| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Katja S Kroker, Georg Rast, Riccardo Giovannini, Anelise Marti, Cornelia Dorner-Ciossek, Holger Rosenbroc. Inhibition of acetylcholinesterase and phosphodiesterase-9A has differential effects on hippocampal early and late LTP. Neuropharmacology. vol 62. issue 5-6. 2012-07-23. PMID:22245562. |
it aims to compensate for the deficit in cholinergic neurotransmission by blocking acetylcholinesterase (ache) and thus increases the concentration of extracellular acetylcholine. |
2012-07-23 |
2023-08-12 |
rat |
| Patrick Vigneault, Sarah Bourgault, Nisrin Kaddar, Bertrand Caillier, Sylvie Pilote, Dany Patoine, Chantale Simard, Benoit Drole. Galantamine (Reminyl) delays cardiac ventricular repolarization and prolongs the QT interval by blocking the HERG current. European journal of pharmacology. vol 681. issue 1-3. 2012-07-20. PMID:22366430. |
galantamine is a reversible inhibitor of acetylcholinesterase and an allosteric-potentiating ligand of the nicotinic acetylcholine receptors. |
2012-07-20 |
2023-08-12 |
Not clear |
| Amajad Iqbal Kazi, Anna Oomme. Monocrotophos induced oxidative damage associates with severe acetylcholinesterase inhibition in rat brain. Neurotoxicology. vol 33. issue 2. 2012-07-09. PMID:22285544. |
organophosphates inhibit acetylcholinesterase and neurotoxicity is primarily a result of acetylcholine induced hyperactivation in different regions of the brain. |
2012-07-09 |
2023-08-12 |
rat |
| Adriana Bolekova, Darina Kluchova, Tatiana Spakovska, Frantisek Dorko, Kvetuse Lovasov. Postnatal development of nitrergic and cholinergic structures in rat spinal cord. Archives italiennes de biologie. vol 149. issue 3. 2012-06-21. PMID:22028090. |
other neurotransmitter is a classical neurotransmitter acetylcholine (ach), regulated by enzyme acetylcholinesterase (ache) that hydrolyses the acetylcholine after its releasing. |
2012-06-21 |
2023-08-12 |
rat |
| Shihua Hou, Zhongmin Ou, Qiang Chen, Baoyan W. Amperometric acetylcholine biosensor based on self-assembly of gold nanoparticles and acetylcholinesterase on the sol-gel/multi-walled carbon nanotubes/choline oxidase composite-modified platinum electrode. Biosensors & bioelectronics. vol 33. issue 1. 2012-06-21. PMID:22230694. |
amperometric acetylcholine biosensor based on self-assembly of gold nanoparticles and acetylcholinesterase on the sol-gel/multi-walled carbon nanotubes/choline oxidase composite-modified platinum electrode. |
2012-06-21 |
2023-08-12 |
Not clear |
| Shihua Hou, Zhongmin Ou, Qiang Chen, Baoyan W. Amperometric acetylcholine biosensor based on self-assembly of gold nanoparticles and acetylcholinesterase on the sol-gel/multi-walled carbon nanotubes/choline oxidase composite-modified platinum electrode. Biosensors & bioelectronics. vol 33. issue 1. 2012-06-21. PMID:22230694. |
a novel acetylcholinesterase (ache)/choline oxidase (chox) bienzyme amperometric acetylcholine biosensor based on gold nanoparticles (aunps) and multi-walled carbon nanotubes (mwcnts) has been successfully developed by self-assembly process in combination of sol-gel technique. |
2012-06-21 |
2023-08-12 |
Not clear |
| Paul W Elsinghorst, Wolfgang Härtig, Daniela Gündisch, Klaus Mohr, Christian Tränkle, Michael Gütscho. A hydrazide linker strategy for heterobivalent compounds as ortho- and allosteric ligands of acetylcholine-binding proteins. Current topics in medicinal chemistry. vol 11. issue 22. 2012-06-11. PMID:22039876. |
the occurrence of orthosteric and allosteric binding sites is a characteristic common feature of several acetylcholine- binding proteins, like acetylcholinesterase or the nicotinic and muscarinic acetylcholine receptors. |
2012-06-11 |
2023-08-12 |
Not clear |
| Paul W Elsinghorst, Wolfgang Härtig, Daniela Gündisch, Klaus Mohr, Christian Tränkle, Michael Gütscho. A hydrazide linker strategy for heterobivalent compounds as ortho- and allosteric ligands of acetylcholine-binding proteins. Current topics in medicinal chemistry. vol 11. issue 22. 2012-06-11. PMID:22039876. |
especially, the development of a hydrazide linker for tacrine-derived heterodimers is highlighted by applications in the inhibition of cholinesterases, the bivalent binding to nicotinic and muscarinic acetylcholine receptors, as well as the histochemical imaging of acetylcholinesterase and amyloid-β. |
2012-06-11 |
2023-08-12 |
Not clear |
| Amy C Halliday, Susan A Greenfiel. From protein to peptides: a spectrum of non-hydrolytic functions of acetylcholinesterase. Protein and peptide letters. vol 19. issue 2. 2012-06-08. PMID:21933122. |
acetylcholinesterase (ache), a member of the α/β-hydrolase fold superfamily of proteins, is a serine hydrolase responsible for the hydrolysis of the well studied neurotransmitter acetylcholine (ach). |
2012-06-08 |
2023-08-12 |
Not clear |
| Haley E Speed, Cory A Blaiss, Ahleum Kim, Michael E Haws, Neal R Melvin, Michael Jennings, Amelia J Eisch, Craig M Powel. Delayed reduction of hippocampal synaptic transmission and spines following exposure to repeated subclinical doses of organophosphorus pesticide in adult mice. Toxicological sciences : an official journal of the Society of Toxicology. vol 125. issue 1. 2012-06-06. PMID:21948870. |
agricultural and household organophosphorus (op) pesticides inhibit acetylcholinesterase (ache), resulting in increased acetylcholine (ach) in the central nervous system. |
2012-06-06 |
2023-08-12 |
mouse |
| Guiling He, Yang Sun, Fei L. RNA interference of two acetylcholinesterase genes in Plutella xylostella reveals their different functions. Archives of insect biochemistry and physiology. vol 79. issue 2. 2012-05-29. PMID:22392769. |
acetylcholinesterase (ache, ec 3.1.1.7) is an important enzyme with a typical function of degrading the neurotransmitter acetylcholine. |
2012-05-29 |
2023-08-12 |
Not clear |
| M Cuartero, J A Ortuño, M S García, F García-Cánova. Assay of acetylcholinesterase activity by potentiometric monitoring of acetylcholine. Analytical biochemistry. vol 421. issue 1. 2012-05-24. PMID:22037292. |
assay of acetylcholinesterase activity by potentiometric monitoring of acetylcholine. |
2012-05-24 |
2023-08-12 |
Not clear |
| Vijayasree V Giridharan, Rajarajan A Thandavarayan, Shinji Sato, Kam Ming Ko, Tetsuya Konish. Prevention of scopolamine-induced memory deficits by schisandrin B, an antioxidant lignan from Schisandra chinensis in mice. Free radical research. vol 45. issue 8. 2012-05-16. PMID:21615274. |
at the same time, a significant impairment of learning and memory occurred when evaluated by passive avoidance task (pat) and morris water maze (mwm) with concomitant increase of acetylcholinesterase (ache) activity and decreased acetylcholine levels. |
2012-05-16 |
2023-08-12 |
mouse |
| Renata da Luz Oliveira, Kelly Juliana Seibt, Eduardo Pacheco Rico, Mauricio Reis Bogo, Carla Denise Bona. Inhibitory effect of lithium on nucleotide hydrolysis and acetylcholinesterase activity in zebrafish (Danio rerio) brain. Neurotoxicology and teratology. vol 33. issue 6. 2012-05-14. PMID:21609761. |
our findings show that lithium treatment can alter ectonucleotidase and acetylcholinesterase activities, which may regulate extracellular nucleotide, nucleoside, and acetylcholine levels. |
2012-05-14 |
2023-08-12 |
zebrafish |
| Denis V Abramochkin, Anastasia A Borodinova, Leonid V Rosenshtrauk. Effects of acetylcholinesterase inhibitor paraoxon denote the possibility of non-quantal acetylcholine release in myocardium of different vertebrates. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. vol 182. issue 1. 2012-05-11. PMID:21761139. |
effects of acetylcholinesterase inhibitor paraoxon denote the possibility of non-quantal acetylcholine release in myocardium of different vertebrates. |
2012-05-11 |
2023-08-12 |
rat |
| Denis V Abramochkin, Anastasia A Borodinova, Leonid V Rosenshtrauk. Effects of acetylcholinesterase inhibitor paraoxon denote the possibility of non-quantal acetylcholine release in myocardium of different vertebrates. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. vol 182. issue 1. 2012-05-11. PMID:21761139. |
these effects were abolished by muscarinic blocker atropine and therefore are caused by acetylcholine, which accumulates in the myocardium due to acetylcholinesterase inhibition even in the absence of vagal input. |
2012-05-11 |
2023-08-12 |
rat |
| Fariba Sharififar, Mansour Mirtajadini, Mohammad Jaber Azampour, Ehsan Zaman. Essential oil and methanolic extract of Zataria multiflora Boiss with anticholinesterase effect. Pakistan journal of biological sciences : PJBS. vol 15. issue 1. 2012-05-08. PMID:22530443. |
one of the most common strategies in the treatment of cognitive disorders is enhancing the acetylcholine level in the brain through the inhibition of acetylcholinesterase. |
2012-05-08 |
2023-08-12 |
Not clear |
| Hanan F Aly, Fateheya M Metwally, Hanaa H Ahme. Neuroprotective effects of dehydroepiandrosterone (DHEA) in rat model of Alzheimer's disease. Acta biochimica Polonica. vol 58. issue 4. 2012-05-02. PMID:22146133. |
also brain cholinergic markers (acetylcholinesterase and acetylcholine) were determined. |
2012-05-02 |
2023-08-12 |
rat |
| Hanan F Aly, Fateheya M Metwally, Hanaa H Ahme. Neuroprotective effects of dehydroepiandrosterone (DHEA) in rat model of Alzheimer's disease. Acta biochimica Polonica. vol 58. issue 4. 2012-05-02. PMID:22146133. |
moreover, significant elevations in brain acetylcholinesterase activity accompanied with significant reduction in acetylcholine level were recorded. |
2012-05-02 |
2023-08-12 |
rat |
| Shuzhen Liao, Yanan Qiao, Wenting Han, Zhaoxia Xie, Zhaoyang Wu, Guoli Shen, Ruqin Y. Acetylcholinesterase liquid crystal biosensor based on modulated growth of gold nanoparticles for amplified detection of acetylcholine and inhibitor. Analytical chemistry. vol 84. issue 1. 2012-05-01. PMID:22148672. |
acetylcholinesterase liquid crystal biosensor based on modulated growth of gold nanoparticles for amplified detection of acetylcholine and inhibitor. |
2012-05-01 |
2023-08-12 |
Not clear |