| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kamil Musilek, Marketa Komloova, Vlasta Zavadova, Ondrej Holas, Martina Hrabinova, Miroslav Pohanka, Vlastimil Dohnal, Florian Nachon, Martin Dolezal, Kamil Kuca, Young-Sik Jun. Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage-initial study for Myasthenia gravis implications. Bioorganic & medicinal chemistry letters. vol 20. issue 5. 2010-05-27. PMID:20138518. |
reversible inhibitors (e.g., pyridostigmine bromide, neostigmine bromide) of carbamate origin are used in the early treatment of myasthenia gravis (mg) to block acetylcholinesterase (ache) native function and conserve efficient amount of acetylcholine for decreasing number of nicotinic receptors. |
2010-05-27 |
2023-08-12 |
human |
| Miroslav Pohanka, Jana Zdarova Karasova, Kamil Kuca, Jiri Pikula, Ondrej Holas, Jan Korabecny, Jiri Caba. Colorimetric dipstick for assay of organophosphate pesticides and nerve agents represented by paraoxon, sarin and VX. Talanta. vol 81. issue 1-2. 2010-05-20. PMID:20188972. |
the principle of the assay is based on enzymatic hydrolysis of acetylcholine into acetic acid and choline by acetylcholinesterase. |
2010-05-20 |
2023-08-12 |
Not clear |
| Richard M van Rijn, In K Rhee, Robert Verpoort. Isolation of acetylcholinesterase inhibitory alkaloids from Nerine bowdenii. Natural product research. vol 24. issue 3. 2010-05-07. PMID:20140801. |
therefore, one of the methods that has proven successful in the treatment of ad is the use of inhibitors of acetylcholinesterase (ache) to supplement the acetylcholine level. |
2010-05-07 |
2023-08-12 |
Not clear |
| Denis V Abramochkin, Leniz F Nurullin, Anastasia A Borodinova, Nadezhda V Tarasova, Galina S Sukhova, Eugen E Nikolsky, Leonid V Rosenshtrauk. Non-quantal release of acetylcholine from parasympathetic nerve terminals in the right atrium of rats. Experimental physiology. vol 95. issue 2. 2010-05-06. PMID:19767403. |
acetylcholinesterase (ache) inhibitors provoke typical cholinergic effects in the isolated right atrium of the rat due to the accumulation of acetylcholine (ach). |
2010-05-06 |
2023-08-12 |
rat |
| John C O'Donnell, John H McDonough, Tsung-Ming Shi. Changes in extracellular striatal acetylcholine and brain seizure activity following acute exposure to nerve agents in freely moving guinea pigs. Toxicology mechanisms and methods. vol 20. issue 3. 2010-04-30. PMID:20163292. |
organophosphorus nerve agents irreversibly inhibit acetylcholinesterase (ache) in the peripheral and central nervous systems, causing an increase in the concentration of acetylcholine (ach) in the synapse or neuromuscular junction and subsequent adverse effects. |
2010-04-30 |
2023-08-12 |
Not clear |
| Kenneth Grasing, Deepan Mathur, Thomas F Newton, Cherilyn DeSouz. Donepezil treatment and the subjective effects of intravenous cocaine in dependent individuals. Drug and alcohol dependence. vol 107. issue 1. 2010-04-22. PMID:19836169. |
acetylcholinesterase (ache) inhibitors increase synaptic levels of acetylcholine (ach) by inhibiting its breakdown. |
2010-04-22 |
2023-08-12 |
human |
| Andrew G Engel, Xin-Ming Shen, Duygu Selcen, Steven M Sin. What have we learned from the congenital myasthenic syndromes. Journal of molecular neuroscience : MN. vol 40. issue 1-2. 2010-04-21. PMID:19688192. |
for example, electrophysiologic studies in patients suffering from sudden episodes of apnea pointed to a defect in acetylcholine resynthesis and chat as the candidate gene (ohno et al., proc natl acad sci usa 98:2017-2022, 2001); refractoriness to anticholinesterase medications and partial or complete absence of acetylcholinesterase (ache) from the endplates (eps) has pointed to one of the two genes (colq and ache ( t )) encoding ache, though mutations were observed only in colq. |
2010-04-21 |
2023-08-12 |
Not clear |
| Terrone L Rosenberr. Strategies to resolve the catalytic mechanism of acetylcholinesterase. Journal of molecular neuroscience : MN. vol 40. issue 1-2. 2010-04-21. PMID:19757206. |
acetylcholinesterase (ache) hydrolyzes its physiological substrate acetylcholine at one of the highest known catalytic rates. |
2010-04-21 |
2023-08-12 |
Not clear |
| N Suganthy, S Karutha Pandian, K Pandima Dev. Neuroprotective effect of seaweeds inhabiting South Indian coastal area (Hare Island, Gulf of Mannar Marine Biosphere Reserve): Cholinesterase inhibitory effect of Hypnea valentiae and Ulva reticulata. Neuroscience letters. vol 468. issue 3. 2010-04-06. PMID:19897016. |
until date the only symptomatic treatment for this disease is based on the "cholinergic hypothesis" where the drugs enhance acetylcholine levels in the brain by inhibiting acetylcholinesterase (ache). |
2010-04-06 |
2023-08-12 |
Not clear |
| Aiping Schuchert-Shi, Peter C Hause. Study of acetylcholinesterase inhibitors using CE with contactless conductivity detection. Electrophoresis. vol 30. issue 19. 2010-02-25. PMID:19757435. |
the hydrolysis of acetylcholine and acetylthiocholine as catalyzed by the enzyme acetylcholinesterase was monitored by ce with contactless conductivity detection by determining the acetate produced in the reaction. |
2010-02-25 |
2023-08-12 |
Not clear |
| Ramakrishna Nirogi, Koteshwara Mudigonda, Vishwottam Kandikere, Ranjithkumar Ponnamanen. Quantification of acetylcholine, an essential neurotransmitter, in brain microdialysis samples by liquid chromatography mass spectrometry. Biomedical chromatography : BMC. vol 24. issue 1. 2010-02-22. PMID:19877295. |
enzymatic hydrolysis of acetylcholine in the synaptic cleft is fast and quickly metabolizes to choline and acetate by acetylcholinesterase. |
2010-02-22 |
2023-08-12 |
human |
| Silke Krüger, Reinhard Lakes-Harla. Changes in the auditory neuropil after deafferentation in adult grasshoppers (Schistocerca gregaria). Arthropod structure & development. vol 39. issue 1. 2010-02-10. PMID:19861171. |
the putative transmitter of the afferents, acetylcholine, was investigated by acetylcholinesterase histochemistry. |
2010-02-10 |
2023-08-12 |
Not clear |
| Iftach Shaked, Ari Meerson, Yochai Wolf, Ran Avni, David Greenberg, Adi Gilboa-Geffen, Hermona Sore. MicroRNA-132 potentiates cholinergic anti-inflammatory signaling by targeting acetylcholinesterase. Immunity. vol 31. issue 6. 2010-02-09. PMID:20005135. |
the brain, via vagal secretion of acetylcholine (ach), suppresses peripheral inflammation by intercepting cytokine production; therefore, we predicted that micrornas targeting acetylcholinesterase (ache) can attenuate inflammation. |
2010-02-09 |
2023-08-12 |
mouse |
| Luke A J O'Neil. Boosting the brain's ability to block inflammation via microRNA-132. Immunity. vol 31. issue 6. 2010-02-09. PMID:20064444. |
(2009) describe how mir-132 mediates an anti-inflammatory effect via the targeting of acetylcholinesterase, leading to an increase in the neurotransmitter acetylcholine. |
2010-02-09 |
2023-08-12 |
Not clear |
| Rui-Xia Xu, Qin Wu, Yong Luo, Qi-Hai Gong, Li-Mei Yu, Xie-Nan Huang, An-Sheng Sun, Jing-Shan Sh. Protective effects of icariin on cognitive deficits induced by chronic cerebral hypoperfusion in rats. Clinical and experimental pharmacology & physiology. vol 36. issue 8. 2010-02-05. PMID:19215241. |
in addition, the decreased hippocampal levels of acetylcholine, acetylcholinesterase and choline acetyltransferase associated with chronic cerebral hypoperfusion were significantly prevented by icariin treatment. |
2010-02-05 |
2023-08-12 |
rat |
| Shyh-Ying Chiou, Chuan-Fu Huang, Mei-Ting Hwang, Gialih Li. Comparison of active sites of butyrylcholinesterase and acetylcholinesterase based on inhibition by geometric isomers of benzene-di-N-substituted carbamates. Journal of biochemical and molecular toxicology. vol 23. issue 5. 2010-02-01. PMID:19827033. |
we have reported that benzene-1,2-, 1,3-, and 1,4-di-n-substituted carbamates (1-15) are characterized as the conformationally constrained inhibitors of acetylcholinesterase and mimic gauche, eclipsed, and anti-conformations of acetylcholine, respectively (j biochem mol toxicol 2007;21:348-353). |
2010-02-01 |
2023-08-12 |
Not clear |
| Anna Hrabovska, Vladimir Farar, Veronique Bernard, Ellen G Duysen, Jiri Brabec, Oksana Lockridge, Jaromir Myslivece. Drastic decrease in dopamine receptor levels in the striatum of acetylcholinesterase knock-out mouse. Chemico-biological interactions. vol 183. issue 1. 2010-01-28. PMID:19818744. |
the acetylcholinesterase knock-out mouse lives to adulthood despite 60-fold elevated acetylcholine concentrations in the brain that are lethal to wild-type animals. |
2010-01-28 |
2023-08-12 |
mouse |
| Amar K Pan. Influence of intrastriatal infusion of dynorphin fragments on overflow of acetylcholine and dopamine in the rat brain. The International journal of neuroscience. vol 119. issue 9. 2010-01-26. PMID:19922362. |
intrastriatal infusions of different doses of the acetylcholinesterase blocker, neostigmine, augmented acetylcholine and inhibited dopamine overflow in a dose-dependent manner. |
2010-01-26 |
2023-08-12 |
rat |
| Jiqu Xu, Shuang Rong, Bijun Xie, Zhida Sun, Li Zhang, Hailei Wu, Ping Yao, Xiping Zhang, Yunjian Zhang, Liegang Li. Rejuvenation of antioxidant and cholinergic systems contributes to the effect of procyanidins extracted from the lotus seedpod ameliorating memory impairment in cognitively impaired aged rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 19. issue 12. 2010-01-25. PMID:19716273. |
in addition, lspc significantly restored acetylcholine (ach) contents and acetylcholinesterase (ache) activities in hippocampus and cerebral cortex of ai animals. |
2010-01-25 |
2023-08-12 |
rat |
| Jana Zdarova Karasova, Jiri Bajgar, Daniel Jun, Ruzena Pavlikova, Kamil Kuc. Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX. Neurotoxicity research. vol 16. issue 4. 2010-01-22. PMID:19728005. |
the toxic effect of organophosphates is attributed to irreversible inhibition of acetylcholinesterase (ache; ec 3.1.1.7), the enzyme that hydrolyses the neurotransmitter acetylcholine. |
2010-01-22 |
2023-08-12 |
rat |