| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yan Qi Liang, Xi Can Tan. Comparative effects of huperzine A, donepezil and rivastigmine on cortical acetylcholine level and acetylcholinesterase activity in rats. Neuroscience letters. vol 361. issue 1-3. 2004-08-30. PMID:15135892. |
the time courses of cortical acetylcholinesterase inhibition with middle doses of these agents mirrored the increases of acetylcholine at the same doses. |
2004-08-30 |
2023-08-12 |
rat |
| Yan Qi Liang, Xi Can Tan. Comparative effects of huperzine A, donepezil and rivastigmine on cortical acetylcholine level and acetylcholinesterase activity in rats. Neuroscience letters. vol 361. issue 1-3. 2004-08-30. PMID:15135892. |
however, acetylcholinesterase inhibition was disproportionately greater after middle dose of rivastigmine than doses of huperzine a and donepezil that increased acetylcholine to a similar extent. |
2004-08-30 |
2023-08-12 |
rat |
| David G Wilkinson, Paul T Francis, Elias Schwam, Jennifer Payne-Parris. Cholinesterase inhibitors used in the treatment of Alzheimer's disease: the relationship between pharmacological effects and clinical efficacy. Drugs & aging. vol 21. issue 7. 2004-08-27. PMID:15132713. |
the common mechanism of action underlying this class of agents is an increase in available acetylcholine through inhibition of the catabolic enzyme, acetylcholinesterase. |
2004-08-27 |
2023-08-12 |
Not clear |
| José L Arreola, Mario H Vargas, Patricia Segura, Jaime Chávez, Bettina Sommer, Verónica Carvajal, Luis M Montañ. Possible role of substance P in the ischemia-reperfusion injury in the isolated rabbit lung. Transplantation. vol 78. issue 2. 2004-08-18. PMID:15280694. |
thus, in isolated rabbit lungs preserved over 24 hours, we evaluated the release of acetylcholine (ach) and substance p (sp), the activity of their major degrading enzymes, acetylcholinesterase (ache) and neutral endopeptidase (nep), and changes in the capillary permeability. |
2004-08-18 |
2023-08-12 |
rabbit |
| Lun-Yi Zang, Hara P Misr. Inactivation of acetylcholinesterase by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride. Molecular and cellular biochemistry. vol 254. issue 1-2. 2004-08-04. PMID:14674691. |
these data suggest that once mptp enters the basal ganglia of the brain, it can inactivate the acetylcholinesterase enzyme and thereby increase the acetylcholine level in the basal ganglia of brain, leading to potential cell dysfunction. |
2004-08-04 |
2023-08-12 |
Not clear |
| Mohamed B Abou-Doni. Organophosphorus ester-induced chronic neurotoxicity. Archives of environmental health. vol 58. issue 8. 2004-07-29. PMID:15259428. |
the primary action is the irreversible inhibition of acetylcholinesterase, resulting in the accumulation of acetylcholine and subsequent overstimulation of the nicotinic and muscarinic acetylcholine receptors, resulting in cholinergic effects. |
2004-07-29 |
2023-08-12 |
human |
| Jeremy Kua, Yingkai Zhang, Angelique C Eslami, John R Butler, J Andrew McCammo. Studying the roles of W86, E202, and Y337 in binding of acetylcholine to acetylcholinesterase using a combined molecular dynamics and multiple docking approach. Protein science : a publication of the Protein Society. vol 12. issue 12. 2004-07-14. PMID:14627729. |
studying the roles of w86, e202, and y337 in binding of acetylcholine to acetylcholinesterase using a combined molecular dynamics and multiple docking approach. |
2004-07-14 |
2023-08-12 |
Not clear |
| Jeremy Kua, Yingkai Zhang, Angelique C Eslami, John R Butler, J Andrew McCammo. Studying the roles of W86, E202, and Y337 in binding of acetylcholine to acetylcholinesterase using a combined molecular dynamics and multiple docking approach. Protein science : a publication of the Protein Society. vol 12. issue 12. 2004-07-14. PMID:14627729. |
a combined molecular dynamics simulation and multiple ligand docking approach is applied to study the roles of the anionic subsite residues (w86, e202, y337) in the binding of acetylcholine (ach) to acetylcholinesterase (ache). |
2004-07-14 |
2023-08-12 |
Not clear |
| Gerald B Downes, Michael Granat. Acetylcholinesterase function is dispensable for sensory neurite growth but is critical for neuromuscular synapse stability. Developmental biology. vol 270. issue 1. 2004-07-02. PMID:15136152. |
the enzyme acetylcholinesterase (ache) terminates synaptic transmission at cholinergic synapses by hydrolyzing the neurotransmitter acetylcholine. |
2004-07-02 |
2023-08-12 |
zebrafish |
| Peter Eye. The role of oximes in the management of organophosphorus pesticide poisoning. Toxicological reviews. vol 22. issue 3. 2004-06-22. PMID:15181665. |
ops act primarily by inhibiting acetylcholinesterase (ache), thereby allowing acetylcholine to accumulate at cholinergic synapses, disturbing transmission at parasympathetic nerve endings, sympathetic ganglia, neuromuscular endplates and certain cns regions. |
2004-06-22 |
2023-08-12 |
human |
| Jure Stojan, Laure Brochier, Carole Alies, Jacques Philippe Colletier, Didier Fournie. Inhibition of Drosophila melanogaster acetylcholinesterase by high concentrations of substrate. European journal of biochemistry. vol 271. issue 7. 2004-05-21. PMID:15030487. |
acetylcholine hydrolysis by acetylcholinesterase is inhibited at high substrate concentrations. |
2004-05-21 |
2023-08-12 |
drosophila_melanogaster |
| Kwok-On Lai, Yu Chen, Hoi-Man Po, Ka-Chun Lok, Ke Gong, Nancy Y I. Identification of the Jak/Stat proteins as novel downstream targets of EphA4 signaling in muscle: implications in the regulation of acetylcholinesterase expression. The Journal of biological chemistry. vol 279. issue 14. 2004-05-11. PMID:14729671. |
by using microarray analysis, we have identified acetylcholinesterase, the critical enzyme that hydrolyzed the neurotransmitter acetylcholine at the nmj, as a downstream target gene of the jak/stat pathway in muscle. |
2004-05-11 |
2023-08-12 |
mouse |
| Fernando Sánchez-Santed, Fernando Cañadas, Pilar Flores, Matilde López-Grancha, Diana Cardon. Long-term functional neurotoxicity of paraoxon and chlorpyrifos: behavioural and pharmacological evidence. Neurotoxicology and teratology. vol 26. issue 2. 2004-05-10. PMID:15019964. |
the major mechanism of acute toxic action is the inhibition of acetylcholinesterase (ache), which is responsible for the degradation of the neurotransmitter acetylcholine. |
2004-05-10 |
2023-08-12 |
Not clear |
| Tsutomu Nakahara, Yuko Kubota, Kenji Sakamoto, Kunio Ishi. The role of cholinesterases in rat urinary bladder contractility. Urological research. vol 31. issue 3. 2004-05-06. PMID:12736766. |
this study examines the effects of inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (buche) on acetylcholine (ach)-induced contraction in rat urinary bladder smooth muscle. |
2004-05-06 |
2023-08-12 |
rat |
| Esperanza Arias, Eva Alés, Nelson H Gabilan, María F Cano-Abad, Mercedes Villarroya, Antonio G García, Manuela G Lópe. Galantamine prevents apoptosis induced by beta-amyloid and thapsigargin: involvement of nicotinic acetylcholine receptors. Neuropharmacology. vol 46. issue 1. 2004-04-05. PMID:14654102. |
galantamine is currently used to treat alzheimer's disease patients; it behaves as a mild blocker of acetylcholinesterase (ache) and has an allosteric modulating action on nicotinic acetylcholine receptors (nachrs). |
2004-04-05 |
2023-08-12 |
human |
| L R Fodero, S S Mok, D Losic, L L Martin, M I Aguilar, C J Barrow, B G Livett, D H Smal. Alpha7-nicotinic acetylcholine receptors mediate an Abeta(1-42)-induced increase in the level of acetylcholinesterase in primary cortical neurones. Journal of neurochemistry. vol 88. issue 5. 2004-03-30. PMID:15009674. |
alpha7-nicotinic acetylcholine receptors mediate an abeta(1-42)-induced increase in the level of acetylcholinesterase in primary cortical neurones. |
2004-03-30 |
2023-08-12 |
mouse |
| Richard T Reid, Marwan N Sabbag. Effects of donepezil treatment on rat nicotinic acetylcholine receptor levels in vivo and in vitro. Journal of Alzheimer's disease : JAD. vol 5. issue 6. 2004-03-25. PMID:14757932. |
research on acetylcholinesterase inhibitors (cheis) indicates that long term exposure increases the level of nicotinic acetylcholine receptors (nachrs) but the effects of donepezil on nachrs are not well studied. |
2004-03-25 |
2023-08-12 |
rat |
| Peter Kasa, Henrietta Papp, Peter Kasa, Magdolna Pakaski, Lajos Balaspir. Effects of amyloid-beta on cholinergic and acetylcholinesterase-positive cells in cultured basal forebrain neurons of embryonic rat brain. Brain research. vol 998. issue 1. 2004-03-22. PMID:14725970. |
the cholinergic neurons and their axon terminals were revealed by vesicular acetylcholine transporter immunohistochemistry and the cholinoceptive cells by acetylcholinesterase histochemical staining. |
2004-03-22 |
2023-08-12 |
rat |
| T Day, S A Greenfiel. A peptide derived from acetylcholinesterase induces neuronal cell death: characterisation of possible mechanisms. Experimental brain research. vol 153. issue 3. 2004-02-26. PMID:13680041. |
acetylcholinesterase (ache) exhibits functions unrelated to the catalysis of acetylcholine (ach) in particular during development. |
2004-02-26 |
2023-08-12 |
rat |
| Koichiro Kawashima, Takeshi Fuji. The lymphocytic cholinergic system and its contribution to the regulation of immune activity. Life sciences. vol 74. issue 6. 2004-02-11. PMID:14654162. |
lymphocytes express most of the cholinergic components found in the nervous system, including acetylcholine (ach), choline acetyltransferase (chat), high affinity choline transporter, muscarinic and nicotinic ach receptors (machrs and nachrs, respectively), and acetylcholinesterase. |
2004-02-11 |
2023-08-12 |
Not clear |