| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tomasz Tuzimski, Anna Petruczyni. Determination of Anti-Alzheimer's Disease Activity of Selected Plant Ingredients. Molecules (Basel, Switzerland). vol 27. issue 10. 2022-05-28. PMID:35630702. |
one of the most important therapeutic strategies is controlling the level of acetylcholine-a neurotransmitter in cholinergic synapses-by blocking the degradation of acetylcholine using acetylcholinesterase inhibitors such as tacrine, galantamine, donepezil and rivastigmine. |
2022-05-28 |
2023-08-13 |
Not clear |
| Vladislav Bugay, Summer Rain Gregory, Matthieu Gibson Belanger-Coast, Raymond Zhao, Robert Brenne. Effects of Sublethal Organophosphate Toxicity and Anti-cholinergics on Electroencephalogram and Respiratory Mechanics in Mice. Frontiers in neuroscience. vol 16. 2022-05-19. PMID:35585917. |
the mechanism of toxicity is through antagonism of acetylcholinesterase, which secondarily causes excess activation of cholinergic receptors leading to seizures, tremors, respiratory depression, and other physiological consequences. |
2022-05-19 |
2023-08-13 |
mouse |
| Kritika Kumari, Laishram R Sing. Trimethylamine N-oxide might impair cholinergic system by affecting the structural integrity of Acetylcholinesterase. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555536. |
trimethylamine n-oxide might impair cholinergic system by affecting the structural integrity of acetylcholinesterase. |
2022-05-13 |
2023-08-13 |
human |
| Aidan Falvey, Santhoshi P Palandira, Eric H Chang, Fernanda M Consolim-Colombo, Kevin J Tracey, Valentin A Pavlo. The Cholinergic Drug Galantamine Ameliorates Acute Respiratory Distress Syndrome in Mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556727. |
cholinergic anti-inflammatory signalling can be activated by galantamine - a centrally acting acetylcholinesterase inhibitor that is also clinically approved (for the treatment of alzheimer's disease). |
2022-05-13 |
2023-08-13 |
mouse |
| Khadija Boukholda, Brahim Gargouri, Bakhta Aouey, Abdelraheim Attaai, Mohamed Abd Elkodous, Mohamed Najimi, Bernd L Fiebich, Michèle Bouchard, Hamadi Fetou. Subacute silica nanoparticle exposure induced oxidative stress and inflammation in rat hippocampus combined with disruption of cholinergic system and behavioral functions. NanoImpact. vol 24. 2022-05-13. PMID:35559817. |
sinps affected the cholinergic system as reflected by reduced acetylcholinesterase (ache) and butyrylcholinesterase (bche) activity. |
2022-05-13 |
2023-08-13 |
rat |
| Eric Herrera, Timothy Barry, Aishwarya Sriraman, Karen Brecht, Sandra DeBus, Ki Ma, Hilary Mccarren, C L Cadieu. Developing a Prenatal Acute Exposure and Medical Countermeasure Evaluation Model for Organophosphate Compounds in a Genetically Modified Mouse. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35560758. |
organophosphate (ops) compounds make up the most common class of pesticides as well as chemical warfare nerve agents (cwna), all of which covalently inhibit the active site of acetylcholinesterase (ache), resulting in intoxication via a cholinergic crisis. |
2022-05-13 |
2023-08-13 |
mouse |
| Vasudevan Mani, Minhajul Arfeen, Sultan Sajid, Yasser Almogbe. Aqueous Ajwa dates seeds extract improves memory impairment in type-2 diabetes mellitus rats by reducing blood glucose levels and enhancing brain cholinergic transmission. Saudi journal of biological sciences. vol 29. issue 4. 2022-05-09. PMID:35531250. |
acetylcholine (ach) and acetylcholinesterase (ache) levels were estimated from brain homogenates to assess cholinergic transmission. |
2022-05-09 |
2023-08-13 |
rat |
| K V Dileep, Kentaro Ihara, Chiemi Mishima-Tsumagari, Mutsuko Kukimoto-Niino, Mayumi Yonemochi, Kazuharu Hanada, Mikako Shirouzu, Kam Y J Zhan. Crystal structure of human acetylcholinesterase in complex with tacrine: Implications for drug discovery. International journal of biological macromolecules. 2022-05-08. PMID:35526766. |
restoration of the cholinergic transmission through acetylcholinesterase (ache) inhibitors is a promising disease modifying therapy. |
2022-05-08 |
2023-08-13 |
human |
| b' Mehmet Koca, U\\xc4\\x9fur G\\xc3\\xbcller, P\\xc4\\xb1nar G\\xc3\\xbcller, Ziya Da\\xc4\\x9falan, Bilal Ni\\xc5\\x9fanc\\xc4\\xb. Design and Synthesis of Novel Dual Cholinesterase Inhibitors: In Vitro Inhibition Studies Supported with Molecular Docking. Chemistry & biodiversity. 2022-04-26. PMID:35470963.' |
the major cholinesterase enzymes, acetylcholinesterase (ache) and butyrylcholinesterase (bche), are important in the therapy of alzheimer's disease (ad) based on the cholinergic hypothesis. |
2022-04-26 |
2023-08-13 |
human |
| Songül Şahi. A single-molecule with multiple investigations: Synthesis, characterization, computational methods, inhibitory activity against Alzheimer's disease, toxicity, and ADME studies. Computers in biology and medicine. vol 146. 2022-04-24. PMID:35462270. |
the main objective of this study is to determine the drug-like properties of the title compound and to demonstrate its acetylcholinesterase inhibitory activity for the cholinergic hypothesis of alzheimer's disease. |
2022-04-24 |
2023-08-13 |
human |
| Sandra Carolina Durán-Cristian. Cholinesterase activity in the eye? Central nervous system agents in medicinal chemistry. 2022-04-18. PMID:35431003. |
on the other hand, acetylcholinesterase, the enzyme responsible for the hydrolysis of acetylcholine, is implicated in cholinergic function. |
2022-04-18 |
2023-08-13 |
Not clear |
| Suksan Changlek, Mohammad Nasiruddin Rana, Moe Pwint Phyu, Naymul Karim, Hideyuki J Majima, Jitbanjong Tangpon. Curcumin Suppresses Lead-Induced Inflammation and Memory Loss in Mouse Model and In Silico Molecular Docking. Foods (Basel, Switzerland). vol 11. issue 6. 2022-03-25. PMID:35327278. |
cur treatment also improved memory loss, learning deficit, and cholinergic dysfunction via elevating acetylcholinesterase (ache) enzymatic activity and protein expression. |
2022-03-25 |
2023-08-13 |
mouse |
| Ezio Giacobini, A Claudio Cuello, Abraham Fishe. Reimagining cholinergic therapy for Alzheimer's disease. Brain : a journal of neurology. 2022-03-15. PMID:35289363. |
restoring the cholinergic system has been a primary means of improving cognition in alzheimer's disease, as four of the six approved therapies are acetylcholinesterase inhibitors (fig 1). |
2022-03-15 |
2023-08-13 |
Not clear |
| Dércia Santos, Montse Perez, Evaristo Perez, Edna Cabecinha, Ana Luzio, Luís Félix, Sandra M Monteiro, Juan Bella. Toxicity of microplastics and copper, alone or combined, in blackspot seabream (Pagellus bogaraveo) larvae. Environmental toxicology and pharmacology. 2022-03-01. PMID:35227885. |
however, the acetylcholinesterase transcript was downregulated in mps, cu and cu10+mps groups, indicating that mps effects in cholinergic neurotransmission may arise after longer exposures. |
2022-03-01 |
2023-08-13 |
Not clear |
| Majid Rasool Kamli, Abeer Abdullah M Sharaf, Jamal S M Sabir, Irfan A Rathe. Phytochemical Screening of Plants (Basel, Switzerland). vol 11. issue 4. 2022-02-26. PMID:35214846. |
phytochemical screening of the inhibition of acetylcholinesterase (ache) by cholinergic agents has been promoted as a potent strategy for treating and managing cognitive decline disorders. |
2022-02-26 |
2023-08-13 |
Not clear |
| Maryam Taheri, Samira Aslani, Hossein Ghafouri, Asadollah Mohammadi, Vaha Akbary Moghaddam, Nastarn Moradi, Hananeh Naeim. Synthesis, in vitro biological evaluation and molecular modelling of new 2-chloro-3-hydrazinopyrazine derivatives as potent acetylcholinesterase inhibitors on PC12 cells. BMC chemistry. vol 16. issue 1. 2022-02-23. PMID:35193649. |
thus, the use of acetylcholinesterase inhibitors (acheis) to block the cholinergic degradation of ach is a promising approach for ad treatment. |
2022-02-23 |
2023-08-13 |
Not clear |
| Yiwen Xiao, Weizhong Liang, De Liu, Zhibin Zhang, Jun Chang, Du Zh. Isolation and acetylcholinesterase inhibitory activity of asterric acid derivatives produced by 3 Biotech. vol 12. issue 3. 2022-02-21. PMID:35186657. |
acetylcholinesterase (ache) inhibitors, which are based on cholinergic damage, remain the mainstream drugs to alleviate ad-related symptoms. |
2022-02-21 |
2023-08-13 |
Not clear |
| Hatice Esra Dura. Pyrimidines: Molecular docking and inhibition studies on carbonic anhydrase and cholinesterases. Biotechnology and applied biochemistry. 2022-02-03. PMID:35112394. |
cholinesterases (ches; ache, acetylcholinesterase and bche, butyrylcholinesterase) inhibitors and their benefits of cholinergic replacement in the treatment of ad have been researched and documented by scientists in various ways to date. |
2022-02-03 |
2023-08-13 |
human |
| Xian-Tao L. Alzheimer's disease therapy based on acetylcholinesterase inhibitor/blocker effects on voltage-gated potassium channels. Metabolic brain disease. 2022-01-31. PMID:35098414. |
to enhance the declined level of acetylcholine (ach) resulting from loss of cholinergic neurons, acetylcholinesterase (ache) inhibitors are developed and successfully approved for ad treatment in the clinic, with a limited therapeutic effectiveness. |
2022-01-31 |
2023-08-13 |
Not clear |
| Camila Fabiani, Brunella Biscussi, Juan Pablo Munafo, Ana Paula Murray, Jeremias Corradi, Silvia Susana Antollin. Molecular pharmacology. 2021-12-31. PMID:34969831. |
since cholinergic deficit is a major factor in this disease, two molecular targets for its treatment are the acetylcholinesterase (ache) and the nicotinic acetylcholine receptors (nachrs). |
2021-12-31 |
2023-08-13 |
Not clear |