| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| James B Machamer, James P Apland, Brittany M Winner, Sarah E Wolfe, Kathleen T Pagarigan, Kevin M Bounader, Shane A Kasten, Michael Adler, Patrick M McNut. Functional basis for dose-dependent antagonism of rat and rabbit neuromuscular transmission by the bis-pyridinium oxime MMB4. Archives of toxicology. vol 94. issue 11. 2021-08-06. PMID:32691075. |
organophosphorus (op) compounds inhibit central and peripheral acetylcholinesterase (ache) activity, overstimulating cholinergic receptors and causing autonomic dysfunction (e.g., bronchoconstriction, excess secretions), respiratory impairment, seizure and death at high doses. |
2021-08-06 |
2023-08-13 |
rat |
| Shawn Collins, Howard Roberts, Ian Hewe. Anesthesia and Perioperative Considerations for Patients With Myasthenia Gravis. AANA journal. vol 88. issue 6. 2021-08-06. PMID:33218385. |
the pathophysiology of myasthenia gravis, cholinergic and myasthenic crises, and perioperative management are discussed; this includes the pharmacology of acetylcholinesterase inhibitors vs sugammadex, extubation criteria, pain management, and risk factors for postoperative myasthenic crisis. |
2021-08-06 |
2023-08-13 |
Not clear |
| Chonny Herrera-Acevedo, Camilo Perdomo-Madrigal, Kenyi Herrera-Acevedo, Ericsson Coy-Barrera, Luciana Scotti, Marcus Tullius Scott. Machine learning models to select potential inhibitors of acetylcholinesterase activity from SistematX: a natural products database. Molecular diversity. vol 25. issue 3. 2021-08-06. PMID:34132933. |
the enzyme acetylcholinesterase (ache) cleaves the ester bonds in acetylcholine and plays an important role in the termination of acetylcholine activity at cholinergic synapses in various regions of the nervous system. |
2021-08-06 |
2023-08-13 |
Not clear |
| George Andrew Reid, Sultan Darves. Distribution of acetylcholinesterase in the hippocampal formation of the Atlantic white-sided dolphin (Lagenorhynchus acutus). The Journal of comparative neurology. vol 529. issue 5. 2021-08-02. PMID:32779183. |
there have been a number of studies detailing the distribution of acetylcholinesterase (ache) in the hippocampal formation of terrestrial mammals with the goal of gaining a greater understanding of some aspects of the cholinergic innervation to this region, as well as its parcellation. |
2021-08-02 |
2023-08-13 |
Not clear |
| Aaron J Polichnowski, Geoffrey A Williamson, Tesha E Blair, Donald B Hoove. Autonomic and cholinergic mechanisms mediating cardiovascular and temperature effects of donepezil in conscious mice. American journal of physiology. Regulatory, integrative and comparative physiology. vol 320. issue 6. 2021-07-28. PMID:33851543. |
donepezil is a centrally acting acetylcholinesterase (ache) inhibitor with therapeutic potential in inflammatory diseases; however, the underlying autonomic and cholinergic mechanisms remain unclear. |
2021-07-28 |
2023-08-13 |
mouse |
| Masato Mashimo, Yasuhiro Moriwaki, Hidemi Misawa, Koichiro Kawashima, Takeshi Fuji. Regulation of Immune Functions by Non-Neuronal Acetylcholine (ACh) via Muscarinic and Nicotinic ACh Receptors. International journal of molecular sciences. vol 22. issue 13. 2021-07-26. PMID:34202925. |
in fact, t cells, b cells, and macrophages all express components of the cholinergic system, including ach, muscarinic, and nicotinic ach receptors (machrs and nachrs), choline acetyltransferase, acetylcholinesterase, and choline transporters. |
2021-07-26 |
2023-08-13 |
Not clear |
| Jakub Jończyk, Jędrzej Kukułowicz, Kamil Łątka, Barbara Malawska, Young-Sik Jung, Kamil Musilek, Marek Bajd. Molecular Modeling Studies on the Multistep Reactivation Process of Organophosphate-Inhibited Acetylcholinesterase and Butyrylcholinesterase. Biomolecules. vol 11. issue 2. 2021-07-22. PMID:33513955. |
their toxic effects result from irreversible blockade of the enzymes acetylcholinesterase and butyrylcholinesterase, which causes overstimulation of the cholinergic system and often leads to serious injury or death. |
2021-07-22 |
2023-08-13 |
human |
| Isabel C T Proença, Luciana K Gonçalves, Felipe Schmitz, Alexandre Mello, Claudia S Funchal, Angela Wyse, Caroline Dan. Purple grape juice consumption during the gestation reduces acetylcholinesterase activity and oxidative stress levels provoked by high-fat diet in hippocampus from adult female rats descendants. Anais da Academia Brasileira de Ciencias. vol 93. issue 2. 2021-07-05. PMID:34190844. |
the enzyme acetylcholinesterase participates in the end of cholinergic transmission and it has been shown that its activity is increased in some diseases that affect the brain, including alzheimer disease. |
2021-07-05 |
2023-08-13 |
rat |
| Thawatchai Khuanjing, Siripong Palee, Siriporn C Chattipakorn, Nipon Chattipakor. The effects of acetylcholinesterase inhibitors on the heart in acute myocardial infarction and heart failure: From cells to patient reports. Acta physiologica (Oxford, England). vol 228. issue 2. 2021-06-25. PMID:31595611. |
acetylcholinesterase inhibitors inhibit acetylcholinesterase and hence increase cholinergic transmission. |
2021-06-25 |
2023-08-13 |
Not clear |
| Bashir Akhlaq Akhoon, Sushil Choudhary, Harshita Tiwari, Ajay Kumar, Manas Ranjan Barik, Laxmi Rathor, Rakesh Pandey, Amit Nargotr. Discovery of a New Donepezil-like Acetylcholinesterase Inhibitor for Targeting Alzheimer's Disease: Computational Studies with Biological Validation. Journal of chemical information and modeling. vol 60. issue 10. 2021-06-17. PMID:32955256. |
so far, donepezil is the only food and drug administration-approved dual-binding site inhibitor of acetylcholinesterase (ache) that can amplify the cholinergic activity and also decrease aβ aggregation in alzheimer patients. |
2021-06-17 |
2023-08-13 |
Not clear |
| Junrong Zhang, Rui Liu, Dechen Zhang, Zhixian Zhang, Jinming Zhu, Li Xu, Yi Gu. Neuroprotective effects of maize tetrapeptide-anchored gold nanoparticles in Alzheimer's disease. Colloids and surfaces. B, Biointerfaces. vol 200. 2021-06-17. PMID:33508658. |
after 16 days of nanopeptide administration, the central cholinergic system function of acetylcholine and cholineacetyltransferase were enhanced, and the level of acetylcholinesterase was reduced. |
2021-06-17 |
2023-08-13 |
mouse |
| Sean X Naughton, Wayne D Beck, Zhe Wei, Guangyu Wu, Peter W Baas, Alvin V Terr. The Carbamate, Physostigmine does not Impair Axonal Transport in Rat Cortical Neurons. Neuroscience insights. vol 16. 2021-06-11. PMID:34104889. |
while most op- and carbamate-based pesticides, and pyridostigmine are relatively potent acetylcholinesterase inhibitors (acheis), this toxicological mechanism is inadequate to explain their long-term health effects, especially when no signs of acute cholinergic toxicity are exhibited. |
2021-06-11 |
2023-08-13 |
rat |
| Kevin G McGarry, Kevin E Schill, Tyson P Winters, Erin E Lemmon, Carol L Sabourin, Jill A Harvilchuck, Robert A Moye. Characterization of Cholinesterases From Multiple Large Animal Species for Medical Countermeasure Development Against Chemical Warfare Nerve Agents. Toxicological sciences : an official journal of the Society of Toxicology. vol 174. issue 1. 2021-06-09. PMID:31879781. |
disruption of cholinergic function through the inhibition of acetylcholinesterase (ache) leads to the accumulation of the neurotransmitter acetylcholine. |
2021-06-09 |
2023-08-13 |
Not clear |
| Shani Vaknine, Hermona Sore. Central and peripheral anti-inflammatory effects of acetylcholinesterase inhibitors. Neuropharmacology. vol 168. 2021-05-27. PMID:32143069. |
acetylcholinesterase (ache) inhibitors modulate acetylcholine hydrolysis and hence play a key role in determining the cholinergic tone and in implementing its impact on the cholinergic blockade of inflammatory processes. |
2021-05-27 |
2023-08-13 |
mouse |
| Pamela Nithzi Bricher Choque, Rodolfo P Vieira, Luis Ulloa, Caren Grabulosa, Maria Claudia Irigoyen, Katia De Angelis, Ana Paula Ligeiro De Oliveira, Kevin J Tracey, Valentin A Pavlov, Fernanda Marciano Consolim-Colomb. The Cholinergic Drug Pyridostigmine Alleviates Inflammation During LPS-Induced Acute Respiratory Distress Syndrome. Frontiers in pharmacology. vol 12. 2021-05-23. PMID:34017249. |
we examined whether pharmacological cholinergic activation using a clinically approved (for myasthenia gravis) cholinergic drug, the acetylcholinesterase inhibitor pyridostigmine alters pulmonary and systemic inflammation in mice with lipopolysaccharide (lps)-induced ards. |
2021-05-23 |
2023-08-13 |
mouse |
| G A Toledo-Ibarra, M I Girón-Pérez, C E Covantes-Rosales, G H Ventura-Ramón, G Pérez-Sánchez, A López-Torres, K J G Diaz-Resendiz, E Becerril-Villanueva, L Pavó. Alterations in the non-neuronal cholinergic system induced by in-vitro exposure to diazoxon in spleen mononuclear cells of Nile tilapia (O. niloticus). Fish & shellfish immunology. vol 108. 2021-05-17. PMID:33285167. |
since the target molecule of diazinon is typically the acetylcholinesterase enzyme (ache), the existence of a non-neuronal cholinergic system in leukocytes makes them susceptible to alterations by diazinon. |
2021-05-17 |
2023-08-13 |
Not clear |
| Muhammed Khairujjaman Mazumder, Anupom Borah, Shuvasish Choudhur. Inhibitory potential of plant secondary metabolites on anti-Parkinsonian drug targets: Relevance to pathophysiology, and motor and non-motor behavioural abnormalities. Medical hypotheses. vol 137. 2021-05-14. PMID:31954292. |
further, pd is associated with non-motor behavioural abnormalities as well, including cognitive impairment and mood disorders, which are caused due to cholinergic neurodegeneration, and thus inhibition of acetylcholinesterase (ache) is suggested. |
2021-05-14 |
2023-08-13 |
Not clear |
| Chang Liu, Chunyu Huang, Ruixue Ma, Wanying Zhai, Jingjing Deng, Tianshu Zho. Cu The Analyst. vol 145. issue 24. 2021-05-14. PMID:33410430. |
cu this work demonstrates a new strategy for sensing cerebrospinal acetylcholinesterase (ache) as a cholinergic biomarker for brain dysfunction based on graphene quantum dot (gqd)-functionalized lanthanide infinite coordination polymer (ln-icp) nanoparticles. |
2021-05-14 |
2023-08-13 |
rat |
| Richard L Rotund. The NMJ as a model synapse: New perspectives on formation, synaptic transmission and maintenance: Acetylcholinesterase at the neuromuscular junction. Neuroscience letters. vol 735. 2021-05-13. PMID:32540360. |
acetylcholinesterase (ache) is an essential enzymatic component of the neuromuscular junction where it is responsible for terminating neurotransmission by the cholinergic motor neurons. |
2021-05-13 |
2023-08-13 |
Not clear |
| E Wigenstam, E Forsberg, A Bucht, L Thor. Efficacy of atropine and scopolamine on airway contractions following exposure to the nerve agent VX. Toxicology and applied pharmacology. vol 419. 2021-05-11. PMID:33785355. |
nerve agents are highly toxic organophosphorus compounds that inhibit acetylcholinesterase resulting in rapid accumulation of the neurotransmitter acetylcholine (ach) causing a cholinergic syndrome including respiratory failure. |
2021-05-11 |
2023-08-13 |
rat |