| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tapan Behl, Ishnoor Kaur, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Sumeet Gupta, Mohammed Albratty, Asim Najmi, Hassan A Alhazmi, Simona Bunga. AChE as a Spark in the Alzheimer's Blaze - Antagonizing Effect of a Cyclized Variant. Ageing research reviews. 2022-11-11. PMID:36368649. |
a significant protein, acetylcholinesterase (ache) becomes dysfunctional as a result of cholinergic neuronal loss in ad pathology. |
2022-11-11 |
2023-08-14 |
Not clear |
| Faezeh Aliakbarzadeh, Mohammad Rafiee, Fariba Khodagholi, Mohammad Reza Khorramizadeh, Hamed Manouchehri, Akbar Eslami, Fatemeh Sayehmiri, Anoushiravan Mohseni-Bandpe. Adverse effects of polystyrene nanoplastic and its binary mixtures with nonylphenol on zebrafish nervous system: From oxidative stress to impaired neurotransmitter system. Environmental pollution (Barking, Essex : 1987). 2022-11-06. PMID:36336178. |
multiple biomarkers concerning with oxidative-stress [catalase (cat) activity and reduced glutathione (gsh) level], cholinergic system [acetylcholinesterase (ache) activity], glutamatergic system [glutamine synthetase (gs) and glutamate dehydrogenase (gdh) activities], energy metabolism [a-ketoglutarate dehydrogenase (a-kgdh) activity], and histological alterations were assessed. |
2022-11-06 |
2023-08-14 |
cat |
| Arwa A Al-Maswary, Molly O'Reilly, Andrew P Holmes, A Damien Walmsley, Paul R Cooper, Ben A Scheve. Exploring the neurogenic differentiation of human dental pulp stem cells. PloS one. vol 17. issue 11. 2022-11-04. PMID:36331951. |
in hdpscs, upregulation of acetylcholinesterase (ache), choline o-acetyltransferase (chat), sodium channel alpha subunit 9 (scn9a), pou class 4 homeobox 1 (pou4f1/brn3a) along with a downregulation of motor neuron and pancreas homeobox 1 (mnx1) indicated that differentiation was more guided toward a cholinergic sensory neuronal lineage. |
2022-11-04 |
2023-08-14 |
human |
| Thankhoe A Rants'o, Lizette L Koekemoer, Jenny-Lee Panayides, Robyn L van Zy. Potential of Essential Oil-Based Anticholinesterase Insecticides against Molecules (Basel, Switzerland). vol 27. issue 20. 2022-10-27. PMID:36296618. |
the cholinergic system, of which acetylcholinesterase (ache) is a key enzyme, is essential to the |
2022-10-27 |
2023-08-14 |
Not clear |
| Shivani Vaidya, Alexandre A Guerin, Leigh C Walker, Andrew J Lawrenc. Clinical Effectiveness of Muscarinic Receptor-Targeted Interventions in Neuropsychiatric Disorders: A Systematic Review. CNS drugs. 2022-10-21. PMID:36269510. |
preclinical and clinical evidence have highlighted disruption of cholinergic signalling in several neuropsychiatric conditions and examined intervention strategies including acetylcholinesterase inhibitors and nicotinic receptor-targeted intervention. |
2022-10-21 |
2023-08-14 |
Not clear |
| Yu Chen, Wenfeng Zhao, Jincheng Si, Yinuo Zheng, Hui Tan, Funa Meng, Guohai Yang, Yingqiu Gu, Lulu Q. Highly selective SERS detection of acetylcholinesterase in human blood based on catalytic reaction. Analytica chimica acta. vol 1232. 2022-10-18. PMID:36257753. |
acetylcholinesterase (ache) is a key hydrolase in the cholinergic system, which directly determines the degradation of neurotransmitters. |
2022-10-18 |
2023-08-14 |
human |
| Teodorico C Ramalho, Alexandre A de Castro, Daniel H S Leal, Jessika P Teixeira, Elaine Fontes Ferreira de Cunha, Kamil Kuc. Assessing the therapeutic and toxicological profile of novel acetylcholinesterase reactivators: value of in silico and in vitro data. Current medicinal chemistry. 2022-10-14. PMID:36239718. |
these toxic substances act through the inhibition of the acetylcholinesterase (ache) enzyme, which results in elevated synaptic acetylcholine (ach) levels, leading to serious adverse effects under the cholinergic syndrome. |
2022-10-14 |
2023-08-14 |
Not clear |
| Dorottya Várkonyi, Bibiána Török, Eszter Sipos, Csilla Lea Fazekas, Krisztina Bánrévi, Pedro Correia, Tiago Chaves, Szidónia Farkas, Adrienn Szabó, Sergio Martínez-Bellver, Balázs Hangya, Dóra Zelen. Investigation of Anxiety- and Depressive-like Symptoms in 4- and 8-Month-Old Male Triple Transgenic Mouse Models of Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 18. 2022-09-23. PMID:36142737. |
acetylcholinesterase histochemistry visualized cholinergic fibers in the cortex. |
2022-09-23 |
2023-08-14 |
mouse |
| Muslum Gok, Nimrod Madrer, Tamara Zorbaz, Estelle R Bennett, David Greenberg, David A Bennett, Hermona Sore. Altered levels of variant cholinesterase transcripts contribute to the imbalanced cholinergic signaling in Alzheimer's and Parkinson's disease. Frontiers in molecular neuroscience. vol 15. 2022-09-19. PMID:36117917. |
acetylcholinesterase and butyrylcholinesterase (ache and bche) are involved in modulating cholinergic signaling, but their roles in alzheimer's and parkinson's diseases (ad and pd) remain unclear. |
2022-09-19 |
2023-08-14 |
Not clear |
| Katelyn N Sette, Navatha Alugabelly, Lauren B Glenn, Shirley X Guo-Ross, M Katherine Parkes, Juliet R Wilson, Caitlin N Seay, Russell L Car. The Mechanistic Basis for the Toxicity Difference Between Juvenile Rats and Mice following Exposure to the Agricultural Insecticide Chlorpyrifos. Toxicology. 2022-09-12. PMID:36096317. |
at high exposure levels, organophosphorus insecticides (ops) exert their toxicity in mammals through the inhibition of brain acetylcholinesterase (ache) leading to the accumulation of acetylcholine in cholinergic synapses and hyperactivity of the nervous system. |
2022-09-12 |
2023-08-14 |
mouse |
| Fauzia Parween, Animesh Sarker, Rinkoo Devi Gupt. Chlorpyrifos and parathion regulate oxidative stress differentially through the expression of paraoxonase 2 in human neuroblastoma cell. Neurotoxicology. 2022-09-04. PMID:36058312. |
these compounds are acetylcholinesterase inhibitors and cause a cholinergic crisis. |
2022-09-04 |
2023-08-14 |
human |
| Ariel A Batallán Burrowes, Olayemi Joseph Olajide, Isabella A Iasenza, Waqqas M Shams, Francis Carter, C Andrew Chapma. Ovariectomy reduces cholinergic modulation of excitatory synaptic transmission in the rat entorhinal cortex. PloS one. vol 17. issue 8. 2022-08-08. PMID:35939438. |
we also assessed the effects of ovariectomy on the cholinergic modulation of excitatory transmission, by comparing the effects of the acetylcholinesterase inhibitor eserine on evoked excitatory synaptic field potentials in brain slices obtained from intact rats, and from ovariectomized rats with or without 17β-estradiol replacement. |
2022-08-08 |
2023-08-14 |
rat |
| Luana C Llanes, Isabelle Kuehlewein, Igor V de França, Luana Veiga da Silva, José W da Cru. Anticholinesterase agents for Alzheimer's Disease treatment: an updated overview. Current medicinal chemistry. 2022-08-05. PMID:35927804. |
the therapeutic strategy adopted herein is the cholinergic hypothesis, for which acetylcholinesterase enzyme (ache) inhibitors constitute the main treatment for the disease. |
2022-08-05 |
2023-08-14 |
Not clear |
| Julie Somkhit, Constantin Yanicostas, Nadia Soussi-Yanicosta. Microglia Remodelling and Neuroinflammation Parallel Neuronal Hyperactivation Following Acute Organophosphate Poisoning. International journal of molecular sciences. vol 23. issue 15. 2022-07-28. PMID:35897817. |
ops cause irreversible acetylcholinesterase (ache) inhibition, inducing the so-called cholinergic syndrome characterized by peripheral manifestations and seizures associated with permanent psychomotor deficits. |
2022-07-28 |
2023-08-14 |
zebrafish |
| Elisabeth Wigenstam, Elisabet Artursson, Anders Bucht, Lina Thor. Supplemental treatment to atropine improves the efficacy to reverse nerve agent induced bronchoconstriction. Chemico-biological interactions. 2022-07-25. PMID:35872047. |
exposure to highly toxic organophosphorus compounds causes inhibition of the enzyme acetylcholinesterase resulting in a cholinergic toxidrome and innervation of receptors in the neuromuscular junction may cause life-threatening respiratory effects. |
2022-07-25 |
2023-08-14 |
rat |
| Giuseppe De Marco, Sabrine Afsa, Mariachiara Galati, Giulia Guerriero, Angela Mauceri, Hedi Ben Mansour, Tiziana Cappell. Time- and dose-dependent biological effects of a sub-chronic exposure to realistic doses of salicylic acid in the gills of mussel Mytilus galloprovincialis. Environmental science and pollution research international. 2022-07-13. PMID:35829880. |
inhibition of the cholinergic system was also reported by reduced acetylcholinesterase (ache) activity, mainly at t12. |
2022-07-13 |
2023-08-14 |
cat |
| Katharina Rump, Caroline Holtkamp, Lars Bergmann, Hartmuth Nowak, Matthias Unterberg, Jennifer Orlowski, Patrick Thon, Zainab Bazzi, Maha Bazzi, Michael Adamzik, Björn Koos, Tim Rahme. Midazolam impacts acetyl-And butyrylcholinesterase genes: An epigenetic explanation for postoperative delirium? PloS one. vol 17. issue 7. 2022-07-08. PMID:35802656. |
consequently, we tested the hypothesis that midazolam indeed changes the expression and activity of cholinergic genes by acetylcholinesterase assay and qpcr. |
2022-07-08 |
2023-08-14 |
human |
| Tess Puopolo, Chang Liu, Hang Ma, Navindra P Seera. Inhibitory Effects of Cannabinoids on Acetylcholinesterase and Butyrylcholinesterase Enzyme Activities. Medical cannabis and cannabinoids. vol 5. issue 1. 2022-06-15. PMID:35702400. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are two cholinergic enzymes catalyzing the reaction of cleaving acetylcholine into acetate and choline at the neuromuscular junction. |
2022-06-15 |
2023-08-14 |
Not clear |
| Jun-Cheng Su, Qianrong Pan, Xingyuan Xu, Xia Wei, Xueping Lei, Peng Zhan. Structurally diverse steroids from an endophyte of Aspergillus tennesseensis 1022LEF attenuates LPS-induced inflammatory response through the cholinergic anti-inflammatory pathway. Chemico-biological interactions. 2022-06-01. PMID:35649461. |
collectively, the present study not only highlighted the potential correlation between steroids and the cholinergic anti-inflammatory pathway, but also identified 8 as a dual-functional modulator via directly inhibition to acetylcholinesterase as well as up-regulation of α7nachr expression. |
2022-06-01 |
2023-08-13 |
Not clear |
| Masato Mashimo, Koichiro Kawashima, Takeshi Fuji. Non-neuronal Cholinergic Muscarinic Acetylcholine Receptors in the Regulation of Immune Function. Biological & pharmaceutical bulletin. vol 45. issue 6. 2022-06-01. PMID:35650095. |
immune cells such as t and b cells, monocytes and macrophages all express most of the cholinergic components of the nervous system, including acetylcholine (ach), choline acetyltransferase (chat), high affinity choline transporter, muscarinic and nicotinic ach receptors (machrs and nachrs, respectively), and acetylcholinesterase (ache). |
2022-06-01 |
2023-08-13 |
Not clear |