| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sabrina G Müller, Ana Paula Pesarico, Suzan G Rosa, Franciele Martini, Cristina W Nogueir. Contribution of cholinergic system and Nrf2/HO-1 signaling to the anti-amnesic action of 7-fluoro-1,3-diphenylisoquinoline-1-amine in mice. Chemico-biological interactions. vol 317. 2020-03-04. PMID:32001261. |
scopolamine induced amnesia and cholinergic dysfunction by increasing the acetylcholinesterase (ache) activity and content, decreasing the muscarinic m1 receptor levels in the prefrontal cortex and hippocampus of mice. |
2020-03-04 |
2023-08-13 |
mouse |
| Huan Wang, Haiyan Zhan. Reconsideration of Anticholinesterase Therapeutic Strategies against Alzheimer's Disease. ACS chemical neuroscience. vol 10. issue 2. 2020-02-26. PMID:30521323. |
recently, an impressive amount of knowledge regarding novel acetylcholinesterase functions, as well as the close association between the central cholinergic system and other key elements for ad pathogenesis, has accumulated, highlighting that this field still has great potential for future drug development. |
2020-02-26 |
2023-08-13 |
Not clear |
| Mira Syahfriena Amir Rawa, Zurina Hassan, Vikneswaran Murugaiyah, Toshihiko Nogawa, Habibah A Waha. Anti-cholinesterase potential of diverse botanical families from Malaysia: Evaluation of crude extracts and fractions from liquid-liquid extraction and acid-base fractionation. Journal of ethnopharmacology. vol 245. 2020-02-18. PMID:31419500. |
enhancement of cholinergic functions in the brain via acetylcholinesterase inhibition is one of the main therapeutic strategies to improve symptoms associated with alzheimer's or related cognitive deficits. |
2020-02-18 |
2023-08-13 |
Not clear |
| Nicolaas I Bohnen, Prabesh Kanel, Zhi Zhou, Robert A Koeppe, Kirk A Frey, William T Dauer, Roger L Albin, Martijn L T M Mülle. Cholinergic system changes of falls and freezing of gait in Parkinson's disease. Annals of neurology. vol 85. issue 4. 2020-02-13. PMID:30720884. |
past acetylcholinesterase positron emission tomography (pet) imaging studies implicate cholinergic changes as significant contributors to pigd features. |
2020-02-13 |
2023-08-13 |
Not clear |
| Jonas Jarczyk, Benito A Yard, Simone Hoege. The Cholinergic Anti-Inflammatory Pathway as a Conceptual Framework to Treat Inflammation-Mediated Renal Injury. Kidney & blood pressure research. vol 44. issue 4. 2020-01-29. PMID:31307039. |
importantly, immune cells in the spleen express most cholinergic system components such as acetylcholine (ach), choline acetyltransferase, acetylcholinesterase, and both muscarinic and nicotinic ach receptors, making communication between both systems possible. |
2020-01-29 |
2023-08-13 |
Not clear |
| Kamin Kim, Nicolaas I Bohnen, Martijn L T M Müller, Cindy Lusti. Compensatory dopaminergic-cholinergic interactions in conflict processing: Evidence from patients with Parkinson's disease. NeuroImage. vol 190. 2020-01-27. PMID:29337277. |
135 patients with parkinson's disease (pd) completed vesicular monoamine transporter type2 (vmat2) and acetylcholinesterase pet scanning to assess the integrity of nigrostriatal dopaminergic, thalamic cholinergic, and cortical cholinergic pathways, and a behavioral test (stroop + task-switching) that puts high demands on conflict processing, an important aspect of executive control. |
2020-01-27 |
2023-08-13 |
Not clear |
| Charlotte Whitmore, Christopher D Lindsay, Mike Bird, Samuel J Gore, Helen Rice, Rebecca L Williams, Christopher M Timperley, A Christopher Gree. Assessment of false transmitters as treatments for nerve agent poisoning. Toxicology letters. vol 321. 2020-01-27. PMID:31830555. |
nerve agents inhibit acetylcholinesterase (ache), leading to a build-up of acetylcholine (ach) and overstimulation at cholinergic synapses. |
2020-01-27 |
2023-08-13 |
human |
| Devashree N Patil, Sushama A Patil, Srinivas Sistla, Jyoti P Jadha. Comparative biophysical characterization: A screening tool for acetylcholinesterase inhibitors. PloS one. vol 14. issue 5. 2020-01-14. PMID:31150404. |
the oldest cholinergic hypothesis is used to elevate the level of cognitive impairment and acetylcholinesterase (ache) comprises the major targeted enzyme in ad. |
2020-01-14 |
2023-08-13 |
Not clear |
| F S Kilic, B Kaygisiz, S Aydin, E Yildirim, S Oner, K Ero. The effects and mechanisms of the action of galangin on spatial memory in rats. Bratislavske lekarske listy. vol 120. issue 12. 2019-12-30. PMID:31855045. |
galangin, a flavonoid compound with acetylcholinesterase inhibitory activity, may improve cognitive functions by enhancing cholinergic transmission. |
2019-12-30 |
2023-08-13 |
rat |
| Yaghoub Pourshojaei, Khalil Eskandari, Ali Asadipou. Highly Significant Scaffolds to Design and Synthesis Cholinesterase Inhibitors as Anti-Alzheimer Agents. Mini reviews in medicinal chemistry. vol 19. issue 19. 2019-12-26. PMID:31538893. |
based on the cholinergic hypothesis, and xray crystallographic determination of the structure of acetylcholinesterase (ache) enzyme, the level of acetylcholine (ach, an important neurotransmitter associated with memory) in the hippocampus and cortex area of the brain has a direct effect on alzheimer. |
2019-12-26 |
2023-08-13 |
Not clear |
| Takayoshi Masuoka, Junsuke Uwada, Makiko Kudo, Hatsumi Yoshiki, Yuka Yamashita, Takanobu Taniguchi, Matomo Nishio, Takaharu Ishibashi, Ikunobu Muramats. Augmentation of Endogenous Acetylcholine Uptake and Cholinergic Facilitation of Hippocampal Long-Term Potentiation by Acetylcholinesterase Inhibition. Neuroscience. vol 404. 2019-12-24. PMID:30708046. |
augmentation of endogenous acetylcholine uptake and cholinergic facilitation of hippocampal long-term potentiation by acetylcholinesterase inhibition. |
2019-12-24 |
2023-08-13 |
Not clear |
| Sun-Ho Han, Jong-Chan Park, Min Soo Byun, Dahyun Yi, Jun Ho Lee, Dong Young Lee, Inhee Mook-Jun. Blood acetylcholinesterase level is a potential biomarker for the early detection of cerebral amyloid deposition in cognitively normal individuals. Neurobiology of aging. vol 73. 2019-12-19. PMID:30316049. |
acetylcholinesterase (ache) is one of the major cholinergic enzymes, and there is no report to show the relationship between caβ accumulation and peripheral ache alteration in early stage of ad pathogenesis. |
2019-12-19 |
2023-08-13 |
Not clear |
| Elena Daskalova, Slavi Delchev, Mariyan Topolov, Stela Dimitrova, Yordanka Uzunova, Stefka Valcheva-Kuzmanova, Maria Kratchanova, Lyudmila Vladimirova-Kitova, Petko Dene. Aronia melanocarpa (Michx.) Elliot fruit juice reveals neuroprotective effect and improves cognitive and locomotor functions of aged rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 132. 2019-12-13. PMID:31306687. |
amj supplementation increased acetylcholinesterase activity in hippocampus, which is a marker of improved functional activity of the cholinergic neurons. |
2019-12-13 |
2023-08-13 |
rat |
| Keisuke Obara, Ayano Fujii, Chiaki Arie, Natsuki Harada, Fumiko Yamaki, Kazuhiro Matsuo, Takashi Yoshio, Yoshio Tanak. Inhibition of Recombinant Human Acetylcholinesterase Activity by Antipsychotics. Pharmacology. vol 104. issue 1-2. 2019-12-09. PMID:31067549. |
eps could be also caused by direct augmentation of cholinergic effects, for example, by acetylcholinesterase (ache) inhibition. |
2019-12-09 |
2023-08-13 |
human |
| D.L. Kirkby, D.N.C. Jones, J.C. Barnes, G.A. Higgin. Effects of anticholinesterase drugs tacrine and E2020, the 5-HT(3) antagonist ondansetron, and the H(3) antagonist thioperamide, in models of cognition and cholinergic function. Behavioural pharmacology. vol 7. issue 6. 2019-11-20. PMID:11224448. |
this study presents a comparison between two inhibitors of acetylcholinesterase, tacrine and e2020 (donepezil), the 5-ht(3) receptor antagonist ondansetron, and the h(3) receptor antagonist thioperamide, in models of cholinergic function and cognition in male, lister hooded rats. |
2019-11-20 |
2023-08-12 |
rat |
| A O. Zupanci. Kinetic response of a membrane-bound acetylcholinesterase to cholinergic activating and blocking agents. FEBS letters. vol 11. issue 4. 2019-11-20. PMID:11945505. |
kinetic response of a membrane-bound acetylcholinesterase to cholinergic activating and blocking agents. |
2019-11-20 |
2023-08-12 |
Not clear |
| Adriana C Werner, Miriéle C Ferraz, Edson H Yoshida, Natalia Tribuiani, Jean A A Gautuz, Monique N Santana, Bruna A Dezzotti, Vanessa G de Miranda, Améris L Foramiglio, Sandro Rostelato-Ferreira, Renata V da Silva Tavares, Stephen Hyslop, Yoko Oshima-Franc. The Facilitatory Effect of Casearia sylvestris Sw. (guaçatonga) Fractions on the Contractile Activity of Mammalian and Avian Neuromuscular Apparatus. Current pharmaceutical biotechnology. 2019-11-20. PMID:25738388. |
the methanolic fraction was chosen for further assays to assess the involvement of: 1) presynaptic sites (axons or nerve terminals), 2) postsynaptic sites (cholinergic receptors, sarcolemma or t-tubules), and 3) the synaptic cleft (acetylcholinesterase enzyme). |
2019-11-20 |
2023-08-13 |
mouse |
| Nursing older people. vol 18. issue 3. 2019-11-20. PMID:27732270. |
the acetylcholinesterase inhibitors (such as aricept) that can be prescribed for early stage dementia work by stimulating the cholinergic system. |
2019-11-20 |
2023-08-13 |
Not clear |
| Omar M E Abdel-Salam, Eman R Youness, Yasser A Khadrawy, Amany A Slee. Acetylcholinesterase, butyrylcholinesterase and paraoxonase 1 activities in rats treated with cannabis, tramadol or both. Asian Pacific journal of tropical medicine. vol 9. issue 11. 2019-11-20. PMID:27890370. |
to investigate the effect of cannabis sativa resin and/or tramadol, two commonly drugs of abuse on acetylcholinesterase and butyrylcholinesterase activities as a possible cholinergic biomarkers of neurotoxicity induced by these agents. |
2019-11-20 |
2023-08-13 |
rat |
| Takeshi Fujii, Masato Mashimo, Yasuhiro Moriwaki, Hidemi Misawa, Shiro Ono, Kazuhide Horiguchi, Koichiro Kawashim. Expression and Function of the Cholinergic System in Immune Cells. Frontiers in immunology. vol 8. 2019-11-20. PMID:28932225. |
t and b cells express most cholinergic system components-e.g., acetylcholine (ach), choline acetyltransferase (chat), acetylcholinesterase, and both muscarinic and nicotinic ach receptors (machrs and nachrs, respectively). |
2019-11-20 |
2023-08-13 |
Not clear |