| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Danish Iqbal, M Salman Khan, Mohd Waiz, Md Tabish Rehman, Mohammed Alaidarous, Azfar Jamal, Abdulaziz S Alothaim, Mohamed F AlAjmi, Bader Mohammed Alshehri, Saeed Banawas, Mohammed Alsaweed, Yahya Madkhali, Abdulrahman Algarni, Suliman A Alsagaby, Wael Alturaik. Exploring the Binding Pattern of Geraniol with Acetylcholinesterase through In Silico Docking, Molecular Dynamics Simulation, and In Vitro Enzyme Inhibition Kinetics Studies. Cells. vol 10. issue 12. 2021-12-24. PMID:34944045. |
acetylcholinesterase (ache) inhibition is a key element in enhancing cholinergic transmission and subsequently relieving major symptoms of several neurological and neuromuscular disorders. |
2021-12-24 |
2023-08-13 |
Not clear |
| Benedikt Schick, Eberhard Barth, Benjamin Mayer, Claire-Louise Weber, Theresa Hagemeyer, Carlos Schönfeld. Prospective, observational, single-centre cohort study with an independent control group matched for age and sex aimed at investigating the significance of cholinergic activity in patients with schizophrenia: study protocol of the CLASH-study. BMJ open. vol 11. issue 12. 2021-12-21. PMID:34930729. |
by contrast, studies in critically ill patients have established the measurement of acetylcholinesterase activity as a suitable surrogate parameter of central cholinergic transmitter balance/possible pathophysiological changes. |
2021-12-21 |
2023-08-13 |
Not clear |
| Donald E Moss, Ruth G Pere. Anti-neurodegenerative benefits of acetylcholinesterase inhibitors in Alzheimer's disease: Nexus of cholinergic and nerve growth factor dysfunction. Current Alzheimer research. 2021-12-16. PMID:34911424. |
anti-neurodegenerative benefits of acetylcholinesterase inhibitors in alzheimer's disease: nexus of cholinergic and nerve growth factor dysfunction. |
2021-12-16 |
2023-08-13 |
Not clear |
| The-Huan Tran, Thi-Thu-Hien Vo, Thi-Quynh-Nhi Vo, Thi-Cam-Nhung Cao, Thai-Son Tra. Synthesis and Evaluation of the Acetylcholinesterase Inhibitory Activities of Some Flavonoids Derived from Naringenin. TheScientificWorldJournal. vol 2021. 2021-12-11. PMID:34887704. |
a research approach in the finding new treatment for ad that has attracted much interest from scientists for a long time is the reestablishment of cholinergic transmission through inhibition of acetylcholinesterase (ache). |
2021-12-11 |
2023-08-13 |
Not clear |
| Ya-Ling Chung, Yi-Chou Hou, I-Kuan Wang, Kuo-Cheng Lu, Tzung-Hai Ye. Organophosphate pesticides and new-onset diabetes mellitus: From molecular mechanisms to a possible therapeutic perspective. World journal of diabetes. vol 12. issue 11. 2021-12-11. PMID:34888010. |
the main action of organophosphate focuses on acetylcholinesterase inhibition, and it therefore contributes to acute cholinergic crisis, intermediate syndrome and delayed neurotoxicity. |
2021-12-11 |
2023-08-13 |
Not clear |
| Iheanyichukwu Wopara, Olusegun G Adebayo, Elizabeth B Umoren, Wadioni Aduema, Adaku V Iwueke, O E Etim, Egelege Aziemeola Pius, Woha Boobondah James, Joel Wod. Involvement of striatal oxido-inflammatory, nitrosative and decreased cholinergic activity in neurobehavioral alteration in adult rat model with oral co-exposure to erythrosine and tartrazine. Heliyon. vol 7. issue 11. 2021-12-11. PMID:34888423. |
oral co-exposure to tartrazine and erythrosine induced decrease in locomotion and exploration, increase anxiety and depression-like behavior and altered the cholinergic system through upregulation of oxido-nitrosative stress, pro-inflammatory cytokine and acetylcholinesterase activity. |
2021-12-11 |
2023-08-13 |
rat |
| Thanit Kunkeaw, Uthaiwan Suttisansanee, Dunyaporn Trachootham, Jirarat Karinchai, Boonrat Chantong, Saranyapin Potikanond, Woorawee Inthachat, Pornsiri Pitchakarn, Piya Temviriyanuku. Diplazium esculentum (Retz.) Sw. reduces BACE-1 activities and amyloid peptides accumulation in Drosophila models of Alzheimer's disease. Scientific reports. vol 11. issue 1. 2021-12-11. PMID:34893659. |
sw., an edible fern, inhibited acetylcholinesterase in vitro, inferring that it might be a promising candidate for ad treatment by supporting cholinergic neurons. |
2021-12-11 |
2023-08-13 |
drosophila_melanogaster |
| Sumei Wang, Qian Zhao, Gaochun Li, Mengwei Wang, Hongliang Liu, Xingchen Yu, Jingwen Chen, Pei Li, Lixin Dong, Guoyu Zhou, Yushan Cui, Mengru Wang, Li Liu, Aiguo Wan. The cholinergic system, intelligence, and dental fluorosis in school-aged children with low-to-moderate fluoride exposure. Ecotoxicology and environmental safety. vol 228. 2021-12-07. PMID:34808511. |
cholinergic system was assessed by the detection of choline acetyltransferase (chat), acetylcholinesterase (ache) and acetylcholine (ach) levels in serum. |
2021-12-07 |
2023-08-13 |
Not clear |
| Liping Yang, Honghui Guo, Yu Kuang, Hui Yang, Xi Zhang, Rong Tang, Dapeng Li, Li L. Neurotoxicity induced by combined exposure of microcystin-LR and nitrite in male zebrafish (Danio rerio): Effects of oxidant-antioxidant system and neurotransmitter system. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 253. 2021-12-06. PMID:34826614. |
the decreases in dopamine content, acetylcholinesterase activity and related gene mrna levels indicated that mc-lr and nitrite adversely affected the normal function of the dopaminergic and cholinergic systems in zebrafish brain. |
2021-12-06 |
2023-08-13 |
zebrafish |
| Shuaizhang Li, Andrew J Li, Jameson Travers, Tuan Xu, Srilatha Sakamuru, Carleen Klumpp-Thomas, Ruili Huang, Menghang Xi. Identification of Compounds for Butyrylcholinesterase Inhibition. SLAS discovery : advancing life sciences R & D. vol 26. issue 10. 2021-12-04. PMID:34269114. |
bche plays a critical role in maintaining normal cholinergic function like acetylcholinesterase (ache) through hydrolyzing acetylcholine (ach). |
2021-12-04 |
2023-08-13 |
Not clear |
| Niraj Kumar Singh, Debapriya Garabad. Quercetin Exhibits α7nAChR/Nrf2/HO-1-Mediated Neuroprotection Against STZ-Induced Mitochondrial Toxicity and Cognitive Impairments in Experimental Rodents. Neurotoxicity research. vol 39. issue 6. 2021-12-03. PMID:34554409. |
quercetin significantly mitigated the stz-induced increase in cholinergic dysfunction, such as the increase in acetylcholinesterase activity, decrease in acetylcholine level, and activity of choline acetyltransferase, and increase in amyloid-beta aggregation and mitochondrial toxicity in respect of mitochondrial bioenergetics, integrity, and oxidative stress in memory-challenged rat hippocampus, prefrontal cortex and, amygdala. |
2021-12-03 |
2023-08-13 |
rat |
| Ryohei Tanaka-Kanegae, Koichiro Hamad. A novel in vitro assay model developed to measure both extracellular and intracellular acetylcholine levels for screening cholinergic agents. PloS one. vol 16. issue 10. 2021-11-30. PMID:34637466. |
cholinergic neurons utilize choline (ch) to synthetize acetylcholine (ach) and contain a high-affinity ch transporter, ch acetyltransferase (chat), ach receptors, and acetylcholinesterase (ache). |
2021-11-30 |
2023-08-13 |
Not clear |
| b' Milena Mlaki\\xc4\\x87, Tena \\xc4\\x8cade\\xc5\\xbe, Danijela Bari\\xc4\\x87, Ivana Pu\\xc4\\x8dek, Ana Ratkovi\\xc4\\x87, \\xc5\\xbdeljko Marini\\xc4\\x87, Kornelija Lasi\\xc4\\x87, Zrinka Kovarik, Irena \\xc5\\xa0kori\\xc4\\x8. New Uncharged 2-Thienostilbene Oximes as Reactivators of Organophosphate-Inhibited Cholinesterases. Pharmaceuticals (Basel, Switzerland). vol 14. issue 11. 2021-11-30. PMID:34832929.' |
the inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (bche) by organophosphates (ops) as nerve agents and pesticides compromises normal cholinergic nerve signal transduction in the peripheral and central nervous systems (cns) leading to cholinergic crisis. |
2021-11-30 |
2023-08-13 |
Not clear |
| Israel Silma. The multiple biological roles of the cholinesterases. Progress in biophysics and molecular biology. vol 162. 2021-11-25. PMID:33307019. |
it is tacitly assumed that the biological role of acetylcholinesterase is termination of synaptic transmission at cholinergic synapses. |
2021-11-25 |
2023-08-13 |
Not clear |
| Alastair J H Brown, Sophie J Bradley, Fiona H Marshall, Giles A Brown, Kirstie A Bennett, Jason Brown, Julie E Cansfield, David M Cross, Chris de Graaf, Brian D Hudson, Louis Dwomoh, João M Dias, James C Errey, Edward Hurrell, Jan Liptrot, Giulio Mattedi, Colin Molloy, Pradeep J Nathan, Krzysztof Okrasa, Greg Osborne, Jayesh C Patel, Mark Pickworth, Nathan Robertson, Shahram Shahabi, Christoffer Bundgaard, Keith Phillips, Lisa M Broad, Anushka V Goonawardena, Stephen R Morairty, Michael Browning, Francesca Perini, Gerard R Dawson, John F W Deakin, Robert T Smith, Patrick M Sexton, Julie Warneck, Mary Vinson, Tim Tasker, Benjamin G Tehan, Barry Teobald, Arthur Christopoulos, Christopher J Langmead, Ali Jazayeri, Robert M Cooke, Prakash Rucktooa, Miles S Congreve, Malcolm Weir, Andrew B Tobi. From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease. Cell. vol 184. issue 24. 2021-11-25. PMID:34822784. |
current therapies for alzheimer's disease seek to correct for defective cholinergic transmission by preventing the breakdown of acetylcholine through inhibition of acetylcholinesterase, these however have limited clinical efficacy. |
2021-11-25 |
2023-08-13 |
Not clear |
| Fauzia Parween, Md Summon Hossain, Kshetra Pal Singh, Rinkoo Devi Gupt. Association between human paraoxonase 2 protein and efficacy of acetylcholinesterase inhibiting drugs used against Alzheimer's disease. PloS one. vol 16. issue 10. 2021-11-23. PMID:34714861. |
since cholinergic deficiency is closely linked with alzheimer's disease (ad) progression, acetylcholinesterase inhibitors (acheis) are the treatment of choice for patients with ad. |
2021-11-23 |
2023-08-13 |
human |
| b' Donald K Blumenthal, Xiaolin Cheng, Mikolai Fajer, Kwok-Yiu Ho, Jacqueline Rohrer, Oksana Gerlits, Palmer Taylor, Puneet Juneja, Andrey Kovalevsky, Zoran Radi\\xc4\\x8. Covalent inhibition of hAChE by organophosphates causes homodimer dissociation through long-range allosteric effects. The Journal of biological chemistry. vol 297. issue 3. 2021-11-22. PMID:34324828.' |
acetylcholinesterase (ec 3.1.1.7), a key acetylcholine-hydrolyzing enzyme in cholinergic neurotransmission, is present in a variety of states in situ, including monomers, c-terminally disulfide-linked homodimers, homotetramers, and up to three tetramers covalently attached to structural subunits. |
2021-11-22 |
2023-08-13 |
human |
| Fanny C F Ip, Guangmiao Fu, Fengzhi Yang, Fangyuan Kang, Peiran Sun, Choi Ying Ling, Kit Cheung, Fangzhou Xie, Yueqing Hu, Lei Fu, Nancy Y I. A tacrine-tetrahydroquinoline heterodimer potently inhibits acetylcholinesterase activity and enhances neurotransmission in mice. European journal of medicinal chemistry. vol 226. 2021-11-22. PMID:34530383. |
acetylcholinesterase (ache) inhibitors have been used to improve cholinergic transmission in the brain for two decades and have proven effective for alleviating symptoms in the early stages of alzheimer's disease. |
2021-11-22 |
2023-08-13 |
mouse |
| Noreen Samad, Farzana Yasmin, Saima Khaliq, Saara Ahmad, - Azizuddin, Sana Mustaf. Diet supplements of banana fruit pulp mitigates repeated noise stress induced behavioral deficits and oxidative stress. Pakistan journal of pharmaceutical sciences. vol 33. issue 5(Supplementary). 2021-11-18. PMID:33832903. |
decreased levels of acetylcholinesterase in bpf+ns treated animals indicated increased cholinergic function which improves learning and memory. |
2021-11-18 |
2023-08-13 |
mouse |
| Ismail O Ishola, Benneth Ben-Azu, Oluwatosin A Adebayo, Abayomi M Ajayi, Iziegbe Lisa Omorodion, Kesiena Emmanuel Edje, Olufunmilayo O Adeyem. Prevention and reversal of ketamine-induced experimental psychosis in mice by the neuroactive flavonoid, hesperidin: The role of oxidative and cholinergic mechanisms. Brain research bulletin. vol 177. 2021-11-18. PMID:34653559. |
brain levels of oxidative/nitrergic (glutathione, superoxide-dismutase, malondialdehyde and nitrite levels) and cholinergic (acetylcholinesterase activity) markers were measured in the prefrontal-cortex, striatum and hippocampus. |
2021-11-18 |
2023-08-13 |
mouse |