| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Peng, I Silman, J Sussman, M Goeldne. Biochemical evaluation of photolabile precursors of choline and of carbamylcholine for potential time-resolved crystallographic studies on cholinesterases. Biochemistry. vol 35. issue 33. 1996-09-30. PMID:8718877. |
the unusual three-dimensional structure of acetylcholinesterase, in which the active site is located at the bottom of a deep and narrow gorge, raises cogent questions concerning traffic of the substrate, acetylcholine, and the products, choline and acetate, to and from the active site. |
1996-09-30 |
2023-08-12 |
Not clear |
| T Irie, K Fukushi, H Namba, M Iyo, H Tamagami, S Nagatsuka, N Ikot. Brain acetylcholinesterase activity: validation of a PET tracer in a rat model of Alzheimer's disease. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 37. issue 4. 1996-08-26. PMID:8691261. |
we developed three radioactive acetylcholine analogs--n[14c]methyl-4-piperidyl acetate ([14c]mp4a), propionate ([14c]mp4p) and isobutyrate ([14c]mp4ib)--as radiotracers for measuring brain acetylcholinesterase (ache) activity in vivo. |
1996-08-26 |
2023-08-12 |
rat |
| R P Driver, R D'Angelo, J C Eisenac. Bolus metoclopramide does not enhance morphine analgesia after cesarean section. Anesthesia and analgesia. vol 82. issue 5. 1996-05-24. PMID:8610862. |
we speculate that increased spinal concentrations of acetylcholine from metoclopramide-induced acetylcholinesterase inhibition is the mechanism responsible for enhanced morphine analgesia from metoclopramide. |
1996-05-24 |
2023-08-12 |
Not clear |
| C S Belfry, F B Cowa. Peptidergic and adrenergic innervation of the lachrymal gland in the euryhaline turtle, Malaclemys terrapin. The Journal of experimental zoology. vol 273. issue 5. 1996-03-12. PMID:8576694. |
there was no immunoreactivity to choline acetyltransferase, the enzyme synthesizing acetylcholine, nor did the histochemical technique for acetylcholinesterase produce positive results. |
1996-03-12 |
2023-08-12 |
Not clear |
| W Tong, E R Collantes, Y Chen, W J Wels. A comparative molecular field analysis study of N-benzylpiperidines as acetylcholinesterase inhibitors. Journal of medicinal chemistry. vol 39. issue 2. 1996-02-28. PMID:8558505. |
these compounds have been found to inhibit the metabolic breakdown of the neurotransmitter acetylcholine (ach) by the enzyme acetylcholinesterase (ache) and hence alleviate memory deficits in patients with alzheimer's disease by potentiating cholinergic transmission. |
1996-02-28 |
2023-08-12 |
human |
| M Camacho, A Agne. Schistosoma: rate of glucose import is altered by acetylcholine interaction with tegumental acetylcholine receptors and acetylcholinesterase. Experimental parasitology. vol 81. issue 4. 1996-02-13. PMID:8543000. |
schistosoma: rate of glucose import is altered by acetylcholine interaction with tegumental acetylcholine receptors and acetylcholinesterase. |
1996-02-13 |
2023-08-12 |
Not clear |
| M Camacho, A Agne. Schistosoma: rate of glucose import is altered by acetylcholine interaction with tegumental acetylcholine receptors and acetylcholinesterase. Experimental parasitology. vol 81. issue 4. 1996-02-13. PMID:8543000. |
the blood dwelling stages of schistosomes have acetylcholinesterase (ache) and nicotinic-like acetylcholine receptors (nachr) on their teguments. |
1996-02-13 |
2023-08-12 |
Not clear |
| N Kishibayashi, T Yokoyama, A Karasaw. Enhancement of defecation and distal colonic motor activity by KW-5092, a novel gastroprokinetic agent, in rats. Archives internationales de pharmacodynamie et de therapie. vol 329. issue 2. 1996-02-06. PMID:8540768. |
kw-5092 ([1-[2-[[[5-(piperidinomethyl)-2-furanyl]- methyl]amino]ethyl]-2-imidazolidinylidene]propanedinitrile fumarate) is a novel gastroprokinetic agent with acetylcholinesterase inhibitory and acetylcholine release facilitatory activity. |
1996-02-06 |
2023-08-12 |
rat |
| N Kishibayashi, T Yokoyama, A Karasaw. Enhancement of defecation and distal colonic motor activity by KW-5092, a novel gastroprokinetic agent, in rats. Archives internationales de pharmacodynamie et de therapie. vol 329. issue 2. 1996-02-06. PMID:8540768. |
the present results suggest that kw-5092 induces the defecation in rats by enhancing the distal colonic motor activity via its acetylcholinesterase inhibitory activity and/or acetylcholine release facilitatory activity. |
1996-02-06 |
2023-08-12 |
rat |
| F Tanzi, E D'Angel. Miniature endplate current kinetics at the mouse neuromuscular junction: effects of temperature and medium viscosity. The European journal of neuroscience. vol 7. issue 9. 1996-01-31. PMID:8528468. |
mathematical simulation further suggests that (i) acetylcholine diffusion kinetics may affect the onset rate of mepcs without, however, being rate-limiting; and (ii) partial, transient acetylcholinesterase inhibition operated by acetylcholine may explain the low temperature sensitivity exhibited by the onset rate of mepcs at high temperatures. |
1996-01-31 |
2023-08-12 |
mouse |
| M Schwarz, D Glick, Y Loewenstein, H Sore. Engineering of human cholinesterases explains and predicts diverse consequences of administration of various drugs and poisons. Pharmacology & therapeutics. vol 67. issue 2. 1996-01-11. PMID:7494866. |
the acetylcholine hydrolyzing enzyme, acetylcholinesterase, primarily functions in nerve conduction, yet it appears in several guises, due to tissue-specific expression, alternative mrna splicing and variable aggregation modes. |
1996-01-11 |
2023-08-12 |
human |
| A A Aljafar. Kinetics for the inhibition of acetylcholinesterase from human erythrocyte by cisplatin. The international journal of biochemistry & cell biology. vol 27. issue 9. 1995-12-26. PMID:7584632. |
since acetylcholine plays a key role in human neurotransmission we characterized the inhibitory effect of cisplatin on the enzyme, acetylcholinesterase. |
1995-12-26 |
2023-08-12 |
human |
| D Julka, R Sandhir, K D Gil. Altered cholinergic metabolism in rat CNS following aluminum exposure: implications on learning performance. Journal of neurochemistry. vol 65. issue 5. 1995-12-04. PMID:7595502. |
al, at a dose of 10 mg/kg of body weight/day for 4 weeks, had a deleterious effect on the activities of biosynthetic (choline acetyltransferase) and hydrolytic (acetylcholinesterase) enzymes of the neurotransmitter acetylcholine. |
1995-12-04 |
2023-08-12 |
rat |
| L A Smith, M A Olson, P J Lafaye, J O Doll. Cloning and expression of mamba toxins. Toxicon : official journal of the International Society on Toxinology. vol 33. issue 4. 1995-11-20. PMID:7570631. |
of the mamba toxins studied to date, many act on voltage-sensitive k+ channels, nicotinic or muscarinic acetylcholine receptors, or acetylcholinesterase. |
1995-11-20 |
2023-08-12 |
cattle |
| A Wawrzeńczyk, K A Nałecz, M J Nałec. Effect of externally added carnitine on the synthesis of acetylcholine in rat cerebral cortex cells. Neurochemistry international. vol 26. issue 6. 1995-10-17. PMID:7670366. |
acetylcholine synthesis was found much higher in suckling animals, both in the absence and presence of acetylcholinesterase (acetylcholine hydrolase, ec 3.1.1.7) inhibitor, paraoxon. |
1995-10-17 |
2023-08-12 |
rat |
| Geoffrey D Robson, Marilyn G Wiebe, Bryan Cunliffe, Anthony P J Trinc. Choline- and acetylcholine-induced changes in the morphology of Fusarium graminearum: evidence for the involvement of the choline transport system and acetylcholinesterase. Microbiology (Reading, England). vol 141 ( Pt 6). 1995-10-13. PMID:7670634. |
acetylcholinesterase inhibitors blocked the morphological response to acetylcholine but had no effect on the response to choline, suggesting the presence of a membrane- or wall-bound acetylcholinesterase that hydrolyses acetylcholine to choline which subsequently induces the morphological response. |
1995-10-13 |
2023-08-12 |
Not clear |
| C Brennan, L P Henderso. Androgen regulation of neuromuscular junction structure and function in a sexually dimorphic muscle of the frog Xenopus laevis. Journal of neurobiology. vol 27. issue 2. 1995-10-02. PMID:7658199. |
in amphibians, the expression of functionally distinct acetylcholine (ach) receptors, the levels of acetylcholinesterase (ache), the extent of multiple innervation, and the structure of individual end plates vary with the contractile properties of the muscle fibers. |
1995-10-02 |
2023-08-12 |
human |
| M Mazier. Cholinergic neurotransmission studied in vivo using positron emission tomography or single photon emission computerized tomography. Pharmacology & therapeutics. vol 66. issue 1. 1995-09-07. PMID:7630931. |
the main cholinergic radioligands, labelled with positron- or gamma-photon-emitting radionuclides, are reviewed with respect to use as in vivo markers of either acetylcholinesterase, vesicular acetylcholine transporter, brain and heart muscarinic receptors, or cholinergic nicotinic receptors. |
1995-09-07 |
2023-08-12 |
Not clear |
| J B Hutchins, J M Bernanke, V E Jefferso. Acetylcholinesterase in the developing ferret retina. Experimental eye research. vol 60. issue 2. 1995-07-14. PMID:7781740. |
the function of acetylcholinesterase (ache) is to terminate the action of acetylcholine at the cholinergic synapse. |
1995-07-14 |
2023-08-12 |
Not clear |
| R E Davis, P D Doyle, R T Carroll, M R Emmerling, J Jae. Cholinergic therapies for Alzheimer's disease. Palliative or disease altering? Arzneimittel-Forschung. vol 45. issue 3A. 1995-06-29. PMID:7763338. |
this can be accomplished by enhancing endogenous levels of acetylcholine (ach) through inhibition of its degradation by acetylcholinesterase on by directly mimicking its actions at postsynaptic muscarinic receptors. |
1995-06-29 |
2023-08-12 |
human |