| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stefano Costanzi, John-Hanson Machado, Moriah Mitchel. Nerve Agents: What They Are, How They Work, How to Counter Them. ACS chemical neuroscience. vol 9. issue 5. 2019-05-21. PMID:29664277. |
nerve agents are organophosphorus chemical warfare agents that exert their action through the irreversible inhibition of acetylcholinesterase, with a consequent overstimulation of cholinergic transmission followed by its shutdown. |
2019-05-21 |
2023-08-13 |
Not clear |
| Maria Rosa Chitolina Schetinger, Tanara V Peres, Letícia P Arantes, Fabiano Carvalho, Valderi Dressler, Graciela Heidrich, Aaron B Bowman, Michael Aschne. Combined exposure to methylmercury and manganese during L1 larval stage causes motor dysfunction, cholinergic and monoaminergic up-regulation and oxidative stress in L4 Caenorhabditis elegans. Toxicology. vol 411. 2019-05-15. PMID:30336192. |
this work aimed to study changes in cholinergic system focusing on acetylcholinesterase (ace-2), monoaminergic system focusing on vesicular monoamine transporter (vmat, cat-1) expression, to address changes in antioxidant enzymatic systems, namely, the expression of superoxide dismutase (sod-3 and sod-4) and catalase (ctl-3), as well as worm reproduction and locomotion. |
2019-05-15 |
2023-08-13 |
caenorhabditis_elegans |
| Abdul Mannan Baig, Zohaib Rana, Sumayya Tariq, Salima Lalani, H R Ahma. Traced on the Timeline: Discovery of Acetylcholine and the Components of the Human Cholinergic System in a Primitive Unicellular Eukaryote Acanthamoeba spp. ACS chemical neuroscience. vol 9. issue 3. 2019-05-07. PMID:29058403. |
we show the evidence for the presence of homology of evolutionary conserved key enzymes of the cholinergic system like choline acetyltransferase (chat) and acetylcholinesterase (ache) in a. castellanii spp., which were found to be near identical to their human counterparts. |
2019-05-07 |
2023-08-13 |
human |
| Bruno Nune. Acute ecotoxicological effects of salicylic acid on the Polychaeta species Hediste diversicolor: evidences of low to moderate pro-oxidative effects. Environmental science and pollution research international. vol 26. issue 8. 2019-05-06. PMID:30684172. |
in order to determine the potential ecotoxicological effects caused by sa, individuals of the marine polychaeta species hediste diversicolor were exposed for 96 h to ecologically relevant concentrations of this compound, and several biochemical endpoints were evaluated, namely the activity of the antioxidant enzymes glutathione peroxidase (gpx) and catalase (cat), the phase ii biotransformation isoenzymes glutathione s-transferases (gsts), the cholinergic enzyme acetylcholinesterase (ache), and the determination of lipoperoxidative damage (thiobarbituric acid-reactive substances (tbars) assay). |
2019-05-06 |
2023-08-13 |
human |
| Seham Mustaf. Effect of pregnancy on the cholinergic responses of the bladder: role of acetylcholinesterase. International urology and nephrology. vol 51. issue 1. 2019-04-29. PMID:30478812. |
effect of pregnancy on the cholinergic responses of the bladder: role of acetylcholinesterase. |
2019-04-29 |
2023-08-13 |
Not clear |
| Seham Mustaf. Effect of pregnancy on the cholinergic responses of the bladder: role of acetylcholinesterase. International urology and nephrology. vol 51. issue 1. 2019-04-29. PMID:30478812. |
the aim of the study is to investigate the cholinergic effect and the role of acetylcholinesterase in the bladder during pregnancy. |
2019-04-29 |
2023-08-13 |
Not clear |
| Niko Amend, Horst Thiermann, Franz Worek, Timo Will. The arrhythmogenic potential of nerve agents and a cardiac safety profile of antidotes - A proof-of-concept study using human induced pluripotent stem cells derived cardiomyocytes (hiPSC-CM). Toxicology letters. vol 308. 2019-04-25. PMID:30858091. |
the directly acting cholinergic compounds acetylcholine and carbachol and the irreversible acetylcholinesterase inhibitor cyclosarin - a highly toxic nerve agent - were assessed. |
2019-04-25 |
2023-08-13 |
human |
| Cassiana Siebert, Carolina Gessinger Bertó, Fernanda Silva Ferreira, Daniella de S Moreira, Tiago Marcon Dos Santos, Angela T S Wys. Vitamin D partially reverses the increase in p-NF-κB/p65 immunocontent and interleukin-6 levels, but not in acetylcholinesterase activity in hippocampus of adult female ovariectomized rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 71. 2019-03-11. PMID:30172894. |
regarding cholinergic system, ovx caused an increase in acetylcholinesterase activity without changing acetylcholinesterase and choline acetyltransferase immunocontents. |
2019-03-11 |
2023-08-13 |
rat |
| Amrita A Chowdhury, Nitin B Gawali, Renuka Munshi, Archana R Juveka. Trigonelline insulates against oxidative stress, proinflammatory cytokines and restores BDNF levels in lipopolysaccharide induced cognitive impairment in adult mice. Metabolic brain disease. vol 33. issue 3. 2019-02-05. PMID:29277879. |
cholinergic involvement during neuroinflammation was evaluated by measuring levels of acetylcholinesterase (ache) enzyme. |
2019-02-05 |
2023-08-13 |
mouse |
| Jonathan R de Almeida, Micheli Figueiro, Wanda Pereira Almeida, Carlos Henrique Tomich de Paula da Silv. Discovery of novel dual acetylcholinesterase inhibitors with antifibrillogenic activity related to Alzheimer's disease. Future medicinal chemistry. vol 10. issue 9. 2019-02-04. PMID:29676170. |
the current pharmacological approach is based on the improvement of cholinergic neurotransmission by inhibiting acetylcholinesterase (ache) with ache inhibitors. |
2019-02-04 |
2023-08-13 |
Not clear |
| S Bretin, A Krazem, N Henkous, C Froger-Colleaux, E Mocaer, C Louis, N Perdaems, A Marighetto, D Beracoche. Synergistic enhancing-memory effect of donepezil and S 47445, an AMPA positive allosteric modulator, in middle-aged and aged mice. Psychopharmacology. vol 235. issue 3. 2019-01-25. PMID:29167913. |
since donepezil, an acetylcholinesterase inhibitor, induces only moderate symptomatic effects on memory in alzheimer's disease patients, an alternative strategy for treatment of cognitive symptoms could be to act simultaneously on both glutamatergic ampa receptors and cholinergic pathways by combining pharmacological treatments. |
2019-01-25 |
2023-08-13 |
mouse |
| Caio R D Assis, Amanda G Linhares, Mariana P Cabrera, Vagne M Oliveira, Kaline C C Silva, Marina Marcuschi, Elba V M Maciel Carvalho, Ranilson S Bezerra, Luiz B Carvalh. Erythrocyte acetylcholinesterase as biomarker of pesticide exposure: new and forgotten insights. Environmental science and pollution research international. vol 25. issue 19. 2018-12-20. PMID:29797194. |
acetylcholinesterase (ache) acts on the hydrolysis of acetylcholine, rapidly removing this neurotransmitter at cholinergic synapses and neuromuscular junctions as well as in neuronal growth and differentiation, modulation of cell adhesion ("electrotactins") and aryl-acylamidase activity (aaa). |
2018-12-20 |
2023-08-13 |
Not clear |
| Snezana Agatonovic-Kustrin, Christine Kettle, David W Morto. A molecular approach in drug development for Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 106. 2018-12-18. PMID:29990843. |
cholinergic signaling, which is important in cognition, is slowly lost in ad, so the first line therapy is to treat symptoms with acetylcholinesterase inhibitors to increase levels of acetylcholine. |
2018-12-18 |
2023-08-13 |
Not clear |
| Marlyete Chagas Araújo, Caio Rodrigo Dias Assis, Kaline Catiely Campos Silva, Kelma Sirleide Souza, Rafael Souto Azevedo, Maria Helena Menezes Estevam Alves, Luciano Clemente Silva, Valdir Luna Silva, Mônica Lúcia Adam, Luiz Bezerra Carvalho Junior, Ranilson Souza Bezerra, Maria Betânia Melo Oliveir. Characterization of brain acetylcholinesterase of bentonic fish Hoplosternum littorale: Perspectives of application in pesticides and metal ions biomonitoring. Aquatic toxicology (Amsterdam, Netherlands). vol 205. 2018-12-12. PMID:30408655. |
acetylcholinesterase (ache; ec 3.1.1.7) is a serine hydrolase, whose main function is to modulate neurotransmission at cholinergic synapses. |
2018-12-12 |
2023-08-13 |
Not clear |
| Vivitri Prasasty, Muhammad Radifar, Enade Istyaston. Natural Peptides in Drug Discovery Targeting Acetylcholinesterase. Molecules (Basel, Switzerland). vol 23. issue 9. 2018-12-11. PMID:30217053. |
acetylcholinesterase-inhibitory peptide has gained much importance since it can inhibit acetylcholinesterase (ache) and increase the availability of acetylcholine in cholinergic synapses, enhancing cholinergic transmission in pharmacological treatment of alzheimer's disease (ad). |
2018-12-11 |
2023-08-13 |
Not clear |
| M D Baldissera, C F Souza, P H Doleski, K L S Moreira, M L da Veiga, M I U M da Rocha, R C V Santos, B Baldisserott. Involvement of cholinergic and adenosinergic systems on the branchial immune response of experimentally infected silver catfish with Streptococcus agalactiae. Journal of fish diseases. vol 41. issue 1. 2018-11-08. PMID:28699699. |
it has been recognized that the cholinergic and adenosinergic systems have an essential role in immune and inflammatory responses during bacterial fish pathogens, such as the enzymes acetylcholinesterase (ache) and adenosine deaminase (ada), which are responsible for catalysis of the anti-inflammatory molecules acetylcholine (ach) and adenosine (ado) respectively. |
2018-11-08 |
2023-08-13 |
Not clear |
| I V Kolykhalo. [Current approaches to optimize treatment of dementia and Alzheimer's disease]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 116. issue 6. 2018-11-05. PMID:28635795. |
to overcome the cholinergic insufficiency, acetylcholinesterase inhibitors (rivastigmine, donepezil and galantamine) are primarily used. |
2018-11-05 |
2023-08-13 |
Not clear |
| Felipe Rocha, Letícia Yumi Sugahara, Fernanda Vitória Leimann, Sara Marchesan de Oliveira, Evelyne da Silva Brum, Ricardo Costa Calhelha, Maria Filomena Barreiro, Isabel C F R Ferreira, Rafael Porto Ineu, Odinei Hess Gonçalve. Nanodispersions of beta-carotene: effects on antioxidant enzymes and cytotoxic properties. Food & function. vol 9. issue 7. 2018-10-29. PMID:29974106. |
the formed nanometric beta-carotene particles resulted in stable colloids, readily dispersed in water, able to modulate acetylcholinesterase (ache) activity, and presenting high potential to control the cholinergic system. |
2018-10-29 |
2023-08-13 |
drosophila_melanogaster |
| Mingjun Zhang, Haihong Li, Liyun Chen, Shuhua Fang, Sitian Xie, Changmin Li. Three-dimensional reconstructed eccrine sweat glands with vascularization and cholinergic and adrenergic innervation. Journal of molecular histology. vol 49. issue 4. 2018-10-22. PMID:29667149. |
the results showed that the fluorescent signals of general neuronal marker protein gene product 9.5, adrenergic nerve fiber marker tyrosine hydroxylase, and cholinergic nerve fiber markers acetylcholinesterase and vasoactive intestinal peptide embraced the 3d reconstructed glands in circular patterns, as the signals appeared in native eccrine sweat glands. |
2018-10-22 |
2023-08-13 |
human |
| Yongfeng Zhang, Jiaqi Wang, Chunyue Wang, Zhiping Li, Xin Liu, Jun Zhang, Jiahui Lu, Di Wan. Pharmacological Basis for the Use of Evodiamine in Alzheimer's Disease: Antioxidation and Antiapoptosis. International journal of molecular sciences. vol 19. issue 5. 2018-10-15. PMID:29883380. |
in the central cholinergic system of ad mice, evo significantly increased the serum levels of acetylcholine and choline acetyltransferase and decreased the level of acetylcholinesterase in the serum, hypothalamus, and brain. |
2018-10-15 |
2023-08-13 |
mouse |