| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Benedikt Zujalovic, Eberhard Bart. Delirium Accompanied by Cholinergic Deficiency and Organ Failure in a 73-Year-Old Critically Ill Patient: Physostigmine as a Therapeutic Option. Case reports in critical care. vol 2015. 2015-11-09. PMID:26550498. |
using the possibility of bedside determination of the acetylcholinesterase activity (ache activity), we assumed to objectify the cholinergic homeostasis within minutes. |
2015-11-09 |
2023-08-13 |
Not clear |
| Eran Finkel, Alex Etlin, Meir Cherniak, Yoav Mor, Aharon Lev-Tov, Lili Angliste. Neuroanatomical basis for cholinergic modulation of locomotor networks by sacral relay neurons with ascending lumbar projections. The Journal of comparative neurology. vol 522. issue 15. 2015-11-02. PMID:24752570. |
histochemical and immunostaining of the sacral cord reveals expression of acetylcholinesterase activity, ability to synthesize acetylcholine, and/or innervation by cholinergic synaptic inputs in significant proportions of fluorescently back-labeled sacral vf neurons. |
2015-11-02 |
2023-08-13 |
rat |
| Eran Finkel, Alex Etlin, Meir Cherniak, Yoav Mor, Aharon Lev-Tov, Lili Angliste. Neuroanatomical basis for cholinergic modulation of locomotor networks by sacral relay neurons with ascending lumbar projections. The Journal of comparative neurology. vol 522. issue 15. 2015-11-02. PMID:24752570. |
we suggest that variations in the sacral level of acetylcholine modulate the sca-induced locomotor rhythm via muscarinic receptor-dependent mechanisms and that the modified activity of sacral vf neurons in the presence of an acetylcholinesterase inhibitor can be partially ascribed to the cholinergic components associated with them. |
2015-11-02 |
2023-08-13 |
rat |
| Martijn L T M Müller, Nicolaas I Bohnen, Vikas Kotagal, Peter J H Scott, Robert A Koeppe, Kirk A Frey, Roger L Albi. Clinical markers for identifying cholinergic deficits in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 30. issue 2. 2015-10-22. PMID:25393613. |
the objective of this retrospective multivariate predictor analysis study was to identify clinical markers indicative of cholinergic deficits in pd patients, as assessed by acetylcholinesterase ([(11) c]pmp) positron emission tomography. |
2015-10-22 |
2023-08-13 |
Not clear |
| Robert Alan Mans, Brian A Warmus, Caroline C Smith, Lori L McMaho. An acetylcholinesterase inhibitor, eserine, induces long-term depression at CA3-CA1 synapses in the hippocampus of adult rats. Journal of neurophysiology. vol 112. issue 10. 2015-10-19. PMID:25143547. |
acetylcholinesterase (ache) inhibitors are commonly prescribed to enhance cholinergic signaling in alzheimer's disease in hopes of rescuing cognitive function, caused, in part, by degeneration of cholinergic innervation to the hippocampus and cortex. |
2015-10-19 |
2023-08-13 |
rat |
| Ashok Kumar, Sorabh Sharma, Ashwani Prashar, Rahul Deshmuk. Effect of licofelone--a dual COX/5-LOX inhibitor in intracerebroventricular streptozotocin-induced behavioral and biochemical abnormalities in rats. Journal of molecular neuroscience : MN. vol 55. issue 3. 2015-10-15. PMID:25204299. |
levels of malondialdehyde (mda), nitrite, reduced glutathione (gsh), and acetylcholinesterase (ache) activity were determined to check oxidative stress and cholinergic function. |
2015-10-15 |
2023-08-13 |
rat |
| Jun Chen, Hongna Pan, Cynthia Chen, Wei Wu, Kevin Iskandar, Jeffrey He, Tetsade Piermartiri, David M Jacobowitz, Qian-Sheng Yu, John H McDonough, Nigel H Greig, Ann M Marin. (-)-Phenserine attenuates soman-induced neuropathology. PloS one. vol 9. issue 6. 2015-10-13. PMID:24955574. |
the irreversible inhibition of the critical cholinergic degradative enzyme acetylcholinesterase (ache) by op nerve agents leads to cholinergic crisis. |
2015-10-13 |
2023-08-13 |
rat |
| Maria-Letizia Campanari, María-Salud García-Ayllón, Olivia Belbin, Joan Galcerán, Alberto Lleó, Javier Sáez-Valer. Acetylcholinesterase modulates presenilin-1 levels and γ-secretase activity. Journal of Alzheimer's disease : JAD. vol 41. issue 3. 2015-09-18. PMID:24699279. |
the cholinergic enzyme acetylcholinesterase (ache) and the catalytic component of the γ-secretase complex, presenilin-1 (ps1), are known to interact. |
2015-09-18 |
2023-08-13 |
human |
| Emilene B S Scherer, Samanta O Loureiro, Fernanda C Vuaden, Aline A da Cunha, Felipe Schmitz, Janaína Kolling, Luiz Eduardo B Savio, Maurício R Bogo, Carla D Bonan, Carlos A Netto, Angela T S Wys. Mild hyperhomocysteinemia increases brain acetylcholinesterase and proinflammatory cytokine levels in different tissues. Molecular neurobiology. vol 50. issue 2. 2015-09-11. PMID:24590316. |
cholinergic signaling controls cytokine production and inflammation through the "cholinergic anti-inflammatory pathway," and brain acetylcholinesterase activity plays a role in this regulation. |
2015-09-11 |
2023-08-12 |
rat |
| Franciele Martini, César Augusto Bruning, Suelen Mendonca Soares, Cristina Wayne Nogueira, Gilson Zen. Inhibitory effect of ebselen on cerebral acetylcholinesterase activity in vitro: kinetics and reversibility of inhibition. Current pharmaceutical design. vol 21. issue 7. 2015-09-11. PMID:25312723. |
there is evidence that ebselen inhibits acetylcholinesterase (ache) activity, an enzyme that plays a key role in the cholinergic system by hydrolyzing acetylcholine (ach), in vitro and ex vivo. |
2015-09-11 |
2023-08-13 |
Not clear |
| Shamsherjit Kaur, Satinderpal Singh, Karan Singh Chahal, Atish Prakas. Potential pharmacological strategies for the improved treatment of organophosphate-induced neurotoxicity. Canadian journal of physiology and pharmacology. vol 92. issue 11. 2015-08-31. PMID:25348489. |
organophosphates (op) are highly toxic compounds that cause cholinergic neuronal excitotoxicity and dysfunction by irreversible inhibition of acetylcholinesterase, resulting in delayed brain damage. |
2015-08-31 |
2023-08-13 |
Not clear |
| Chang-Ning Hao, Yi-Qin Shi, Ze-En Cheng, Xianwu Chen. Beyond autonomic neuromodulation: acetylcholinesterase inhibitor against peripheral artery disease. International journal of cardiology. vol 178. 2015-08-28. PMID:25464264. |
the acetylcholinesterase inhibitor (achei)-based therapeutic strategies have been shown to have vasculoprotective properties in the animal model of hindlimb ischemia due to its activation of the endothelial cholinergic system. |
2015-08-28 |
2023-08-13 |
Not clear |
| Robert Zdanowski, Małgorzata Krzyżowska, Sławomir Lewicki, Piotr Rutkowski, Monika Leśniak, Marek Saracyn, Marcin Niemcewicz, Aleksander Michalski, Marek Kowalczy. Effect of isopropyl methylphosphonofluoridate (IMPF) poisoning on selected immunological parameters of angiogenesis. Annals of agricultural and environmental medicine : AAEM. vol 21. issue 4. 2015-08-28. PMID:25528912. |
acetylcholinesterase (ache) and cholinergic receptors play an important role in the immune system, including lymphocyte-induced angiogenesis. |
2015-08-28 |
2023-08-13 |
mouse |
| Mohamed A Elnasharty, Ahmed Sayed-Ahme. Expression and localization of pChAT as a novel method to study cholinergic innervation of rat adrenal gland. Acta histochemica. vol 116. issue 8. 2015-08-20. PMID:25239149. |
cholinergic innervation of the rat adrenal gland has been analyzed previously using cholinergic markers including acetylcholinesterase (ache), choline acetyltransferase (chat) and vesicular acetylcholine transporter (vacht). |
2015-08-20 |
2023-08-13 |
rat |
| Hui-Jun Xi, Ren-Pei Wu, Jing-Jing Liu, Ling-Juan Zhang, Zhao-Shen L. Role of acetylcholinesterase in lung cancer. Thoracic cancer. vol 6. issue 4. 2015-08-14. PMID:26273392. |
acetylcholinesterase (ache) plays a key role in catalytic hydrolysis of cholinergic neurotransmitters. |
2015-08-14 |
2023-08-13 |
Not clear |
| Bombi Lee, Bong-Jun Sur, Jeong-Jun Han, Insop Shim, Song Her, Yang-Seok Lee, Hye-Jung Lee, Dae-Hyun Hah. Oral administration of squid lecithin-transphosphatidylated phosphatidylserine improves memory impairment in aged rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 56. 2015-07-31. PMID:25058912. |
biochemical alterations in the hippocampal cholinergic system, including changes in choline acetyltransferase and acetylcholinesterase immunoreactivity, were consistent with the behavioral results. |
2015-07-31 |
2023-08-13 |
rat |
| Awanish Mishra, Rajesh Kumar Goe. Adjuvant anticholinesterase therapy for the management of epilepsy-induced memory deficit: a critical pre-clinical study. Basic & clinical pharmacology & toxicology. vol 115. issue 6. 2015-07-28. PMID:24890882. |
as cholinergic approach has widely been practiced for the restoration of memory in various neurodegenerative disorders, this study was envisaged to evaluate add on effect of acetylcholinesterase inhibitor (tacrine) with phenytoin in pentylenetetrazole-kindling-induced learning and memory deficit in mice. |
2015-07-28 |
2023-08-13 |
mouse |
| Koneni V Sashidhara, Ram K Modukuri, Pooja Jadiya, Ranga Prasad Dodda, Manoj Kumar, Balasubramaniam Sridhar, Vikash Kumar, Rizwanul Haque, Mohammad Imran Siddiqi, Aamir Nazi. Benzofuran-chalcone hybrids as potential multifunctional agents against Alzheimer's disease: synthesis and in vivo studies with transgenic Caenorhabditis elegans. ChemMedChem. vol 9. issue 12. 2015-07-24. PMID:25251917. |
these compounds were also found to decrease acetylcholinesterase (ache) levels, reduce oxidative stress in the worms, lower lipid content, and to provide protection against chemically induced cholinergic neurodegeneration. |
2015-07-24 |
2023-08-13 |
human |
| Ian R Macdonald, Kenneth Rockwood, Earl Martin, Sultan Darves. Cholinesterase inhibition in Alzheimer's disease: is specificity the answer? Journal of Alzheimer's disease : JAD. vol 42. issue 2. 2015-07-20. PMID:24898642. |
acetylcholinesterase (ache) catalyzes the hydrolysis of the cholinergic neurotransmitter acetylcholine. |
2015-07-20 |
2023-08-13 |
Not clear |
| Mohammad Z Ahmad, Javed Ahmad, Saima Amin, Mahfoozur Rahman, Mohammad Anwar, Neha Mallick, Farhan J Ahmad, Ziyaur Rahman, Mohammad A Kamal, Sohail Akhte. Role of nanomedicines in delivery of anti-acetylcholinesterase compounds to the brain in Alzheimer's disease. CNS & neurological disorders drug targets. vol 13. issue 8. 2015-07-02. PMID:25345516. |
potentiation of central cholinergic activity by using acetylcholinesterase inhibitors (achei) is considered as one of the major pharmacological means for the management of ad. |
2015-07-02 |
2023-08-13 |
Not clear |