| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christopher D Herzog, Kelly A Nowak, Martin Sarter, John P Brun. Microdialysis without acetylcholinesterase inhibition reveals an age-related attenuation in stimulated cortical acetylcholine release. Neurobiology of aging. vol 24. issue 6. 2003-10-29. PMID:12927768. |
microdialysis without acetylcholinesterase inhibition reveals an age-related attenuation in stimulated cortical acetylcholine release. |
2003-10-29 |
2023-08-12 |
rat |
| I Amy Bany, Meng-Qiu Dong, Michael R Koell. Genetic and cellular basis for acetylcholine inhibition of Caenorhabditis elegans egg-laying behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 22. 2003-10-02. PMID:12954868. |
in addition, increasing synaptic acetylcholine by reducing acetylcholinesterase activity, with either mutations or the inhibitor aldicarb, decreased egg laying. |
2003-10-02 |
2023-08-12 |
caenorhabditis_elegans |
| Sultan Darvesh, David A Hopkin. Differential distribution of butyrylcholinesterase and acetylcholinesterase in the human thalamus. The Journal of comparative neurology. vol 463. issue 1. 2003-08-29. PMID:12811800. |
it has been hypothesized that acetylcholinesterase (ache) and butyrylcholinesterase (buche) are coregulators of the duration of action of acetylcholine in cholinergic neurotransmission, suggesting that buche may also have an important role in the brain. |
2003-08-29 |
2023-08-12 |
human |
| Edgar Luttmann, Elmar Linnemann, Gregor Fel. Galanthamine as bis-functional ligand for the acetylcholinesterase. Journal of molecular modeling. vol 8. issue 6. 2003-08-18. PMID:12140604. |
acetylcholinesterase plays a key role in the development of alzheimer's disease as this enzyme is responsible for cleavage of the neurotransmitter acetylcholine, and, according to recent investigations, also promotes aggregation of beta-amyloid peptides, which causes plaque formation in synaptic areas. |
2003-08-18 |
2023-08-12 |
Not clear |
| Susana G Rossi, Ian M Dickerson, Richard L Rotund. Localization of the calcitonin gene-related peptide receptor complex at the vertebrate neuromuscular junction and its role in regulating acetylcholinesterase expression. The Journal of biological chemistry. vol 278. issue 27. 2003-08-18. PMID:12707285. |
together, these studies suggest a specific role for cgrp released by spinal cord motoneurons in modulating synaptic transmission at the neuromuscular junction by locally inhibiting the expression of acetylcholinesterase, the enzyme responsible for terminating acetylcholine neurotransmission. |
2003-08-18 |
2023-08-12 |
Not clear |
| Vladimir Piotrovsky, Achiel Van Peer, Nancy Van Osselaer, Martin Armstrong, Jeroen Aerssen. Galantamine population pharmacokinetics in patients with Alzheimer's disease: modeling and simulations. Journal of clinical pharmacology. vol 43. issue 5. 2003-08-18. PMID:12751272. |
galantamine is a reversible, competitive inhibitor of acetylcholinesterase and an allosteric modulator of nicotinic acetylcholine receptors. |
2003-08-18 |
2023-08-12 |
Not clear |
| Kaustubha D Patil, Robin A Buerki, Popat N Pati. Potentiation of acetylcholine action by huperzine-A and physostigmine on some vertebrate effectors, including human iris sphincter muscle. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. vol 19. issue 2. 2003-08-07. PMID:12804058. |
the main objective of this investigation was to compare the acetylcholine potentiating action of huperzine-a with acetylcholinesterase inhibitor physostigmine on the frog rectus abdominus muscle, rat phrenic nerve diaphragm preparation, guinea pig ileum and human iris sphincter muscle. |
2003-08-07 |
2023-08-12 |
human |
| H L Fernandez, M Chen, I Nadelhaft, J A Dur. Calcitonin gene-related peptides: their binding sites and receptor accessory proteins in adult mammalian skeletal muscles. Neuroscience. vol 119. issue 2. 2003-07-30. PMID:12770550. |
thus, gracilis muscles express cgrpalpha-specific binding sites which are predominantly localized in the muscle's motor endplate regions where ramp1, rcp, cgrpalpha, acetylcholine receptors, and acetylcholinesterase are detected in high concentrations. |
2003-07-30 |
2023-08-12 |
rat |
| H L Fernandez, M Chen, I Nadelhaft, J A Dur. Calcitonin gene-related peptides: their binding sites and receptor accessory proteins in adult mammalian skeletal muscles. Neuroscience. vol 119. issue 2. 2003-07-30. PMID:12770550. |
when considered together with earlier studies on the same neuromuscular preparation, the present work further suggests that the motoneuron-dependent trophic control of acetylcholine receptors and acetylcholinesterase in skeletal muscle endplates is partly mediated by nerve-derived cgrpalpha activating specific receptors which are highly sensitive to the truncated peptide hcgrp8-37. |
2003-07-30 |
2023-08-12 |
rat |
| Jonathan R Genzen, Daniel S McGehe. Short- and long-term enhancement of excitatory transmission in the spinal cord dorsal horn by nicotinic acetylcholine receptors. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 11. 2003-07-16. PMID:12748382. |
inhibition of acetylcholinesterase with methamidophos also enhanced transmission, demonstrating a similar effect of endogenous acetylcholine. |
2003-07-16 |
2023-08-12 |
rat |
| Nigel H Greig, Debomoy K Lahiri, Kumar Sambamurt. Butyrylcholinesterase: an important new target in Alzheimer's disease therapy. International psychogeriatrics. vol 14 Suppl 1. 2003-07-03. PMID:12636181. |
acetylcholinesterase (ache) predominates in the healthy brain, with butyrylcholinesterase (buche) considered to play a minor role in regulating brain acetylcholine (ach) levels. |
2003-07-03 |
2023-08-12 |
Not clear |
| Marko Golicnik, Jure Stoja. Transient kinetic approach to the study of acetylcholinesterase reversible inhibition by eseroline. Journal of enzyme inhibition and medicinal chemistry. vol 17. issue 5. 2003-06-17. PMID:12683744. |
the kinetic rate constants for interaction of (-)-eseroline-(3as-cis)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo-[2,3-b]indol-5-ol with electric eel acetylcholinesterase (ec 3.1.1.7, acetylcholine acetylhydrolase) were measured at a low substrate concentration according to a transient kinetic approach by using a rapid experimental technique. |
2003-06-17 |
2023-08-12 |
Not clear |
| J Arredondo, L L Hall, A Ndoye, A I Chernyavsky, D L Jolkovsky, S A Grand. Muscarinic acetylcholine receptors regulating cell cycle progression are expressed in human gingival keratinocytes. Journal of periodontal research. vol 38. issue 1. 2003-06-10. PMID:12558941. |
we have previously reported the presence in human gingival keratinocytes (gkc) of choline acetyltransferase, the acetylcholine (ach) synthesizing enzyme, acetylcholinesterase, the ach degrading enzyme, and alpha 3, alpha 5, alpha 7, beta 2 as well as alpha 9 nicotinic ach receptor subunits. |
2003-06-10 |
2023-08-12 |
human |
| Victoria Zarotsky, John J Sramek, Neal R Cutle. Galantamine hydrobromide: an agent for Alzheimer's disease. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. vol 60. issue 5. 2003-06-03. PMID:12635450. |
galantamine acts both as a reversible competitive inhibitor of acetylcholinesterase (ache) and as an allosteric modulator of nicotinic acetylcholine receptors. |
2003-06-03 |
2023-08-12 |
Not clear |
| Masahiro Fujita, Mohammed S Al-Tikriti, Gilles Tamagnan, Sami S Zoghbi, Ali Bozkurt, Ronald M Baldwin, Robert B Inni. Influence of acetylcholine levels on the binding of a SPECT nicotinic acetylcholine receptor ligand [123I]5-I-A-85380. Synapse (New York, N.Y.). vol 48. issue 3. 2003-05-30. PMID:12645036. |
the purpose of this study was to determine whether increases in acetylcholine (ach) levels induced by an acetylcholinesterase inhibitor, physostigmine, inhibit in vivo binding of [(123)i]5-iodo-3-(2(s)-2-azetidinyl-methoxy) pyridine (5-i-a-85380), a single photon emission computed tomography ligand for the high-affinity type nicotinic ach receptor (nachr). |
2003-05-30 |
2023-08-12 |
Not clear |
| H J Bennett, T D White, K Semb. Activation of cholinergic and adrenergic receptors increases the concentration of extracellular adenosine in the cerebral cortex of unanesthetized rat. Neuroscience. vol 117. issue 1. 2003-05-21. PMID:12605898. |
both acetylcholine and the acetylcholinesterase inhibitor neostigmine increased extracellular adenosine levels, and the effect of neostigmine was blocked by the nicotinic receptor antagonist mecamylamine. |
2003-05-21 |
2023-08-12 |
rat |
| D S Woodruff-Pak, R W Vogel, G L Wen. Mecamylamine interactions with galantamine and donepezil: effects on learning, acetylcholinesterase, and nicotinic acetylcholine receptors. Neuroscience. vol 117. issue 2. 2003-05-21. PMID:12614684. |
mecamylamine interactions with galantamine and donepezil: effects on learning, acetylcholinesterase, and nicotinic acetylcholine receptors. |
2003-05-21 |
2023-08-12 |
Not clear |
| Sultan Darvesh, Ryan Walsh, Earl Marti. Enantiomer effects of huperzine A on the aryl acylamidase activity of human cholinesterases. Cellular and molecular neurobiology. vol 23. issue 1. 2003-05-20. PMID:12701885. |
acetylcholinesterase (ache, ec 3.1.1.7) and butyrylcholinesterase (buche, ec 3.1.1.8) are serine hydrolase enzymes that catalyze the hydrolysis of acetylcholine. |
2003-05-20 |
2023-08-12 |
human |
| S S STEIN, D E KOSHLAN. Mechanism of hydrolysis of acetylcholine catalyzed by acetylcholinesterase and by hydroxide ion. Archives of biochemistry and biophysics. vol 45. issue 2. 2003-05-01. PMID:13081156. |
mechanism of hydrolysis of acetylcholine catalyzed by acetylcholinesterase and by hydroxide ion. |
2003-05-01 |
2023-08-12 |
Not clear |
| I SPADOLINI, A GIACHETT. [The action of acetylcholinesterase in the demonstration of the diphasic effect of acetylcholine on the amphibian heart]. Bollettino della Societa italiana di biologia sperimentale. vol 29. issue 3. 2003-05-01. PMID:13081853. |
[the action of acetylcholinesterase in the demonstration of the diphasic effect of acetylcholine on the amphibian heart]. |
2003-05-01 |
2023-08-12 |
Not clear |