| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R B Barlow, J T Hamilto. Effects of some isomers and analogues of nicotine on junctional transmission. British journal of pharmacology and chemotherapy. vol 18. issue 3. 2009-07-29. PMID:19108160. |
all the compounds have been tested for their ability to block transmission on the superior cervical ganglion of the cat and on the rat diaphragm preparation, and most of them for ability to inhibit the enzymatic hydrolysis of acetylcholine, using an acetone-powder of dog caudate nucleus as a source of acetylcholinesterase. |
2009-07-29 |
2023-08-12 |
rat |
| K Nakayama, H Katsu, K Kitazum. Effect of distigmine bromide on the central cholinergic system. Journal of psychopharmacology (Oxford, England). vol 23. issue 2. 2009-07-28. PMID:18515453. |
distigmine bromide (3, 3'-[hexamethylenebis (methyliminocarbonyloxy)] bis (1-methylpyridinium) dibromide), an acetylcholinesterase (ache) inhibitor, produced a time-dependent and dose-dependent increase in acetylcholine (ach) levels in the medial prefrontal cortex of rats. |
2009-07-28 |
2023-08-12 |
rat |
| José Pedro Lopes de Almeida, Filomena Almeida Carvalho, Ana Santos Silva-Herdade, Teresa Santos-Freitas, Carlota Saldanh. Redox thiol status plays a central role in the mobilization and metabolism of nitric oxide in human red blood cells. Cell biology international. vol 33. issue 3. 2009-07-13. PMID:19101643. |
we assessed the redox thiol status influence on nitric oxide (no) metabolism and efflux in erythrocytes stimulated with acetylcholinesterase substrate (acetylcholine, ach) and inhibitor (velnacrine maleate, vm). |
2009-07-13 |
2023-08-12 |
human |
| M Rosas-Ballina, K J Trace. Cholinergic control of inflammation. Journal of internal medicine. vol 265. issue 6. 2009-07-13. PMID:19493060. |
we recapitulate additional sources of acetylcholine and their contribution to the inflammatory response, as well as acetylcholine regulation by acetylcholinesterase as a means to attenuate inflammation. |
2009-07-13 |
2023-08-12 |
Not clear |
| Ellen G Duysen, Bin Li, Oksana Lockridg. The butyrylcholinesterase knockout mouse a research tool in the study of drug sensitivity, bio-distribution, obesity and Alzheimer's disease. Expert opinion on drug metabolism & toxicology. vol 5. issue 5. 2009-07-08. PMID:19416087. |
bche serves as a backup for acetylcholinesterase by hydrolyzing the neurotransmitter acetylcholine in acetylcholinesterase knockout mice. |
2009-07-08 |
2023-08-12 |
mouse |
| James F Dillman, Christopher S Phillips, Denise M Kniffin, Christina P Tompkins, Tracey A Hamilton, Robert K Ka. Gene expression profiling of rat hippocampus following exposure to the acetylcholinesterase inhibitor soman. Chemical research in toxicology. vol 22. issue 4. 2009-07-07. PMID:19281266. |
acute exposure to soman causes acetylcholinesterase inhibition, resulting in excessive levels of acetylcholine. |
2009-07-07 |
2023-08-12 |
rat |
| F A Carvalho, J P Lopes de Almeida, T Freitas-Santos, C Saldanh. Modulation of erythrocyte acetylcholinesterase activity and its association with G protein-band 3 interactions. The Journal of membrane biology. vol 228. issue 2. 2009-06-26. PMID:19294450. |
circulating acetylcholine, substrate of membrane acetylcholinesterase (ache), is known to enhance the band 3 protein degree of phosphorylation. |
2009-06-26 |
2023-08-12 |
Not clear |
| Anne-Marie O'Donnell, Prem Pur. Cholinergic innervation in the developing chick cloaca and colorectum. Journal of pediatric surgery. vol 44. issue 2. 2009-06-09. PMID:19231541. |
acetylcholinesterase (ache) is an enzyme involved in hydrolysing acetylcholine during its metabolism. |
2009-06-09 |
2023-08-12 |
human |
| Hiroshi Murabayashi, Hirofumi Kuramoto, Katsushi Ishikawa, Jun Iwamoto, Kiyoshi Miyakawa, Kunio Tanaka, Mitsuo Sekikawa, Motoki Sasaki, Nobuo Kitamura, Yukio Oomor. Acetylcholinesterase activity, choline acetyltransferase and vesicular acetylcholine transporter immunoreactivities in the rat adrenal gland during postnatal development. Anatomical record (Hoboken, N.J. : 2007). vol 292. issue 3. 2009-05-19. PMID:19248156. |
acetylcholinesterase activity, choline acetyltransferase and vesicular acetylcholine transporter immunoreactivities in the rat adrenal gland during postnatal development. |
2009-05-19 |
2023-08-12 |
rat |
| Hiroshi Murabayashi, Hirofumi Kuramoto, Katsushi Ishikawa, Jun Iwamoto, Kiyoshi Miyakawa, Kunio Tanaka, Mitsuo Sekikawa, Motoki Sasaki, Nobuo Kitamura, Yukio Oomor. Acetylcholinesterase activity, choline acetyltransferase and vesicular acetylcholine transporter immunoreactivities in the rat adrenal gland during postnatal development. Anatomical record (Hoboken, N.J. : 2007). vol 292. issue 3. 2009-05-19. PMID:19248156. |
from postnatal-day-0 to postnatal-day-2, a few acetylcholinesterase (ache)-active and choline acetytransferase (chat)-immunoreactive nerve fibers and relatively numerous vesicular acetylcholine transporter (vacht)-immunoreactive puncta were observed in the rat adrenal medulla. |
2009-05-19 |
2023-08-12 |
rat |
| Yuki Takada-Takatori, Toshiaki Kume, Yasuhiko Izumi, Yuta Ohgi, Tetsuhiro Niidome, Takeshi Fujii, Hachiro Sugimoto, Akinori Akaik. Roles of nicotinic receptors in acetylcholinesterase inhibitor-induced neuroprotection and nicotinic receptor up-regulation. Biological & pharmaceutical bulletin. vol 32. issue 3. 2009-04-28. PMID:19252271. |
donepezil, galantamine and tacrine are acetylcholinesterase inhibitors used for the treatment of alzheimer's disease, and were believed to be symptomatic drugs whose therapeutic effects are achieved by slowing the hydrolysis of acetylcholine at synaptic termini. |
2009-04-28 |
2023-08-12 |
rat |
| B P Paudya. Organophosphorus poisoning. JNMA; journal of the Nepal Medical Association. vol 47. issue 172. 2009-04-14. PMID:19079407. |
the toxicity of these op pesticides is due to the irreversible inhibition of acetylcholinesterase (ache) enzyme leading to accumulation of acetylcholine and subsequent over-activation of cholinergic receptors in various parts of the body. |
2009-04-14 |
2023-08-12 |
Not clear |
| Eun-Joo Shin, Jong Seok Chae, Seok Joo Park, Sun Cheol Kim, Kyo Hwan Koo, Kiyofumi Yamada, Toshitaka Nabeshima, Hyoung-Chun Ki. Growth hormone-releaser diet attenuates beta-amyloid(1-42)-induced cognitive impairment via stimulation of the insulin-like growth factor (IGF)-1 receptor in mice. Journal of pharmacological sciences. vol 109. issue 1. 2009-03-30. PMID:19151546. |
we show here that the gh-releaser diet significantly attenuated a beta(1-42)-induced impairment in context-dependent conditioned fear, with a reduction in gh levels and changes in hippocampal acetylcholine, acetylcholinesterase, choline acetyltransferase, insulin-like growth factor (igf)-1, and igf-1-receptor activity in mice. |
2009-03-30 |
2023-08-12 |
mouse |
| Anuradha Nallapaneni, Jing Liu, Subramanya Karanth, Carey Pop. Pharmacological enhancement of endocannabinoid signaling reduces the cholinergic toxicity of diisopropylfluorophosphate. Neurotoxicology. vol 29. issue 6. 2009-03-26. PMID:18765251. |
diisopropylfluorophosphate (dfp) elicits cholinergic toxicity by inhibiting acetylcholinesterase, leading to accumulation of the neurotransmitter acetylcholine and excessive stimulation of cholinergic receptors throughout the body. |
2009-03-26 |
2023-08-12 |
rat |
| J A J Martyn, M Jonsson Fagerlund, L I Eriksso. Basic principles of neuromuscular transmission. Anaesthesia. vol 64 Suppl 1. 2009-03-20. PMID:19222426. |
the acetylcholine immediately detaches from the receptor and is hydrolysed by acetylcholinesterase enzyme. |
2009-03-20 |
2023-08-12 |
Not clear |
| Monica Mohan, Peter K Carpenter, Cathy Bennet. Donepezil for dementia in people with Down syndrome. The Cochrane database of systematic reviews. issue 1. 2009-03-19. PMID:19160328. |
donepezil a reversible inhibitor of acetylcholinesterase, which is thought to maintain levels of acetylcholine, and is reported to have some benefits for people with ad in the general population. |
2009-03-19 |
2023-08-12 |
Not clear |
| Monica Mohan, Cathy Bennett, Peter K Carpente. Galantamine for dementia in people with Down syndrome. The Cochrane database of systematic reviews. issue 1. 2009-03-19. PMID:19160342. |
galantamine both inhibits the activity of acetylcholinesterase and increases the level of acetylcholine. |
2009-03-19 |
2023-08-12 |
Not clear |
| Monica Mohan, Cathy Bennett, Peter K Carpente. Rivastigmine for dementia in people with Down syndrome. The Cochrane database of systematic reviews. issue 1. 2009-03-19. PMID:19160344. |
rivastigmine is a "pseudo-irreversible" inhibitor of acetylcholinesterase, which is thought to maintain levels of acetylcholine. |
2009-03-19 |
2023-08-12 |
Not clear |
| André Nieoullon, Danièle Bentué-Ferrer, Régis Bordet, Magda Tsolaki, Hans Först. Importance of circadian rhythmicity in the cholinergic treatment of Alzheimer's disease: focus on galantamine*. Current medical research and opinion. vol 24. issue 12. 2009-03-18. PMID:19032118. |
the importance of taking into account circadian rhythmicity and acetylcholine (ach) levels when considering acetylcholinesterase inhibitors, galantamine in particular, in the treatment of patients with ad is discussed. |
2009-03-18 |
2023-08-12 |
Not clear |
| Gürdal Orhan, Ilkay Orhan, Neşe Subutay-Oztekin, Fikri Ak, Bilge Sene. Contemporary anticholinesterase pharmaceuticals of natural origin and their synthetic analogues for the treatment of Alzheimer's disease. Recent patents on CNS drug discovery. vol 4. issue 1. 2009-03-17. PMID:19149713. |
therefore, the most important therapeutic approach has emerged as inhibition of acetylcholinesterase (ache), which is the key enzyme in the breakdown of acetylcholine. |
2009-03-17 |
2023-08-12 |
Not clear |