| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Toshiaki Kume, Mitsuhiro Sugimoto, Yuki Takada, Toshiaki Yamaguchi, Atsushi Yonezawa, Hiroshi Katsuki, Hachiro Sugimoto, Akinori Akaik. Up-regulation of nicotinic acetylcholine receptors by central-type acetylcholinesterase inhibitors in rat cortical neurons. European journal of pharmacology. vol 527. issue 1-3. 2006-02-08. PMID:16313899. |
we previously reported that donepezil, a central-type acetylcholinesterase inhibitor, showed neuroprotective action via alpha4-and alpha7-nicotinic acetylcholine receptors against glutamate neurotoxicity in rat cortical culture. |
2006-02-08 |
2023-08-12 |
rat |
| Francesca Borrelli, Inmaculada Posadas, Raffaele Capasso, Gabriella Aviello, Valeria Ascione, Francesco Capass. Effect of caffeic acid phenethyl ester on gastric acid secretion in vitro. European journal of pharmacology. vol 521. issue 1-3. 2006-01-25. PMID:16183057. |
our results show that cape increases gastric acid secretion stimulated by an acetylcholine agonist receptor likely through inhibition of acetylcholinesterase activity. |
2006-01-25 |
2023-08-12 |
mouse |
| Yehudit Hasin, Nili Avidan, Dani Bercovich, Amos D Korczyn, Israel Silman, Jacques S Beckmann, Joel L Sussma. Analysis of genetic polymorphisms in acetylcholinesterase as reflected in different populations. Current Alzheimer research. vol 2. issue 2. 2006-01-18. PMID:15974920. |
acetylcholinesterase (ache) plays a crucial physiological role in termination of impulse transmission at cholinergic synapses through rapid hydrolysis of acetylcholine. |
2006-01-18 |
2023-08-12 |
human |
| Nigel H Greig, Tadanobu Utsuki, Donald K Ingram, Yue Wang, Giancarlo Pepeu, Carla Scali, Qian-Sheng Yu, Jacek Mamczarz, Harold W Holloway, Tony Giordano, DeMao Chen, Katsutoshi Furukawa, Kumar Sambamurti, Arnold Brossi, Debomoy K Lahir. Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 47. 2006-01-12. PMID:16275899. |
like acetylcholinesterase, butyrylcholinesterase (bche) inactivates the neurotransmitter acetylcholine (ach) and is hence a viable therapeutic target in alzheimer's disease, which is characterized by a cholinergic deficit. |
2006-01-12 |
2023-08-12 |
mouse |
| Filomena A Carvalho, Luís M Graça, João Martins-Silva, Carlota Saldanh. Biochemical characterization of human umbilical vein endothelial cell membrane bound acetylcholinesterase. The FEBS journal. vol 272. issue 21. 2005-12-13. PMID:16262697. |
acetylcholinesterase is an enzyme whose best-known function is to hydrolyze the neurotransmitter acetylcholine. |
2005-12-13 |
2023-08-12 |
human |
| Jacques Barik, Federico Dajas-Bailador, Susan Wonnacot. Cellular responses to nicotinic receptor activation are decreased after prolonged exposure to galantamine in human neuroblastoma cells. British journal of pharmacology. vol 145. issue 8. 2005-12-02. PMID:15937519. |
in this study, we have examined cellular responses of neuroblastoma sh-sy5y cells after chronic treatment with galantamine, a drug used to treat alzheimer's disease that has a dual mechanism of action: inhibition of acetylcholinesterase and allosteric potentiation of nicotinic acetylcholine receptors (nachr). |
2005-12-02 |
2023-08-12 |
human |
| Horst Thiermann, Peter Eyer, Franz Worek, Ladislaus Szinic. Effects of oximes on muscle force and acetylcholinesterase activity in isolated mouse hemidiaphragms exposed to paraoxon. Toxicology. vol 214. issue 3. 2005-11-21. PMID:16040183. |
toxicity of organophosphates (op) is caused by inhibition of acetylcholinesterase (ache), resulting in accumulation of acetylcholine. |
2005-11-21 |
2023-08-12 |
mouse |
| Claudia L Barthold, Joshua G Schie. Organic phosphorus compounds--nerve agents. Critical care clinics. vol 21. issue 4. 2005-11-15. PMID:16168308. |
the major mechanism of opc toxicity is through inhibition of acetylcholinesterase in neuronal synapses leading to excess acetylcholine and overstimulation of target organs. |
2005-11-15 |
2023-08-12 |
Not clear |
| J Mokrý, M Jakubesová, J Svihra, J Urdzik, M Hudec, G Nosálová, J Klimen. Reactivity of urinary bladder smooth muscle in guinea pigs to acetylcholine and carbachol--participation of acetylcholinesterase. Physiological research. vol 54. issue 4. 2005-10-19. PMID:15588146. |
reactivity of urinary bladder smooth muscle in guinea pigs to acetylcholine and carbachol--participation of acetylcholinesterase. |
2005-10-19 |
2023-08-12 |
Not clear |
| Chang-Seon Myung, Hyeon-Cheol Shin, Hai Ying Bao, Soo Jeong Yeo, Bong Ho Lee, Jong Seong Kan. Improvement of memory by dieckol and phlorofucofuroeckol in ethanol-treated mice: possible involvement of the inhibition of acetylcholinesterase. Archives of pharmacal research. vol 28. issue 6. 2005-09-22. PMID:16042079. |
overall, the memory-enhancing abilities of dieckol and pff may result from, at least in part, the increment of the brain level of acetylcholine by inhibiting acetylcholinesterase. |
2005-09-22 |
2023-08-12 |
mouse |
| Mario Roberto Senger, Eduardo Pacheco Rico, Marcelo de Bem Arizi, Denis Broock Rosemberg, Renato Dutra Dias, Maurício Reis Bogo, Carla Denise Bona. Carbofuran and malathion inhibit nucleotide hydrolysis in zebrafish (Danio rerio) brain membranes. Toxicology. vol 212. issue 2-3. 2005-09-16. PMID:15951093. |
since acetylcholine and atp are co-released at the synapse and the acetylcholinesterase inhibition is an important target for pesticide action, here we verified the effect of exposure in vitro and in vivo to carbofuran and malathion on ectonucleotidase activities from brain membranes of zebrafish. |
2005-09-16 |
2023-08-12 |
zebrafish |
| Xia Liu, Sandeep Sood, Hattie Liu, Richard L Horne. Opposing muscarinic and nicotinic modulation of hypoglossal motor output to genioglossus muscle in rats in vivo. The Journal of physiology. vol 565. issue Pt 3. 2005-09-12. PMID:15817635. |
eserine, an acetylcholinesterase inhibitor, also decreased the amplitude of respiratory-related gg activity (36.4 +/- 11.3% at 1.0 microm) indicating that endogenous acetylcholine modulates gg activity. |
2005-09-12 |
2023-08-12 |
rat |
| Israel Silman, Joel L Sussma. Acetylcholinesterase: 'classical' and 'non-classical' functions and pharmacology. Current opinion in pharmacology. vol 5. issue 3. 2005-09-08. PMID:15907917. |
the synaptic enzyme acetylcholinesterase (ache) terminates transmission at cholinergic synapses by rapidly hydrolysing acetylcholine. |
2005-09-08 |
2023-08-12 |
Not clear |
| Stevan R Emmett, Susan A Greenfiel. Correlation between dopaminergic neurons, acetylcholinesterase and nicotinic acetylcholine receptors containing the alpha3- or alpha5-subunit in the rat substantia nigra. Journal of chemical neuroanatomy. vol 30. issue 1. 2005-09-06. PMID:15975762. |
correlation between dopaminergic neurons, acetylcholinesterase and nicotinic acetylcholine receptors containing the alpha3- or alpha5-subunit in the rat substantia nigra. |
2005-09-06 |
2023-08-12 |
rat |
| Nancy S Foldi, Richard E C White, Lynn A Schaefe. Detecting effects of donepezil on visual selective attention using signal detection parameters in Alzheimer's disease. International journal of geriatric psychiatry. vol 20. issue 5. 2005-08-29. PMID:15852461. |
but, despite the widespread use of acetylcholinesterase inhibitors (ache-i) to augment available acetylcholine in ad, measures of attentional function have not been used to assess the drug response. |
2005-08-29 |
2023-08-12 |
Not clear |
| Paul A Dabisch, David C Burnett, Dennis B Miller, Edward M Jakubowski, William T Muse, Jeffry S Forster, Jacqueline A Scotto, Jill R Jarvis, Emily A Davis, Stanley W Hulet, Sharon A Reutter, Robert J Mioduszewski, Sandra A Thomso. Tolerance to the miotic effect of sarin vapor in rats after multiple low-level exposures. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. vol 21. issue 3. 2005-08-26. PMID:15969635. |
inhibition of acetylcholinesterase (ache) by the organophosphorous compound sarin (gb) results in the accumulation of acetylcholine and excessive cholinergic stimulation. |
2005-08-26 |
2023-08-12 |
rat |
| Marcella Reale, Carla Iarlori, Francesco Gambi, Isabella Lucci, Mirella Salvatore, Domenico Gamb. Acetylcholinesterase inhibitors effects on oncostatin-M, interleukin-1 beta and interleukin-6 release from lymphocytes of Alzheimer's disease patients. Experimental gerontology. vol 40. issue 3. 2005-08-25. PMID:15763393. |
one strategy for treatment of ad has been to use acetylcholinesterase (ache) inhibitors to increase the levels of acetylcholine and enhancing cholinergic activity in the affected regions of the brain. |
2005-08-25 |
2023-08-12 |
Not clear |
| Fernando Cañadas, Diana Cardona, Eva Dávila, Fernando Sánchez-Sante. Long-term neurotoxicity of chlorpyrifos: spatial learning impairment on repeated acquisition in a water maze. Toxicological sciences : an official journal of the Society of Toxicology. vol 85. issue 2. 2005-08-18. PMID:15772369. |
their major mechanism of acute toxic action is the inhibition of acetylcholinesterase, which is responsible for the degradation of the neurotransmitter acetylcholine. |
2005-08-18 |
2023-08-12 |
rat |
| Yehudit Hasin, Nili Avidan, Dani Bercovich, Amos Korczyn, Israel Silman, Jacques S Beckmann, Joel L Sussma. A paradigm for single nucleotide polymorphism analysis: the case of the acetylcholinesterase gene. Human mutation. vol 24. issue 5. 2005-07-29. PMID:15459952. |
acetylcholinesterase (ache) plays a crucial physiological role in termination of impulse transmission at cholinergic synapses through rapid hydrolysis of acetylcholine. |
2005-07-29 |
2023-08-12 |
human |
| Hiroto Tachikawa, Manabu Igarashi, Jun Nishihira, Teruo Ishibash. Ab initio model study on acetylcholinesterase catalysis: potential energy surfaces of the proton transfer reactions. Journal of photochemistry and photobiology. B, Biology. vol 79. issue 1. 2005-07-29. PMID:15792875. |
ab initio molecular orbital (mo) and hybrid density functional theory (dft) calculations have been applied to the initial step of the acylation reaction catalyzed by acetylcholinesterase (ache), which is the nucleophiric addition of ser200 in catalytic triads to a neurotransmitter acetylcholine (ach). |
2005-07-29 |
2023-08-12 |
Not clear |