| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Simone Phillips, Jose Suarez-Torres, Harvey Checkoway, Dolores Lopez-Paredes, Sheila Gahagan, Jose Ricardo Suarez-Lope. Acetylcholinesterase activity and thyroid hormone levels in Ecuadorian adolescents living in agricultural settings where organophosphate pesticides are used. International journal of hygiene and environmental health. vol 233. 2021-10-25. PMID:33581413. |
organophosphates are frequently applied insecticides that inhibit acetylcholinesterase (ache) activity resulting in cholinergic overstimulation. |
2021-10-25 |
2023-08-13 |
Not clear |
| Namrita Halder, Girdhari La. Cholinergic System and Its Therapeutic Importance in Inflammation and Autoimmunity. Frontiers in immunology. vol 12. 2021-10-14. PMID:33936095. |
the cholinergic system includes the neurotransmitter\ molecule, acetylcholine (ach), cholinergic receptors (achrs), choline acetyltransferase (chat) enzyme, and acetylcholinesterase (ache) enzyme. |
2021-10-14 |
2023-08-13 |
Not clear |
| Anna Modoni, Alessia Mastrorosa, Gregorio Spagni, Amelia Evol. Cholinergic hyperactivity in patients with myasthenia gravis with MuSK antibodies: A neurophysiological study. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. vol 132. issue 8. 2021-10-11. PMID:34147009. |
patients with myasthenia gravis associated with muscle-specific tyrosine kinase antibodies (musk-mg) often manifest signs of cholinergic hyperactivity with standard doses of acetylcholinesterase inhibitors (ache-is). |
2021-10-11 |
2023-08-13 |
Not clear |
| Antonio Monroy-Noyola, Damianys Almenares-Lopez, Eugenio Vilanova Gisber. Hydrolysis of chiral organophosphorus compounds by phosphotriesterases and mammalian paraoxonase-1. Frontiers in bioscience (Landmark edition). vol 26. 2021-10-06. PMID:33049692. |
acute exposure of humans to these mixtures induces the covalent modification of acetylcholinesterase (ache) and neuropathy target esterase (nte) and causes a cholinergic syndrome or organophosphate-induced delayed polyneuropathy syndrome (opidp). |
2021-10-06 |
2023-08-13 |
Not clear |
| Muharrem Kalaycı, Cüneyt Türkeş, Mustafa Arslan, Yeliz Demir, Şükrü Beydemi. Novel benzoic acid derivatives: Synthesis and biological evaluation as multitarget acetylcholinesterase and carbonic anhydrase inhibitors. Archiv der Pharmazie. vol 354. issue 3. 2021-10-06. PMID:33155700. |
the utility of cholinergic replacement by acetylcholinesterase (ache) inhibitors in ad treatment has been well documented so far. |
2021-10-06 |
2023-08-13 |
human |
| Chetan Thingore, Viplav Kshirsagar, Archana Juveka. Amelioration of oxidative stress and neuroinflammation in lipopolysaccharide-induced memory impairment using Rosmarinic acid in mice. Metabolic brain disease. vol 36. issue 2. 2021-10-05. PMID:33068223. |
imbalance in the cholinergic system was analyzed by measuring the acetylcholinesterase (ache) activity. |
2021-10-05 |
2023-08-13 |
mouse |
| Eng Leng Saw, James T Pearson, Daryl O Schwenke, Pujika Emani Munasinghe, Hirotsugu Tsuchimochi, Shruti Rawal, Sean Coffey, Philip Davis, Richard Bunton, Isabelle Van Hout, Yuko Kai, Michael J A Williams, Yoshihiko Kakinuma, Martin Fronius, Rajesh Katar. Activation of the cardiac non-neuronal cholinergic system prevents the development of diabetes-associated cardiovascular complications. Cardiovascular diabetology. vol 20. issue 1. 2021-10-05. PMID:33618724. |
recent evidence suggests that cardiomyocytes possess a non-neuronal cholinergic system (nncs) that comprises of choline acetyltransferase (chat), choline transporter 1 (cht1), vesicular acetylcholine transporter (vacht), acetylcholinesterase (ache) and type-2 muscarinic ach receptors (m |
2021-10-05 |
2023-08-13 |
Not clear |
| Aijaz Ahmad Malik, Suvash Chandra Ojha, Nalini Schaduangrat, Chanin Nantasenama. ABCpred: a webserver for the discovery of acetyl- and butyryl-cholinesterase inhibitors. Molecular diversity. 2021-10-05. PMID:34609711. |
acetylcholinesterase (ache) hydrolyses ach and inhibits the cholinergic transmission. |
2021-10-05 |
2023-08-13 |
Not clear |
| Jayme Cannon, Shengzhuang Tang, Seok Ki Cho. Caged Oxime Reactivators Designed for the Light Control of Acetylcholinesterase Reactivation Photochemistry and photobiology. 2021-10-04. PMID:34558680. |
caged oxime reactivators designed for the light control of acetylcholinesterase reactivation despite its promising role in the active control of biological functions by light, photocaging remains untested in acetylcholinesterase (ache), a key enzyme in the cholinergic family. |
2021-10-04 |
2023-08-13 |
Not clear |
| Oksana Gerlits, Matthew P Blakeley, David A Keen, Zoran Radić, Andrey Kovalevsk. Room temperature crystallography of human acetylcholinesterase bound to a substrate analogue 4K-TMA: Towards a neutron structure. Current research in structural biology. vol 3. 2021-09-21. PMID:34541552. |
acetylcholinesterase (ache) catalyzes hydrolysis of acetylcholine thereby terminating cholinergic nerve impulses for efficient neurotransmission. |
2021-09-21 |
2023-08-13 |
human |
| Nagendra N Dudi-Venkata, Hidde M Kroon, Sergei Bedrikovetski, Luke Traeger, Mark Lewis, Matthew J Lawrence, Ronald A Hunter, James W Moore, Michelle L Thomas, Tarik Sammou. PyRICo-Pilot: pyridostigmine to reduce the duration of postoperative ileus after colorectal surgery - a phase II study. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland. vol 23. issue 8. 2021-09-15. PMID:34021689. |
acetylcholinesterase inhibitors such as pyridostigmine increase gastrointestinal (gi) motility through a cholinergic anti-inflammatory pathway. |
2021-09-15 |
2023-08-13 |
Not clear |
| Hye-Jin Eom, Md Niamul Haque, Somyeong Lee, Jae-Sung Rhe. Exposure to metals premixed with microplastics increases toxicity through bioconcentration and impairs antioxidant defense and cholinergic response in a marine mysid. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 249. 2021-09-08. PMID:34284068. |
moreover, co-exposure inhibited acetylcholinesterase activity at both stages, suggesting cholinergic impairment. |
2021-09-08 |
2023-08-13 |
Not clear |
| Paulo L Pfitzinger, Laura Fangmann, Kun Wang, Elke Demir, Engin Gürlevik, Bettina Fleischmann-Mundt, Jennifer Brooks, Jan G D'Haese, Steffen Teller, Andreas Hecker, Moritz Jesinghaus, Carsten Jäger, Lei Ren, Rouzanna Istvanffy, Florian Kühnel, Helmut Friess, Güralp Onur Ceyhan, Ihsan Ekin Demi. Indirect cholinergic activation slows down pancreatic cancer growth and tumor-associated inflammation. Journal of experimental & clinical cancer research : CR. vol 39. issue 1. 2021-09-06. PMID:33357230. |
here, we investigated the role of indirect cholinergic activation on pca progression through inhibition of acetylcholinesterase (ache) via clinically available ache-inhibitors, i.e. |
2021-09-06 |
2023-08-13 |
Not clear |
| Dhanasak Dhanasobhon, Maria-Carmen Medrano, Léa J Becker, Yunuen Moreno-Lopez, Sehrazat Kavraal, Charlotte Bichara, Rémy Schlichter, Perrine Inquimbert, Ipek Yalcin, Matilde Cordero-Erausqui. Enhanced analgesic cholinergic tone in the spinal cord in a mouse model of neuropathic pain. Neurobiology of disease. vol 155. 2021-09-03. PMID:33845128. |
the alterations thus appear to be in the neurons receiving the cholinergic signaling, which is confirmed by the fact that subthreshold doses of acetylcholinesterase (ache) inhibitors in sham animals become anti-allodynic in cuff mice and by the altered expression of the β2 nicotinic receptor subunit. |
2021-09-03 |
2023-08-13 |
mouse |
| Dhanasak Dhanasobhon, Maria-Carmen Medrano, Léa J Becker, Yunuen Moreno-Lopez, Sehrazat Kavraal, Charlotte Bichara, Rémy Schlichter, Perrine Inquimbert, Ipek Yalcin, Matilde Cordero-Erausqui. Enhanced analgesic cholinergic tone in the spinal cord in a mouse model of neuropathic pain. Neurobiology of disease. vol 155. 2021-09-03. PMID:33845128. |
the spinal cholinergic system is responsible for an analgesic tone that can be exacerbated by acetylcholinesterase inhibitors, a property used in the clinic to relief acute pain (child birth, post-op). |
2021-09-03 |
2023-08-13 |
mouse |
| Nikolina Maček Hrvat, Zrinka Kovari. Counteracting poisoning with chemical warfare nerve agents. Arhiv za higijenu rada i toksikologiju. vol 71. issue 4. 2021-08-30. PMID:33410774. |
phosphylation of the pivotal enzyme acetylcholinesterase (ache) by nerve agents (nas) leads to irreversible inhibition of the enzyme and accumulation of neurotransmitter acetylcholine, which induces cholinergic crisis, that is, overstimulation of muscarinic and nicotinic membrane receptors in the central and peripheral nervous system. |
2021-08-30 |
2023-08-13 |
Not clear |
| Xue-Lian Qi, Ruifeng Liu, Balbir Singh, David Bestue, Albert Compte, Almira I Vazdarjanova, David T Blake, Christos Constantinidi. Nucleus basalis stimulation enhances working memory by stabilizing stimulus representations in primate prefrontal cortical activity. Cell reports. vol 36. issue 5. 2021-08-27. PMID:34348147. |
cholinergic agonists and acetylcholinesterase inhibitors can enhance cognitive functioning, as does intermittent electrical stimulation of the cortical source of acetylcholine, the nucleus basalis (nb) of meynert. |
2021-08-27 |
2023-08-13 |
human |
| Zohreh Zare, Sam Zarbakhsh, Shamim Mashhadban, Afshin Moradgholi, Moslem Mohammad. Apoptosis is involved in paraoxon-induced histological changes in rat cerebellum. Drug and chemical toxicology. 2021-08-20. PMID:34412520. |
acute toxicity of organophosphorus compounds is primarily caused by inhibition of acetylcholinesterase (ache) at cholinergic synapses. |
2021-08-20 |
2023-08-13 |
rat |
| Sakib Aman, Shrebash Paul, Fazle Rabbi Chowdhur. Management of Organophosphorus Poisoning: Standard Treatment and Beyond. Critical care clinics. vol 37. issue 3. 2021-08-18. PMID:34053713. |
organophosphorus causes an acute cholinergic syndrome by inhibiting acetylcholinesterase. |
2021-08-18 |
2023-08-13 |
Not clear |
| Thales Quintão Chagas, Ítalo Nascimento Freitas, Mateus Flores Montalvão, Rafael Henrique Nobrega, Monica Rodrigues Ferreira Machado, Ives Charlie-Silva, Amanda Pereira da Costa Araújo, Abraão Tiago Batista Guimarães, Tenilce Gabriela da Silva Alvarez, Guilherme Malafai. Multiple endpoints of polylactic acid biomicroplastic toxicity in adult zebrafish (Danio rerio). Chemosphere. vol 277. 2021-08-16. PMID:34384178. |
on the other hand, it was enough to cause behavioral changes (in shoal) predictive of co-specific social interaction and anti-predatory defensive response deficit likely related to cholinergic changes inferred by increased acetylcholinesterase activity and redox imbalance. |
2021-08-16 |
2023-08-13 |
zebrafish |