| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Edna Blotnick-Rubin, Lili Angliste. Fine Localization of Acetylcholinesterase in the Synaptic Cleft of the Vertebrate Neuromuscular Junction. Frontiers in molecular neuroscience. vol 11. 2020-09-30. PMID:29725289. |
acetylcholinesterase (ache) is concentrated at cholinergic synapses, where it is a major factor in controlling the duration of transmitter action. |
2020-09-30 |
2023-08-13 |
mouse |
| Xiao-Qiao Zhang, Li Li, Jiang-Tao Huo, Min Cheng, Lin-Hong L. Effects of repetitive transcranial magnetic stimulation on cognitive function and cholinergic activity in the rat hippocampus after vascular dementia. Neural regeneration research. vol 13. issue 8. 2020-09-30. PMID:30106050. |
rtms treatment for 30 days significantly improved learning and memory function, increased acetylcholinesterase and choline acetyltransferase activity, increased the density of cholinergic neurons, and increased the number of bdnf-immunoreactive cells. |
2020-09-30 |
2023-08-13 |
rat |
| Woo Bin Yoon, Hyeon Jun Choi, Ji Eun Kim, Ji Won Park, Mi Ju Kang, Su Ji Bae, Young Ju Lee, You Sang Choi, Kil Soo Kim, Young-Suk Jung, Joon-Yong Cho, Dae Youn Hwang, Hyun Keun Son. Comparison of scopolamine-induced cognitive impairment responses in three different ICR stocks. Laboratory animal research. vol 34. issue 4. 2020-09-30. PMID:30671121. |
to determine cholinergic dysfunction induction by spl exposure, activity of acetylcholinesterase (ache) assessed in the three icr stocks revealed no difference of acetylcholinesterase activity. |
2020-09-30 |
2023-08-13 |
mouse |
| Sedigheh Bakhtiari, Nahid Beladi Moghadam, Marjan Ehsani, Hamed Mortazavi, Siamak Sabour, Mahin Bakhsh. Can Salivary Acetylcholinesterase be a Diagnostic Biomarker for Alzheimer? Journal of clinical and diagnostic research : JCDR. vol 11. issue 1. 2020-09-29. PMID:28274046. |
due to the specific biosynthesis of acetylcholinesterase (ache) of cholinergic neurons, the enzyme has been proposed as a potential biochemical marker of cholinergic activity. |
2020-09-29 |
2023-08-13 |
Not clear |
| Mark E Gurne. Genetic Association of Phosphodiesterases With Human Cognitive Performance. Frontiers in molecular neuroscience. vol 12. 2020-09-29. PMID:30800055. |
notably absent was genetic association in healthy subjects to targets of cns drug discovery designed to improve cognition in disease states by the modulation of cholinergic [acetylcholinesterase (ache), choline acetyltransferase (chat), nicotinic alpha 7 acetylcholine receptor (chrna7)], serotonergic (htr6), histaminergic (hrh3), or glutamatergic (grm5) pathways. |
2020-09-29 |
2023-08-13 |
human |
| Jabril Eldufani, Gilbert Blais. The role of acetylcholinesterase inhibitors such as neostigmine and rivastigmine on chronic pain and cognitive function in aging: A review of recent clinical applications. Alzheimer's & dementia (New York, N. Y.). vol 5. 2020-09-29. PMID:31194017. |
acetylcholinesterase inhibitors (ache-is) have been proven as an efficient therapeutic resource for significant improvement in dementia of alzheimer's disease and chronic pain due to the fact that cholinergic deficit is considered as an early finding in cognitive impairment and persisting pain. |
2020-09-29 |
2023-08-13 |
Not clear |
| Valentina Gatta, Guadalupe Mengod, Marcella Reale, Ada Maria Tat. Possible Correlation between Cholinergic System Alterations and Neuro/Inflammation in Multiple Sclerosis. Biomedicines. vol 8. issue 6. 2020-09-28. PMID:32521719. |
the correlation between the increased activity of the cholinergic hydrolyzing enzymes acetylcholinesterase and butyrylcholinesterase, the reduced levels of acetylcholine and the increase of pro-inflammatory cytokines production were recently described in immune cells of ms patients. |
2020-09-28 |
2023-08-13 |
mouse |
| Chanjuan Zhang, Likun Hu, Dong Liu, Jian Huang, Wenhan Li. Circumdatin D Exerts Neuroprotective Effects by Attenuating LPS-Induced Pro-Inflammatory Responses and Downregulating Acetylcholinesterase Activity Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32523534. |
circumdatin d exerts neuroprotective effects by attenuating lps-induced pro-inflammatory responses and downregulating acetylcholinesterase activity alzheimer's disease (ad) is a prevalent neurodegenerative disorder with multifactorial causes, of which systemic inflammation may play a key role to promote neurodegeneration, and acetylcholinesterase (ache) is a target protein to induce cholinergic transmission. |
2020-09-28 |
2023-08-13 |
Not clear |
| Joana Ferreira, Sara Santos, Helena Pereir. Evidence-based complementary and alternative medicine : eCAM. vol 2020. 2020-09-28. PMID:32765630. |
acetylcholinesterase (ache) inhibitors are used to treat alzheimer's patients because they enhance cholinergic neurotransmission. |
2020-09-28 |
2023-08-13 |
Not clear |
| Jee Hyun Yi, Daniel J Whitcomb, Se Jin Park, Celia Martinez-Perez, Saviana A Barbati, Scott J Mitchell, Kwangwook Ch. M1 muscarinic acetylcholine receptor dysfunction in moderate Alzheimer's disease pathology. Brain communications. vol 2. issue 2. 2020-09-28. PMID:32766549. |
acetylcholinesterase inhibitors are one of the few treatment options for alzheimer's disease, where levels of available acetylcholine are enhanced to counteract the cholinergic loss. |
2020-09-28 |
2023-08-13 |
Not clear |
| I V Litvinenko, S A Zhivolupov, I N Samartsev, A Yu Kravchuk, M N Vorobyova, E V Yakovlev, Yu S Butakov. [Cholinergic profile as a target of rational therapy of central nervous system diseases and injuries]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 120. issue 2. 2020-09-17. PMID:32307408. |
a comparative analysis of the clinical efficacy of cholinergic drugs and acetylcholinesterase inhibitors (ihe), as well as their combination, in the treatment of cerebrovascular disease and consequences of intracranial injury according to clinical, instrumental and laboratory dynamic observations. |
2020-09-17 |
2023-08-13 |
Not clear |
| Kyle A Brown, Nikolay M Filipov, John J Wagne. Dorsoventral-Specific Effects of Nerve Agent Surrogate Diisopropylfluorophosphate on Synaptic Transmission in the Mouse Hippocampus. The Journal of pharmacology and experimental therapeutics. vol 373. issue 1. 2020-09-08. PMID:31907304. |
although there has been an increasing appreciation for functional differences between the dorsal (dh) and ventral (vh) hippocampal sectors, there is a lack of information characterizing the cholinergic and noncholinergic mechanisms of acetylcholinesterase inhibitors on synaptic transmission along the hippocampal dorsoventral axis. |
2020-09-08 |
2023-08-13 |
mouse |
| Hatice Esra Aslan, Yeliz Demir, Muhammet Serhat Özaslan, Fikret Türkan, Şükrü Beydemir, Ömer Irfan Küfrevioğl. The behavior of some chalcones on acetylcholinesterase and carbonic anhydrase activity. Drug and chemical toxicology. vol 42. issue 6. 2020-07-21. PMID:29860891. |
acetylcholinesterase (ache) is a serine hydrolase and mostly abundant at neuromuscular junctions and cholinergic brain synapses. |
2020-07-21 |
2023-08-13 |
human |
| Md Tanvir Kabir, Md Sahab Uddin, Mst Marium Begum, Shanmugam Thangapandiyan, Md Sohanur Rahman, Lotfi Aleya, Bijo Mathew, Muniruddin Ahmed, George E Barreto, Ghulam Md Ashra. Cholinesterase Inhibitors for Alzheimer's Disease: Multitargeting Strategy Based on Anti-Alzheimer's Drugs Repositioning. Current pharmaceutical design. vol 25. issue 33. 2020-06-12. PMID:31593530. |
acetylcholinesterase (ache) remains a highly viable target for the symptomatic improvement in ad because cholinergic deficit is a consistent and early finding in ad. |
2020-06-12 |
2023-08-13 |
Not clear |
| Prayasee Baruah, Grace Basumatary, Semen O Yesylevskyy, Kripamoy Aguan, Ghanashyam Bez, Sivaprasad Mitr. Novel coumarin derivatives as potent acetylcholinesterase inhibitors: insight into efficacy, mode and site of inhibition. Journal of biomolecular structure & dynamics. vol 37. issue 7. 2020-06-02. PMID:29663860. |
the inhibitory efficacy of two substituted coumarin derivatives on the activity of neurodegenerative enzyme acetylcholinesterase (ache) was assessed in aqueous buffer as well as in the presence of human serum albumin (hsa) and compared against standard cholinergic ad drug, donepezil (don). |
2020-06-02 |
2023-08-13 |
human |
| Xin Wang, Ping Li, Qi Ding, Chuanchen Wu, Wen Zhang, Bo Tan. Observation of Acetylcholinesterase in Stress-Induced Depression Phenotypes by Two-Photon Fluorescence Imaging in the Mouse Brain. Journal of the American Chemical Society. vol 141. issue 5. 2020-05-27. PMID:30638380. |
acetylcholinesterase (ache), a key hydrolase in the cholinergic system, directly determines the degradation of neurotransmitters. |
2020-05-27 |
2023-08-13 |
mouse |
| Marinela Couselo-Seijas, Jose N López-Canoa, Rosa M Agra-Bermejo, Esther Díaz-Rodriguez, Angel L Fernandez, Jose M Martinez-Cereijo, Dario Durán-Muñoz, Susana B Bravo, Alba Velo, Laila González-Melchor, Xesus A Fernández-López, Jose L Martínez-Sande, Javier García-Seara, Jose R González-Juanatey, Moises Rodriguez-Mañero, Sonia Eira. Cholinergic activity regulates the secretome of epicardial adipose tissue: Association with atrial fibrillation. Journal of cellular physiology. vol 234. issue 7. 2020-05-04. PMID:30480808. |
cholinergic fibers in eat were detected by vesicular ach transporter levels and/or acetylcholinesterase activity. |
2020-05-04 |
2023-08-13 |
Not clear |
| Aaron Kucinski, Kyra B Phillips, Ajeesh Koshy Cherian, Martin Sarte. Rescuing the attentional performance of rats with cholinergic losses by the M1 positive allosteric modulator TAK-071. Psychopharmacology. vol 237. issue 1. 2020-04-10. PMID:31620809. |
contrasting with the extensive evidence indicating an essential role of cholinergic activity in mediating cognitive, specifically attentional abilities, treatment with conventional acetylcholinesterase inhibitors (acheis) has not fulfilled the promise of efficacy of pro-cholinergic treatments. |
2020-04-10 |
2023-08-13 |
Not clear |
| Leticia B Wessler, Hemelin R Farias, Julia F Ronsani, Gabriela Candiotto, Paulo C L Dos Santos, Jade de Oliveira, Eduardo P Rico, Emilio L Strec. Acute exposure to leucine modifies behavioral parameters and cholinergic activity in zebrafish. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 78. 2020-04-03. PMID:31589917. |
in addition, we evaluated the effects of high levels of leucine in the acetylcholinesterase (ache) and choline acetyltransferase (chat) activities, components of cholinergic neurotransmission system. |
2020-04-03 |
2023-08-13 |
zebrafish |
| Lilly Toker, Israel Silman, Tzviya Zeev-Ben-Mordehai, Joel L Sussman, Lawrence M Schopfer, Oksana Lockridg. Polyproline-rich peptides associated with Torpedo californica acetylcholinesterase tetramers. Chemico-biological interactions. vol 319. 2020-03-16. PMID:32087110. |
acetylcholinesterase (ache) terminates cholinergic neurotransmission by hydrolyzing acetylcholine. |
2020-03-16 |
2023-08-13 |
Not clear |