| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Kalogiannis, S L Grupke, P E Potter, J G Edwards, R M Chemelli, Y Y Kisanuki, M Yanagisawa, C S Leonar. Narcoleptic orexin receptor knockout mice express enhanced cholinergic properties in laterodorsal tegmental neurons. The European journal of neuroscience. vol 32. issue 1. 2011-01-13. PMID:20576035. |
mrna for choline acetyltransferase (chat), vesicular acetylcholine transporter (vacht) and the high-affinity choline transporter (cht1) but not acetylcholinesterase (ache) was significantly higher in samples from dko than wild-type (wt) mice. |
2011-01-13 |
2023-08-12 |
mouse |
| L B Pagliosa, S C Monteiro, K B Silva, J P de Andrade, J Dutilh, J Bastida, M Cammarota, J A S Zuanazz. Effect of isoquinoline alkaloids from two Hippeastrum species on in vitro acetylcholinesterase activity. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 17. issue 8-9. 2010-12-03. PMID:19969445. |
the treatment of neurological disorders and neurodegenerative diseases is related to the levels of acetylcholine (ach) through the inhibition of acetylcholinesterase (ache). |
2010-12-03 |
2023-08-12 |
Not clear |
| Clarisse B S Roepcke, Susanne B Muench, Holger Schulze, Till T Bachmann, Till Bachmann, Rolf D Schmid, Bernhard Haue. Analysis of phosphorothionate pesticides using a chloroperoxidase pretreatment and acetylcholinesterase biosensor detection. Journal of agricultural and food chemistry. vol 58. issue 15. 2010-11-22. PMID:20614938. |
acetylcholinesterase (ache) is responsible for the hydrolysis of acetylcholine in the nervous system. |
2010-11-22 |
2023-08-12 |
Not clear |
| Einor Ben Assayag, Shani Shenhar-Tsarfaty, Keren Ofek, Lilach Soreq, Irena Bova, Ludmila Shopin, Ronan M G Berg, Shlomo Berliner, Itzhak Shapira, Natan M Bornstein, Hermona Sore. Serum cholinesterase activities distinguish between stroke patients and controls and predict 12-month mortality. Molecular medicine (Cambridge, Mass.). vol 16. issue 7-8. 2010-11-08. PMID:20464061. |
previous studies implicated acetylcholinesterase (ache) involvement in stroke, and circulating ache activity reflects inflammatory response, since acetylcholine suppresses inflammation. |
2010-11-08 |
2023-08-12 |
Not clear |
| Ana Viñuela, L Basten Snoek, Joost A G Riksen, Jan E Kammeng. Genome-wide gene expression analysis in response to organophosphorus pesticide chlorpyrifos and diazinon in C. elegans. PloS one. vol 5. issue 8. 2010-11-04. PMID:20808445. |
organophosphorus pesticides (ops) were originally designed to affect the nervous system by inhibiting the enzyme acetylcholinesterase, an important regulator of the neurotransmitter acetylcholine. |
2010-11-04 |
2023-08-12 |
caenorhabditis_elegans |
| M Inês Vicente, Pedro F Costa, Pedro A Lim. Galantamine inhibits slowly inactivating K+ currents with a dual dose-response relationship in differentiated N1E-115 cells and in CA1 neurones. European journal of pharmacology. vol 634. issue 1-3. 2010-11-01. PMID:20184872. |
galantamine, one of the major drugs used in alzheimer's disease therapy, is a relatively weak acetylcholinesterase inhibitor and an allosteric potentiating ligand of nicotinic acetylcholine receptors. |
2010-11-01 |
2023-08-12 |
rat |
| Alessandro Martorana, Zaira Esposito, Giacomo Koc. Beyond the cholinergic hypothesis: do current drugs work in Alzheimer's disease? CNS neuroscience & therapeutics. vol 16. issue 4. 2010-10-21. PMID:20560995. |
this has led to the development of drugs able to prevent acetylcholine hydrolysis (acetylcholinesterase inhibitors). |
2010-10-21 |
2023-08-12 |
Not clear |
| Ghada A BinSaif, Abdullah Al Samary, Saad Al Mohize. Failure of botulinum toxin treatment for localized vitiligo. Journal of drugs in dermatology : JDD. vol 9. issue 9. 2010-10-18. PMID:20865840. |
it was found that acetylcholine concentration increased with a significantly reduced expression of acetylcholinesterase in vitiliginous patches that return to normal upon repigmentation. |
2010-10-18 |
2023-08-12 |
Not clear |
| Ruey-an Doong, Pin-Shang Lee, Kowthalam Anith. Simultaneous determination of biomarkers for Alzheimer's disease using sol-gel-derived optical array biosensor. Biosensors & bioelectronics. vol 25. issue 11. 2010-09-30. PMID:20444591. |
the fluorescent dye, carboxy snarf-1-dextran, was co-immobilized with glutamate dehydrogenase and acetylcholinesterase for sensing glutamate and acetylcholine, respectively, while amplex red and fitc-dextran were immobilized with horseradish peroxidase for determination of beta-amyloid and hydrogen peroxide (h(2)o(2)). |
2010-09-30 |
2023-08-12 |
human |
| Steeve Hervé Thany, Hélène Tricoire-Leignel, Bruno Lapie. Identification of cholinergic synaptic transmission in the insect nervous system. Advances in experimental medicine and biology. vol 683. 2010-09-30. PMID:20737784. |
a major criteria initially used to localize cholinergic neuronal elements in nervous systems tissues that involve acetylcholine (ach) as neurotransmitter is mainly based on immunochemical studies using choline acetyltransferase (chat), an enzyme which catalyzes ach biosynthesis and the ach degradative enzyme named acetylcholinesterase (ache). |
2010-09-30 |
2023-08-12 |
Not clear |
| C B Weinberg, J R Sanes, Z W Hal. Formation of neuromuscular junctions in adult rats: accumulation of acetylcholine receptors, acetylcholinesterase, and components of synaptic basal lamina. Developmental biology. vol 84. issue 2. 2010-09-09. PMID:20737863. |
formation of neuromuscular junctions in adult rats: accumulation of acetylcholine receptors, acetylcholinesterase, and components of synaptic basal lamina. |
2010-09-09 |
2023-08-12 |
rat |
| Su Che. Highly pure phospholipids based brain docosahexaenoic acid transporters. Recent patents on CNS drug discovery. vol 5. issue 2. 2010-09-07. PMID:19832689. |
the strategy of the current therapy focuses on increasing availability of brain acetylcholine concentration, and use of acetylcholinesterase inhibitors has become the main approach to symptomatic treatment. |
2010-09-07 |
2023-08-12 |
Not clear |
| Peter Eyer, Franz Worek, Horst Thiermann, Michael Eddlesto. Paradox findings may challenge orthodox reasoning in acute organophosphate poisoning. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:19883634. |
it is generally accepted that inhibition of acetylcholinesterase (ache) is the most important acute toxic action of organophosphorus compounds, leading to accumulation of acetylcholine followed by a dysfunction of cholinergic signaling. |
2010-09-01 |
2023-08-12 |
mouse |
| Hay Dvir, Israel Silman, Michal Harel, Terrone L Rosenberry, Joel L Sussma. Acetylcholinesterase: from 3D structure to function. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:20138030. |
by rapid hydrolysis of the neurotransmitter, acetylcholine, acetylcholinesterase terminates neurotransmission at cholinergic synapses. |
2010-09-01 |
2023-08-12 |
human |
| Hay Dvir, Israel Silman, Michal Harel, Terrone L Rosenberry, Joel L Sussma. Acetylcholinesterase: from 3D structure to function. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:20138030. |
the determination of the crystal structure of torpedo californica acetylcholinesterase permitted visualization, for the first time, at atomic resolution, of a binding pocket for acetylcholine. |
2010-09-01 |
2023-08-12 |
human |
| Julian R Haigh, Michael Adler, James P Apland, Sharad S Deshpande, Charles B Barham, Patrick Desmond, Irwin Koplovitz, David E Lenz, Richard K Gordo. Protection by pyridostigmine bromide of marmoset hemi-diaphragm acetylcholinesterase activity after soman exposure. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:20144889. |
organophosphate (op) chemical warfare agents such as gd exert their toxic effects by inhibiting acetylcholinesterase (ache) from terminating the action of acetylcholine at postsynaptic sites in cholinergic nerve terminals (including crucial peripheral muscle such as diaphragm). |
2010-09-01 |
2023-08-12 |
marmoset |
| Séverine M Sigoillot, Francine Bourgeois, Claire Lega. Cholinesterases regulation in the absence of ColQ. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:20153305. |
one of these molecules is acetylcholinesterase (ache) that regulates acetylcholine levels. |
2010-09-01 |
2023-08-12 |
Not clear |
| Heidi Q Xie, K Wing Leung, Vicky P Chen, Gallant K L Chan, Sherry L Xu, Ava J Y Guo, Kevin Y Zhu, Ken Y Z Zheng, Cathy W Bi, Janis Y X Zhan, Wallace K P Chan, Roy C Y Choi, Karl W K Tsi. PRiMA directs a restricted localization of tetrameric AChE at synapses. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:20178777. |
acetylcholinesterase (ache), a highly polymorphic enzyme with various splicing variants and molecular isoforms, plays an essential role in the cholinergic neurotransmission by hydrolyzing acetylcholine into choline and acetate. |
2010-09-01 |
2023-08-12 |
Not clear |
| Klara Bulc Rozman, Romulo Araoz, Kristina Sepcić, Jordi Molgo, Dusan Supu. Parazoanthoxanthin A blocks Torpedo nicotinic acetylcholine receptors. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:20230806. |
since it is a potent acetylcholinesterase inhibitor, it may also bind to nicotinic acetylcholine receptors (nachrs). |
2010-09-01 |
2023-08-12 |
xenopus_laevis |
| Kelvin Kin-Kwan Wong, Jacky Chi-Ki Ngo, Sijie Liu, Huang-Quan Lin, Chun Hu, Pang-Chui Shaw, David Chi-Cheong Wa. Interaction study of two diterpenes, cryptotanshinone and dihydrotanshinone, to human acetylcholinesterase and butyrylcholinesterase by molecular docking and kinetic analysis. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:20350537. |
current therapeutic intervention for ad is primarily based on the inhibition of brain acetylcholinesterase (ache) to restore the brain acetylcholine level. |
2010-09-01 |
2023-08-12 |
human |