| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aleksandar R Zivkovic, Georgina M Paul, Stefan Hofer, Karsten Schmidt, Thorsten Brenner, Markus A Weigand, Sebastian O Decke. Increased Enzymatic Activity of Acetylcholinesterase Indicates the Severity of the Sterile Inflammation and Predicts Patient Outcome following Traumatic Injury. Biomolecules. vol 13. issue 2. 2023-02-25. PMID:36830636. |
acetylcholinesterase (ache), an enzyme responsible for the hydrolysis of acetylcholine, plays an essential role in controlling cholinergic activity. |
2023-02-25 |
2023-08-14 |
Not clear |
| Vasudevan Mani, Minhajul Arfeen, Devendra Kumar Dhaked, Hamdoon A Mohammed, Palanisamy Amirthalingam, Hossam A Elsis. Neuroprotective Effect of Methanolic Ajwa Seed Extract on Lipopolysaccharide-Induced Memory Dysfunction and Neuroinflammation: In Vivo, Molecular Docking and Dynamics Studies. Plants (Basel, Switzerland). vol 12. issue 4. 2023-02-25. PMID:36840284. |
molecular modeling results revealed that the compound's ellagic acid, epicatechin, catechin, kaempferol, quercetin, and apigenin have the potential to act as a dual inhibitor of acetylcholinesterase (ache) and cox-2 and can be responsible for the improvement of both cholinergic and inflammatory conditions, while the cinnamic acid, hesperidin, hesperetin, narengin, and rutin compounds are responsible only for the improvement of cholinergic transmission. |
2023-02-25 |
2023-08-14 |
rat |
| Aravinda Babu, Mathew John, M J Liji, E Maria, S J Bhaskar, B K Binukmar, Ayyiliath M Sajith, Eeda Koti Reddy, K V Dileep, K Suni. Sub-pocket-focused designing of tacrine derivatives as potential acetylcholinesterase inhibitors. Computers in biology and medicine. vol 155. 2023-02-25. PMID:36841058. |
human acetylcholinesterase (hache) has a potential role in the management of acetylcholine, one of the neurotransmitters that modulate the overall activity of cholinergic system, ache inhibitors have a greater impact in the therapeutics. |
2023-02-25 |
2023-08-14 |
human |
| Yvonne J Rosenberg, Kelly Garcia, Justin Diener, Dennis Sullivan, Scott Donahue, Lingjun Mao, Jonathan Lees, Xiaoming Jiang, Lori A Urban, Jeremiah D Momper, Kwok-Yiu Ho, Palmer Taylo. A single post-exposure oxime RS194B treatment rapidly reactivates acetylcholinesterase and reverses acute symptoms in macaques exposed to diethylphosphorothioate parathion and chlorpyrifos insecticides. Journal of neurochemistry. 2023-02-14. PMID:36786545. |
similar to nerve agents, insecticides are neurotoxins which target and inhibit acetylcholinesterase (ache) in central and peripheral synapses in the cholinergic nervous system. |
2023-02-14 |
2023-08-14 |
mouse |
| Stergiani-Chrysovalanti Peitzika, Eleni Pontik. A Review on Recent Approaches on Molecular Docking Studies of Novel Compounds Targeting Acetylcholinesterase in Alzheimer Disease. Molecules (Basel, Switzerland). vol 28. issue 3. 2023-02-11. PMID:36770750. |
low levels of acetylcholine and abnormal levels of beta-amyloid, t protein aggregation, inflammation, and oxidative stress, have been associated with ad, and therefore, research has been oriented towards the cholinergic system and primarily on acetylcholinesterase (ache) inhibitors. |
2023-02-11 |
2023-08-14 |
Not clear |
| Kexin Li, Yulong Liu, Yanqin Liu, Qian Li, Lei Guo, Jianwei Xi. The kinetic and molecular docking analysis of interactions between three V-type nerve agents and four human cholinesterases. Chemico-biological interactions. 2023-01-28. PMID:36708975. |
their primary toxicity was the consequence of the covalent inhibition of the pivotal acetylcholinesterase (ache), which induces overstimulation of cholinergic receptors and overaccumulation of cholines, eventually leading to death by respiratory arrest. |
2023-01-28 |
2023-08-14 |
human |
| Ignazio Schino, Mariangela Cantore, Modesto de Candia, Cosimo D Altomare, Catarina Maria, João Barros, Vasco Cachatra, Patrícia Calado, Karina Shimizu, Adilson A Freitas, Maria C Oliveira, Maria J Ferreira, José N C Lopes, Nicola A Colabufo, Amélia P Raute. Exploring Mannosylpurines as Copper Chelators and Cholinesterase Inhibitors with Potential for Alzheimer's Disease. Pharmaceuticals (Basel, Switzerland). vol 16. issue 1. 2023-01-21. PMID:36678552. |
alzheimer's disease (ad) is characterized by a progressive cholinergic neurotransmission imbalance, with a decrease of acetylcholinesterase (ache) activity followed by a significant increase of butyrylcholinesterase (bche) in the later ad stages. |
2023-01-21 |
2023-08-14 |
Not clear |
| Raquel B M de Almeida, Deyse B Barbosa, Mayra R do Bomfim, Jéssika A O Amparo, Bruno S Andrade, Silvia L Costa, Joaquín M Campos, Jorddy N Cruz, Cleydson B R Santos, Franco H A Leite, Mariana B Botur. Identification of a Novel Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase: In Vitro and In Silico Studies. Pharmaceuticals (Basel, Switzerland). vol 16. issue 1. 2023-01-21. PMID:36678592. |
the enhancement of cholinergic functions via acetylcholinesterase (ache) and butyrylcholinesterase (buche) inhibition is considered a valuable therapeutic strategy for the treatment of alzheimer's disease. |
2023-01-21 |
2023-08-14 |
Not clear |
| Jason K Russell, Shalonda M Ingram, Laura B Teal, Craig W Lindsley, Carrie K Jone. M ACS chemical neuroscience. 2023-01-19. PMID:36655909. |
indirect-acting muscarinic cholinergic receptor agonists, such as acetylcholinesterase inhibitors (acheis), remain the only fda-approved treatments for the cognitive impairments observed in ad that target the cholinergic system. |
2023-01-19 |
2023-08-14 |
Not clear |
| Melvin Selim Atay, Suat Sari, Ebru Bodu. Molecular and Computational Analysis Identify Statins as Selective Inhibitors of Human Butyrylcholinesterase. The protein journal. 2023-01-17. PMID:36648628. |
cholinesterase enzyme family consists of acetylcholinesterase (ache, 3.1.1.7), the major enzyme responsible for hydrolysis of acetylcholine at cholinergic synapses, and butyrylcholinesterase (bche, 3.1.1.8) a detoxification enzyme of plasma. |
2023-01-17 |
2023-08-14 |
human |
| Abdulla M A Mahmoud, Eman M Mantawy, Sara A Wahdan, Ramy M Ammar, Ebtehal El-Demerdas. Vildagliptin restores cognitive function and mitigates hippocampal neuronal apoptosis in cisplatin-induced chemo-brain: Imperative roles of AMPK/Akt/CREB/ BDNF signaling cascades. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 159. 2023-01-14. PMID:36640673. |
notably, vilda boosted cholinergic neurotransmission through the downregulation of the acetylcholinesterase enzyme. |
2023-01-14 |
2023-08-14 |
human |
| Nicolaas I Bohnen, Stiven Roytman, Prabesh Kanel, Martijn L T M Müller, Peter J H Scott, Kirk A Frey, Roger L Albin, Robert A Koepp. Progression of regional cortical cholinergic denervation in Parkinson's disease. Brain communications. vol 4. issue 6. 2022-12-26. PMID:36569603. |
we used serial acetylcholinesterase pet ligand imaging to characterize the trajectory of regional cholinergic synapse deficits in parkinson's disease, testing the hypothesis of posterior-to-anterior progression of cortical cholinergic deficits. |
2022-12-26 |
2023-08-14 |
human |
| Júlia L B Simões, Leilane D Sobierai, Inayá F Leal, Miriam V R Dos Santos, João Victor Coiado, Margarete D Bagatin. Action of the purinergic and cholinergic anti-inflammatory pathways on oxidative stress in patients with Alzheimer's disease in the context of the COVID-19 pandemic. Neuroscience. 2022-12-16. PMID:36526078. |
herein, we focused on acetylcholinesterase inhibitors, responsible for the degradation of ach in the synaptic cleft, and muscarinic and nicotinic receptor agonists of the cholinergic system owing to the therapeutic potential of the cholinergic anti-inflammatory pathway in ad associated with sars-cov-2 infection. |
2022-12-16 |
2023-08-14 |
Not clear |
| Erkan Kilinc, Ibrahim Ethem Torun, Yasemin Baranoglu Kilin. Meningeal mast cell-mediated mechanisms of cholinergic system modulation in neurogenic inflammation underlying the pathophysiology of migraine. The European journal of neuroscience. 2022-12-09. PMID:36485173. |
effects of cholinergic agents (acetylcholinesterase inhibitor neostigmine, or acetylcholine, and muscarinic antagonist atropine) and mast cell stabilizer cromolyn or their combinations were tested in the in-vivo and in-vitro experiments. |
2022-12-09 |
2023-08-14 |
rat |
| Saritha S L Silva, Luciane V Tureck, Leonardo C Souza, João V M Hortega, Ana Luiza Piumbini, Mayza D Teixeira, Lupe Furtado-Alle Writing-Reviewing, Maria A B F Vital, Ricardo L R Souz. Animal model of Alzheimer's disease induced by streptozotocin: new insights about cholinergic pathway. Brain research. 2022-11-27. PMID:36436686. |
disorders of the cholinergic system are well known to be involved in the pathogenesis of ad, characterized by increased acetylcholinesterase (ache) and butyrylcholinesterase (bche) and decreased acetyltransferase (chat) enzymatic activities. |
2022-11-27 |
2023-08-14 |
human |
| Mohan Kumar Dash, Md Saydur Rahma. Molecular and biochemical responses to tributyltin (TBT) exposure in the American oyster: Triggers of stress-induced oxidative DNA damage and prooxidant-antioxidant imbalance in tissues by TBT. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2022-11-25. PMID:36427667. |
in this study, we investigated the effects of tbt on 8'-hydroxy-2'-deoxyguanosine (8-ohdg, a biomarker of pro-mutagenic dna lesion), double-stranded dna (dsdna), dinitrophenyl protein (dnp, a biomarker on reactive oxygen species, ros), 3-nitrotyrosine protein (ntp, a biomarker of reactive nitrogen species, rns), catalase (cat, an antioxidant), and acetylcholinesterase (ache, a cholinergic enzyme) expressions in the gills and digestive glands of oysters. |
2022-11-25 |
2023-08-14 |
cat |
| b' Irene \\xc3\\x81lvarez-Berbel, Alba Espargar\\xc3\\xb3, Antonio Viayna, Ana Bel\\xc3\\xa9n Caballero, Maria Ant\\xc3\\xb2nia Busquets, Patrick G\\xc3\\xa1mez, Francisco Javier Luque, Raimon Sabat\\xc3\\xa. Three to Tango: Inhibitory Effect of Quercetin and Apigenin on Acetylcholinesterase, Amyloid-\\xce\\xb2 Aggregation and Acetylcholinesterase-Amyloid Interaction. Pharmaceutics. vol 14. issue 11. 2022-11-11. PMID:36365159.' |
since acetylcholinesterase (ache) promotes the formation of such plaques, the inhibition of this enzyme could slow down the progression of amyloid-β aggregation, hence being complementary to the palliative treatment of cholinergic decline. |
2022-11-11 |
2023-08-14 |
Not clear |
| Tapan Behl, Ishnoor Kaur, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Sumeet Gupta, Mohammed Albratty, Asim Najmi, Hassan A Alhazmi, Simona Bunga. AChE as a Spark in the Alzheimer's Blaze - Antagonizing Effect of a Cyclized Variant. Ageing research reviews. 2022-11-11. PMID:36368649. |
a significant protein, acetylcholinesterase (ache) becomes dysfunctional as a result of cholinergic neuronal loss in ad pathology. |
2022-11-11 |
2023-08-14 |
Not clear |
| Faezeh Aliakbarzadeh, Mohammad Rafiee, Fariba Khodagholi, Mohammad Reza Khorramizadeh, Hamed Manouchehri, Akbar Eslami, Fatemeh Sayehmiri, Anoushiravan Mohseni-Bandpe. Adverse effects of polystyrene nanoplastic and its binary mixtures with nonylphenol on zebrafish nervous system: From oxidative stress to impaired neurotransmitter system. Environmental pollution (Barking, Essex : 1987). 2022-11-06. PMID:36336178. |
multiple biomarkers concerning with oxidative-stress [catalase (cat) activity and reduced glutathione (gsh) level], cholinergic system [acetylcholinesterase (ache) activity], glutamatergic system [glutamine synthetase (gs) and glutamate dehydrogenase (gdh) activities], energy metabolism [a-ketoglutarate dehydrogenase (a-kgdh) activity], and histological alterations were assessed. |
2022-11-06 |
2023-08-14 |
cat |
| Arwa A Al-Maswary, Molly O'Reilly, Andrew P Holmes, A Damien Walmsley, Paul R Cooper, Ben A Scheve. Exploring the neurogenic differentiation of human dental pulp stem cells. PloS one. vol 17. issue 11. 2022-11-04. PMID:36331951. |
in hdpscs, upregulation of acetylcholinesterase (ache), choline o-acetyltransferase (chat), sodium channel alpha subunit 9 (scn9a), pou class 4 homeobox 1 (pou4f1/brn3a) along with a downregulation of motor neuron and pancreas homeobox 1 (mnx1) indicated that differentiation was more guided toward a cholinergic sensory neuronal lineage. |
2022-11-04 |
2023-08-14 |
human |