferentially regulated by inhibitory dopamine D2 receptors. European journal of pharmacology. vol 317. issue 2-3. 1997-04-03. PMID:8997608. |
acetylcholine measurements were conducted in the presence of 10 nmol/l of the acetylcholinesterase inhibitor neostigmine in the microdialysis perfusate. |
1997-04-03 |
2023-08-12 |
rat |
| C P Webb, S Nedergaard, K Giles, S A Greenfiel. Involvement of the NMDA receptor in a non-cholinergic action of acetylcholinesterase in guinea-pig substantia nigra pars compacta neurons. The European journal of neuroscience. vol 8. issue 4. 1997-04-03. PMID:9081636. |
butyrylcholinesterase, a protein of similar molecular weight to acetylcholinesterase, which also hydrolyses acetylcholine, had no effect whatsoever. |
1997-04-03 |
2023-08-12 |
human |
| M G Garguilo, A C Michae. Amperometric microsensors for monitoring choline in the extracellular fluid of brain. Journal of neuroscience methods. vol 70. issue 1. 1997-04-02. PMID:8982984. |
coinjections of neostigmine and acetylcholine significantly lowered the choline response recorded with the microsensors, confirming that the response following the injections of acetylcholine alone was due to the activity of endogenous acetylcholinesterase. |
1997-04-02 |
2023-08-12 |
rat |
| L Glass-Marmor, M Chen-Zion, R Beitne. Effects of carbamylcholine and pyridostigmine on cytoskeleton-bound and cytosolic phosphofructokinase and ATP levels in different rat tissues. General pharmacology. vol 27. issue 7. 1997-04-01. PMID:8981075. |
the effects of carbamylcholine (cach) (acetylcholine agonist) and pyridostigmine (pyr) (acetylcholinesterase inhibitor), on the activity of cytoskeleton-bound and cytosolic phosphofructokinase (pfk), the rate-limiting enzyme in glycolysis, and atp levels, were studied in rat tibialis anterior (ta) muscle, heart, and brain. |
1997-04-01 |
2023-08-12 |
rat |
| G Testylier, R W Dyke. Acetylcholine release from frontal cortex in the waking rat measured by microdialysis without acetylcholinesterase inhibitors: effects of diisopropylfluorophosphate. Brain research. vol 740. issue 1-2. 1997-03-19. PMID:8973828. |
acetylcholine release from frontal cortex in the waking rat measured by microdialysis without acetylcholinesterase inhibitors: effects of diisopropylfluorophosphate. |
1997-03-19 |
2023-08-12 |
rat |
| E Giacobini, D Zhu X, E Williams, K A Sherma. The effect of the selective reversible acetylcholinesterase inhibitor E2020 on extracellular acetylcholine and biogenic amine levels in rat cortex. Neuropharmacology. vol 35. issue 2. 1997-03-05. PMID:8734490. |
the effect of the selective reversible acetylcholinesterase inhibitor e2020 on extracellular acetylcholine and biogenic amine levels in rat cortex. |
1997-03-05 |
2023-08-12 |
rat |
| H Holgert, H Lagercrantz, A Dagerlind, B K Hartman, C Cozzari, S Brimijoin, T Hökfel. Effects of immunological sympathectomy on postnatal peptide expression in the rat adrenal medulla. Brain research. Developmental brain research. vol 97. issue 1. 1997-02-27. PMID:8946057. |
administration of monoclonal antibodies against acetylcholinesterase (ache-mabs) to adult rats leads to a selective degeneration of the acetylcholine esterase-(ache), choline acetyltransferase-(chat) and enkephalin-(enk) positive preganglionic fibres of the splanchnic nerve innervating the adrenal gland. |
1997-02-27 |
2023-08-12 |
rat |
| K Yamamoto, M Shimizu, H Ohtani, M Hayashi, Y Sawada, T Ig. Toxicodynamic analysis of cardiac effects induced by four cholinesterase inhibitors in rats. The Journal of pharmacy and pharmacology. vol 48. issue 9. 1997-02-24. PMID:8910857. |
significant correlation was observed between bradycardiac ec50 values obtained by effect-compartment model analysis and inhibitory constant (ki) to acetylcholinesterase in-vitro, suggesting that the bradycardiac response was induced by inhibition of this enzyme and following elevation of acetylcholine concentration in the synaptic elect. |
1997-02-24 |
2023-08-12 |
rat |
| J Stojan, M Zork. Kinetic characterization of all steps of the interaction between acetylcholinesterase and eserine. Biochimica et biophysica acta. vol 1337. issue 1. 1997-02-21. PMID:9003439. |
the three-step carbamylenzyme mechanism of the action of eserine on acetylcholinesterase (acetylcholine acetylhydrolase, ec 3.1.1.7) has been known for a long time, but its complete kinetic characterization has never been done. |
1997-02-21 |
2023-08-12 |
Not clear |
| J J Dally, J A Temlett, S A Greenfiel. Differential release of acetylcholinesterase in vivo, from the guinea pig substantia nigra compared to the caudate putamen following dopamine depletion. Neuropharmacology. vol 35. issue 5. 1997-02-13. PMID:8887965. |
in the substantia nigra acetylcholinesterase may have a novel role unrelated to acetylcholine but linked instead to dopamine. |
1997-02-13 |
2023-08-12 |
Not clear |
| W R Schafer, B M Sanchez, C J Kenyo. Genes affecting sensitivity to serotonin in Caenorhabditis elegans. Genetics. vol 143. issue 3. 1997-02-06. PMID:8807295. |
several of these mutations have previously been shown to confer resistance to acetylcholinesterase inhibitors, suggesting that they may affect acetylcholine release. |
1997-02-06 |
2023-08-12 |
caenorhabditis_elegans |
| D O Carpenter, W M King, M J McCreer. The role of glutamate reuptake in regulation of glutamate responses in Aplysia neurons. Acta biologica Hungarica. vol 46. issue 2-4. 1997-02-03. PMID:8853707. |
these results demonstrate that the glutamate reuptake system has an important role in regulation of the responses to glutamate which is similar to that of acetylcholinesterase in regulation of responses to acetylcholine. |
1997-02-03 |
2023-08-12 |
aplysia |
| L Glass-Marmor, R Beitne. Effects of carbamylcholine and pyridostigmine on mitochondrial-bound hexokinase in skeletal muscle and heart. Biochemical and molecular medicine. vol 57. issue 1. 1997-01-24. PMID:8812728. |
we show here that carbamylcholine (acetylcholine agonist) or pyridostigmine (acetylcholinesterase inhibitor), drugs which are widely used in medical treatments, exerted a rapid reduction in mitochondrial-bound hexokinase. |
1997-01-24 |
2023-08-12 |
Not clear |
| L Glass-Marmor, R Beitne. Effects of carbamylcholine and pyridostigmine on mitochondrial-bound hexokinase in skeletal muscle and heart. Biochemical and molecular medicine. vol 57. issue 1. 1997-01-24. PMID:8812728. |
increased concentration of acetylcholine, occurring in various diseases or induced by acetylcholinesterase inhibitors, was reported to cause deterioration of mitochondrial function, resulting in heart and muscle damage. |
1997-01-24 |
2023-08-12 |
Not clear |
| C A Hawkins, S A Greenfiel. Comparison of the behavioural effects of infusion of carbachol and acetylcholinesterase into the rat substantia nigra. Pharmacology, biochemistry, and behavior. vol 55. issue 1. 1997-01-23. PMID:8870040. |
it has been postulated for many years that acetylcholinesterase (ache) may play a nonclassical role in the substantia nigra, unrelated to its ability to hydrolyse acetylcholine. |
1997-01-23 |
2023-08-12 |
rat |
| Y Loewenstein-Lichtenstein, D Glick, N Gluzman, M Sternfeld, H Zakut, H Sore. Overlapping drug interaction sites of human butyrylcholinesterase dissected by site-directed mutagenesis. Molecular pharmacology. vol 50. issue 6. 1997-01-23. PMID:8967962. |
to delineate the protein domains that are responsible for this phenomenon, we mutated residues within the rim of the active site gorge, the region parallel to the peripheral site in the homologous enzyme acetylcholinesterase [ache (acetylcholine acetyl hydrolase); ec 3.1.1.7], the oxyanion hole, and the choline-binding site. |
1997-01-23 |
2023-08-12 |
human |