| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohammad Sadegh Sadeghi Googheri, Mohammad Reza Housaindokht, Hassan Sabzya. Reaction mechanism and free energy profile for acylation of Candida Antarctica lipase B with methylcaprylate and acetylcholine: density functional theory calculations. Journal of molecular graphics & modelling. vol 54. 2015-09-01. PMID:25459765. |
candida antarctica lipase b (calb), a specific enzyme to catalyze the hydrolysis of esters, can be a good candidate for acetylcholine (ach) hydrolysis instead of acetylcholinesterase. |
2015-09-01 |
2023-08-13 |
Not clear |
| Benjamín Pérez-Aguilar, Cecilio J Vidal, Guillermina Palomec, Fernando García-Dolores, María Concepción Gutiérrez-Ruiz, Leticia Bucio, José Luis Gómez-Olivares, Luis Enrique Gómez-Quiro. Acetylcholinesterase is associated with a decrease in cell proliferation of hepatocellular carcinoma cells. Biochimica et biophysica acta. vol 1852. issue 7. 2015-08-27. PMID:25869328. |
acetylcholinesterase (ache), the enzyme that rapidly splits acetylcholine into acetate and choline, presents non-cholinergic functions through which may participate in the control of cell proliferation and apoptosis. |
2015-08-27 |
2023-08-13 |
human |
| Wesley G Corrêa, Marina T Durand, Christiane Becari, Geisa C S V Tezini, Jussara M do Carmo, Mauro de Oliveira, Cibele M Prado, Rubens Fazan, Helio C Salgad. Pyridostigmine prevents haemodynamic alterations but does not affect their nycthemeral oscillations in infarcted mice. Autonomic neuroscience : basic & clinical. vol 187. 2015-08-26. PMID:25434306. |
the increase in acetylcholine yielded by pyridostigmine (pyr), an acetylcholinesterase inhibitor, was evaluated for its effect on the haemodynamic responses-mean arterial pressure (map) and heart rate (hr)-and their nycthemeral oscillation in mice before and one week after myocardial infarction (mi). |
2015-08-26 |
2023-08-13 |
mouse |
| Ana Claudia Souza, Andressa Souza, Liciane Fernandes Medeiros, Carla De Oliveira, Vanessa Leal Scarabelot, Rosane Souza Da Silva, Mauricio Reis Bogo, Katiucia Marques Capiotti, Luiza Wilges Kist, Carla D Bonan, Wolnei Caumo, Iraci L S Torre. Maternal caffeine exposure alters neuromotor development and hippocampus acetylcholinesterase activity in rat offspring. Brain research. vol 1595. 2015-08-21. PMID:25451122. |
the objective of this study was to evaluate the effects of maternal caffeine intake on the neuromotor development of rat offspring and on acetylcholine degradation and acetylcholinesterase (ache) expression in the hippocampus of 14-day-old infant rats. |
2015-08-21 |
2023-08-13 |
rat |
| Mohamed A Elnasharty, Ahmed Sayed-Ahme. Expression and localization of pChAT as a novel method to study cholinergic innervation of rat adrenal gland. Acta histochemica. vol 116. issue 8. 2015-08-20. PMID:25239149. |
cholinergic innervation of the rat adrenal gland has been analyzed previously using cholinergic markers including acetylcholinesterase (ache), choline acetyltransferase (chat) and vesicular acetylcholine transporter (vacht). |
2015-08-20 |
2023-08-13 |
rat |
| Fen Wang, Xianzhong Zeng, Yangbo Zhu, Dan Ning, Junxia Liu, Chunlei Liu, Xuemei Jia, Defa Zh. Effects of thyroxine and donepezil on hippocampal acetylcholine content, acetylcholinesterase activity, synaptotagmin-1 and SNAP-25 expression in hypothyroid adult rats. Molecular medicine reports. vol 11. issue 2. 2015-07-30. PMID:25371181. |
effects of thyroxine and donepezil on hippocampal acetylcholine content, acetylcholinesterase activity, synaptotagmin-1 and snap-25 expression in hypothyroid adult rats. |
2015-07-30 |
2023-08-13 |
rat |
| Fen Wang, Xianzhong Zeng, Yangbo Zhu, Dan Ning, Junxia Liu, Chunlei Liu, Xuemei Jia, Defa Zh. Effects of thyroxine and donepezil on hippocampal acetylcholine content, acetylcholinesterase activity, synaptotagmin-1 and SNAP-25 expression in hypothyroid adult rats. Molecular medicine reports. vol 11. issue 2. 2015-07-30. PMID:25371181. |
the present study has investigated the effect of t4 and donepezil (don; an acetylcholinesterase (ache) inhibitor) treatment on the hypothyroidism-induced alterations of acetylcholine (ach) content and ache activity. |
2015-07-30 |
2023-08-13 |
rat |
| Armando Méndez-Garrido, Maricarmen Hernández-Rodríguez, Rafael Zamorano-Ulloa, José Correa-Basurto, Jessica Elena Mendieta-Wejebe, Daniel Ramírez-Rosales, Martha Cecilia Rosales-Hernánde. In vitro effect of H2O 2, some transition metals and hydroxyl radical produced via fenton and fenton-like reactions, on the catalytic activity of AChE and the hydrolysis of ACh. Neurochemical research. vol 39. issue 11. 2015-07-29. PMID:25096900. |
it is well known that the principal biomolecules involved in alzheimer's disease (ad) are acetylcholinesterase (ache), acetylcholine (ach) and the amyloid beta peptide of 42 amino acid residues (aβ42). |
2015-07-29 |
2023-08-13 |
Not clear |
| Ian R Macdonald, Kenneth Rockwood, Earl Martin, Sultan Darves. Cholinesterase inhibition in Alzheimer's disease: is specificity the answer? Journal of Alzheimer's disease : JAD. vol 42. issue 2. 2015-07-20. PMID:24898642. |
acetylcholinesterase (ache) catalyzes the hydrolysis of the cholinergic neurotransmitter acetylcholine. |
2015-07-20 |
2023-08-13 |
Not clear |
| Jean-Dominique Gallezot, Irina Esterlis, Frederic Bois, Ming-Qiang Zheng, Shu-Fei Lin, Tracy Kloczynski, John H Krystal, Yiyun Huang, Osama Sabri, Richard E Carson, Kelly P Cosgrov. Evaluation of the sensitivity of the novel α4β2* nicotinic acetylcholine receptor PET radioligand 18F-(-)-NCFHEB to increases in synaptic acetylcholine levels in rhesus monkeys. Synapse (New York, N.Y.). vol 68. issue 11. 2015-06-26. PMID:25043426. |
the goal of this study was to assess the sensitivity of 18f-(-)-ncfheb-pet to increases in synaptic acetylcholine concentration induced by acetylcholinesterase inhibitors. |
2015-06-26 |
2023-08-13 |
monkey |
| Vendula Sepsova, Jana Z Karasova, Gunnar Tobin, Daniel Jun, Jan Korabecny, Pavla Cabelova, Katerina Janska, Jan Krusek, Kristyna Skrenkova, Kamil Kuca, Ondrej Souku. Cholinergic properties of new 7-methoxytacrine-donepezil derivatives. General physiology and biophysics. vol 34. issue 2. 2015-06-18. PMID:25504063. |
organophosphorus nerve agents inhibit acetylcholinesterase (ache) which causes the breakdown of the transmitter acetylcholine (ach) in the synaptic cleft. |
2015-06-18 |
2023-08-13 |
Not clear |
| Gulseher Sarah Sirin, Yingkai Zhan. How is acetylcholinesterase phosphonylated by soman? An ab initio QM/MM molecular dynamics study. The journal of physical chemistry. A. vol 118. issue 39. 2015-06-16. PMID:24786171. |
acetylcholinesterase (ache) is a crucial enzyme in the cholinergic nerve system that hydrolyzes acetylcholine (ach) and terminates synaptic signals by reducing the effective concentration of ach in the synaptic clefts. |
2015-06-16 |
2023-08-13 |
Not clear |
| Rui Zhang, Jingzhu Zhang, Lingduo Fang, Xi Li, Yue Zhao, Wanying Shi, Li A. Neuroprotective effects of sulforaphane on cholinergic neurons in mice with Alzheimer's disease-like lesions. International journal of molecular sciences. vol 15. issue 8. 2015-06-05. PMID:25196440. |
however, spectrophotometry revealed no significant difference in acetylcholine level or the activity of choline acetyltransferase or acetylcholinesterase in the cerebral cortex among groups of control and ad-like mice with and without sulforaphane treatment. |
2015-06-05 |
2023-08-13 |
mouse |
| Avital Stern, Matteo Guidotti, Eleonora Shaubi, Mary Popov, Charles Linder, Eliahu Heldman, Sarina Grinber. Steric environment around acetylcholine head groups of bolaamphiphilic nanovesicles influences the release rate of encapsulated compounds. International journal of nanomedicine. vol 9. 2015-05-11. PMID:24531296. |
two bolaamphiphilic compounds with identical acetylcholine (ach) head groups, but with different lengths of an alkyl chain pendant adjacent to the head group, as well as differences between their hydrophobic skeleton, were investigated for their ability to self-assemble into vesicles that release their encapsulated content upon hydrolysis of their head groups by acetylcholinesterase (ache). |
2015-05-11 |
2023-08-12 |
Not clear |
| Jian-Rong Cai, Li-Na Zhou, En Ha. A sensitive amperometric acetylcholine biosensor based on carbon nanosphere and acetylcholinesterase modified electrode for detection of pesticide residues. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. vol 30. issue 6. 2015-04-20. PMID:24919672. |
a sensitive amperometric acetylcholine biosensor based on carbon nanosphere and acetylcholinesterase modified electrode for detection of pesticide residues. |
2015-04-20 |
2023-08-13 |
Not clear |
| Haineng Xu, Zhengxuan Shen, Jing Xiao, Yu Yang, Weidan Huang, Zhiming Zhou, Jiani Shen, Yizhun Zhu, Xin-Yuan Liu, Liang Ch. Acetylcholinesterase overexpression mediated by oncolytic adenovirus exhibited potent anti-tumor effect. BMC cancer. vol 14. 2015-04-20. PMID:25220382. |
acetylcholinesterase (ache) mainly functions as an efficient terminator for acetylcholine signaling transmission. |
2015-04-20 |
2023-08-13 |
Not clear |
| Shani Shenhar-Tsarfaty, Shlomo Berliner, Natan M Bornstein, Hermona Sore. Cholinesterases as biomarkers for parasympathetic dysfunction and inflammation-related disease. Journal of molecular neuroscience : MN. vol 53. issue 3. 2015-04-06. PMID:24254221. |
acetylcholine, the main parasympathetic neurotransmitter and inflammation regulator, is hydrolyzed by the two closely homologous enzymes, acetylcholinesterase and butyrylcholinesterase (ache and bche, respectively), which are also expressed in the serum. |
2015-04-06 |
2023-08-12 |
Not clear |
| Karina Silvia Matos, Elaine F F da Cunha, Ruben Abagyan, Teodorico C Ramalh. Computational evidence for the reactivation process of human acetylcholinesterase inhibited by carbamates. Combinatorial chemistry & high throughput screening. vol 17. issue 6. 2015-04-06. PMID:24344993. |
acetylcholinesterase (ache) is responsible for hydrolysis of acetylcholine (ach), a function, which if disrupted, leads to cholinergic syndrome. |
2015-04-06 |
2023-08-12 |
human |
| Jonah Cheung, Veena Beri, Kazuro Shiomi, Terrone L Rosenberr. Acetylcholinesterase complexes with the natural product inhibitors dihydrotanshinone I and territrem B: binding site assignment from inhibitor competition and validation through crystal structure determination. Journal of molecular neuroscience : MN. vol 53. issue 3. 2015-04-06. PMID:24573600. |
acetylcholinesterase (ache) is a critical enzyme that regulates neurotransmission by degrading the neurotransmitter acetylcholine in synapses of the nervous system. |
2015-04-06 |
2023-08-12 |
human |
| Qi Sun, Da-Yong Peng, Sheng-Gang Yang, Xiao-Lei Zhu, Wen-Chao Yang, Guang-Fu Yan. Syntheses of coumarin-tacrine hybrids as dual-site acetylcholinesterase inhibitors and their activity against butylcholinesterase, Aβ aggregation, and β-secretase. Bioorganic & medicinal chemistry. vol 22. issue 17. 2015-04-06. PMID:25088549. |
exploring small-molecule acetylcholinesterase (ache) inhibitors to slow the breakdown of acetylcholine (ach) represents the mainstream direction for alzheimer's disease (ad) therapy. |
2015-04-06 |
2023-08-13 |
human |