| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hind Yassmine Chennai, Salah Belaidi, Lotfi Bourougaa, Mebarka Ouassaf, Leena Sinha, Abdelouahid Samadi, Samir Chtit. Identification of Potent Acetylcholinesterase Inhibitors as New Candidates for Alzheimer Disease via Virtual Screening, Molecular Docking, Dynamic Simulation, and Molecular Mechanics-Poisson-Boltzmann Surface Area Calculations. Molecules (Basel, Switzerland). vol 29. issue 6. 2024-03-28. PMID:38542869. |
huperzine a (hup) plays a crucial role in alzheimer's therapy by enhancing cognitive function through increased cholinergic activity as a reversible acetylcholinesterase (ache) inhibitor. |
2024-03-28 |
2024-03-30 |
Not clear |
| Dora Kolić, Vesna Pehar, Zrinka Kovari. Environmental exposure to glyphosate does not inhibit human acetylcholinesterase and butyrylcholinesterase. Arhiv za higijenu rada i toksikologiju. vol 75. issue 1. 2024-03-28. PMID:38548375. |
chemically, glyphosate belongs to a large family of organophosphorus pesticides, which exert a neurotoxic effect by inhibiting acetylcholinesterase (ache) and butyrylcholinesterase (bche), enzymes of the cholinergic system essential for maintaining neurotransmission. |
2024-03-28 |
2024-03-31 |
human |
| Kim Alfred E Inting, Anthony N Pian. Irinotecan-Induced Transient Dysarthria in a Patient With Metastatic Colorectal Cancer: A Case Report. Cureus. vol 16. issue 2. 2024-03-21. PMID:38510900. |
this temporal correlation suggests a drug-induced effect, proposed to be related to cholinergic hyperactivity associated with the drug's reversible inhibition of acetylcholinesterase. |
2024-03-21 |
2024-03-23 |
Not clear |
| Folake Olubukola Asejeje, Michael Abayomi Abiola, Oluwatobi Adewumi Adeyemo, Olalekan Bukunmi Ogunro, Abayomi Mayowa Ajay. Exogenous monosodium glutamate exacerbates lipopolysaccharide-induced neurobehavioral deficits, oxidative damage, neuroinflammation, and cholinergic dysfunction in rat brain. Neuroscience letters. 2024-03-03. PMID:38432355. |
moreover, msg aggravated lps-induced cholinergic dysfunction, as demonstrated by increased activity of acetylcholinesterase (ache) in the brain. |
2024-03-03 |
2024-03-06 |
rat |
| Charles Neu, Ricardo Esper Treml, Philipp Baumbach, Markus Engelmann, Claudius Gebhardt, Juliane Götze, Sina M Coldewe. Cholinesterase activities and sepsis-associated encephalopathy in viral versus nonviral sepsis. Canadian journal of anaesthesia = Journal canadien d'anesthesie. 2024-03-01. PMID:38429621. |
blood acetylcholinesterase (ache) and butyrylcholinesterase (bche) activities have been proposed as surrogate parameters for the cholinergic function of the central nervous system. |
2024-03-01 |
2024-03-04 |
Not clear |
| Yazhong Ma, Xiaotong Wang, Xin Li, Xi Chen, Zhifeng Teng, Xuekun Wang, Jie Yang, Guoyun Li. COP-22 Alleviates D-Galactose-Induced Brain Aging by Attenuating Oxidative Stress, Inflammation, and Apoptosis in Mice. Molecular neurobiology. 2024-02-12. PMID:38347285. |
for brain protection, cop-22 could resist d-gal-induced oxidative stress by increasing the activity of antioxidative defense enzymes and enhancing antioxidant capacity in the brain tissue; cop-22 could improve the dysfunction of the cholinergic system by decreasing the increased activity of acetylcholinesterase and increasing the reduced content of acetylcholine induced by d-gal; and cop-22 could protect nerve cells of the brain. |
2024-02-12 |
2024-02-15 |
mouse |
| F Javier Luque, Diego Muñoz-Torrer. Acetylcholinesterase: A Versatile Template to Coin Potent Modulators of Multiple Therapeutic Targets. Accounts of chemical research. 2024-02-09. PMID:38333993. |
conspectusthe enzyme acetylcholinesterase (ache) hydrolyzes the neurotransmitter acetylcholine (ach) at cholinergic synapses of the peripheral and central nervous system. |
2024-02-09 |
2024-02-11 |
human |
| Lei Xing, Pinyi Ma, Fangfang Che. A novel turn-on near-infrared fluorescent probe for highly sensitive in vitro and in vivo detection of acetylcholinesterase activity. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. vol 310. 2024-01-30. PMID:38290281. |
acetylcholinesterase (ache) is a key enzyme in the cholinergic pathway of the nervous systems, with its aberrant expression linked to various diseases. |
2024-01-30 |
2024-02-02 |
mouse |
| Yonat Tzur, Serafima Dubnov, Nimrod Madrer, Adi Bar, Bettina Nadorp, Nibha Mishra, Paul Heppenstall, Estelle R Bennett, David S Greenberg, Katarzyna Winek, Hermona Sore. Ribosomal protein L24 mediates mammalian microRNA processing in an evolutionarily conserved manner. Cellular and molecular life sciences : CMLS. vol 81. issue 1. 2024-01-23. PMID:38261097. |
to investigate the mechanism(s) underlying the expression of primate-specific micrornas (mirs), we sought dna regulatory elements and proteins mediating expression of the primate-specific hsa-mir-608 (mir-608), which is located in the sema4g gene and facilitates the cholinergic blockade of inflammation by targeting acetylcholinesterase mrna. |
2024-01-23 |
2024-01-25 |
mouse |
| b' Suzana \\xc5\\xbdunec, Donna Vadlja, Alma Rami\\xc4\\x87, Antonio Zandona, Nikola Marakovi\\xc4\\x87, Iva Brekalo, Ines Primo\\xc5\\xbei\\xc4\\x8d, Maja Katalini\\xc4\\x8. Profiling Novel Quinuclidine-Based Derivatives as Potential Anticholinesterase Drugs: Enzyme Inhibition and Effects on Cell Viability. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203326.' |
the enzymes acetylcholinesterase, ache, and butyrylcholinesterase, bche, responsible for hydrolyzing ach, can fine-tune the cholinergic system's activity and are, therefore, excellent pharmacological targets to address a range of medical conditions. |
2024-01-11 |
2024-01-13 |
Not clear |
| Mikael Ham Sembiring, Okta Nursanti, Tesia Aisyah Rahmani. Molecular docking and toxicity studies of nerve agents against acetylcholinesterase (AChE). Journal of receptor and signal transduction research. 2024-01-08. PMID:38189350. |
acetylcholinesterase (ache) is a cholinergic enzyme that plays an essential role in the autonomic nervous system. |
2024-01-08 |
2024-01-10 |
Not clear |
| Ya-Nan Zhang, Xin-Lu Chen, Ling-Yu Guo, Pei-Ran Jiang, Hui Lu, Kai Pan, Lei Guo, Yu-Ting Hu, Ai-Min Ba. Downregulation of peripheral luteinizing hormone rescues ovariectomy-associated cognitive deficits in APP/PS1 mice. Neurobiology of aging. vol 135. 2024-01-07. PMID:38185053. |
we and others found that the transcription factor early growth response-1 (egr1) regulates cholinergic function including the expression of acetylcholinesterase (ache) and plays a significant role in cognitive decline of ad. |
2024-01-07 |
2024-01-10 |
mouse |
| Jarrod A Gott, Sina Stücker, Philipp Kanske, Jan Haaker, Martin Dresle. Acetylcholine and metacognition during sleep. Consciousness and cognition. vol 117. 2023-12-02. PMID:38042119. |
while recent studies using acetylcholinesterase inhibitors suggest a potential role of acetylcholine in the occurrence of lucid dreaming, the underlying mechanisms by which this effect is produced remains un-modelled and unknown; with the causal link between cholinergic mechanisms and upstream psychological states being complex and elusive. |
2023-12-02 |
2023-12-10 |
Not clear |
| S V Kuznetsov, V A Sizonov, L E Dmitriev. Participation of Modulating Rhythms of the Decasecond Range in Intersystem Correlation Interactions in Early Rat Ontogeny. Bulletin of experimental biology and medicine. 2023-11-17. PMID:37978147. |
in p16 the activation of cholinergic structures, caused by the introduction of the acetylcholinesterase inhibitor physostigmine (eserine) leads to significant disturbances in the degree of correlation in the d1 range. |
2023-11-17 |
2023-11-20 |
rat |
| Xia Mu, Shengwei Yuan, Dinglin Zhang, Rui Lai, Chenyi Liao, Guohui L. Selective modulation of alkali metal ions on acetylcholinesterase. Physical chemistry chemical physics : PCCP. 2023-11-07. PMID:37934509. |
acetylcholinesterase (ache) is an important hydrolase in cholinergic synapses and a candidate target in the treatment of alzheimer's disease. |
2023-11-07 |
2023-11-08 |
human |
| Nalinee Kongkaew, Kowit Hengphasatporn, Yuwanda Injongkol, Pitchayathida Mee-Udorn, Liyi Shi, Panupong Mahalapbutr, Phornphimon Maitarad, Ryuhei Harada, Yasuteru Shigeta, Thanyada Rungrotmongkol, Alisa S Vangna. Design of electron-donating group substituted 2-PAM analogs as antidotes for organophosphate insecticide poisoning. RSC advances. vol 13. issue 46. 2023-11-06. PMID:37928857. |
the inhibition of acetylcholinesterase (ache) by ops leads to the overstimulation of cholinergic receptors, ultimately resulting in respiratory arrest, seizures, and death. |
2023-11-06 |
2023-11-08 |
Not clear |
| Ritu, Prakash Chandra, Asmita Da. "Cholinergic side Effect-Free anticancer drugs: paving the way for safer and more effective cancer treatment". Journal of biomolecular structure & dynamics. 2023-10-27. PMID:37885319. |
irinotecan-treated patients have developed cholinergic syndrome due to acetylcholinesterase (ache) enzyme inhibition. |
2023-10-27 |
2023-11-08 |
human |
| Archisman Mahapatra, Priya Gupta, Anjali Suman, Shubhendu Shekhar Ray, Rahul Kumar Sing. PFOS-induced dyslipidemia and impaired cholinergic neurotransmission in developing zebrafish: Insight into its mechanisms. Neurotoxicology and teratology. vol 100. 2023-10-14. PMID:37805080. |
additionally, pfos exposure led to impaired cholinergic neurotransmission, evidenced by a concentration-dependent inhibition of acetylcholinesterase activity, altered gene expressions related to neural development and function, and reduced na |
2023-10-14 |
2023-11-08 |
zebrafish |
| Shuoqi Jiang, Qiuya Gu, Xiaobin Y. Detection of insecticides by Tetronarce californica acetylcholinesterase via expression and in silico analysis. Applied microbiology and biotechnology. 2023-10-13. PMID:37831186. |
the acetylcholinesterase (ache) is involved in termination of synaptic transmission at cholinergic synapses and plays a vital role in the insecticide detection and inhibitor screening. |
2023-10-13 |
2023-10-15 |
Not clear |
| Masarra Joda, Karen A Waters, Rita Machaalan. Choline-acetyltransferase (ChAT) and acetylcholinesterase (AChE) in the human infant dorsal motor nucleus of the Vagus (DMNV), and alterations according to sudden infant death syndrome (SIDS) category. Neurobiology of disease. 2023-10-09. PMID:37813167. |
amongst other molecules, the cholinergic system consists of choline-acetyltransferase (chat, - synthesis enzyme), acetylcholinesterase (ache - primary hydrolysis enzyme), and butyrylcholinesterase (buche - secondary hydrolysis enzyme). |
2023-10-09 |
2023-10-15 |
human |