| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eric M Prager, Vassiliki Aroniadou-Anderjaska, Camila P Almeida-Suhett, Taiza H Figueiredo, James P Apland, Maria F M Brag. Acetylcholinesterase inhibition in the basolateral amygdala plays a key role in the induction of status epilepticus after soman exposure. Neurotoxicology. vol 38. 2014-10-24. PMID:23817175. |
it is well-established that seizure initiation is due to excessive cholinergic activity triggered by the nerve agent-induced irreversible inhibition of acetylcholinesterase (ache). |
2014-10-24 |
2023-08-12 |
rat |
| H Ji, M F Rabbi, B Labis, V A Pavlov, K J Tracey, J E Ghi. Central cholinergic activation of a vagus nerve-to-spleen circuit alleviates experimental colitis. Mucosal immunology. vol 7. issue 2. 2014-10-17. PMID:23881354. |
central cholinergic activation induced by the acetylcholinesterase inhibitor galantamine or a muscarinic acetylcholine receptor agonist treatments resulted in reduced mucosal inflammation associated with decreased major histocompatibility complex ii level and pro-inflammatory cytokine secretion by splenic cd11c⁺ cells mediated by α7nachr signaling. |
2014-10-17 |
2023-08-12 |
mouse |
| Surbhi Gupta, Bhupesh Sharm. Pharmacological modulation of I(1)-imidazoline and α2-adrenoceptors in sub acute brain ischemia induced vascular dementia. European journal of pharmacology. vol 723. 2014-10-07. PMID:24333661. |
cholinergic status was assessed by brain acetylcholinesterase (ache) activity. |
2014-10-07 |
2023-08-12 |
mouse |
| Rodrigo Medeiros, Nicholas A Castello, David Cheng, Masashi Kitazawa, David Baglietto-Vargas, Kim N Green, Timothy A Esbenshade, Robert S Bitner, Michael W Decker, Frank M LaFerl. α7 Nicotinic receptor agonist enhances cognition in aged 3xTg-AD mice with robust plaques and tangles. The American journal of pathology. vol 184. issue 2. 2014-09-18. PMID:24269557. |
cholinergic system dysfunction is an early and salient feature of ad, and enhancing cholinergic signaling with acetylcholinesterase inhibitors is currently the primary strategy for improving cognition. |
2014-09-18 |
2023-08-12 |
mouse |
| Sathya N Prasad, Muralidhar. Neuroprotective effect of geraniol and curcumin in an acrylamide model of neurotoxicity in Drosophila melanogaster: relevance to neuropathy. Journal of insect physiology. vol 60. 2014-08-24. PMID:24231732. |
while acr elevated the activity of acetylcholinesterase in head/body regions, marked diminution in enzyme activity ensued with co-exposure to phytoconstituents suggesting their potency to mitigate cholinergic function. |
2014-08-24 |
2023-08-12 |
human |
| Shunichiro Shinagawa, Masahiro Shiget. [Acetylcholinesterase inhibitors for treatment of Alzheimer's disease]. Brain and nerve = Shinkei kenkyu no shinpo. vol 66. issue 5. 2014-08-15. PMID:24807367. |
acetylcholinesterase inhibitors (acheis) were developed under the cholinergic hypothesis of ad. |
2014-08-15 |
2023-08-13 |
Not clear |
| Antoine-Scott Badin, John Eraifej, Susan Greenfiel. High-resolution spatio-temporal bioactivity of a novel peptide revealed by optical imaging in rat orbitofrontal cortex in vitro: possible implications for neurodegenerative diseases. Neuropharmacology. vol 73. 2014-08-13. PMID:23711548. |
acetylcholinesterase (ache) is now well known to have a secondary, non-enzymatic function independent of cholinergic transmission. |
2014-08-13 |
2023-08-12 |
rat |
| H Eimar, A Perez Lara, I Tamimi, P Márquez Sánchez, I Gormaz Talavera, F Rojas Tomba, T García de la Oliva, F Tamim. Acetylcholinesterase inhibitors and healing of hip fracture in Alzheimer's disease patients: a retrospective cohort study. Journal of musculoskeletal & neuronal interactions. vol 13. issue 4. 2014-08-11. PMID:24292615. |
this study was designed to assess effects of cholinergic stimulation using acetylcholinesterase inhibitors (acheis), a group of drugs that stimulate cholinergic receptors and are used to treat alzheimer's disease (ad), on healing of hip fractures. |
2014-08-11 |
2023-08-12 |
Not clear |
| Per Johansson, Erik G Almqvist, Jan-Ove Johansson, Niklas Mattsson, Ulf Andreasson, Oskar Hansson, Anders Wallin, Kaj Blennow, Henrik Zetterberg, Johan Svensso. Cerebrospinal fluid (CSF) 25-hydroxyvitamin D concentration and CSF acetylcholinesterase activity are reduced in patients with Alzheimer's disease. PloS one. vol 8. issue 11. 2014-08-05. PMID:24312390. |
little is known of vitamin d concentration in cerebrospinal fluid (csf) in alzheimer's disease (ad) and its relation with csf acetylcholinesterase (ache) activity, a marker of cholinergic function. |
2014-08-05 |
2023-08-12 |
Not clear |
| Athina A Strilakou, Stylianos T Tsakiris, Konstantinos G Kalafatakis, Aikaterini T Stylianaki, Petros L Karkalousos, Andreas V Koulouris, Iordanis S Mourouzis, Charis A Liap. Carnitine modulates crucial myocardial adenosine triphosphatases and acetylcholinesterase enzyme activities in choline-deprived rats. Canadian journal of physiology and pharmacology. vol 92. issue 1. 2014-07-25. PMID:24383876. |
choline is also the precursor of acetylcholine (cholinergic component of the heart's autonomic nervous system), whose levels are regulated by acetylcholinesterase (ache). |
2014-07-25 |
2023-08-12 |
rat |
| Marta Pera, Pelayo Camps, Diego Muñoz-Torrero, Belen Perez, Albert Badia, M Victoria Clos Guille. Undifferentiated and differentiated PC12 cells protected by huprines against injury induced by hydrogen peroxide. PloS one. vol 8. issue 9. 2014-07-18. PMID:24086337. |
huprines, a group of potent acetylcholinesterase inhibitors (acheis), have shown a broad cholinergic pharmacological profile. |
2014-07-18 |
2023-08-12 |
mouse |
| Lindley A Maryoung, Ramon Lavado, Daniel Schlen. Impacts of hypersaline acclimation on the acute toxicity of the organophosphate chlorpyrifos to salmonids. Aquatic toxicology (Amsterdam, Netherlands). vol 152. 2014-07-18. PMID:24799192. |
in contrast, mrna expression of neurological targets: calcium calmodulin dependent protein kinase ii delta, chloride intracellular channel 4, and g protein alpha i1 were upregulated in saltwater acclimated fish, consistent with diminished neuronal signaling which may protect animals from cholinergic overload associated with acetylcholinesterase inhibition. |
2014-07-18 |
2023-08-13 |
Not clear |
| Hajer Attig, Naouel Kamel, Susanna Sforzini, Alessandro Dagnino, Jebali Jamel, Hamadi Boussetta, Aldo Viarengo, Mohamed Bann. Effects of thermal stress and nickel exposure on biomarkers responses in Mytilus galloprovincialis (Lam). Marine environmental research. vol 94. 2014-07-11. PMID:24424117. |
the cholinergic system was monitored using the acetylcholinesterase activity (ache). |
2014-07-11 |
2023-08-12 |
cat |
| Sumantra Sarkar, Madhumita Nandi, Rakesh Mondal, Sandip Kumar Manda. Organophosphorus-induced extrapyramidal intermediate syndrome in an adolescent suicide attempt survivor. Journal of neurosciences in rural practice. vol 5. issue 3. 2014-07-08. PMID:25002771. |
the victims of organophosphorus (op) pesticide poisoning usually present with acute cholinergic crisis, due to the inhibition of the enzyme acetylcholinesterase. |
2014-07-08 |
2023-08-13 |
Not clear |
| Orit Chai, Adi Sommer, Gabriel Zimmerman, Hermona Soreq, Alon Friedman, Tali Bdolah-Abram, Itamar Aroch, Merav H Shami. Acetylcholinesterase activity in the cerebrospinal fluid of dogs with seizures. Veterinary journal (London, England : 1997). vol 198. issue 1. 2014-06-19. PMID:23988333. |
recent studies in animal models have focused on the role of cholinergic elements, mainly acetylcholinesterase (ache) and the 'readthrough' acetylcholinesterase isoform (ache-r), in seizures. |
2014-06-19 |
2023-08-12 |
dog |
| Raffaele Nardone, Yvonne Höller, Monica Storti, Monica Christova, Frediano Tezzon, Stefan Golaszewski, Eugen Trinka, Francesco Brig. Thiamine deficiency induced neurochemical, neuroanatomical, and neuropsychological alterations: a reappraisal. TheScientificWorldJournal. vol 2013. 2014-06-13. PMID:24235882. |
the loss of cholinergic cells in the basal forebrain region results in decreased cholinergic input to the hippocampus and the cortex and reduced choline acetyltransferase and acetylcholinesterase activities and function, as well as in acetylcholine receptor downregulation within these brain regions. |
2014-06-13 |
2023-08-12 |
human |
| Anastasia A Borodinova, Denis V Abramochkin, Galina S Sukhov. Non-quantal release of acetylcholine in rat atrial myocardium is inhibited by noradrenaline. Experimental physiology. vol 98. issue 12. 2014-06-02. PMID:23975902. |
during the incubation of myocardium in the presence of acetylcholinesterase (ache) inhibitors, non-quantal ach release leads to accumulation of ach in the myocardium and cholinergic effects, which are proportional to the intensity of non-quantal secretion. |
2014-06-02 |
2023-08-12 |
rat |
| V K Vijaya. Prenatal and postnatal development of synapses and acetylcholinesterase staining in the dentate gyrus of the rhesus monkey. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 1. issue 2. 2014-06-02. PMID:24875720. |
morphogenesis, distribution of cholinergic enzyme acetylcholinesterase and synaptogenesis in the dentate gyrus of the rhesus monkey during the pre- and postnatal periods of development were examined using histological, histochemical and ultrastructural methods. |
2014-06-02 |
2023-08-13 |
rat |
| Ha Young Shin, Hyung Jun Park, Hyo Eun Lee, Young-Chul Choi, Seung Min Ki. Clinical and Electrophysiologic Responses to Acetylcholinesterase Inhibitors in MuSK-Antibody-Positive Myasthenia Gravis: Evidence for Cholinergic Neuromuscular Hyperactivity. Journal of clinical neurology (Seoul, Korea). vol 10. issue 2. 2014-05-15. PMID:24829597. |
clinical and electrophysiologic responses to acetylcholinesterase inhibitors in musk-antibody-positive myasthenia gravis: evidence for cholinergic neuromuscular hyperactivity. |
2014-05-15 |
2023-08-13 |
Not clear |
| Shafiq Ahmad Tariq, Haroon Khan, Abdul Jalil Popalzai, Iftikhar-ud-Din Niazi, Safiulla. Attenuation of erythrocytic acetyl cholinesterase by paracetamol and chloroquine: evidence in an in vitro study. Pakistan journal of pharmaceutical sciences. vol 27. issue 2. 2014-05-12. PMID:24577912. |
in conclusion, the cholinergic intervention by paracetamol in this study suggested a new mechanism for its analgesic activity as acetylcholinesterase inhibitors have already shown both peripheral and central analgesic activity, while the cholinergic activation by chloroquine provided explanation for some of its side effects. |
2014-05-12 |
2023-08-12 |
Not clear |