| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Martha Cecilia Rosales Hernández, Marycruz Olvera-Valdez, Jazziel Velazquez Toledano, Jessica Elena Mendieta Wejebe, Leticia Guadalupe Fragoso Morales, Alejandro Cru. Exploring the Benzazoles Derivatives as Pharmacophores for AChE, BACE1, and as Anti-Aβ Aggregation to Find Multitarget Compounds against Alzheimer's Disease. Molecules (Basel, Switzerland). vol 29. issue 19. 2024-10-16. PMID:39407708. |
ad is a multifactorial disease in which several pharmacological targets have been identified-some are involved with amyloid beta (aβ) production, such as beta secretase (bace1) and beta amyloid aggregation, while others are involved with the cholinergic system as acetylcholinesterase (ache) and butirylcholinesterase (bche) and nicotinic and muscarinic receptors, as well as the hyperphosphorylation of microtubule-associated protein (tau). |
2024-10-16 |
2024-10-18 |
Not clear |
| Paula Belén Salazar, Fernando Gabriel Dupuy, Mariana C Fiori, Samantha M Stanfield, Jon McCord, Guillermo A Altenberg, Carlos Javier Minah. Nanodisc-associated acetylcholinesterase as a novel model system of physiological relevant membrane-bound cholinesterases. Inhibition by phenolic compounds. Biochimica et biophysica acta. Biomembranes. 2024-10-08. PMID:39378913. |
acetylcholinesterase (ache) plays a pivotal role in the cholinergic system, and its inhibition is sought after in a wide range of applications, from insect control to alzheimer's disease treatment. |
2024-10-08 |
2024-10-11 |
human |
| Guangyuan Fan, Tao Pan, Xingyu Ji, Changyou Jiang, Feifei Wang, Xing Liu, Lan Ma, Qiumin L. Paternal preconception donepezil exposure enhances learning in offspring. Behavioral and brain functions : BBF. vol 20. issue 1. 2024-09-29. PMID:39342229. |
the present study sought to investigate the potential influence of paternal use of donepezil, a specific reversible central acetylcholinesterase inhibitor that activates the cholinergic system to promote cognition, on offspring. |
2024-09-29 |
2024-10-01 |
Not clear |
| Ilona Mojzych, Anna Zawadzka, Kryspin Andrzejewski, Monika Jampolska, Zuzana Bednarikova, Miroslav Gancar, Zuzana Gazova, Maciej Mazur, Katarzyna Kaczyńsk. A Novel Tetrahydroacridine Derivative with Potent Acetylcholinesterase Inhibitory Properties and Dissociative Capability against Aβ42 Fibrils Confirmed by In Vitro Studies. International journal of molecular sciences. vol 25. issue 18. 2024-09-28. PMID:39337556. |
treatment is mainly based on acetylcholinesterase (ache) inhibitors such as donepezil, rivastigmine, and galantamine, which exhibit numerous adverse cardiovascular and gastrointestinal effects due to excessive stimulation of peripheral cholinergic activity involving muscarinic receptors. |
2024-09-28 |
2024-10-01 |
Not clear |
| Lijun Wang, Jian Liu, Wenqian Gui, Rong Zhang, Xinmei Li, Liancheng Fang, Hui Li, Dandan Pan, Wenling Y. Molecular interaction mechanisms on (-)-epigallocatechin-3-gallate improving activities of inhibited acetylcholinesterase by selected organophosphorus pesticides in vitro & vivo. Scientific reports. vol 14. issue 1. 2024-09-27. PMID:39333189. |
(-)-epigallocatechin-3-gallate (egcg) is reported to have benefits for the treatment of alzheimer's disease by binding with acetylcholinesterase (ache) to enhance the cholinergic neurotransmission. |
2024-09-27 |
2024-10-01 |
zebrafish |
| Olawande Bamisi, Adesua Olukayode Oluwalabani, Tolulope Timothy Arogundade, Olayemi Joseph Olajid. Neuroinflammation and oxidative redox imbalance drive memory dysfunction in adolescent rats prenatally exposed to Datura Stramonium. Neurotoxicology and teratology. 2024-09-20. PMID:39303770. |
whereas increased expression of acetylcholinesterase and ldh was seen in adolescent rats prenatally infused d. stramonium, acetylcholine levels were downregulated in both hippocampal and pfc lysates, suggesting cholinergic and metabolic dysfunctions. |
2024-09-20 |
2024-09-23 |
rat |
| Zahra Tayarani-Najaran, Mahla Dehghanpour Farashah, Seyed Ahmad Emami, Elham Ramazani, Naghmeh Shahraki, Elham Hadipou. Protective effects of betanin, a novel acetylcholinesterase inhibitor, against H Molecular biology reports. vol 51. issue 1. 2024-09-16. PMID:39283367. |
protective effects of betanin, a novel acetylcholinesterase inhibitor, against h dysfunction of the cholinergic system and increased oxidative stress have a crucial role in cognitive disorders including alzheimer's disease (ad). |
2024-09-16 |
2024-09-19 |
Not clear |
| Chhatrapal Patel, Richa Patel, Anuradha Kesharwani, Laxmi Rao, Nishant Sudhir Jai. Central cholinergic transmission modulates endocannabinoid-induced marble-burying behavior in mice. Behavioural brain research. 2024-09-15. PMID:39278464. |
with various cholinergic agents like acetylcholine (ach), acetylcholinesterase inhibitor (achei), neostigmine, nicotine, machr antagonist, atropine, and nachr antagonist, mecamylamine. |
2024-09-15 |
2024-09-18 |
mouse |
| Zhenfei Yan, Wei Liao, Hangshuo Liu, Xiaoyi Zhang, Qingsong Lin, Chenglian Feng, Fengchang W. Temperature dependent cholinergic synapse induced by triphenyl phosphate and tris(1.3-dichloroisopropyl) phosphate via thyroid hormone synthesis in Cyprinus carpio. Journal of hazardous materials. vol 480. 2024-09-14. PMID:39276737. |
both compounds have been identified as environmental hormones that mimic thyroid hormone activity and potentially inhibit acetylcholinesterase, leading to neurodevelopmental disorders characterized by brain tissue damage and disrupted cholinergic synapses, such as axon guidance and regeneration. |
2024-09-14 |
2024-09-18 |
Not clear |
| Ivan Kong, Gary Ka-Wing Yuen, Qi-Yun Wu, Maggie Sui-Sui Guo, Jin Gao, Tina Ting-Xia Dong, Karl Wah-Keung Tsi. Acetylcholine regulates the melanogenesis of retinal pigment epithelia cells via a cAMP-dependent pathway: A non-neuronal function of cholinergic system in retina. Heliyon. vol 10. issue 16. 2024-09-10. PMID:39253121. |
the mrna and protein expressions of cholinergic molecules, e.g., acetylcholinesterase (ache), butyrylcholinesterase (bche), and melanogenic molecules i.e., tyrosinase (tyr), microphthalmia-associated transcription factor (mitf), and melanin pigment were measured during melanogenesis of cultured arpe-19 cells. |
2024-09-10 |
2024-09-13 |
human |
| Aditya Anand, Munesh Kumar, S K Tando. Organophosphorus poisoning causing haemorrhagic pancreatitis - a case series. The Medico-legal journal. 2024-09-10. PMID:39253837. |
organophosphorus is a nerve poison that causes irreversible inhibition of acetylcholinesterase, which leads to the accumulation of acetylcholine, resulting in excessive cholinergic stimulation of several organ systems. |
2024-09-10 |
2024-09-13 |
Not clear |
| Paula Moyano, Andrea Flores, Javier San Juan, Jimena García, María José Anadón, Jose Carlos Plaza, Maria Victoria Naval, María de la Cabeza Fernández, Lucía Guerra-Menéndez, Javier Del Pin. Imidacloprid unique and repeated treatment produces cholinergic transmission disruption and apoptotic cell death in SN56 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-09-09. PMID:39251036. |
bf sn56 cholinergic wild-type or acetylcholinesterase (ache), β-amyloid-precursor-protein (βapp), tau, glycogen-synthase-kinase-3-beta (gsk3β), beta-site-amyloid-precursor-protein-cleaving enzyme 1 (bace1), and/or nuclear-factor-erythroid-2-related-factor-2 (nrf2) silenced cells were treated for 1 and 14 days with imi (1 μm to 800 μm) with or without recombinant heat-shock-protein-70 (rhsp70), recombinant proteasome 20s (rp20s) and with or without n-acetyl-cysteine (nac) to determine the possible mechanisms that mediate this effect. |
2024-09-09 |
2024-09-13 |
Not clear |
| Gabriele Horn, Franziska Frielingsdorf, Tobias Demel, Simone Rothmiller, Franz Worek, Niko Amen. Concentration-dependent effects of the nerve agents cyclosarin and VX on cytochrome P450 in a HepaRG cell-based liver model. Journal of applied toxicology : JAT. 2024-09-04. PMID:39228234. |
op can induce the uncontrolled overstimulation of the cholinergic system through inhibition of the enzyme acetylcholinesterase (ache). |
2024-09-04 |
2024-09-06 |
Not clear |
| Manikanta Nelakuditi, Sunil Kumar, Suhail M Shaikh, Avinash Parepalli, M Jayanth Kuma. A Narrative Review on Magnesium Sulfate as a Game Changer in Reducing ICU Stays in Organophosphate Poisoning Cases. Cureus. vol 16. issue 7. 2024-08-28. PMID:39188488. |
the toxic effects of op compounds arise from their inhibition of acetylcholinesterase, leading to an accumulation of acetylcholine and a subsequent cholinergic crisis, which can be fatal if not promptly treated. |
2024-08-28 |
2024-08-30 |
Not clear |
| Na Xie, Brandon A Bickley, Aaron D Gros. GABA-gated chloride channel mutation (Rdl) induces cholinergic physiological compensation resulting in cross resistance in Drosophila melanogaster. Pesticide biochemistry and physiology. vol 203. 2024-07-31. PMID:39084765. |
we provide evidence that compensation for the rdl mutation influences the cholinergic system, where an increase in acetylcholinesterase gene expression and enzyme activity results in neurophysiological changes and cross resistance to a carbamate insecticide (propoxur oral resistance ratio (rr) of 63) and an organophosphate insecticide (dichlorvos oral rr of 7). |
2024-07-31 |
2024-08-03 |
drosophila_melanogaster |
| Manish Moghe, Sang-Soo Kim, Miaoyin Guan, Antonina Rait, Kathleen F Pirollo, Joe B Harford, Esther H Chan. scL-2PAM: A Novel Countermeasure That Ameliorates Neuroinflammation and Neuronal Losses in Mice Exposed to an Anticholinesterase Organophosphate. International journal of molecular sciences. vol 25. issue 14. 2024-07-27. PMID:39062781. |
previously, we have demonstrated that scl-2pam, a nanoformulation designed to enter the brain via receptor-mediated transcytosis, is superior to unencapsulated 2-pam for reactivating brain acetylcholinesterase, ameliorating cholinergic crisis, and improving survival rates for paraoxon-exposed mice. |
2024-07-27 |
2024-07-29 |
mouse |
| Sofía Pastene-Burgos, Evelyn Muñoz-Nuñez, Soledad Quiroz-Carreño, Edgar Pastene-Navarrete, Luis Espinoza Catalan, Luis Bustamante, Julio Alarcón-Eno. Ceanothanes Derivatives as Peripheric Anionic Site and Catalytic Active Site Inhibitors of Acetylcholinesterase: Insights for Future Drug Design. International journal of molecular sciences. vol 25. issue 13. 2024-07-13. PMID:39000410. |
acetylcholinesterase (ache) plays a key role in the regulation of the cholinergic system and particularly in the formation of amyloid plaques; therefore, the inhibition of ache has become one of the most promising strategies for the treatment of ad, particularly concerning ache inhibitors that interact with the peripheral anionic site (pas). |
2024-07-13 |
2024-07-15 |
Not clear |
| Ji-Woon Kim, Benjamin Kleinfelter, Ege T Kavalali, Lisa M Monteggi. Distinct synaptic mechanisms drive the behavioral response to acute stress and rapid correction by ketamine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-07-02. PMID:38956176. |
we studied this premise using systemic administration of the acetylcholinesterase inhibitor physostigmine, which has been shown to rapidly elicit a shorter-term period of depressed mood in humans via cholinergic mechanisms. |
2024-07-02 |
2024-07-06 |
mouse |
| Allison Carles, Matthias Hoffmann, Matthias Scheiner, Lucie Crouzier, Christelle Bertrand-Gaday, Arnaud Chatonnet, Michael Decker, Tangui Mauric. The selective butyrylcholinesterase inhibitor UW-MD-95 shows symptomatic and neuroprotective effects in a pharmacological mouse model of Alzheimer's disease. CNS neuroscience & therapeutics. vol 30. issue 6. 2024-06-18. PMID:38887858. |
clinically available drugs mainly target acetylcholinesterase (ache) and indirectly sustain cholinergic neuronal tonus. |
2024-06-18 |
2024-06-21 |
mouse |
| Zora-Maya Keith, Crystal Munoz, Cindy Acon-Chen, Tsung-Ming Shi. Seizure suppression and neuroprotection in soman-exposed rats following delayed intramuscular treatment of adenosine A Toxicology and applied pharmacology. 2024-05-22. PMID:38777098. |
seizure suppression and neuroprotection in soman-exposed rats following delayed intramuscular treatment of adenosine a soman produces excitotoxic effects by inhibiting acetylcholinesterase in the cholinergic synapses and neuromuscular junctions and resulting in soman-induced sustained status epilepticus (sse). |
2024-05-22 |
2024-05-27 |
rat |