| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Neha Singhal, Rui Xu, Paul T Marti. Distinct contributions of Galgt1 and Galgt2 to carbohydrate expression and function at the mouse neuromuscular junction. Molecular and cellular neurosciences. vol 51. issue 3-4. 2013-04-16. PMID:22982027. |
loss of galgt2 increased intracellular accumulation of acetylcholine receptors and acetylcholinesterase within skeletal myofibers, suggesting an additional role for galgt2 in neuromuscular stability. |
2013-04-16 |
2023-08-12 |
mouse |
| b' Marjana Grandi\\xc4\\x8d, Romulo Ar\\xc3\\xa1oz, Jordi Molg\\xc3\\xb3, Tom Turk, Kristina Sep\\xc4\\x8di\\xc4\\x87, Evelyne Benoit, Robert Frange\\xc5\\xb. The non-competitive acetylcholinesterase inhibitor APS12-2 is a potent antagonist of skeletal muscle nicotinic acetylcholine receptors. Toxicology and applied pharmacology. vol 265. issue 2. 2013-04-15. PMID:23046821.' |
the non-competitive acetylcholinesterase inhibitor aps12-2 is a potent antagonist of skeletal muscle nicotinic acetylcholine receptors. |
2013-04-15 |
2023-08-12 |
mouse |
| Jamie K Lau, Kathleen C Brown, Brent A Thornhill, Clayton M Crabtree, Aaron M Dom, Theodore R Witte, W Elaine Hardman, Christopher A McNees, Cody A Stover, A Betts Carpenter, Haitao Luo, Yi C Chen, Brandon S Shiflett, Piyali Dasgupt. Inhibition of cholinergic signaling causes apoptosis in human bronchioalveolar carcinoma. Cancer research. vol 73. issue 4. 2013-04-15. PMID:23222296. |
in this study, we show that human bacs produce acetylcholine (ach) and contain several cholinergic factors including acetylcholinesterase (ache), choline acetyltransferase (chat), choline transporter 1 (cht1, slc5a7), vesicular acetylcholine transporter (vacht, slc18a3), and nach receptors (achrs, chrnas). |
2013-04-15 |
2023-08-12 |
mouse |
| Rebecca L Ashare, Riju Ray, Caryn Lerman, Andrew A Strasse. Cognitive effects of the acetylcholinesterase inhibitor, donepezil, in healthy, non-treatment seeking smokers: a pilot feasibility study. Drug and alcohol dependence. vol 126. issue 1-2. 2013-04-08. PMID:22595038. |
endogenous acetylcholine levels, which are modulated by acetylcholinesterase inhibitors (acheis), play an important role in smoking behavior and cognition. |
2013-04-08 |
2023-08-12 |
Not clear |
| Venugopal L, Dharma Rao V, Srinivas Rao M, Mallikarjuna . "Toxic Pancreatitis with an Intra-Abdominal Abscess which was Caused by Organophosphate Poisoning (OP)". Journal of clinical and diagnostic research : JCDR. vol 7. issue 2. 2013-04-02. PMID:23543622. |
organophosphate insecticides are the potent inhibitors of the acetylcholinesterase enzyme which lead to an increased acetylcholine activity, which are responsible for symptoms such as abdominal pain, diarrhoea, vomiting and hypersalivation. |
2013-04-02 |
2023-08-12 |
Not clear |
| Hongna Pan, Xian-zhang Hu, David M Jacobowitz, Cynthia Chen, John McDonough, Kerry Van Shura, Megan Lyman, Ann M Marin. Alpha-linolenic acid is a potent neuroprotective agent against soman-induced neuropathology. Neurotoxicology. vol 33. issue 5. 2013-03-21. PMID:22884490. |
nerve agents cause toxicity to peripheral and central sites through the irreversible inhibition of acetylcholinesterase, the enzyme that metabolizes acetylcholine. |
2013-03-21 |
2023-08-12 |
Not clear |
| Bhupesh Sharma, Nirmal Sing. Experimental hypertension induced vascular dementia: pharmacological, biochemical and behavioral recuperation by angiotensin receptor blocker and acetylcholinesterase inhibitor. Pharmacology, biochemistry, and behavior. vol 102. issue 1. 2013-03-14. PMID:22507914. |
furthermore, doca-salt treatment has shown a significant impairment of vascular endothelial function (doca attenuated acetylcholine induced endothelium dependent relaxation), with a significant reduction in serum nitrite/nitrate levels, along with increased aortic, serum and brain oxidative stress levels (aortic superoxide anion, serum and brain thiobarbituric acid reactive species, brain glutathione) and brain acetylcholinesterase activity. |
2013-03-14 |
2023-08-12 |
rat |
| Gopenath Thangaraj, Alexander Greif, Gesine Bachmann, Paul G Laye. Intricate paths of cells and networks becoming "Cholinergic" in the embryonic chicken retina. The Journal of comparative neurology. vol 520. issue 14. 2013-03-08. PMID:22886733. |
choline acetyltransferase (chat) and acetylcholinesterase (ache) are the decisive enzymatic activities regulating the availability of acetylcholine (ach) at a given synaptic or nonsynaptic locus. |
2013-03-08 |
2023-08-12 |
chicken |
| Edna Blotnick, Yasmine Hamra-Amitai, Chen Wald, Talma Brenner, Lili Angliste. Changes in acetylcholinesterase in experimental autoimmune myasthenia gravis and in response to treatment with a specific antisense. The European journal of neuroscience. vol 36. issue 8. 2013-03-06. PMID:22805122. |
controlled regulation of synaptic nicotinic acetylcholine receptors (achrs) and acetylcholinesterase (ache), together with maintenance of a dynamic balance between them, is a requirement for proper function of cholinergic synapses. |
2013-03-06 |
2023-08-12 |
rat |
| Gulseher Sarah Sirin, Yanzi Zhou, Lee Lior-Hoffmann, Shenglong Wang, Yingkai Zhan. Aging mechanism of soman inhibited acetylcholinesterase. The journal of physical chemistry. B. vol 116. issue 40. 2013-02-25. PMID:22984913. |
acetylcholinesterase (ache) is a crucial enzyme in the cholinergic nervous system that hydrolyzes neurotransmitter acetylcholine (ach) and terminates synaptic signals. |
2013-02-25 |
2023-08-12 |
Not clear |
| Wei-Wei Zhang, Qi-Xin Sun, Yin-Hui Liu, Wei Gao, Yan-Hai Li, Kun Lu, Zhuo Wan. Chronic administration of Liu Wei Dihuang protects rat's brain against D-galactose-induced impairment of cholinergic system. Sheng li xue bao : [Acta physiologica Sinica]. vol 63. issue 3. 2013-02-21. PMID:21681343. |
acetylcholine (ach) content, activities of choline acetyltransferase (chat) and acetylcholinesterase (ache) in visual cortex were assayed. |
2013-02-21 |
2023-08-12 |
rat |
| Laura E Sperling, Janine Klaczinski, Corina Schütz, Lydia Rudolph, Paul G Laye. Mouse acetylcholinesterase enhances neurite outgrowth of rat R28 cells through interaction with laminin-1. PloS one. vol 7. issue 5. 2013-01-24. PMID:22570738. |
the enzyme acetylcholinesterase (ache) terminates synaptic transmission at cholinergic synapses by hydrolyzing the neurotransmitter acetylcholine, but can also exert 'non-classical', morpho-regulatory effects on developing neurons such as stimulation of neurite outgrowth. |
2013-01-24 |
2023-08-12 |
mouse |
| Vera Lucia Sardá Ribeiro, Cláudia Vanzella, Felipe dos Santos Moysés, Jaqueline Campiol Dos Santos, João Ricardo Souza Martins, Gilsane Lino von Poser, Ionara Rodrigues Siqueir. Effect of Calea serrata Less. n-hexane extract on acetylcholinesterase of larvae ticks and brain Wistar rats. Veterinary parasitology. vol 189. issue 2-4. 2013-01-24. PMID:22608349. |
acetylcholinesterase (ache), an enzyme that hydrolyses acetylcholine (ach) at cholinergic synapses, is a target for pesticides and its inhibition by organophosphates leads to paralysis and death of arthropods. |
2013-01-24 |
2023-08-12 |
rat |
| Mathilde M Triquigneaux, Marilyn Ehrenshaft, Esther Roth, Israel Silman, Yakov Ashani, Ronald P Mason, Lev Weiner, Leesa J Deterdin. Targeted oxidation of Torpedo californica acetylcholinesterase by singlet oxygen: identification of N-formylkynurenine tryptophan derivatives within the active-site gorge of its complex with the photosensitizer methylene blue. The Biochemical journal. vol 448. issue 1. 2013-01-14. PMID:22888904. |
the principal role of ache (acetylcholinesterase) is termination of impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter acetylcholine. |
2013-01-14 |
2023-08-12 |
Not clear |
| Sean H White, Neil S Magosk. Acetylcholine-evoked afterdischarge in Aplysia bag cell neurons. Journal of neurophysiology. vol 107. issue 10. 2013-01-09. PMID:22323635. |
recording from the intact bag cell neuron cluster showed acetylcholine to evoke prominent depolarization, which often led to extended bursting, but only in the presence of the acetylcholinesterase inhibitor neostigmine. |
2013-01-09 |
2023-08-12 |
aplysia |
| Thomas J Hopkins, Laura E Rupprecht, Matthew R Hayes, Julie A Blendy, Heath D Schmid. Galantamine, an acetylcholinesterase inhibitor and positive allosteric modulator of nicotinic acetylcholine receptors, attenuates nicotine taking and seeking in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 10. 2013-01-09. PMID:22669169. |
galantamine, an acetylcholinesterase inhibitor and positive allosteric modulator of nicotinic acetylcholine receptors, attenuates nicotine taking and seeking in rats. |
2013-01-09 |
2023-08-12 |
mouse |
| Thomas J Hopkins, Laura E Rupprecht, Matthew R Hayes, Julie A Blendy, Heath D Schmid. Galantamine, an acetylcholinesterase inhibitor and positive allosteric modulator of nicotinic acetylcholine receptors, attenuates nicotine taking and seeking in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 10. 2013-01-09. PMID:22669169. |
galantamine is an acetylcholinesterase inhibitor that also acts as a positive allosteric modulator of nicotinic acetylcholine receptors. |
2013-01-09 |
2023-08-12 |
mouse |
| Minoru Tada, Keiko Gengyo-Ando, Tetsuo Kobayashi, Masamitsu Fukuyama, Shohei Mitani, Kenji Kontani, Toshiaki Katad. Neuronally expressed Ras-family GTPase Di-Ras modulates synaptic activity in Caenorhabditis elegans. Genes to cells : devoted to molecular & cellular mechanisms. vol 17. issue 9. 2013-01-03. PMID:22897658. |
loss of function of drn-1 conferred resistance to the acetylcholinesterase inhibitor aldicarb and partially suppressed the aldicarb-hypersensitive phenotypes of heterotrimeric g-protein mutants, in which acetylcholine release is up-regulated. |
2013-01-03 |
2023-08-12 |
caenorhabditis_elegans |
| Zhenxin Zhang, Lu Yu, Maren Gaudig, Barbara Schäuble, Ute Richar. Galantamine versus donepezil in Chinese patients with Alzheimer's disease: results from a randomized, double-blind study. Neuropsychiatric disease and treatment. vol 8. 2012-12-13. PMID:23233806. |
galantamine is an acetylcholinesterase inhibitor that may also act via allosteric modulation of nicotinic acetylcholine receptors. |
2012-12-13 |
2023-08-12 |
Not clear |
| Ian R Macdonald, Earl Martin, Terrone L Rosenberry, Sultan Darves. Probing the peripheral site of human butyrylcholinesterase. Biochemistry. vol 51. issue 36. 2012-12-04. PMID:22901043. |
acetylcholinesterase (ache) and butyrylcholinesterase (buche) catalyze the hydrolysis of the neurotransmitter acetylcholine and, thereby, function as coregulators of cholinergic neurotransmission. |
2012-12-04 |
2023-08-12 |
human |