| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Andrey Kovalevsky, Donald K Blumenthal, Xiaolin Cheng, Palmer Taylor, Zoran Radi\\xc4\\x8. Limitations in current acetylcholinesterase structure-based design of oxime antidotes for organophosphate poisoning. Annals of the New York Academy of Sciences. vol 1378. issue 1. 2017-07-19. PMID:27371941.' |
acetylcholinesterase (ache; ec 3.1.1.7), an essential enzyme of cholinergic neurotransmission in vertebrates, is a primary target in acute nerve agent and organophosphate (op) pesticide intoxication. |
2017-07-19 |
2023-08-13 |
Not clear |
| Xu Rui, Li Wenfang, Cheng Jing, Chen Meng, Ding Chengcheng, Xu Jiqu, Rong Shuan. Neuroprotective effects of phytosterol esters against high cholesterol-induced cognitive deficits in aged rat. Food & function. vol 8. issue 3. 2017-07-07. PMID:28256666. |
furthermore, pse improved cholinergic activities by restoring the acetylcholine (ach) content and decreasing acetylcholinesterase (ache) activity in the cerebral cortex, as well as by elevating choline acetyl transferase (chat) activity in the hippocampus and the cerebral cortex. |
2017-07-07 |
2023-08-13 |
rat |
| Alireza Basiri, Michelle Xiao, Alec McCarthy, Debashis Dutta, Siddappa N Byrareddy, Martin Conda-Sherida. Design and synthesis of new piperidone grafted acetylcholinesterase inhibitors. Bioorganic & medicinal chemistry letters. vol 27. issue 2. 2017-06-27. PMID:27914796. |
a common strategy to improve the well-being of ad patients consists on the inhibition of acetylcholinesterase with the concomitant increase of the neurotransmitter acetylcholine at cholinergic synapses. |
2017-06-27 |
2023-08-13 |
Not clear |
| Ritsuko Inoue, Takeo Suzuki, Kinya Nishimura, Masami Miur. Nicotinic acetylcholine receptor-mediated GABAergic inputs to cholinergic interneurons in the striosomes and the matrix compartments of the mouse striatum. Neuropharmacology. vol 105. 2017-06-22. PMID:26808315. |
although striatal neurons are strongly innervated by intrinsic cholinergic interneurons, acetylcholinesterase is expressed more abundantly in the matrix than in the striosomes. |
2017-06-22 |
2023-08-13 |
mouse |
| Matthew Udakis, Victoria Louise Wright, Susan Wonnacott, Christopher Philip Baile. Integration of inhibitory and excitatory effects of α7 nicotinic acetylcholine receptor activation in the prelimbic cortex regulates network activity and plasticity. Neuropharmacology. vol 105. 2017-06-21. PMID:26921769. |
these actions were distinguished by their differential dependence on local acetylcholine (ach): potentiation of endogenous cholinergic signalling with the positive allosteric modulator, pnu-120596, enhanced spontaneous excitatory events, an effect that was further increased by inhibition of acetylcholinesterase. |
2017-06-21 |
2023-08-13 |
mouse |
| Maja Katalinić, Nikolina Maček Hrvat, Krešimir Baumann, Sara Morasi Piperčić, Sandro Makarić, Srđanka Tomić, Ozren Jović, Tomica Hrenar, Ante Miličević, Dubravko Jelić, Suzana Žunec, Ines Primožič, Zrinka Kovari. A comprehensive evaluation of novel oximes in creation of butyrylcholinesterase-based nerve agent bioscavengers. Toxicology and applied pharmacology. vol 310. 2017-05-31. PMID:27654152. |
a well-considered treatment of acute nerve agents poisoning involves the exogenous administration of butyrylcholinesterase (bche, ec 3.1.1.8) as a stoichiometric bioscavenger efficient in preventing cholinergic crises caused by acetylcholinesterase (ache, ec 3.1.1.7) inhibition. |
2017-05-31 |
2023-08-13 |
mouse |
| Jianqiao Zhang, Leiming Zhang, Xue Sun, Yanting Yang, Liang Kong, Chengwen Lu, Guangyao Lv, Tian Wang, Hongbo Wang, Fenghua F. Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment Ameliorate Acetaminophen-Induced Liver Injury in Mice via Central Cholinergic System Regulation. The Journal of pharmacology and experimental therapeutics. vol 359. issue 2. 2017-05-26. PMID:27535978. |
acetylcholinesterase inhibitors for alzheimer's disease treatment ameliorate acetaminophen-induced liver injury in mice via central cholinergic system regulation. |
2017-05-26 |
2023-08-13 |
mouse |
| Wenwen Lian, Jiansong Fang, Lvjie Xu, Wei Zhou, De Kang, Wandi Xiong, Hao Jia, Ai-Lin Liu, Guan-Hua D. DL0410 Ameliorates Memory and Cognitive Impairments Induced by Scopolamine via Increasing Cholinergic Neurotransmission in Mice. Molecules (Basel, Switzerland). vol 22. issue 3. 2017-05-18. PMID:28272324. |
dl0410 was discovered as a dual inhibitor of acetylcholinesterase (ache) and butyrylcholinestease (buche), with potent efficiency in in-vitro experiments, but its in vivo effect on the cholinergic model has not been evaluated, and its action mechanism has also not been illustrated. |
2017-05-18 |
2023-08-13 |
mouse |
| Santokh Gill, Yangxun Hou, Nanqin Li, Olga Pulido, Wayne Bower. Developmental neurotoxicity of polybrominated diphenyl ethers mixture de71 in Sprague-Dawley rats. Journal of toxicology and environmental health. Part A. vol 79. issue 12. 2017-05-12. PMID:27294297. |
these changes occurred in a number of the markers of the cholinergic system, including acetylcholinesterase, muscarinic and nicotinic receptors, and structural gene,s including those of neurofilaments, cell adhesion molecules including n-cadherin and camkii, and cytokines. |
2017-05-12 |
2023-08-13 |
rat |
| Ganiyu Oboh, Omodesola O Ogunruku, Sunday I Oyeleye, Tosin A Olasehinde, Ayokunle O Ademosun, Aline Augusti Boligo. Phenolic Extracts from Clerodendrum volubile Leaves Inhibit Cholinergic and Monoaminergic Enzymes Relevant to the Management of Some Neurodegenerative Diseases. Journal of dietary supplements. vol 14. issue 3. 2017-04-03. PMID:27753518. |
this study investigated the inhibitory effects of phenolic-rich extracts from clerodendrum volubile leaves on cholinergic [acetylcholinesterase (ache) and butyrylcholinesterase (bche)] and monoaminergic [monoamine oxidase (mao)] enzymes' activities and pro-oxidants [fe |
2017-04-03 |
2023-08-13 |
Not clear |
| Yael Abreu-Villaça, Monique Correa-Santos, Ana C Dutra-Tavares, Danielle Paes-Branco, Andre Nunes-Freitas, Alex C Manhães, Cláudio C Filgueiras, Anderson Ribeiro-Carvalh. A ten fold reduction of nicotine yield in tobacco smoke does not spare the central cholinergic system in adolescent mice. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 52. 2017-03-27. PMID:27287270. |
these decrements were separable from effects on choline acetyltransferase and acetylcholinesterase activities, suggesting cholinergic synaptic impairment. |
2017-03-27 |
2023-08-13 |
mouse |
| Matheus D Baldissera, Carine F Souza, Pedro Henrique Doleski, Guerino B Júnior, Agueda C de Vargas, Bernardo Baldisserott. Involvement of cholinergic and purinergic systems during the inflammatory response caused by Aeromonas hydrophila in Rhamdia quelen. Microbial pathogenesis. vol 99. 2017-03-27. PMID:27521226. |
the aim of this study was to evaluate the cholinergic (acetylcholinesterase (ache) and butyrylcholinesterase (bche)) and purinergic (adenosine deaminase (ada)) systems in head kidney, spleen, total blood and serum samples in experimentally infected fish with a. hydrophila, and the involvement of these systems during the inflammatory process. |
2017-03-27 |
2023-08-13 |
Not clear |
| Matheus D Baldissera, Carine F Souza, Thirssa H Grando, Aleksandro S da Silva, Silvia G Monteir. Involvement of oxidative stress, cholinergic and adenosinergic systems on renal damage caused by Trypanosoma evansi infection: Relationship with lipid peroxidation. Microbial pathogenesis. vol 99. 2017-03-27. PMID:27565091. |
the aim of this study was to evaluate the oxidative stress variables, and enzymes of cholinergic (acetylcholinesterase (ache) and butyrylcholinesterase (bche)) and adenosinergic (adenosine deaminase (ada)) systems in renal tissue, as well as the relationship between these systems and lipid peroxidation. |
2017-03-27 |
2023-08-13 |
cat |
| Jintanaporn Wattanathorn, Chatchada Sutalangk. Novel Food Supplement "CP1" Improves Motor Deficit, Cognitive Function, and Neurodegeneration in Animal Model of Parkinson's Disease. Rejuvenation research. vol 19. issue 4. 2017-03-21. PMID:26414358. |
based on pivotal roles of oxidative stress, dopaminergic and cholinergic systems on the pathophysiology of parkinson's disease (pd), the searching for functional food for patients attacked with pd from cyperus rotundus and zingiber officinale, the substances possessing antioxidant activity, and the suppression effects on monoamine oxidase b (mao-b) and acetylcholinesterase (ache) have been considered. |
2017-03-21 |
2023-08-13 |
rat |
| Hyolanda M Grosskopf, Rhayana K Grosskopf, Angelisa H Biazus, Marta L R Leal, Nathieli B Bottari, Mariana S Alves, Maria Rosa C Schetinger, Vera M Morsch, Gustavo Machado, Matheus D Baldissera, Aleksandro S Da Silv. Supplementation with copper edetate in control of Haemonchus contortus of sheep, and its effect on cholinesterase's and superoxide dismutase activities. Experimental parasitology. vol 173. 2017-03-13. PMID:28007539. |
cholinergic system was evaluated to determine the acetylcholinesterase (ache) activity in total blood and butyrylcholinesterase (bche) activity in serum. |
2017-03-13 |
2023-08-13 |
cat |
| Daniela Galimberti, Elio Scarpin. Old and new acetylcholinesterase inhibitors for Alzheimer's disease. Expert opinion on investigational drugs. vol 25. issue 10. 2017-03-10. PMID:27459153. |
acheis reversibly inhibit acetylcholinesterase (ache), thus increasing the availability of acetylcholine in cholinergic synapses, enhancing cholinergic transmission. |
2017-03-10 |
2023-08-13 |
Not clear |
| Shubham Misra, Kanwaljit Chopra, V R Sinha, Bikash Medh. Galantamine-loaded solid-lipid nanoparticles for enhanced brain delivery: preparation, characterization, in vitro and in vivo evaluations. Drug delivery. vol 23. issue 4. 2017-03-09. PMID:26405825. |
galantamine hydrobromide, a promising acetylcholinesterase inhibitor is reported to be associated with cholinergic side effects. |
2017-03-09 |
2023-08-13 |
rat |
| Mikihiko Arikawa, Yoshihiko Kakinuma, Tatsuya Noguchi, Hiroshi Todaka, Takayuki Sat. Donepezil, an acetylcholinesterase inhibitor, attenuates LPS-induced inflammatory response in murine macrophage cell line RAW 264.7 through inhibition of nuclear factor kappa B translocation. European journal of pharmacology. vol 789. 2017-03-06. PMID:27373848. |
these results suggest that a cholinergic anti-inflammatory pathway would not be involved in the anti-inflammatory effect of donepezil and that the specific characteristics of donepezil in suppressing the lps-induced cytokine release and the nf-κb activation would be independent of its acetylcholinesterase inhibition. |
2017-03-06 |
2023-08-13 |
mouse |
| Roman Roy, Flavia Niccolini, Gennaro Pagano, Marios Politi. Cholinergic imaging in dementia spectrum disorders. European journal of nuclear medicine and molecular imaging. vol 43. issue 7. 2017-02-24. PMID:26984612. |
spect and pet studies using selective radioligands for cholinergic markers, such as [(11)c]mp4a and [(11)c]pmp pet for acetylcholinesterase (ache), [(123)i]5ia spect for the α4β2 nicotinic acetylcholine receptor and [(123)i]ibvm spect for the vesicular acetylcholine transporter, have been developed in an attempt to clarify those aspects of the diseases that remain unclear. |
2017-02-24 |
2023-08-13 |
Not clear |
| İlhami Gülçin, Andrea Scozzafava, Claudiu T Supuran, Hulya Akıncıoğlu, Zeynep Koksal, Fikret Turkan, Saleh Alwase. The effect of caffeic acid phenethyl ester (CAPE) on metabolic enzymes including acetylcholinesterase, butyrylcholinesterase, glutathione S-transferase, lactoperoxidase, and carbonic anhydrase isoenzymes I, II, IX, and XII. Journal of enzyme inhibition and medicinal chemistry. vol 31. issue 6. 2017-02-21. PMID:26453427. |
acetylcholinesterase (ache) is responsible for acetyl choline (ach) hydrolysis and plays a fundamental role in nerve impulse transmission by terminating the action of the ach neurotransmitter at cholinergic synapses and neuromuscular junctions. |
2017-02-21 |
2023-08-13 |
human |