| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paul M Nagy, Isabelle Auber. B6eGFPChAT mice overexpressing the vesicular acetylcholine transporter exhibit spontaneous hypoactivity and enhanced exploration in novel environments. Brain and behavior. vol 3. issue 4. 2014-01-01. PMID:24381809. |
focus has been on blocking acetylcholinesterase (ache) and enhancing ach synthesis to improve cholinergic neurotransmission. |
2014-01-01 |
2023-08-12 |
mouse |
| Eran Nizri, Talma Brenne. Modulation of inflammatory pathways by the immune cholinergic system. Amino acids. vol 45. issue 1. 2013-12-18. PMID:22194043. |
theses effects are mediated by cholinergic muscarinic and nicotinic receptors and other cholinergic components present in immune cells, such as acetylcholinesterase (ache) and cholineacetyltransferase. |
2013-12-18 |
2023-08-12 |
Not clear |
| Sabine Pompeia, Juliana Ramos Gouveia, José Carlos Fernandes Galduró. Acute mood effect of donepezil in young, healthy volunteers. Human psychopharmacology. vol 28. issue 3. 2013-12-18. PMID:23653426. |
chronic use of the acetylcholinesterase inhibitor donepezil has been found to improve mood or to induce mania/hypomania in many neuropsychiatric patients with altered cholinergic and dopaminergic tone. |
2013-12-18 |
2023-08-12 |
human |
| Veena Beri, Scott A Wildman, Kazuro Shiomi, Ziyad F Al-Rashid, Jonah Cheung, Terrone L Rosenberr. The natural product dihydrotanshinone I provides a prototype for uncharged inhibitors that bind specifically to the acetylcholinesterase peripheral site with nanomolar affinity. Biochemistry. vol 52. issue 42. 2013-12-12. PMID:24040835. |
cholinergic synaptic transmission often requires extremely rapid hydrolysis of acetylcholine by acetylcholinesterase (ache). |
2013-12-12 |
2023-08-12 |
Not clear |
| Takuya Abe, Yoshitomi Kanemitu, Masateru Nakasone, Ichiro Kawahata, Tohru Yamakuni, Akira Nakajima, Naoto Suzuki, Masazumi Nishikawa, Takanori Hishinuma, Yoshihisa Tomiok. SLC10A4 is a protease-activated transporter that transports bile acids. Journal of biochemistry. vol 154. issue 1. 2013-12-10. PMID:23589386. |
rat slc10a4 is predominantly expressed in rat cholinergic neurons; therefore, te671 cells expressing the acetylcholine receptor and acetylcholinesterase were used. |
2013-12-10 |
2023-08-12 |
rat |
| T Antonelli, M C Tomasini, M Castellazzi, P Sola, C Tamborino, D Ferraro, L Ferraro, E Granier. Biological markers in cerebrospinal fluid for axonal impairment in multiple sclerosis: acetylcholinesterase activity cannot be considered a useful biomarker. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 34. issue 5. 2013-12-09. PMID:23247598. |
the correlation between the cholinergic system and the cognitive dysfunction in ms has led to studies on the use of acetylcholinesterase inhibitors (achei). |
2013-12-09 |
2023-08-12 |
human |
| T Antonelli, M C Tomasini, M Castellazzi, P Sola, C Tamborino, D Ferraro, L Ferraro, E Granier. Biological markers in cerebrospinal fluid for axonal impairment in multiple sclerosis: acetylcholinesterase activity cannot be considered a useful biomarker. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 34. issue 5. 2013-12-09. PMID:23247598. |
the acetylcholinesterase (ache), essential enzyme for the regulation of turnover of acetylcholine, can be considered the most important biochemical indicator of cholinergic signaling in the nervous system. |
2013-12-09 |
2023-08-12 |
human |
| Yusuke Tsuno, Nathan W Schultheiss, Michael E Hasselm. In vivo cholinergic modulation of the cellular properties of medial entorhinal cortex neurons. The Journal of physiology. vol 591. issue 10. 2013-12-05. PMID:23529129. |
consistent with data from in vitro studies, cholinergic activation by systemic application of the acetylcholinesterase inhibitor, physostigmine, resulted in decreased sag amplitude, increased sag time constant and a decrease of the peak resonance frequency. |
2013-12-05 |
2023-08-12 |
rat |
| E G Kakani, M Trakala, E Drosopoulou, P Mavragani-Tsipidou, K D Mathiopoulo. Genomic structure, organization and localization of the acetylcholinesterase locus of the olive fruit fly, Bactrocera oleae. Bulletin of entomological research. vol 103. issue 1. 2013-12-02. PMID:22967668. |
acetylcholinesterase (ache), encoded by the ace gene, is a key enzyme of cholinergic neurotransmission. |
2013-12-02 |
2023-08-12 |
drosophila_melanogaster |
| L Stan Leung, Jingyi Ma, Bixia Shen, Ilan Nachim, Tao Lu. Medial septal lesion enhances general anesthesia response. Experimental neurology. vol 247. 2013-11-26. PMID:23376225. |
lesion of the medial septum was confirmed by thionin-stained histological sections as well as loss of acetylcholinesterase (ache) staining in the hippocampus, indicating a depletion of septohippocampal cholinergic afferents. |
2013-11-26 |
2023-08-12 |
rat |
| Jose R Suarez-Lopez, David R Jacobs, John H Himes, Bruce H Alexande. Acetylcholinesterase activity, cohabitation with floricultural workers, and blood pressure in Ecuadorian children. Environmental health perspectives. vol 121. issue 5. 2013-11-19. PMID:23359481. |
acetylcholinesterase (ache) inhibitors are commonly used pesticides that can effect hemodynamic changes through increased cholinergic stimulation. |
2013-11-19 |
2023-08-12 |
Not clear |
| María Elena Sale. Cholinergic drugs as therapeutic tools in inflammatory diseases: participation of neuronal and non-neuronal cholinergic systems. Anti-inflammatory & anti-allergy agents in medicinal chemistry. vol 12. issue 2. 2013-11-12. PMID:23360259. |
this knowledge led to expand the role of ach as a neurotransmitter and to consider it as a "cytotransmitter" and also to evaluate the existence of a non-neuronal cholinergic system comprising ach, chat, acetylcholinesterase, and the nicotinic and muscarinic ach receptors, outside the nervous system. |
2013-11-12 |
2023-08-12 |
Not clear |
| Franziska Mohr, Martina Zimmermann, Jochen Klei. Mice heterozygous for AChE are more sensitive to AChE inhibitors but do not respond to BuChE inhibition. Neuropharmacology. vol 67. 2013-11-04. PMID:23147415. |
an impaired central cholinergic system is at least partly involved in alzheimer's disease (ad) pathogenesis, with cholinergic markers such as acetylcholinesterase (ache) activity and protein levels decreasing as cognitive decline progresses. |
2013-11-04 |
2023-08-12 |
mouse |
| b' Mirjana B Colovi\\xc4\\x87, Danijela Z Krsti\\xc4\\x87, Tamara D Lazarevi\\xc4\\x87-Pa\\xc5\\xa1ti, Aleksandra M Bond\\xc5\\xbei\\xc4\\x87, Vesna M Vasi\\xc4\\x8. Acetylcholinesterase inhibitors: pharmacology and toxicology. Current neuropharmacology. vol 11. issue 3. 2013-11-01. PMID:24179466.' |
acetylcholinesterase is involved in the termination of impulse transmission by rapid hydrolysis of the neurotransmitter acetylcholine in numerous cholinergic pathways in the central and peripheral nervous systems. |
2013-11-01 |
2023-08-12 |
Not clear |
| G A Reid, N Chilukuri, S Darves. Butyrylcholinesterase and the cholinergic system. Neuroscience. vol 234. 2013-10-25. PMID:23305761. |
the cholinergic neurotransmitter acetylcholine is synthesized by choline acetyltransferase (chat) and its action terminated by acetylcholinesterase (ache) and butyrylcholinesterase (buche). |
2013-10-25 |
2023-08-12 |
mouse |
| Preet Anand, Baldev Sing. A review on cholinesterase inhibitors for Alzheimer's disease. Archives of pharmacal research. vol 36. issue 4. 2013-10-25. PMID:23435942. |
cholinesterase inhibitors enhance cholinergic transmission directly by inhibiting the enzyme acetylcholinesterase (ache) which hydrolyses acetylcholine. |
2013-10-25 |
2023-08-12 |
Not clear |
| Xiugong Gao, Hsiuling Lin, Radharaman Ray, Prabhati Ra. Toxicogenomic studies of human neural cells following exposure to organophosphorus chemical warfare nerve agent VX. Neurochemical research. vol 38. issue 5. 2013-10-22. PMID:23440544. |
op compounds are considered acting primarily via cholinergic pathways by binding irreversibly to acetylcholinesterase, an important regulator of the neurotransmitter acetylcholine. |
2013-10-22 |
2023-08-12 |
human |
| Andreia Nunes, Sérgio M Marques, Catarina Quintanova, Diana F Silva, Sandra M Cardoso, Sílvia Chaves, M Amélia Santo. Multifunctional iron-chelators with protective roles against neurodegenerative diseases. Dalton transactions (Cambridge, England : 2003). vol 42. issue 17. 2013-10-22. PMID:23487286. |
the linkers between these two main functional groups were selected on the basis of virtual screening, so that the final molecule could further inhibit the acetylcholinesterase, responsible for the cholinergic losses. |
2013-10-22 |
2023-08-12 |
Not clear |
| Mary J Palmer, Christopher Moffat, Nastja Saranzewa, Jenni Harvey, Geraldine A Wright, Christopher N Connoll. Cholinergic pesticides cause mushroom body neuronal inactivation in honeybees. Nature communications. vol 4. 2013-10-22. PMID:23535655. |
honeybees are exposed to two widely used classes of cholinergic pesticide: neonicotinoids (nicotinic receptor agonists) and organophosphate miticides (acetylcholinesterase inhibitors). |
2013-10-22 |
2023-08-12 |
Not clear |
| M Ratia, L Giménez-Llort, P Camps, D Muñoz-Torrero, B Pérez, M V Clos, A Badi. Huprine X and huperzine A improve cognition and regulate some neurochemical processes related with Alzheimer's disease in triple transgenic mice (3xTg-AD). Neuro-degenerative diseases. vol 11. issue 3. 2013-10-17. PMID:22626981. |
thus, enhancement of the central cholinergic neurotransmission has been regarded as one of the most promising strategies for the symptomatic treatment of ad, mainly by means of reversible acetylcholinesterase inhibitors (acheis). |
2013-10-17 |
2023-08-12 |
mouse |