| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mikhail Stepanichev, Daniil Markov, Natalia Pasikova, Natalia Gulyaev. Behavior and the cholinergic parameters in olfactory bulbectomized female rodents: Difference between rats and mice. Behavioural brain research. vol 297. 2016-09-15. PMID:26431763. |
no effect of obx on the number of cholinergic neurons in the medial septum-diagonal band as well as on the acetylcholine content and acetylcholinesterase activity in the septum, hippocampus, and neocortex could be detected. |
2016-09-15 |
2023-08-13 |
mouse |
| Susanne Hainke, Johannes Wildmann, Adriana Del Re. Deletion of muscarinic type 1 acetylcholine receptors alters splenic lymphocyte functions and splenic noradrenaline concentration. International immunopharmacology. vol 29. issue 1. 2016-09-14. PMID:26002586. |
the spleen does not receive cholinergic innervation, but it has been reported that lymphocytes themselves can produce acetylcholine, and express acetylcholine receptors and acetylcholinesterase. |
2016-09-14 |
2023-08-13 |
mouse |
| Dandan He, Hui Wu, Yue Wei, Wei Liu, Fei Huang, Hailian Shi, Beibei Zhang, Xiaojun Wu, Changhong Wan. Effects of harmine, an acetylcholinesterase inhibitor, on spatial learning and memory of APP/PS1 transgenic mice and scopolamine-induced memory impairment mice. European journal of pharmacology. vol 768. 2016-09-13. PMID:26526348. |
taken together, all these results suggested that harmine could ameliorate impaired memory by enhancement of cholinergic neurotransmission via inhibiting the activity of acetylcholinesterase, which may contribute to its clinical use in the therapy of neurological diseases characterized with acetylcholinesterase deficiency. |
2016-09-13 |
2023-08-13 |
mouse |
| João H D Blanco, Ada C Gastaldi, Camila B Gardim, João E Araujo, Marcus V Simões, Luciano F L Oliveira, Eduardo E V Carvalho, Hugo C D Souz. Chronic cholinergic stimulation promotes changes in cardiovascular autonomic control in spontaneously hypertensive rats. Autonomic neuroscience : basic & clinical. vol 193. 2016-08-28. PMID:26471065. |
on the other hand, cholinergic stimulation through inhibition of acetylcholinesterase appears to have beneficial effects on cardiac autonomic control. |
2016-08-28 |
2023-08-13 |
rat |
| Azadeh Karami, Helga Eyjolfsdottir, Swetha Vijayaraghavan, Göran Lind, Per Almqvist, Ahmadul Kadir, Bengt Linderoth, Niels Andreasen, Kaj Blennow, Anders Wall, Eric Westman, Daniel Ferreira, Maria Kristoffersen Wiberg, Lars-Olof Wahlund, Åke Seiger, Agneta Nordberg, Lars Wahlberg, Taher Darreh-Shori, Maria Eriksdotte. Changes in CSF cholinergic biomarkers in response to cell therapy with NGF in patients with Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 11. issue 11. 2016-08-26. PMID:25676388. |
the purpose of this study was to see if ec-ngf therapy will alter csf levels of cholinergic biomarkers, chat, and acetylcholinesterase. |
2016-08-26 |
2023-08-13 |
Not clear |
| Tetsade Piermartiri, Hongna Pan, Taiza H Figueiredo, Ann M Marin. α-Linolenic Acid, A Nutraceutical with Pleiotropic Properties That Targets Endogenous Neuroprotective Pathways to Protect against Organophosphate Nerve Agent-Induced Neuropathology. Molecules (Basel, Switzerland). vol 20. issue 11. 2016-08-19. PMID:26569216. |
op nerve agents inhibit the critical enzyme acetylcholinesterase (ache) that rapidly leads to a cholinergic crisis involving multiple organs. |
2016-08-19 |
2023-08-13 |
Not clear |
| Franz Worek, Martina Schilha, Katharina Neumaier, Nadine Aurbek, Timo Wille, Horst Thiermann, Kai Keh. On-site analysis of acetylcholinesterase and butyrylcholinesterase activity with the ChE check mobile test kit-Determination of reference values and their relevance for diagnosis of exposure to organophosphorus compounds. Toxicology letters. vol 249. 2016-08-16. PMID:27033775. |
however, in case of unspecific signs and of delayed onset of cholinergic crisis a rapid, reliable and on-site analysis of acetylcholinesterase (ache) and butyrylcholinesterase (bche) activity would be of great value. |
2016-08-16 |
2023-08-13 |
human |
| Emily J Henderson, Stephen R Lord, Matthew A Brodie, Daisy M Gaunt, Andrew D Lawrence, Jacqueline C T Close, A L Whone, Y Ben-Shlom. Rivastigmine for gait stability in patients with Parkinson's disease (ReSPonD): a randomised, double-blind, placebo-controlled, phase 2 trial. The Lancet. Neurology. vol 15. issue 3. 2016-08-09. PMID:26795874. |
in the respond trial we aimed to assess whether ameliorating this cholinergic deficit with the acetylcholinesterase inhibitor rivastigmine would reduce gait variability. |
2016-08-09 |
2023-08-13 |
Not clear |
| Alya Annabi, Ines Bini Dhouib, Aicha Jrad Lamine, Nargès El Golli, Najoua Gharbi, Saloua El Fazâa, Mohamed Montassar Lasra. Recovery by N-acetylcysteine from subchronic exposure to Imidacloprid-induced hypothalamic-pituitary-adrenal (HPA) axis tissues injury in male rats. Toxicology mechanisms and methods. vol 25. issue 7. 2016-08-02. PMID:26024013. |
furthermore, the hypothalamic and pituitary acetylcholinesterase activity and calcium level were significantly increased highlighting the alteration of cholinergic activity. |
2016-08-02 |
2023-08-13 |
rat |
| Abdul Hameed, Syeda T Zehra, Syed J A Shah, Khalid M Khan, Rima D Alharthy, Norbert Furtmann, Jürgen Bajorath, Muhammad N Tahir, Jamshed Iqba. Syntheses, cholinesterases inhibition, and molecular docking studies of pyrido[2,3-b]pyrazine derivatives. Chemical biology & drug design. vol 86. issue 5. 2016-08-01. PMID:25951978. |
cholinesterases, acetylcholinesterase (ache) and butyrylcholinesterase (bche), have a role in cholinergic deficit which evidently leads to alzheimer's disease (ad). |
2016-08-01 |
2023-08-13 |
Not clear |
| Mullah Muhaiminul Islam, Arun Bahadur Gurung, Atanu Bhattacharjee, Kripamoy Aguan, Sivaprasad Mitr. Human serum albumin reduces the potency of acetylcholinesterase inhibitor based drugs for Alzheimer's disease. Chemico-biological interactions. vol 249. 2016-08-01. PMID:26902639. |
human serum albumin (hsa) induced modulation of acetylcholinesterase (ache) inhibition activity of four well-known cholinergic inhibitors like tacrine hydrochloride (tac), donepezil hydrochloride monohydrate (don), (-) huperzine a (hupa), eserine (ese) was monitored quantitatively by ellman's method. |
2016-08-01 |
2023-08-13 |
human |
| Dirk Steinritz, Florian Eyer, Franz Worek, Horst Thiermann, Harald Joh. Repetitive obidoxime treatment induced increase of red blood cell acetylcholinesterase activity even in a late phase of a severe methamidophos poisoning: A case report. Toxicology letters. vol 244. 2016-06-29. PMID:26200596. |
symptoms of poisoning are characterized by acute cholinergic crisis caused by inhibition of acetylcholinesterase. |
2016-06-29 |
2023-08-13 |
Not clear |
| Peng Wu, Yuandai Luo, Lifang Zhen, Xianda Hu, Ying Shang, Yinuo Liao, Huiyuan Xue, Fukai Huang, Wei Xia. Rannasangpei Is a Therapeutic Agent in the Treatment of Vascular Dementia. Evidence-based complementary and alternative medicine : eCAM. vol 2016. 2016-06-13. PMID:27293454. |
elisa revealed that the treatments with both doses of rsnp could reinstate the cholinergic activity in the vd animals by elevating the production of choline acetyltransferase (chat) and reducing the acetylcholinesterase (ache); the treatment of rsnp could also reboot the level of superoxide dismutase (sod) and decrease malondialdehyde (mda). |
2016-06-13 |
2023-08-13 |
rat |
| Piotr Draczkowski, Anna Tomaszuk, Pawel Halczuk, Maciej Strzemski, Dariusz Matosiuk, Krzysztof Jozwia. Determination of affinity and efficacy of acetylcholinesterase inhibitors using isothermal titration calorimetry. Biochimica et biophysica acta. vol 1860. issue 5. 2016-06-09. PMID:26586471. |
acetylcholinesterase (ache), an enzyme rapidly terminating nerve signals at synapses of cholinergic neurons is an important drug target in treatment of alzheimer's disease and related memory loss conditions. |
2016-06-09 |
2023-08-13 |
Not clear |
| Cecilia Engdahl, Sofie Knutsson, Sten-Åke Fredriksson, Anna Linusson, Göran Bucht, Fredrik Ekströ. Acetylcholinesterases from the Disease Vectors Aedes aegypti and Anopheles gambiae: Functional Characterization and Comparisons with Vertebrate Orthologues. PloS one. vol 10. issue 10. 2016-06-06. PMID:26447952. |
a potential target for the development of insecticides with reduced off-target toxicity is the cholinergic enzyme acetylcholinesterase (ache). |
2016-06-06 |
2023-08-13 |
mouse |
| Miroslav Pohanka, Petr Dobe. Caffeine inhibits acetylcholinesterase, but not butyrylcholinesterase. International journal of molecular sciences. vol 14. issue 5. 2016-05-26. PMID:23698772. |
in the present work, we focused on the question whether caffeine can inhibit acetylcholinesterase (ache) and/or, butyrylcholinesterase (bche), the two enzymes participating in cholinergic neurotransmission. |
2016-05-26 |
2023-08-12 |
human |
| Sarah J Judge, Claire Y Savy, Matthew Campbell, Rebecca Dodds, Larissa Kruger Gomes, Grace Laws, Anna Watson, Peter G Blain, Christopher M Morris, Sarah E Gartsid. Mechanism for the acute effects of organophosphate pesticides on the adult 5-HT system. Chemico-biological interactions. vol 245. 2016-05-26. PMID:26721196. |
to male hooded lister rats inhibited the activity of the cholinergic enzyme acetylcholinesterase in blood and in the hippocampus, dorsal raphe nucleus (drn), striatum and prefrontal cortex. |
2016-05-26 |
2023-08-13 |
rat |
| Brena P Teodorak, Gabriela K Ferreira, Giselli Scaini, Letícia B Wessler, Alexandra S Heylmann, Pedro Deroza, Samira S Valvassori, Alexandra I Zugno, João Quevedo, Emilio L Strec. Acute administration of fenproporex increased acetylcholinesterase activity in brain of young rats. Anais da Academia Brasileira de Ciencias. vol 87. issue 2 Suppl. 2016-05-23. PMID:26247155. |
considering that fenproporex effects on the central nervous system are still poorly known and that acetylcholinesterase is a regulatory enzyme which is involved in cholinergic synapses and may indirectly modulate the release of dopamine, the present study investigated the effects of acute administration of fenproporex on acetylcholinesterase activity in brain of young rats. |
2016-05-23 |
2023-08-13 |
rat |
| Brena P Teodorak, Gabriela K Ferreira, Giselli Scaini, Letícia B Wessler, Alexandra S Heylmann, Pedro Deroza, Samira S Valvassori, Alexandra I Zugno, João Quevedo, Emilio L Strec. Acute administration of fenproporex increased acetylcholinesterase activity in brain of young rats. Anais da Academia Brasileira de Ciencias. vol 87. issue 2 Suppl. 2016-05-23. PMID:26247155. |
in conclusion, in the present study we demonstrated that acute administration of fenproporex exerts an effect in the cholinergic system causing an increase in the activity of acetylcholinesterase in a dose-dependent manner in the hippocampus and posterior cortex. |
2016-05-23 |
2023-08-13 |
rat |
| Tetsade C B Piermartiri, Hongna Pan, Jun Chen, John McDonough, Neil Grunberg, James P Apland, Ann M Marin. Alpha-Linolenic Acid-Induced Increase in Neurogenesis is a Key Factor in the Improvement in the Passive Avoidance Task After Soman Exposure. Neuromolecular medicine. vol 17. issue 3. 2016-05-20. PMID:25920465. |
exposure to organophosphorous (op) nerve agents such as soman inhibits the critical enzyme acetylcholinesterase (ache) leading to excessive acetylcholine accumulation in synapses, resulting in cholinergic crisis, status epilepticus and brain damage in survivors. |
2016-05-20 |
2023-08-13 |
Not clear |