| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Surya Pratap Singh, Dwijendra Gupt. Discovery of potential inhibitor against human acetylcholinesterase: a molecular docking and molecular dynamics investigation. Computational biology and chemistry. vol 68. 2018-04-26. PMID:28432980. |
human acetylcholinesterase (hache), an important enzyme in neuronal signaling, is responsible for the degradation of acetylcholine which in turn prevents the post synaptic signal transmissions. |
2018-04-26 |
2023-08-13 |
human |
| Shi-Jie Zhang, Ting-Ting Xu, Lin Li, Yu-Min Xu, Zi-Ling Qu, Xin-Chen Wang, Shui-Qing Huang, Yi Luo, Na-Chuan Luo, Ping Lu, Ya-Fei Shi, Xin Yang, Qi Wan. Bushen-Yizhi formula ameliorates cognitive dysfunction through SIRT1/ER stress pathway in SAMP8 mice. Oncotarget. vol 8. issue 30. 2018-04-23. PMID:28521305. |
bsyz decreases the activity of acetylcholinesterase (ache), and increases the activity of choline acetyltransferase (chat) and the concentration of acetylcholine (ach) in both hippocampus and cortex. |
2018-04-23 |
2023-08-13 |
mouse |
| Adam Kostelnik, Alexander Cegan, Miroslav Pohank. Anti-Parkinson Drug Biperiden Inhibits Enzyme Acetylcholinesterase. BioMed research international. vol 2017. 2018-04-23. PMID:28785576. |
it acts as antagonist of muscarinic receptor activated by acetylcholine while the enzyme acetylcholinesterase (ache) cleaves acetylcholine in synaptic junction into choline and acetic acid. |
2018-04-23 |
2023-08-13 |
Not clear |
| Shruti Pandey, Debapriya Garabad. Piracetam Facilitates the Anti-Amnesic but not Anti-Diabetic Activity of Metformin in Experimentally Induced Type-2 Diabetic Encephalopathic Rats. Cellular and molecular neurobiology. vol 37. issue 5. 2018-02-23. PMID:27585927. |
further, the combination attenuated reduced acetylcholine level and increased acetylcholinesterase activity, increased glycogen synthase kinase-3β level and decreased brain-derived neurotropic factor level in hippocampus and pre-frontal cortex of encephalopathic animals. |
2018-02-23 |
2023-08-13 |
rat |
| Ruchi Malik, Bhanwar Singh Choudhary, Shubham Srivastava, Pakhuri Mehta, Manish Sharm. Identification of novel acetylcholinesterase inhibitors through e-pharmacophore-based virtual screening and molecular dynamics simulations. Journal of biomolecular structure & dynamics. vol 35. issue 15. 2018-02-23. PMID:27782777. |
to date, the successful therapeutic strategy to treat ad is maintaining the levels of acetylcholine via inhibiting acetylcholinesterase (ache). |
2018-02-23 |
2023-08-13 |
Not clear |
| Sreejith Mangalath, Silja Abraham, Joshy Josep. pH-Responsive Fluorescence Enhancement in Graphene Oxide-Naphthalimide Nanoconjugates: A Fluorescence Turn-On Sensor for Acetylcholine. Chemistry (Weinheim an der Bergstrasse, Germany). vol 23. issue 47. 2018-02-20. PMID:28621503. |
a ph-sensitive, fluorescence "turn-on" sensor based on a graphene oxide-naphthalimide (go-ni) nanoconjugate for the detection of acetylcholine (ach) by monitoring the enzymatic activity of acetylcholinesterase (ache) in aqueous solution is reported. |
2018-02-20 |
2023-08-13 |
Not clear |
| Georgi Stavrakov, Irena Philipova, Dimitrina Zheleva, Mariyana Atanasova, Spiro Konstantinov, Irini Doytchinov. Docking-based Design of Galantamine Derivatives with Dual-site Binding to Acetylcholinesterase. Molecular informatics. vol 35. issue 6-7. 2018-02-12. PMID:27492242. |
the enzyme acetylcholinesterase is a key target in the treatment of alzheimer's disease because of its ability to hydrolyze acetylcholine via the catalytic binding site and to accelerate the aggregation of amyloid-β peptide via the peripheral anionic site (pas). |
2018-02-12 |
2023-08-13 |
Not clear |
| Stacey A Rimkus, David A Wassarma. A pharmacological screen for compounds that rescue the developmental lethality of a Drosophila ATM mutant. PloS one. vol 13. issue 1. 2018-02-05. PMID:29338042. |
ronnel and other suppressor compounds are known to cause mitochondrial dysfunction or to inhibit the enzyme acetylcholinesterase, which controls the levels of the neurotransmitter acetylcholine, suggesting that detrimental consequences of reduced atm kinase activity can be rescued by inhibiting the function of mitochondria or increasing acetylcholine levels. |
2018-02-05 |
2023-08-13 |
drosophila_melanogaster |
| Rui Cheng, Yali Jia, Lili Dai, Chunsheng Liu, Jianghua Wang, Guangyu Li, Liqin Y. Tris(1,3-dichloro-2-propyl) phosphate disrupts axonal growth, cholinergic system and motor behavior in early life zebrafish. Aquatic toxicology (Amsterdam, Netherlands). vol 192. 2018-01-29. PMID:28898785. |
furthermore, tdcipp exposure at 900μg/l significantly increased the activity of acetylcholinesterase (ache) enzyme, and decreased the total acetylcholine (ach) concentration. |
2018-01-29 |
2023-08-13 |
zebrafish |
| Chen Chen, Yake Zheng, Tianwen Wu, Chuanjie Wu, Xuan Chen. Oral administration of grape seed polyphenol extract restores memory deficits in chronic cerebral hypoperfusion rats. Behavioural pharmacology. vol 28. issue 2 and 3-Spec Issue. 2018-01-11. PMID:27984208. |
a morris water maze task was used to evaluate memory, the levels of acetylcholinesterase, choline acetyltransferase, acetylcholine were used to evaluate cholinergic function, and oxidative stress was assessed by measuring the enzyme activity of superoxide dismutase, glutathione peroxidase, malonic dialdehyde, and catalase. |
2018-01-11 |
2023-08-13 |
rat |
| Yang Jin, Jian Peng, Xiaona Wang, Dong Zhang, Tianyin Wan. Ameliorative Effect of Ginsenoside Rg1 on Lipopolysaccharide-Induced Cognitive Impairment: Role of Cholinergic System. Neurochemical research. vol 42. issue 5. 2018-01-09. PMID:28078612. |
furthermore, ginsenoside rg1 treatment prevented lps-induced decrease of acetylcholine (ach) levels and increase of acetylcholinesterase (ache) activity. |
2018-01-09 |
2023-08-13 |
rat |
| Cong Lu, Liming Dong, Jingwei Lv, Yan Wang, Bei Fan, Fengzhong Wang, Xinmin Li. 20(S)-protopanaxadiol (PPD) alleviates scopolamine-induced memory impairment via regulation of cholinergic and antioxidant systems, and expression of Egr-1, c-Fos and c-Jun in mice. Chemico-biological interactions. vol 279. 2018-01-03. PMID:29133030. |
ppd regulated cholinergic function by inhibiting scop-induced elevation of acetylcholinesterase (ache) activity, decline of choline acetyltransferase (chat) activity and decrease of acetylcholine (ach) level. |
2018-01-03 |
2023-08-13 |
mouse |
| Jong Min Kim, Seon Kyeong Park, Tian Jiao Guo, Jin Yong Kang, Jeong Su Ha, Du Sang Lee, Uk Lee, Ho Jin He. Anti-amnesic effect of Dendropanax morbifera via JNK signaling pathway on cognitive dysfunction in high-fat diet-induced diabetic mice. Behavioural brain research. vol 312. 2017-12-19. PMID:27288590. |
in animal experiments using y-maze, passive avoidance and morris water maze tests, the cognitive and behavioral disorders in hfd-induced diabetic mice were considerably recovered by regulating cholinergic systems, including acetylcholine (ach) levels and acetylcholinesterase (ache) inhibition, and antioxidant systems, including superoxide dismutase (sod), glutathione (gsh), oxidized gsh, and malondialdehyde (mda) levels. |
2017-12-19 |
2023-08-13 |
mouse |
| Asmaa Fahmy Khafag. Exogenous phosphatidylcholine supplementation retrieve aluminum-induced toxicity in male albino rats. Environmental science and pollution research international. vol 24. issue 18. 2017-12-15. PMID:28523611. |
results revealed that aluminum chloride treatment leading to a significant elevation in serum aspartate aminotransferase, serum alanine aminotransferase, urea, creatinine, malondialdehyde, serum cytokines (tumor necrosis factor-α, interleukin-6), and brain content of acetylcholine, as well as a significant reduction in serum-reduced glutathione, serum testosterone, and brain content of acetylcholinesterase. |
2017-12-15 |
2023-08-13 |
rat |
| Asmaa Fahmy Khafag. Exogenous phosphatidylcholine supplementation retrieve aluminum-induced toxicity in male albino rats. Environmental science and pollution research international. vol 24. issue 18. 2017-12-15. PMID:28523611. |
however, it does not affect the brain content of acetylcholine and acetylcholinesterase. |
2017-12-15 |
2023-08-13 |
rat |
| Guozhen Qiu, Shengqiang Chen, Jialing Guo, Jie Wu, Yong-Hong Y. Alpha-asarone improves striatal cholinergic function and locomotor hyperactivity in Fmr1 knockout mice. Behavioural brain research. vol 312. 2017-12-13. PMID:27316341. |
to elucidate the mechanism underlying this improvement, we evaluated the expressions of various cholinergic markers, as well as acetylcholinesterase (ache) activity and acetylcholine (ach) levels, in the striatum of fmr1 ko mice. |
2017-12-13 |
2023-08-13 |
mouse |
| Shih-Hsin Kan, Steven Q Le, Quang D Bui, Braeden Benedict, Jesse Cushman, Mark S Sands, Patricia I Dickso. Behavioral deficits and cholinergic pathway abnormalities in male Sanfilippo B mice. Behavioural brain research. vol 312. 2017-12-13. PMID:27340089. |
we found a 12.4% reduction in mean acetylcholinesterase activity (p<0.001) and no difference in choline acetyltransferase activity or acetylcholine in whole brain of affected male animals compared to controls. |
2017-12-13 |
2023-08-13 |
mouse |
| António José Gabriel, Maria Rosário Almeida, Maria Helena Ribeiro, João Durães, Miguel Tábuas-Pereira, Ana Cristina Pinheiro, Rui Pascoal, Isabel Santana, Inês Baldeira. Association between butyrylcholinesterase and cerebrospinal fluid biomarkers in Alzheimer's disease patients. Neuroscience letters. vol 641. 2017-12-12. PMID:28108398. |
the deficit of cholinergic activity is one of the main findings in alzheimer's disease (ad), and is related to the synthesis of acetylcholine, and the hydrolysing enzymes, acetylcholinesterase and butyrylcholinesterase (buche). |
2017-12-12 |
2023-08-13 |
Not clear |
| Sunita Thapa, Min Lv, Hui X. Acetylcholinesterase: A Primary Target for Drugs and Insecticides. Mini reviews in medicinal chemistry. vol 17. issue 17. 2017-12-05. PMID:28117022. |
acetylcholinesterase is a serine hydrolase that terminates the action of the neurotransmitter acetylcholine by hydrolyzing it into acetic acid and choline. |
2017-12-05 |
2023-08-13 |
Not clear |
| Annamaria Martorana, Valentina Giacalone, Riccardo Bonsignore, Andrea Pace, Carla Gentile, Ivana Pibiri, Silvestre Buscemi, Antonino Lauria, Antonio Palumbo Piccionell. Heterocyclic Scaffolds for the Treatment of Alzheimer's Disease. Current pharmaceutical design. vol 22. issue 26. 2017-11-29. PMID:27189601. |
it has been demonstrated that both acetylcholinesterase (ache) and butyrylcholinesterase (buche) enzymes are not only responsible of acetylcholine levels, but also play an pivotal role in aβ-aggregation during the early stages of senile plaque formation. |
2017-11-29 |
2023-08-13 |
Not clear |