| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tamara Lazarevic-Pasti, Andreja Leskovac, Tatjana Momic, Sandra Petrovic, Vesna Vasi. Modulators of Acetylcholinesterase Activity: From Alzheimer's Disease to Anti-Cancer Drugs. Current medicinal chemistry. vol 24. issue 30. 2017-11-29. PMID:28685687. |
acetylcholinesterase (ache) is involved in the termination of impulse transmission by rapid hydrolysis of the neurotransmitter acetylcholine in numerous cholinergic pathways in the central and peripheral nervous systems. |
2017-11-29 |
2023-08-13 |
Not clear |
| Yuehua Guo, Kaili Yang, Jiachen Sun, Jie Wu, Huangxian J. A pH-responsive colorimetric strategy for DNA detection by acetylcholinesterase catalyzed hydrolysis and cascade amplification. Biosensors & bioelectronics. vol 94. 2017-11-20. PMID:28388529. |
a ph-responsive colorimetric strategy was designed for sensitive and convenient biosensing by introducing acetylcholinesterase (ache) catalyzed hydrolysis of acetylcholine to change solution ph and phenol red as an indicator. |
2017-11-20 |
2023-08-13 |
Not clear |
| Mirna Ezzat Sorial, Nesrine Salah El Dine El Saye. Protective effect of valproic acid in streptozotocin-induced sporadic Alzheimer's disease mouse model: possible involvement of the cholinergic system. Naunyn-Schmiedeberg's archives of pharmacology. vol 390. issue 6. 2017-11-08. PMID:28188358. |
the mice also exhibited a decrease in acetylcholine (ach) and neprilysin (nep) levels accompanied by an increase in acetylcholinesterase (ache) activity. |
2017-11-08 |
2023-08-13 |
mouse |
| Mohammad Nazim, Akio Masuda, Mohammad Alinoor Rahman, Farhana Nasrin, Jun-Ichi Takeda, Kenji Ohe, Bisei Ohkawara, Mikako Ito, Kinji Ohn. Competitive regulation of alternative splicing and alternative polyadenylation by hnRNP H and CstF64 determines acetylcholinesterase isoforms. Nucleic acids research. vol 45. issue 3. 2017-10-30. PMID:28180311. |
acetylcholinesterase (ache), encoded by the ache gene, hydrolyzes the neurotransmitter acetylcholine to terminate synaptic transmission. |
2017-10-30 |
2023-08-13 |
human |
| Shuaizhang Li, Ruili Huang, Samuel Solomon, Yitong Liu, Bin Zhao, Michael F Santillo, Menghang Xi. Identification of acetylcholinesterase inhibitors using homogenous cell-based assays in quantitative high-throughput screening platforms. Biotechnology journal. vol 12. issue 5. 2017-10-25. PMID:28294544. |
acetylcholinesterase (ache) is an enzyme responsible for metabolism of acetylcholine, a neurotransmitter associated with muscle movement, cognition, and other neurobiological processes. |
2017-10-25 |
2023-08-13 |
human |
| Asante R Kamkwalala, Paul A Newhous. Beyond Acetylcholinesterase Inhibitors: Novel Cholinergic Treatments for Alzheimer's Disease. Current Alzheimer research. vol 14. issue 4. 2017-10-04. PMID:27697062. |
currently, the most widely prescribed treatment for ad is acetylcholinesterase inhibitor medications, which work by partially blocking the degradation of acetylcholine in the synapse and enabling more of the neurotransmitter to reach and activate cholinergic receptors. |
2017-10-04 |
2023-08-13 |
human |
| Sultan Darves. Butyrylcholinesterase as a Diagnostic and Therapeutic Target for Alzheimer's Disease. Current Alzheimer research. vol 13. issue 10. 2017-10-02. PMID:27040140. |
the serine hydrolase butyrylcholinesterase (bche), like the related enzyme acetylcholinesterase (ache), co-regulates metabolism of the neurotransmitter acetylcholine. |
2017-10-02 |
2023-08-13 |
mouse |
| Melissa A Pickett, Michael K Dush, Nanette M Nascone-Yode. Acetylcholinesterase plays a non-neuronal, non-esterase role in organogenesis. Development (Cambridge, England). vol 144. issue 15. 2017-10-02. PMID:28684626. |
acetylcholinesterase (ache) is crucial for degrading acetylcholine at cholinergic synapses. |
2017-10-02 |
2023-08-13 |
Not clear |
| Miranda L Xu, Cathy W C Bi, Etta Y L Liu, Tina T X Dong, Karl W K Tsi. Wnt3a induces the expression of acetylcholinesterase during osteoblast differentiation via the Runx2 transcription factor. The Journal of biological chemistry. vol 292. issue 30. 2017-09-26. PMID:28607150. |
acetylcholinesterase (ache) hydrolyzes acetylcholine to terminate cholinergic transmission in neurons. |
2017-09-26 |
2023-08-13 |
human |
| Thomas Driant, Florian Nachon, Cyril Ollivier, Pierre-Yves Renard, Etienne Dera. On the Influence of the Protonation States of Active Site Residues on AChE Reactivation: A QM/MM Approach. Chembiochem : a European journal of chemical biology. vol 18. issue 7. 2017-09-19. PMID:28106328. |
acetylcholinesterase (ache), an enzyme of the serine hydrolase superfamily, is a mediator of signal transmission at cholinergic synapses by catalyzing acetylcholine cleavage into acetate and choline. |
2017-09-19 |
2023-08-13 |
Not clear |
| Alon Simchovitz, Michael T Heneka, Hermona Sore. Personalized genetics of the cholinergic blockade of neuroinflammation. Journal of neurochemistry. vol 142 Suppl 2. 2017-09-07. PMID:28326544. |
cholinomirs coordinate the cognitive and inflammatory aspects of cholinergic signaling by targeting major cholinergic transcripts including the acetylcholine hydrolyzing enzyme acetylcholinesterase (ache). |
2017-09-07 |
2023-08-13 |
Not clear |
| Pascal Kessler, Pascale Marchot, Marcela Silva, Denis Serven. The three-finger toxin fold: a multifunctional structural scaffold able to modulate cholinergic functions. Journal of neurochemistry. vol 142 Suppl 2. 2017-09-07. PMID:28326549. |
by blocking the activity of the nicotinic and muscarinic acetylcholine receptors or by inhibiting the enzyme acetylcholinesterase, three-finger fold toxins interfere most drastically with neuromuscular junction functioning. |
2017-09-07 |
2023-08-13 |
Not clear |
| Nikola Maraković, Goran Šink. The Lock is the Key: Development of Novel Drugs through Receptor Based Combinatorial Chemistry. Acta chimica Slovenica. vol 64. issue 1. 2017-09-07. PMID:28380234. |
huisgen's cycloaddition can be applied to various receptors including acetylcholinesterase, acetylcholine binding protein, carbonic anhydrase-ii, serine/threonine-protein kinase and minor groove of dna. |
2017-09-07 |
2023-08-13 |
Not clear |
| Richard D Burke, Spencer W Todd, Eric Lumsden, Roger J Mullins, Jacek Mamczarz, William P Fawcett, Rao P Gullapalli, William R Randall, Edna F R Pereira, Edson X Albuquerqu. Developmental neurotoxicity of the organophosphorus insecticide chlorpyrifos: from clinical findings to preclinical models and potential mechanisms. Journal of neurochemistry. vol 142 Suppl 2. 2017-09-07. PMID:28791702. |
clinical manifestations of an acute exposure of humans to op insecticides include a well-defined cholinergic crisis that develops as a result of the irreversible inhibition of acetylcholinesterase (ache), the enzyme that hydrolyzes the neurotransmitter acetylcholine (ach). |
2017-09-07 |
2023-08-13 |
Not clear |
| Hugo R Arias, Federica Ravazzini, Katarzyna M Targowska-Duda, Agnieszka A Kaczor, Dominik Feuerbach, Juan C Boffi, Piotr Draczkowski, Dirk Montag, Brandon M Brown, Ana Belén Elgoyhen, Krzysztof Jozwiak, Giulia Pui. Positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of other ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content. The international journal of biochemistry & cell biology. vol 76. 2017-09-04. PMID:27129924. |
positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of other ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content. |
2017-09-04 |
2023-08-13 |
mouse |
| Hugo R Arias, Federica Ravazzini, Katarzyna M Targowska-Duda, Agnieszka A Kaczor, Dominik Feuerbach, Juan C Boffi, Piotr Draczkowski, Dirk Montag, Brandon M Brown, Ana Belén Elgoyhen, Krzysztof Jozwiak, Giulia Pui. Positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of other ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content. The international journal of biochemistry & cell biology. vol 76. 2017-09-04. PMID:27129924. |
the activity of positive allosteric modulators (pams) of α7 nicotinic acetylcholine receptors (achrs), including 3-furan-2-yl-n-p-tolyl-acrylamide (pam-2), 3-furan-2-yl-n-o-tolylacrylamide (pam-3), and 3-furan-2-yl-n-phenylacrylamide (pam-4), was tested on a variety of ligand- [i.e., human (h) α7, rat (r) α9α10, hα3-containing achrs, mouse (m) 5-ht3ar, and several glutamate receptors (glurs)] and voltage-gated (i.e., sodium and potassium) ion channels, as well as on acetylcholinesterase (ache) and β-amyloid (aβ) content. |
2017-09-04 |
2023-08-13 |
mouse |
| Young-Ji Shiao, Muh-Hwan Su, Hang-Ching Lin, Chi-Rei W. Echinacoside ameliorates the memory impairment and cholinergic deficit induced by amyloid beta peptides via the inhibition of amyloid deposition and toxicology. Food & function. vol 8. issue 6. 2017-08-14. PMID:28581010. |
intracisternal infusion with aβ 1-42 by an osmotic pump caused cognitive deficits, an increase in amyloid deposition and acetylcholinesterase activities, and a decrease in the brain's levels of acetylcholine and dopamine. |
2017-08-14 |
2023-08-13 |
mouse |
| Wan Nurul Nazneem Wan Othman, Sook Yee Liew, Kooi Yeong Khaw, Vikneswaran Murugaiyah, Marc Litaudon, Khalijah Awan. Cholinesterase inhibitory activity of isoquinoline alkaloids from three Cryptocarya species (Lauraceae). Bioorganic & medicinal chemistry. vol 24. issue 18. 2017-08-10. PMID:27492195. |
acetylcholinesterase and butyrylcholinesterase are two enzymes involved in the breaking down of the neurotransmitter acetylcholine. |
2017-08-10 |
2023-08-13 |
Not clear |
| Chunxia Chen, Luying Huang, Zhihuan Nong, Yaoxuan Li, Wan Chen, Jianping Huang, Xiaorong Pan, Guangwei Wu, Yingzhong Li. Hyperbaric Oxygen Prevents Cognitive Impairments in Mice Induced by D-Galactose by Improving Cholinergic and Anti-apoptotic Functions. Neurochemical research. vol 42. issue 4. 2017-08-04. PMID:28078611. |
moreover, hbo significantly increased the levels of choline acetyltransferase and acetylcholine and decreased the activity of acetylcholinesterase in the hippocampus. |
2017-08-04 |
2023-08-13 |
mouse |
| Hilary S McCarren, John H McDonoug. Anticonvulsant discovery through animal models of status epilepticus induced by organophosphorus nerve agents and pesticides. Annals of the New York Academy of Sciences. vol 1374. issue 1. 2017-07-31. PMID:27258770. |
these compounds induce status epilepticus (se) by irreversibly blocking the ability of acetylcholinesterase to break down acetylcholine at neural synapses. |
2017-07-31 |
2023-08-13 |
mouse |