| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ilkay Erdogan Orha. Nature: a substantial source of auspicious substances with acetylcholinesterase inhibitory action. Current neuropharmacology. vol 11. issue 4. 2014-01-01. PMID:24381529. |
acetylcholinesterase (ache) (ec 3.1.1.7) is an important enzyme that breaks down of acetylcholine in synaptic cleft in neuronal junctions. |
2014-01-01 |
2023-08-12 |
Not clear |
| Alireza Aliabadi, Alireza Foroumadi, Ahmad Mohammadi-Farani, Mahdi Garmsiri Mahva. Synthesis and Evaluation of Anti-acetylcholinesterase Activity of 2-(2-(4-(2-Oxo-2-phenylethyl)piperazin-1-yl) ethyl)Isoindoline-1,3-dione Derivatives with Potential Anti-Alzheimer Effects. Iranian journal of basic medical sciences. vol 16. issue 10. 2013-12-31. PMID:24379961. |
acetylcholinesterase inhibitors such as donepezil can enhance the duration of action of acetylcholine (ach) and therefore, through this mechanism improve the symptoms of ad. |
2013-12-31 |
2023-08-12 |
Not clear |
| Hanaa H Ahmed, Ahmed M Salem, Gilane M Sabry, Ahmed A Husein, Soheir E Koto. Possible therapeutic uses of Salvia triloba and Piper nigrum in Alzheimer's disease-induced rats. Journal of medicinal food. vol 16. issue 5. 2013-12-12. PMID:23631499. |
levels of brain acetylcholine (ach), serum and brain acetylcholinesterase (ache) activity, c-reactive protein (crp), total nuclear factor kappa-b (nf-κb), and monocyte chemoattractant protein-1 (mcp-1) were estimated. |
2013-12-12 |
2023-08-12 |
rat |
| Veena Beri, Scott A Wildman, Kazuro Shiomi, Ziyad F Al-Rashid, Jonah Cheung, Terrone L Rosenberr. The natural product dihydrotanshinone I provides a prototype for uncharged inhibitors that bind specifically to the acetylcholinesterase peripheral site with nanomolar affinity. Biochemistry. vol 52. issue 42. 2013-12-12. PMID:24040835. |
cholinergic synaptic transmission often requires extremely rapid hydrolysis of acetylcholine by acetylcholinesterase (ache). |
2013-12-12 |
2023-08-12 |
Not clear |
| T Antonelli, M C Tomasini, M Castellazzi, P Sola, C Tamborino, D Ferraro, L Ferraro, E Granier. Biological markers in cerebrospinal fluid for axonal impairment in multiple sclerosis: acetylcholinesterase activity cannot be considered a useful biomarker. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 34. issue 5. 2013-12-09. PMID:23247598. |
the acetylcholinesterase (ache), essential enzyme for the regulation of turnover of acetylcholine, can be considered the most important biochemical indicator of cholinergic signaling in the nervous system. |
2013-12-09 |
2023-08-12 |
human |
| Najoua Mejri, Nadia Malek Said, Sihem Guizani, Imen Essouissi, Mouldi Said. Preliminary studies of acetylcholinesterase activity in the rat brain using N-phenylferrocenecarboxamide labelled by the technetium-99m. Nuclear medicine and biology. vol 40. issue 4. 2013-11-26. PMID:23465564. |
the reduction of acetylcholinesterase (ache) activity in the brain has been measured in dementia disorders such as alzheimer's disease and dementia with lewy bodies using (11)c and (18)f-labeled acetylcholine analogues. |
2013-11-26 |
2023-08-12 |
rat |
| Najoua Mejri, Nadia Malek Said, Sihem Guizani, Imen Essouissi, Mouldi Said. Preliminary studies of acetylcholinesterase activity in the rat brain using N-phenylferrocenecarboxamide labelled by the technetium-99m. Nuclear medicine and biology. vol 40. issue 4. 2013-11-26. PMID:23465564. |
our aim was to develop a new 99mtc-labeled acetylcholine analogue: n-phenylferrocenecarboxamide labelled with technetium-99m (99mtc-tpcc) to study acetylcholinesterase activity. |
2013-11-26 |
2023-08-12 |
rat |
| Shakti D Pachauri, Priya Ranjan P Verma, Anil K Dwivedi, Santoshkumar Tota, Kiran Khandelwal, Jitendra K Saxena, Chandishwar Nat. Ameliorative effect of Noni fruit extract on streptozotocin-induced memory impairment in mice. Behavioural pharmacology. vol 24. issue 4. 2013-11-11. PMID:23838966. |
stz caused memory impairment in morris water maze and passive avoidance tests along with reduced brain levels of atp, bdnf, and acetylcholine and increased acetylcholinesterase activity and oxidative stress. |
2013-11-11 |
2023-08-12 |
mouse |
| Shakti D Pachauri, Priya Ranjan P Verma, Anil K Dwivedi, Santoshkumar Tota, Kiran Khandelwal, Jitendra K Saxena, Chandishwar Nat. Ameliorative effect of Noni fruit extract on streptozotocin-induced memory impairment in mice. Behavioural pharmacology. vol 24. issue 4. 2013-11-11. PMID:23838966. |
treatment with noni extract (100 mg/kg) prevented the stz-induced memory impairment in both behavioral tests along with reduced oxidative stress and acetylcholinesterase activity, and increased brain levels of bdnf, acetylcholine, and atp level. |
2013-11-11 |
2023-08-12 |
mouse |
| b' Mirjana B Colovi\\xc4\\x87, Danijela Z Krsti\\xc4\\x87, Tamara D Lazarevi\\xc4\\x87-Pa\\xc5\\xa1ti, Aleksandra M Bond\\xc5\\xbei\\xc4\\x87, Vesna M Vasi\\xc4\\x8. Acetylcholinesterase inhibitors: pharmacology and toxicology. Current neuropharmacology. vol 11. issue 3. 2013-11-01. PMID:24179466.' |
acetylcholinesterase is involved in the termination of impulse transmission by rapid hydrolysis of the neurotransmitter acetylcholine in numerous cholinergic pathways in the central and peripheral nervous systems. |
2013-11-01 |
2023-08-12 |
Not clear |
| G A Reid, N Chilukuri, S Darves. Butyrylcholinesterase and the cholinergic system. Neuroscience. vol 234. 2013-10-25. PMID:23305761. |
the cholinergic neurotransmitter acetylcholine is synthesized by choline acetyltransferase (chat) and its action terminated by acetylcholinesterase (ache) and butyrylcholinesterase (buche). |
2013-10-25 |
2023-08-12 |
mouse |
| Preet Anand, Baldev Sing. A review on cholinesterase inhibitors for Alzheimer's disease. Archives of pharmacal research. vol 36. issue 4. 2013-10-25. PMID:23435942. |
cholinesterase inhibitors enhance cholinergic transmission directly by inhibiting the enzyme acetylcholinesterase (ache) which hydrolyses acetylcholine. |
2013-10-25 |
2023-08-12 |
Not clear |
| Xiugong Gao, Hsiuling Lin, Radharaman Ray, Prabhati Ra. Toxicogenomic studies of human neural cells following exposure to organophosphorus chemical warfare nerve agent VX. Neurochemical research. vol 38. issue 5. 2013-10-22. PMID:23440544. |
op compounds are considered acting primarily via cholinergic pathways by binding irreversibly to acetylcholinesterase, an important regulator of the neurotransmitter acetylcholine. |
2013-10-22 |
2023-08-12 |
human |
| Qingwei Ruan, Fang Liu, Zhanjuan Gao, Deqiu Kong, Xiaona Hu, Dongmei Shi, Zhijun Bao, Zhuowei Y. The anti-inflamm-aging and hepatoprotective effects of huperzine A in D-galactose-treated rats. Mechanisms of ageing and development. vol 134. issue 3-4. 2013-09-30. PMID:23313706. |
acetylcholinesterase inhibitors (achei) can enhance cholinergic transmission and act as anti-inflammatory agents via immunocompetent cells expressing α-7 acetylcholine receptors (achr). |
2013-09-30 |
2023-08-12 |
rat |
| Jia Zhang, Yan-feng Zhen, Pu-Bu-Ci-Ren, Li-gang Song, Wei-na Kong, Tie-mei Shao, Xue Li, Xi-qing Cha. Salidroside attenuates beta amyloid-induced cognitive deficits via modulating oxidative stress and inflammatory mediators in rat hippocampus. Behavioural brain research. vol 244. 2013-09-30. PMID:23396166. |
after behavioral testing, the rats were sacrificed and hippocampi were removed for biochemical assays (reactive oxygen species (ros), superoxide dismutase (sod), glutathione peroxidase (gpx), malondialdehyde (mda), acetylcholinesterase (ache), acetylcholine (ach)) and molecular biological analysis (cu/zn-sod, mn-sod, gpx, nicotinamide adenine dinucleotide phosphate (nadph) oxidase, nuclear factor κb (nf-κb), inhibitor of κb-alpha (iκbα), cyclooxygenase-2 (cox-2), inducible nitric oxide synthase (inos), receptor for advanced glycation end products (rage)). |
2013-09-30 |
2023-08-12 |
rat |
| Girish Beedessee, Avin Ramanjooloo, Rashmee Surnam-Boodhun, Rob W M van Soest, Daniel E P Mari. Acetylcholinesterase-inhibitory activities of the extracts from sponges collected in mauritius waters. Chemistry & biodiversity. vol 10. issue 3. 2013-09-17. PMID:23495160. |
the use of acetylcholinesterase (ache) inhibitors to retard the hydrolysis of acetylcholine has been suggested as a promising strategy for ad treatment. |
2013-09-17 |
2023-08-12 |
Not clear |
| William C Motel, Andrew Coop, Christopher W Cunningha. Cholinergic modulation by opioid receptor ligands: potential application to Alzheimer's disease. Mini reviews in medicinal chemistry. vol 13. issue 3. 2013-08-12. PMID:22931533. |
galantamine is a reversible, competitive acetylcholinesterase (ache) inhibitor and allosteric potentiating ligand of nicotinic acetylcholine receptors (nachr-apl) that shares many common structural elements with morphinan-based opioids. |
2013-08-12 |
2023-08-12 |
Not clear |
| Lei An, Zhuo Yang, Tao Zhan. Melamine induced spatial cognitive deficits associated with impairments of hippocampal long-term depression and cholinergic system in Wistar rats. Neurobiology of learning and memory. vol 100. 2013-07-23. PMID:23231966. |
water maze behavior and long-term depression (ltd) in hippocampal ca3-ca1 pathway were measured, followed by enzyme linked immunosorbent assay (elisa), by which acetylcholine (ach) level and acetylcholinesterase (ache) activity were determined. |
2013-07-23 |
2023-08-12 |
rat |
| Tetsufumi Sato, Hideki Nakatsuk. [Anticholinesterases; peripheral and central effects]. Masui. The Japanese journal of anesthesiology. vol 62. issue 1. 2013-07-18. PMID:23431890. |
the drugs have slightly different pharmacological properties, but they all work by inhibiting the breakdown of acetylcholine, an important neurotransmitter associated with memory, by blocking the enzyme acetylcholinesterase. |
2013-07-18 |
2023-08-12 |
Not clear |
| Ahmad Mohammadi-Farani, Aram Ahmadi, Hamid Nadri, Alireza Aliabad. Synthesis, docking and acetylcholinesterase inhibitory assessment of 2-(2-(4-Benzylpiperazin-1-yl)ethyl)isoindoline-1,3-dione derivatives with potential anti-Alzheimer effects. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. vol 21. issue 1. 2013-07-09. PMID:23758724. |
in recent years, acetylcholinesterase (ache) inhibitors like donepezil with prevention of acetylcholine hydrolysis can enhance the duration of action of acetylcholine in synaptic cleft and improve the dementia associated with alzheimer's disease. |
2013-07-09 |
2023-08-12 |
Not clear |