| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ignaz Wessler, Rosmarie Michel-Schmidt, Charles James Kirkpatric. pH-dependent hydrolysis of acetylcholine: Consequences for non-neuronal acetylcholine. International immunopharmacology. vol 29. issue 1. 2016-09-14. PMID:25929445. |
acetylcholine is inactivated by acetylcholinesterase and butyrylcholinesterase and thereby its cellular signalling is stopped. |
2016-09-14 |
2023-08-13 |
human |
| Shino Oikawa, Asuka Mano, Mitsue Iketani, Yoshihiko Kakinum. Nicotinic receptor-dependent and -independent effects of galantamine, an acetylcholinesterase inhibitor, on the non-neuronal acetylcholine system in C2C12 cells. International immunopharmacology. vol 29. issue 1. 2016-09-14. PMID:25979761. |
nicotinic receptor-dependent and -independent effects of galantamine, an acetylcholinesterase inhibitor, on the non-neuronal acetylcholine system in c2c12 cells. |
2016-09-14 |
2023-08-13 |
Not clear |
| Susanne Hainke, Johannes Wildmann, Adriana Del Re. Deletion of muscarinic type 1 acetylcholine receptors alters splenic lymphocyte functions and splenic noradrenaline concentration. International immunopharmacology. vol 29. issue 1. 2016-09-14. PMID:26002586. |
the spleen does not receive cholinergic innervation, but it has been reported that lymphocytes themselves can produce acetylcholine, and express acetylcholine receptors and acetylcholinesterase. |
2016-09-14 |
2023-08-13 |
mouse |
| Malte Haupt, Vivien Kauschke, Jonas Sender, Marian Kampschulte, Anna Kovtun, Lutz Dürselen, Christian Heiss, Katrin Susanne Lip. Bone status of adult female butyrylcholinesterase gene-deficient mice. International immunopharmacology. vol 29. issue 1. 2016-09-14. PMID:26138460. |
butyrylcholinesterase (bche) degrades acetylcholine in addition to acetylcholinesterase (ache) which is involved in embryonic development of limbs. |
2016-09-14 |
2023-08-13 |
mouse |
| Vivien Kauschke, Mathias Kneffel, Wolfgang Floel, Sonja Hartmann, Marian Kampschulte, Lutz Dürselen, Anita Ignatius, Reinhard Schnettler, Christian Heiss, Katrin Susanne Lip. Bone status of acetylcholinesterase-knockout mice. International immunopharmacology. vol 29. issue 1. 2016-09-14. PMID:26250336. |
acetylcholinesterase (ache) hydrolyzes acetylcholine (ach) to acetate and choline and thereby terminates nerve impulse transmission. |
2016-09-14 |
2023-08-13 |
mouse |
| Christina Nassenstein, Silke Wiegand, Katrin S Lips, Guanfeng Li, Jochen Klein, Wolfgang Kumme. Cholinergic activation of the murine trachealis muscle via non-vesicular acetylcholine release involving low-affinity choline transporters. International immunopharmacology. vol 29. issue 1. 2016-09-14. PMID:26278668. |
in addition to quantal, vesicular release of acetylcholine (ach), there is also non-quantal release at the motor endplate which is insufficient to evoke postsynaptic responses unless acetylcholinesterase (ache) is inhibited. |
2016-09-14 |
2023-08-13 |
mouse |
| b' Danijela B Vu\\xc4\\x8devi\\xc4\\x87, Ivana B Cerovi\\xc4\\x87, Du\\xc5\\xa1an R Mladenovi\\xc4\\x87, Milena N Veskovi\\xc4\\x87, Ivana Stevanovi\\xc4\\x87, Bojan Z Jorga\\xc4\\x8devi\\xc4\\x87, Rada Je\\xc5\\xa1i\\xc4\\x87 Vuki\\xc4\\x87evi\\xc4\\x87, Tatjana S Radosavljevi\\xc4\\x8. Methionine-choline deprivation alters liver and brain acetylcholinesterase activity in C57BL6 mice. General physiology and biophysics. vol 35. issue 3. 2016-09-13. PMID:27174897.' |
choline and methionine are precursors of acetylcholine, whose hydrolysis is catalyzed by acetylcholinesterase (ache). |
2016-09-13 |
2023-08-13 |
mouse |
| Michael F Santillo, Yitong Li. A fluorescence assay for measuring acetylcholinesterase activity in rat blood and a human neuroblastoma cell line (SH-SY5Y). Journal of pharmacological and toxicological methods. vol 76. 2016-09-12. PMID:26165232. |
acetylcholinesterase (ache) is an enzyme responsible for metabolism of the neurotransmitter acetylcholine, and inhibition of ache can have therapeutic applications (e.g., drugs for alzheimer's disease) or neurotoxic consequences (e.g., pesticides). |
2016-09-12 |
2023-08-13 |
human |
| Jean-Luc Fattebert, Edmond Y Lau, Brian J Bennion, Patrick Huang, Felice C Lightston. Large-Scale First-Principles Molecular Dynamics Simulations with Electrostatic Embedding: Application to Acetylcholinesterase Catalysis. Journal of chemical theory and computation. vol 11. issue 12. 2016-09-09. PMID:26642985. |
we obtained finite-temperature sampling by first-principles molecular dynamics for the acylation reaction of acetylcholine catalyzed by acetylcholinesterase. |
2016-09-09 |
2023-08-13 |
Not clear |
| Saw Simeon, Nuttapat Anuwongcharoen, Watshara Shoombuatong, Aijaz Ahmad Malik, Virapong Prachayasittikul, Jarl E S Wikberg, Chanin Nantasenama. Probing the origins of human acetylcholinesterase inhibition via QSAR modeling and molecular docking. PeerJ. vol 4. 2016-09-07. PMID:27602288. |
acetylcholinesterase (ache) is an enzyme that catalyzes the breakdown of the neurotransmitter acetylcholine that is essential for cognition and memory. |
2016-09-07 |
2023-08-13 |
human |
| Allister Vale, Marcello Lott. Organophosphorus and carbamate insecticide poisoning. Handbook of clinical neurology. vol 131. 2016-08-18. PMID:26563788. |
both organophosphorus (op) and carbamate insecticides inhibit acetylcholinesterase (ache), which results in accumulation of acetylcholine (ach) at autonomic and some central synapses and at autonomic postganglionic and neuromuscular junctions. |
2016-08-18 |
2023-08-13 |
human |
| Sehan Lee, Mace G Barro. Development of 3D-QSAR Model for Acetylcholinesterase Inhibitors Using a Combination of Fingerprint, Molecular Docking, and Structure-Based Pharmacophore Approaches. Toxicological sciences : an official journal of the Society of Toxicology. vol 148. issue 1. 2016-08-16. PMID:26202430. |
acetylcholinesterase (ache), a serine hydrolase vital for regulating the neurotransmitter acetylcholine in animals, has been used as a target for drugs and pesticides. |
2016-08-16 |
2023-08-13 |
Not clear |
| Chand D Basha, Rajarami G Redd. Long-term changes in brain cholinergic system and behavior in rats following gestational exposure to lead: protective effect of calcium supplement. Interdisciplinary toxicology. vol 8. issue 4. 2016-08-03. PMID:27486377. |
biochemical analysis showed decrease in synaptosomal acetylcholinesterase (ache) activity and an increase in acetylcholine (ach) levels in the cortex, cerebellum and hippocampus on pnd 14, pnd 21, pnd 28 and in the four-month age group of rats following pb exposure. |
2016-08-03 |
2023-08-13 |
rat |
| Aiying Du, Jing Xie, Kaijie Guo, Lei Yang, Yihan Wan, Qi OuYang, Xuejin Zhang, Xin Niu, Lu Lu, Jun Wu, Xuejun Zhan. A novel role for synaptic acetylcholinesterase as an apoptotic deoxyribonuclease. Cell discovery. vol 1. 2016-07-27. PMID:27462404. |
in addition to terminating neurotransmission by hydrolyzing acetylcholine, synaptic acetylcholinesterase (aches) has been found to have a pro-apoptotic role. |
2016-07-27 |
2023-08-13 |
Not clear |
| b' Matej Ku\\xc4\\x8dera, Anna Hrabovsk\\xc3\\xa. [Cholinergic system of the heart]. Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti. vol 64. issue 6. 2016-07-25. PMID:26841700.' |
the effect of acetylcholine in the heart is terminated by cholinesterases acetylcholinesterase and butyrylcholinesterase. |
2016-07-25 |
2023-08-13 |
Not clear |
| Gökhan Demirci, Yasemin İspirli Doğaç, Mustafa Tek. A selective molecularly imprinted polymer for immobilization of acetylcholinesterase (AChE): an active enzyme targeted and efficient method. Journal of molecular recognition : JMR. vol 28. issue 11. 2016-07-19. PMID:25857716. |
in the present study, we immobilized acetylcholinesterase (ache) enzyme onto acetylcholine removed imprinted polymer and acetylcholine containing polymer. |
2016-07-19 |
2023-08-13 |
Not clear |
| Hammad Saleem, Irshad Ahmad, Muhammad Nabeel Shahid, Muhammad Shoaib Ali Gill, Muhammad Faisal Nadeem, Waqas Mahmood, Imran Rashi. IN VITRO ACETYLCHOLINESTERASE AND BUTYRYLCHOLINESTERASE INHIBITORY POTENTIALS OF JATROPHA GOSSYPIFOLIA PLANT EXTRACTS. Acta poloniae pharmaceutica. vol 73. issue 2. 2016-06-20. PMID:27180434. |
inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (buche), which breakdown acetylcholine and butyrylcholine, are considered as a promising strategy in the management of alzheimer's disease (ad). |
2016-06-20 |
2023-08-13 |
Not clear |
| Franziska Mohr, Eric Krejci, Martina Zimmermann, Jochen Klei. Dysfunctional Presynaptic M2 Receptors in the Presence of Chronically High Acetylcholine Levels: Data from the PRiMA Knockout Mouse. PloS one. vol 10. issue 10. 2016-06-10. PMID:26506622. |
activation of the m2 receptor limits acetylcholine (ach) release, especially when ach levels are increased because acetylcholinesterase (ache) activity is acutely inhibited. |
2016-06-10 |
2023-08-13 |
mouse |
| Christopher D Ruark, Richard R Chapleau, Deirdre A Mahle, Jeffery M Gearhar. Organophosphorus Inhibition and Characterization of Recombinant Guinea Pig Acetylcholinesterase. Protein and peptide letters. vol 22. issue 10. 2016-05-23. PMID:26216268. |
organophosphorus (op) pesticides and nerve agents have been designed to inhibit the hydrolysis of the neurotransmitter acetylcholine by covalently binding to the active site serine of acetylcholinesterase while alzheimer drugs and prophylactics, such as tacrine, are characterized by reversible binding. |
2016-05-23 |
2023-08-13 |
human |
| Tetsade C B Piermartiri, Hongna Pan, Jun Chen, John McDonough, Neil Grunberg, James P Apland, Ann M Marin. Alpha-Linolenic Acid-Induced Increase in Neurogenesis is a Key Factor in the Improvement in the Passive Avoidance Task After Soman Exposure. Neuromolecular medicine. vol 17. issue 3. 2016-05-20. PMID:25920465. |
exposure to organophosphorous (op) nerve agents such as soman inhibits the critical enzyme acetylcholinesterase (ache) leading to excessive acetylcholine accumulation in synapses, resulting in cholinergic crisis, status epilepticus and brain damage in survivors. |
2016-05-20 |
2023-08-13 |
Not clear |