| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sumanpreet Kaur, Sheemona Chowdhary, Deepak Kumar, Rajasri Bhattacharyya, Dibyajyoti Banerje. Organophosphorus and carbamate pesticides: molecular toxicology and laboratory testing. Clinica chimica acta; international journal of clinical chemistry. 2023-10-07. PMID:37805177. |
both inhibit acetylcholinesterase (ache) and cholinergic symptoms are mainly used for the diagnosis of pesticide poisoning. |
2023-10-07 |
2023-10-15 |
Not clear |
| Raissa Alves da Conceição, Natalia von Ranke, Luciana Azevedo, Daiana Franco, Nathalia Fonseca Nadur, Arthur Eugen Kummerle, Maria Letícia de C Barbosa, Alessandra M T Souz. Structure-based design of new N-benzyl-piperidine derivatives as multitarget-directed AChE/BuChE inhibitors for Alzheimer's disease. Journal of cellular biochemistry. 2023-10-05. PMID:37796142. |
based on the cholinergic hypothesis and considering the well-established role of butyrylcholinesterase (buche) in advanced stages of ad, the chemical structure of the acetylcholinesterase (ache) inhibitor drug donepezil (1) was rationally modified for the design of new n-benzyl-piperidine derivatives (4a-d) as potential multitarget-direct ache and buche inhibitors. |
2023-10-05 |
2023-10-07 |
Not clear |
| Elif Tugce Karoglu-Eravsar, Melek Umay Tuz-Sasik, Aysenur Karaduman, Ayse Gokce Keskus, Ayca Arslan-Ergul, Ozlen Konu, Hulusi Kafaligonul, Michelle M Adam. Long-term Acetylcholinesterase Depletion Alters the Levels of Key Synaptic Proteins while Maintaining Neuronal Markers in the Aging Zebrafish (Danio rerio) Brain. Gerontology. 2023-10-04. PMID:37793352. |
interventions targeting cholinergic neurotransmission like acetylcholinesterase (ache) inhibition distinguish potential mechanisms to delay age-related impairments and attenuate deficits related to neurodegenerative diseases. |
2023-10-04 |
2023-10-07 |
zebrafish |
| Yuan Li, Mengyao Wu, Mengmeng Kong, Shaomei Sui, Qi Wang, Yan He, Jinsong G. Impact of Donepezil Supplementation on Alzheimer's Disease-like Pathology and Gut Microbiome in APP/PS1 Mice. Microorganisms. vol 11. issue 9. 2023-09-28. PMID:37764150. |
donepezil hydrochloride (dh), which enhances cholinergic activity by blocking acetylcholinesterase (ache), is one of the first-line drugs for ad treatment approved by the food and drug administration (fda) of the usa. |
2023-09-28 |
2023-10-07 |
mouse |
| Abdullah A Elgazar, Ramadan A El-Domany, Wagdy M Eldehna, Farid A Badri. Theophylline-based hybrids as acetylcholinesterase inhibitors endowed with anti-inflammatory activity: synthesis, bioevaluation, RSC advances. vol 13. issue 36. 2023-08-31. PMID:37649576. |
theophylline-based hybrids as acetylcholinesterase inhibitors endowed with anti-inflammatory activity: synthesis, bioevaluation, in this study, we investigated the conjugation of theophylline with different compounds of natural origin hoping to construct new hybrids with dual activity against cholinergic and inflammatory pathways as potential agents for the treatment of alzheimer's disease (ad). |
2023-08-31 |
2023-09-07 |
Not clear |
| Robert E Blair, Elisa Hawkins, Lauren R Pinchbeck, Robert J DeLorenzo, Laxmikant S Deshpand. The Journal of pharmacology and experimental therapeutics. 2023-08-29. PMID:37643794. |
op exposure inhibits the acetylcholinesterase enzyme, causing cholinergic overstimulation that can evolve into status epilepticus (se) and produce lethality. |
2023-08-29 |
2023-09-07 |
rat |
| Leeyup Chung, Miao Jing, Yulong Li, Andrew R Tappe. Feed-forward activation of habenula cholinergic neurons by acetylcholine. Neuroscience. 2023-08-12. PMID:37572877. |
supporting a role for ach in modulating mhb activity, acetylcholinesterase inhibitors (aceis) increased the firing rate of mhb cholinergic neurons in mouse habenula slices, an effect blocked by achr antagonists and mediated by ach which was detected via expressing fluorescent ach sensors in mhbin vivo. |
2023-08-12 |
2023-08-16 |
mouse |
| Yasco Aracava, Edson X Albuquerque, Edna F R Pereir. (R,S)-trihexyphenidyl, acting via a muscarinic receptor-independent mechanism, inhibits hippocampal glutamatergic and GABAergic synaptic transmissions: Potential relevance for treatment of organophosphorus intoxication. Neuropharmacology. 2023-08-07. PMID:37549771. |
preclinical studies have reported that, compared to the muscarinic receptor (machr) antagonist atropine, (r,s)-trihexyphenidyl (thp) more effectively counters the cholinergic crisis, seizures, and neuropathology triggered by organophosphorus (op)-induced acetylcholinesterase (ache) inhibition. |
2023-08-07 |
2023-08-14 |
Not clear |
| Julia Schumacher, Prabesh Kanel, Martin Dyrba, Alexander Storch, Nicolaas I Bohnen, Stefan Teipel, Michel J Groth. Structural and molecular cholinergic imaging markers of cognitive decline in Parkinson's disease. Brain : a journal of neurology. 2023-07-05. PMID:37403733. |
we conclude that degeneration of the posterior basal forebrain in parkinson's disease is accompanied by functional cortical changes in acetylcholinesterase activity and that both pet and mri cholinergic imaging markers are independently associated with multi-domain cognitive deficits in parkinson's disease without dementia. |
2023-07-05 |
2023-08-14 |
human |
| Somyeong Lee, Md Niamul Haque, Do-Hee Lee, Jae-Sung Rhe. Comparison of the effects of sublethal concentrations of biofoulants, copper pyrithione and zinc pyrithione on a marine mysid - A multigenerational study. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2023-07-02. PMID:37394131. |
based on the 1/10 noecs and noec values calculated from 96 h-toxicity test, survival and growth, intermolt duration, feeding, and the number of newborn juveniles were measured by evaluating enzymatic activity of detoxification parameter glutathione s-transferase (gst) and cholinergic biomarker acetylcholinesterase (ache) in the marine mysid exposed to 96 h-noecs of cupt and znpt for four weeks across three generations. |
2023-07-02 |
2023-08-14 |
Not clear |
| Ana Paula Murray, Brunella Biscussi, Valeria Cavallaro, Martina Donozo, Silvana A Rodrigue. Naturally Occurring Cholinesterase Inhibitors from Plants, Fungi, Algae, and Animals: A Review of the Most Effective Inhibitors Reported in 2012-2022. Current neuropharmacology. 2023-06-26. PMID:37357520. |
since the development of the "cholinergic hypothesis" as an important therapeutic approach in the treatment of alzheimer's disease (ad), the scientific community has made a remarkable effort to discover new and effective molecules with the ability to inhibit the enzyme acetylcholinesterase (ache). |
2023-06-26 |
2023-08-14 |
Not clear |
| Meghan Gage, Akhil A Vinithakumari, Shankumar Mooyottu, Thimmasettappa Thippeswam. Gut dysbiosis following organophosphate, diisopropylfluorophosphate (DFP), intoxication and saracatinib oral administration. Frontiers in microbiomes. vol 1. 2023-06-12. PMID:37304619. |
organophosphate nerve agents (opnas) act as irreversible inhibitors of acetylcholinesterase and can lead to cholinergic crisis including salivation, lacrimation, urination, defecation, gastrointestinal distress, respiratory distress, and seizures. |
2023-06-12 |
2023-08-14 |
Not clear |
| Lindsay H Burns, Zhe Pei, Hoau-Yan Wan. Targeting α7 nicotinic acetylcholine receptors and their protein interactions in Alzheimer's disease drug development. Drug development research. 2023-06-09. PMID:37291958. |
the decades-old cholinergic hypothesis of alzheimer's disease (ad) led to clinical testing and fda approval of acetylcholinesterase inhibitor drugs. |
2023-06-09 |
2023-08-14 |
Not clear |
| Binita Pradhan, Sujan Pandey, Aliska Niroula, Nishob Adhikari, Nibedita Chapagain, Sailesh Pradha. Mean Cholinesterase Level among Organophosphorus Poisoning Patients Visiting the Emergency Department in a Tertiary Care Centre: A Descriptive Cross-sectional Study. JNMA; journal of the Nepal Medical Association. vol 61. issue 257. 2023-05-19. PMID:37203908. |
through the inhibition of acetylcholinesterase, organophosphorus poisoning is characterised by the clinical picture of acute cholinergic crisis. |
2023-05-19 |
2023-08-14 |
Not clear |
| Stiven Roytman, Rebecca Paalanen, Alexis Griggs, Simon David, Chatkaew Pongmala, Robert A Koeppe, Peter J H Scott, Uros Marusic, Prabesh Kanel, Nico I Bohne. Cholinergic system correlates of postural control changes in Parkinson's disease freezers. Brain : a journal of neurology. 2023-04-22. PMID:37086478. |
the goal of this cross-sectional study is to examine cerebral cholinergic system changes that associate with inter-sensory postural control processing features as assessed by dynamic computerized posturography and acetylcholinesterase pet. |
2023-04-22 |
2023-08-14 |
human |
| Sara Bibi, Rabia Habib, Sania Shafiq, Syed Sayyam Abbas, Shaiza Khan, Syed Ali Musstjab Akber Shah Eqani, Eugenie Nepovimova, Mansoor Shaukat Khan, Kamil Kuca, Syed Muhammad Nurulai. Influence of the chronic groundwater fluoride consumption on cholinergic enzymes, ACHE and BCHE gene SNPs and pro-inflammatory cytokines: A study with Pakistani population groups. The Science of the total environment. 2023-04-08. PMID:37030382. |
cholinergic status, acetylcholinesterase and butyrylcholinesterase gene snps and pro-inflammatory cytokines were examined. |
2023-04-08 |
2023-08-14 |
human |
| Mohammed Shaban, Franklin Sosa, Muhammad Yasir Anwar, Irhoboudu Dickson Atogwe, Misbahuddin Khaj. Small Bowel Enteritis and Myocardial Depression Complicating Organophosphorus Poison in a Patient With Sleeve Gastrectomy and Intestinal Bypass Surgeries: An Atypical Presentation. Cureus. vol 15. issue 2. 2023-04-03. PMID:37007328. |
acute op toxicity is caused by inhibiting the acetylcholinesterase (ache) enzyme, resulting in a cholinergic surge. |
2023-04-03 |
2023-08-14 |
Not clear |
| Nyzil Massey, Suraj Sundara Vasanthi, Manikandan Samidurai, Meghan Gage, Nikhil Rao, Christina Meyer, Thimmasettappa Thippeswam. 1400 W, a selective inducible nitric oxide synthase inhibitor, mitigates early neuroinflammation and nitrooxidative stress in diisopropylfluorophosphate-induced short-term neurotoxicity rat model. Frontiers in molecular neuroscience. vol 16. 2023-04-03. PMID:37008784. |
opna exposure at sub-lethal concentrations induces irreversible inhibition of acetylcholinesterase and cholinergic toxidrome and develops |
2023-04-03 |
2023-08-14 |
rat |
| Li-Hua Lee, Shu-Ching Wu, Cheng-Feng Ho, Wan-Lin Liang, Yi-Chien Liu, Chia-Ju Cho. White matter hyperintensities in cholinergic pathways may predict poorer responsiveness to acetylcholinesterase inhibitor treatment for Alzheimer's disease. PloS one. vol 18. issue 3. 2023-03-31. PMID:37000849. |
white matter hyperintensities in cholinergic pathways may predict poorer responsiveness to acetylcholinesterase inhibitor treatment for alzheimer's disease. |
2023-03-31 |
2023-08-14 |
Not clear |
| b' Rudolf Vrabec, Gerald Blunden, Lucie Cahl\\xc3\\xadkov\\xc3\\xa. Natural Alkaloids as Multi-Target Compounds towards Factors Implicated in Alzheimer\'s Disease. International journal of molecular sciences. vol 24. issue 5. 2023-03-11. PMID:36901826.' |
the current treatment, based on the cholinergic hypothesis, is only symptomatic and mainly involves the restoration of acetylcholine (ach) levels through the inhibition of acetylcholinesterase (ache). |
2023-03-11 |
2023-08-14 |
Not clear |