| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Haroon Khan, Marya, Surriya Amin, Mohammad Amjad Kamal, Seema Pate. Flavonoids as acetylcholinesterase inhibitors: Current therapeutic standing and future prospects. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 101. 2018-10-02. PMID:29635895. |
acetylcholinesterase (ache), a serine hydrolase, is primarily responsible for the termination of signal transmission in the cholinergic system, owing to its outstanding hydrolyzing potential. |
2018-10-02 |
2023-08-13 |
Not clear |
| Jeong Su Ha, Jong Min Kim, Seon Kyeong Park, Jin Yong Kang, Du Sang Lee, Uk Lee, Dae-Ok Kim, Sung-Gil Choi, Ho Jin He. Anti-amyloidogenic properties of an ethyl acetate fraction from Actinidia arguta in Aβ Food & function. vol 9. issue 6. 2018-10-01. PMID:29786737. |
furthermore, efaa showed the ameliorating effect of cholinergic functions by increasing acetylcholine (ach) levels and decreasing acetylcholinesterase (ache) activity, and protected antioxidant systems by increasing superoxide dismutase (sod) and decreasing the oxidized glutathione (gsh)/total gsh and malondialdehyde (mda) in the brain. |
2018-10-01 |
2023-08-13 |
mouse |
| Berthold Drexler, Thomas Seeger, Franz Worek, Horst Thiermann, Bernd Antkowiak, Christian Grasshof. Midazolam is effective to reduce cortical network activity in organotypic cultures during severe cholinergic overstimulation with soman. Toxicology letters. vol 297. 2018-09-24. PMID:30165091. |
extensive cholinergic overstimulation was induced by increasing acetylcholine levels and simultaneously treating the slices with soman to block acetylcholinesterase activity. |
2018-09-24 |
2023-08-13 |
Not clear |
| Robert Zdanowski, Monika Leśniak, Urszula Karczmarczyk, Marek Saracyn, Marek Bilski, Anna Kiepura, Jacek Z Kubiak, Sławomir Lewick. The Effects of Isopropyl Methylphosphono-Fluoridate (IMPF) Poisoning on Tumor Growth and Angiogenesis in BALB/C Mice. Annals of transplantation. vol 23. 2018-09-18. PMID:29422483. |
background acetylcholinesterase (ache) and cholinergic receptors have an important role in the immune system and angiogenesis. |
2018-09-18 |
2023-08-13 |
mouse |
| Flávia V Soares, Alexandre A de Castro, Ander F Pereira, Daniel H S Leal, Daiana T Mancini, Ondrej Krejcar, Teodorico C Ramalho, Elaine F F da Cunha, Kamil Kuc. Theoretical Studies Applied to the Evaluation of the DFPase Bioremediation Potential against Chemical Warfare Agents Intoxication. International journal of molecular sciences. vol 19. issue 4. 2018-09-17. PMID:29690585. |
they are called neurotoxic agents because of their action on the nervous system, inhibiting the acetylcholinesterase (ache) enzyme and resulting in a cholinergic crisis. |
2018-09-17 |
2023-08-13 |
Not clear |
| Samuel Legeay, Nicolas Clere, Véronique Apaire-Marchais, Sébastien Faure, Bruno Lapie. Unusual modes of action of the repellent DEET in insects highlight some human side effects. European journal of pharmacology. vol 825. 2018-09-06. PMID:29477656. |
according to emerging literature reports, deet side effects in humans involve new molecular targets including the cholinergic system, acetylcholinesterase (ache), muscarinic m1 and m3 receptor and the participation of the second messenger nitric oxide (no). |
2018-09-06 |
2023-08-13 |
human |
| A Kroth, V Mackedanz, C Matté, A T S Wyse, M F M Ribeiro, W A Partat. Effect of Sciatic Nerve Transection on acetylcholinesterase activity in spinal cord and skeletal muscles of the bullfrog Lithobates catesbeianus. Brazilian journal of biology = Revista brasleira de biologia. vol 78. issue 2. 2018-09-05. PMID:28977043. |
in some vertebrate tissues, this condition decreases acetylcholinesterase (ache) activity, the enzyme responsible for fast hydrolysis of released acetylcholine in cholinergic synapses. |
2018-09-05 |
2023-08-13 |
rat |
| Oluwafemi Adeleke Ojo, Adebola Busola Ojo, Basiru Olaitan Ajiboye, Babatunji Emmanuel Oyinloye, Ayodele Jacob Akinyemi, Mary Abiola Okesola, Aline Augusti Boligon, Marli Matiko Anraku de Campo. Chromatographic fingerprint analysis, antioxidant properties, and inhibition of cholinergic enzymes (acetylcholinesterase and butyrylcholinesterase) of phenolic extracts from Irvingia gabonensis (Aubry-Lecomte ex O'Rorke) Baill bark. Journal of basic and clinical physiology and pharmacology. vol 29. issue 2. 2018-08-29. PMID:29381472. |
chromatographic fingerprint analysis, antioxidant properties, and inhibition of cholinergic enzymes (acetylcholinesterase and butyrylcholinesterase) of phenolic extracts from irvingia gabonensis (aubry-lecomte ex o'rorke) baill bark. |
2018-08-29 |
2023-08-13 |
Not clear |
| Oluwafemi Adeleke Ojo, Adebola Busola Ojo, Basiru Olaitan Ajiboye, Babatunji Emmanuel Oyinloye, Ayodele Jacob Akinyemi, Mary Abiola Okesola, Aline Augusti Boligon, Marli Matiko Anraku de Campo. Chromatographic fingerprint analysis, antioxidant properties, and inhibition of cholinergic enzymes (acetylcholinesterase and butyrylcholinesterase) of phenolic extracts from Irvingia gabonensis (Aubry-Lecomte ex O'Rorke) Baill bark. Journal of basic and clinical physiology and pharmacology. vol 29. issue 2. 2018-08-29. PMID:29381472. |
this work characterized the phenolic composition, evaluated the cholinergic enzymes (acetylcholinesterase, ache and butyrylcholinesterase, bche) inhibition, and assessed the antioxidant activity of phenolic extracts from i. gabonensis (aubry-lecomte ex o'rorke) baill bark. |
2018-08-29 |
2023-08-13 |
Not clear |
| Alessandra S Kiametis, Mônica A Silva, Luiz A S Romeiro, João B L Martins, Ricardo Gargan. Potential acetylcholinesterase inhibitors: molecular docking, molecular dynamics, and in silico prediction. Journal of molecular modeling. vol 23. issue 2. 2018-08-28. PMID:28185116. |
to modulate positively the cholinergic function through the inhibition of the acetylcholinesterase, a set of candidates was designed from a natural compound extracted from the cashew nutshell liquid, anacardic acid. |
2018-08-28 |
2023-08-13 |
Not clear |
| M R Kumar, G R Redd. Influence of age on arsenic-induced behavioral and cholinergic perturbations: Amelioration with zinc and α-tocopherol. Human & experimental toxicology. vol 37. issue 3. 2018-08-27. PMID:29233033. |
cholinergic studies in three brain regions (cerebral cortex, cerebellum, and hippocampus) of different age groups also showed significant increase in acetylcholine levels and a decrease in acetylcholinesterase activity. |
2018-08-27 |
2023-08-13 |
rat |
| Cong Lu, Jingwei Lv, Liming Dong, Ning Jiang, Yan Wang, Qiong Wang, Yinghui Li, Shanguang Chen, Bei Fan, Fengzhong Wang, Xinmin Li. Neuroprotective effects of 20(S)-protopanaxatriol (PPT) on scopolamine-induced cognitive deficits in mice. Phytotherapy research : PTR. vol 32. issue 6. 2018-08-20. PMID:29468740. |
ppt also significantly improved cholinergic system reactivity and suppressed oxidative stress, indicated by inhibition of acetylcholinesterase activity, elevation of acetylcholine levels, increasing superoxide dismutase activity and lowering levels of malondialdehyde in the hippocampus. |
2018-08-20 |
2023-08-13 |
mouse |
| Urban Košak, Boris Brus, Damijan Knez, Roman Šink, Simon Žakelj, Jurij Trontelj, Anja Pišlar, Jasna Šlenc, Martina Gobec, Marko Živin, Larisa Tratnjek, Martina Perše, Kinga Sałat, Adrian Podkowa, Barbara Filipek, Florian Nachon, Xavier Brazzolotto, Anna Więckowska, Barbara Malawska, Jure Stojan, Irena Mlinarič Raščan, Janko Kos, Nicolas Coquelle, Jacques-Philippe Colletier, Stanislav Gobe. Development of an in-vivo active reversible butyrylcholinesterase inhibitor. Scientific reports. vol 6. 2018-08-14. PMID:28000737. |
similar to acetylcholinesterase, butyrylcholinesterase (bche) contributes to the termination of cholinergic neurotransmission. |
2018-08-14 |
2023-08-13 |
mouse |
| Mullah Muhaiminul Islam, Mostofa Ataur Rohman, Arun Bahadur Gurung, Atanu Bhattacharjee, Kripamoy Aguan, Sivaprasad Mitr. Correlation of cholinergic drug induced quenching of acetylcholinesterase bound thioflavin-T fluorescence with their inhibition activity. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. vol 189. 2018-08-10. PMID:28822269. |
correlation of cholinergic drug induced quenching of acetylcholinesterase bound thioflavin-t fluorescence with their inhibition activity. |
2018-08-10 |
2023-08-13 |
Not clear |
| Shreesh Raj Sammi, Jitendra K Rawat, Neetu Raghav, Ajay Kumar, Subhadeep Roy, Manjari Singh, Swetlana Gautam, Rajnish K Yadav, Uma Devi, Rakesh Pandey, Gaurav Kaithwa. Galantamine attenuates N,N-dimethyl hydrazine induced neoplastic colon damage by inhibiting acetylcholinesterase and bimodal regulation of nicotinic cholinergic neurotransmission. European journal of pharmacology. vol 818. 2018-08-06. PMID:29074413. |
galantamine attenuates n,n-dimethyl hydrazine induced neoplastic colon damage by inhibiting acetylcholinesterase and bimodal regulation of nicotinic cholinergic neurotransmission. |
2018-08-06 |
2023-08-13 |
rat |
| Júlia Relat, Belén Pérez, Pelayo Camps, Diego Muñoz-Torrero, Albert Badia, M Victòria Clo. Huprine X Attenuates The Neurotoxicity Induced by Kainic Acid, Especially Brain Inflammation. Basic & clinical pharmacology & toxicology. vol 122. issue 1. 2018-07-30. PMID:28724203. |
huprine x (hx) is a synthetic anticholinesterasic compound that exerts a potent inhibitory action on acetylcholinesterase (ache) activity, an agonist effect on cholinergic receptors, neuroprotective activity in different neurotoxicity models in vivo and in vitro and cognition enhancing effects in non-transgenic (c57bl/6) and transgenic (3xtg-ad, appswe) mice. |
2018-07-30 |
2023-08-13 |
mouse |
| Weiping Huang, Senzhi Zhu, Xingqiang Liu, Linqiang Huang, Yongli Han, Qianpeng Han, Di Xie, Hongke Zen. [Cholinergic anti-inflammatory pathway involves in the neuroprotective effect of huperzine A on sepsis-associated encephalopathy]. Zhonghua wei zhong bing ji jiu yi xue. vol 28. issue 5. 2018-07-30. PMID:29920043. |
to explore whether the cholinergic anti-inflammatory pathway is involved in the neuroprotective effect of acetylcholinesterase inhibitor huperzine a (hupa) on sepsis-associated encephalopathy (sae) by observing the effect of hupa on the expressions of choline acetyltransferase (chat) and cholinergic muscarinic receptor m1 (chrm1) of sepsis rats. |
2018-07-30 |
2023-08-13 |
rat |
| Terrone L Rosenberry, Xavier Brazzolotto, Ian R Macdonald, Marielle Wandhammer, Marie Trovaslet-Leroy, Sultan Darvesh, Florian Nacho. Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study. Molecules (Basel, Switzerland). vol 22. issue 12. 2018-07-17. PMID:29186056. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) hydrolyze the neurotransmitter acetylcholine and, thereby, function as coregulators of cholinergic neurotransmission. |
2018-07-17 |
2023-08-13 |
human |
| Aniélen D Silva, Nathieli B Bottari, Guilherme M do Carmo, Matheus D Baldissera, Carine F Souza, Vanessa S Machado, Vera M Morsch, Maria Rosa C Schetinger, Ricardo E Mendes, Silvia G Monteiro, Aleksandro S Da Silv. Chagas disease: modulation of the inflammatory response by acetylcholinesterase in hematological cells and brain tissue. Molecular and cellular biochemistry. vol 438. issue 1-2. 2018-07-09. PMID:28766165. |
chagas disease is an acute or chronic illness that causes severe inflammatory response, and consequently, it may activate the inflammatory cholinergic pathway, which is regulated by cholinesterases, including the acetylcholinesterase. |
2018-07-09 |
2023-08-13 |
mouse |
| Aniélen D Silva, Nathieli B Bottari, Guilherme M do Carmo, Matheus D Baldissera, Carine F Souza, Vanessa S Machado, Vera M Morsch, Maria Rosa C Schetinger, Ricardo E Mendes, Silvia G Monteiro, Aleksandro S Da Silv. Chagas disease: modulation of the inflammatory response by acetylcholinesterase in hematological cells and brain tissue. Molecular and cellular biochemistry. vol 438. issue 1-2. 2018-07-09. PMID:28766165. |
thus, the aim of this study was to investigate whether trypanosoma cruzi infection can alter the activity of acetylcholinesterase and acetylcholine levels in mice, and whether these alterations are linked to the inflammatory cholinergic signaling pathway. |
2018-07-09 |
2023-08-13 |
mouse |