| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fanny C F Ip, Guangmiao Fu, Fengzhi Yang, Fangyuan Kang, Peiran Sun, Choi Ying Ling, Kit Cheung, Fangzhou Xie, Yueqing Hu, Lei Fu, Nancy Y I. A tacrine-tetrahydroquinoline heterodimer potently inhibits acetylcholinesterase activity and enhances neurotransmission in mice. European journal of medicinal chemistry. vol 226. 2021-11-22. PMID:34530383. |
acetylcholinesterase (ache) inhibitors have been used to improve cholinergic transmission in the brain for two decades and have proven effective for alleviating symptoms in the early stages of alzheimer's disease. |
2021-11-22 |
2023-08-13 |
mouse |
| Noreen Samad, Farzana Yasmin, Saima Khaliq, Saara Ahmad, - Azizuddin, Sana Mustaf. Diet supplements of banana fruit pulp mitigates repeated noise stress induced behavioral deficits and oxidative stress. Pakistan journal of pharmaceutical sciences. vol 33. issue 5(Supplementary). 2021-11-18. PMID:33832903. |
decreased levels of acetylcholinesterase in bpf+ns treated animals indicated increased cholinergic function which improves learning and memory. |
2021-11-18 |
2023-08-13 |
mouse |
| Ismail O Ishola, Benneth Ben-Azu, Oluwatosin A Adebayo, Abayomi M Ajayi, Iziegbe Lisa Omorodion, Kesiena Emmanuel Edje, Olufunmilayo O Adeyem. Prevention and reversal of ketamine-induced experimental psychosis in mice by the neuroactive flavonoid, hesperidin: The role of oxidative and cholinergic mechanisms. Brain research bulletin. vol 177. 2021-11-18. PMID:34653559. |
brain levels of oxidative/nitrergic (glutathione, superoxide-dismutase, malondialdehyde and nitrite levels) and cholinergic (acetylcholinesterase activity) markers were measured in the prefrontal-cortex, striatum and hippocampus. |
2021-11-18 |
2023-08-13 |
mouse |
| Christine N Metz, Valentin A Pavlo. Treating disorders across the lifespan by modulating cholinergic signaling with galantamine. Journal of neurochemistry. vol 158. issue 6. 2021-11-17. PMID:33219523. |
cholinergic drugs, including the centrally acting acetylcholinesterase inhibitor, galantamine, which are in clinical use for the treatment of alzheimer's disease and other neurodegenerative and neuropsychiatric disorders, have been rediscovered as anti-inflammatory agents. |
2021-11-17 |
2023-08-13 |
Not clear |
| Heidi Qunhui Xie, Yongchao Ma, Hualing Fu, Tuan Xu, Yali Luo, Yiyun Liu, Yangsheng Chen, Li Xu, Yingjie Xia, Bin Zha. New perspective on the regulation of acetylcholinesterase via the aryl hydrocarbon receptor. Journal of neurochemistry. vol 158. issue 6. 2021-11-17. PMID:33278027. |
acetylcholinesterase (ache, ec 3.1.1.7) plays important roles in cholinergic neurotransmission and has been widely recognized as a biomarker for monitoring pollution by organophosphate (op) and carbamate pesticides. |
2021-11-17 |
2023-08-13 |
Not clear |
| Aisha Siddiqui, Zahoor Shah, Rao Nargis Jahan, Iekhsan Othman, Yatinesh Kumar. Mechanistic role of boswellic acids in Alzheimer's disease: Emphasis on anti-inflammatory properties. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 144. 2021-11-17. PMID:34607104. |
it is also involved in inhibiting the acetylcholinesterase (ache) activity in the cholinergic pathway and improve choline levels as well as its binding with nicotinic receptors to produce anti-inflammatory effects. |
2021-11-17 |
2023-08-13 |
Not clear |
| Hyoeun Yoo, Hyun-Sook Ki. Cacao powder supplementation attenuates oxidative stress, cholinergic impairment, and apoptosis in D-galactose-induced aging rat brain. Scientific reports. vol 11. issue 1. 2021-11-15. PMID:34504131. |
the levels of serum malondialdehyde (mda), advanced glycation end-products (ages), brain and liver mda, the indicators of the d-galactose induced oxidative stress were significantly decreased in lc and hc but increased in g. the acetylcholinesterase (ache) activity of brain showed that the cholinergic impairment was significantly lower in lc, and hc than g. furthermore, the expression levels of catalase (cat), phospho-akt/akt, and procaspase-3 were significantly increased in lc and hc. |
2021-11-15 |
2023-08-13 |
rat |
| Stephen Adeniyi Adefegha, Charles Elias Assmann, Maria Rosa Chitolina Schetinger, Cinthia Melazzo de Andrade, Tatiana Emanuell. Moringa oleifera modulates cholinergic and purinergic enzymes activity in BV-2 microglial cells. Metabolic brain disease. vol 36. issue 4. 2021-11-12. PMID:33394288. |
furthermore, the effect of moringa oleifera on enzymes of cholinergic (acetylcholinesterase) and purinergic (nucleoside triphosphate diphosphohydrolase; ntpdase, 5' nucleotidase and adenosine deaminase; ada) systems in bv-2 microglial cells were determined. |
2021-11-12 |
2023-08-13 |
Not clear |
| Vibhav Varshney, Debapriya Garabad. Ang (1-7)/Mas receptor-axis activation promotes amyloid beta-induced altered mitochondrial bioenergetics in discrete brain regions of Alzheimer's disease-like rats. Neuropeptides. vol 86. 2021-11-12. PMID:33508525. |
moreover, there was a significant increase in the level of aβ42, decrease in the cholinergic function (in terms of decreased acetylcholine and activity of cholinesterase, and increased activity of acetylcholinesterase), mitochondrial function, integrity and bioenergetics, and apoptosis in all the rat brain regions. |
2021-11-12 |
2023-08-13 |
rat |
| Yavuz Osman Birdane, Gulcan Avci, Fatih Mehmet Birdane, Ruhi Turkmen, Orkun Atik, Hulya Ati. The protective effects of erdosteine on subacute diazinon-induced oxidative stress and inflammation in rats. Environmental science and pollution research international. 2021-11-12. PMID:34766221. |
this toxication has been reported to be shaped not through cholinergic syndromes that are experienced as a result of acetylcholinesterase inhibition, which is the primary effect of these cases. |
2021-11-12 |
2023-08-13 |
rat |
| Yuki Takada-Takator. [Donepezil Reduces Amyloid Precursor Protein Endocytosis by Resulting from Increase in the Expression of Sorting Nexin Protein 33]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 141. issue 6. 2021-11-11. PMID:34078793. |
donepezil, the most widely used drug for the treatment of alzheimer's disease (ad), is an acetylcholinesterase (ache) inhibitor and is thought to improve cognition by stimulating cholinergic neurotransmission. |
2021-11-11 |
2023-08-13 |
rat |
| Samuel Adetunji Onasanwo, Vanessa O Adamaigbo, Olusegun G Adebayo, Spiff E Eleaze. Moringa oleifera-supplemented diet protect against cortico-hippocampal neuronal degeneration in scopolamine-induced spatial memory deficit in mice: role of oxido-inflammatory and cholinergic neurotransmission pathway. Metabolic brain disease. vol 36. issue 8. 2021-11-11. PMID:34669098. |
thereafter, markers of cholinergic system inhibition (acetylcholinesterase; ache) and oxido-inflammatory stress (malonaldehyde, mda; nitrite; superoxide dismutase, sod; tumor necrosis factor-alpha, tnf-α) and histo-morphology of the cortico-hippocampal neuron were measured. |
2021-11-11 |
2023-08-13 |
mouse |
| Samuel Adetunji Onasanwo, Vanessa O Adamaigbo, Olusegun G Adebayo, Spiff E Eleaze. Moringa oleifera-supplemented diet protect against cortico-hippocampal neuronal degeneration in scopolamine-induced spatial memory deficit in mice: role of oxido-inflammatory and cholinergic neurotransmission pathway. Metabolic brain disease. vol 36. issue 8. 2021-11-11. PMID:34669098. |
however, mo-sd significantly ameliorated oxido-inflammatory stress, restored cholinergic transmission via acetylcholinesterase inhibition and maintains neuronal integrity in the mice brain at both phases. |
2021-11-11 |
2023-08-13 |
mouse |
| Balázs Knakker, Vilmos Oláh, Attila Trunk, Balázs Lendvai, György Lévay, István Hernád. Delay-dependent cholinergic modulation of visual short-term memory in rhesus macaques. Behavioural brain research. vol 396. 2021-11-09. PMID:32891649. |
then, we studied how cholinergic neuromodulation influences vwm maintenance using the muscarinic receptor antagonist scopolamine administered alone as transient amnestic treatment, and in combination with two doses of the acetylcholinesterase inhibitor donepezil, a widely used alzheimer's medication probing for the reversal of scopolamine-induced impairments. |
2021-11-09 |
2023-08-13 |
Not clear |
| Karen G João, Romeu A Videira, Fátima Paiva-Martins, Patrícia Valentão, David M Pereira, Paula B Andrad. Homarine Alkyl Ester Derivatives as Promising Acetylcholinesterase Inhibitors. ChemMedChem. vol 16. issue 21. 2021-11-05. PMID:34342141. |
reversible acetylcholinesterase (ache) inhibitors are key therapeutic tools to modulate the cholinergic connectivity compromised in several degenerative pathologies. |
2021-11-05 |
2023-08-13 |
rat |
| Sean M Mooney-Leber, Dana Zeid, Prescilla Garcia-Trevizo, Laurel R Seemiller, Molly A Bogue, Stephen C Grubb, Gary Peltz, Thomas J Goul. Genetic Differences in Dorsal Hippocampus Acetylcholinesterase Activity Predict Contextual Fear Learning Across Inbred Mouse Strains. Frontiers in psychiatry. vol 12. 2021-11-05. PMID:34733190. |
since cholinergic signaling is affected by genetic background, we examined the genetic relationship between activity levels of acetylcholinesterase (ache), the primary enzyme involved in the acetylcholine metabolism, and learning using a panel of 20 inbred mouse strains. |
2021-11-05 |
2023-08-13 |
mouse |
| Ochuko L Erukainure, Nontokozo Z Msomi, Brian K Beseni, Veronica F Salau, Omamuyovwi M Ijomone, Neil A Koorbanally, Md Shahidul Isla. Cola nitida infusion modulates cardiometabolic activities linked to cardiomyopathy in diabetic rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 154. 2021-11-01. PMID:34129900. |
the activities of acetylcholinesterase, and atpase were significantly elevated, with suppressed entpdase and 5'nucleotodase activities in hearts of t2d rats depicting cholinergic and purinergic dysfunctions. |
2021-11-01 |
2023-08-13 |
rat |
| Ansab Akhtar, Mahendra Bishnoi, Sangeeta Pilkhwal Sa. Sodium orthovanadate improves learning and memory in intracerebroventricular-streptozotocin rat model of Alzheimer's disease through modulation of brain insulin resistance induced tau pathology. Brain research bulletin. vol 164. 2021-10-29. PMID:32784004. |
estimation of oxidative stress, mitochondrial dysfunction as complex i, ii, iii, iv activity, cholinergic function as acetylcholinesterase activity, elisa for phosphorylated tau protein and insulin degrading enzyme (ide), neuroinflammation as nf-κb gene expression and insulin signaling functioning as q-rt-pcr for ir, irs-1, pi3k, akt, gsk-3β gene expression were performed. |
2021-10-29 |
2023-08-13 |
rat |
| Kristian Stær, Alex Iranzo, Morten G Stokholm, Karen Østergaard, Mónica Serradell, Marit Otto, Kristina B Svendsen, Alicia Garrido, Dolores Vilas, Joan Santamaria, Arne Møller, Carles Gaig, David J Brooks, Per Borghammer, Eduardo Tolosa, Nicola Paves. Cortical cholinergic dysfunction correlates with microglial activation in the substantia innominata in REM sleep behavior disorder. Parkinsonism & related disorders. vol 81. 2021-10-29. PMID:33099132. |
in vivo pet studies in patients with isolated rem sleep behavior disorder (irbd) have shown presence of neuroinflammation (microglial activation) in the substantia nigra, and reduced cortical acetylcholinesterase activity, suggestive of cholinergic dysfunction, that was more widespread in patients with poorer cognitive performances. |
2021-10-29 |
2023-08-13 |
Not clear |
| Kristian Stær, Alex Iranzo, Morten G Stokholm, Karen Østergaard, Mónica Serradell, Marit Otto, Kristina B Svendsen, Alicia Garrido, Dolores Vilas, Joan Santamaria, Arne Møller, Carles Gaig, David J Brooks, Per Borghammer, Eduardo Tolosa, Nicola Paves. Cortical cholinergic dysfunction correlates with microglial activation in the substantia innominata in REM sleep behavior disorder. Parkinsonism & related disorders. vol 81. 2021-10-29. PMID:33099132. |
this study aimed to explore whether reduced cortical acetylcholinesterase activity in irbd is linked to microglial activation in the substantia innominata (si), the major source of cholinergic input to the cortex. |
2021-10-29 |
2023-08-13 |
Not clear |