| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P M Nagy, I Auber. Overexpression of the vesicular acetylcholine transporter increased acetylcholine release in the hippocampus. Neuroscience. vol 218. 2012-11-16. PMID:22641085. |
in addition to current strategies being developed, such as the use of acetylcholinesterase inhibitors, enhancing acetylcholine (ach) release may be critical for optimal cholinergic neurotransmission. |
2012-11-16 |
2023-08-12 |
mouse |
| Wilson K W Luk, Vicky P Chen, Roy C Y Choi, Karl W K Tsi. N-linked glycosylation of dimeric acetylcholinesterase in erythrocytes is essential for enzyme maturation and membrane targeting. The FEBS journal. vol 279. issue 17. 2012-11-08. PMID:22805525. |
acetylcholinesterase (ache) is well-known for its cholinergic functions in the nervous system; however, this enzyme is also found in other tissues where its function is still not understood. |
2012-11-08 |
2023-08-12 |
human |
| Takaaki Mori, Jun Maeda, Hitoshi Shimada, Makoto Higuchi, Hitoshi Shinotoh, Shu-ichi Ueno, Tetsuya Suhar. Molecular imaging of dementia. Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society. vol 12. issue 2. 2012-10-29. PMID:22712644. |
meanwhile, brain cholinergic function can be estimated by measuring acetylcholinesterase activity in the brain with pet and radiolabeled acetylcholine analogues. |
2012-10-29 |
2023-08-12 |
mouse |
| Nicolaas I Bohnen, Martijn L T M Müller, Vikas Kotagal, Robert A Koeppe, Michael R Kilbourn, Sid Gilman, Roger L Albin, Kirk A Fre. Heterogeneity of cholinergic denervation in Parkinson's disease without dementia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 32. issue 8. 2012-10-15. PMID:22569194. |
cholinergic projection changes were heterogeneous for 65 out of 101 pd subjects who had neocortical and thalamic acetylcholinesterase activity within the normal range. |
2012-10-15 |
2023-08-12 |
human |
| Nicolaas I Bohnen, Martijn L T M Müller, Vikas Kotagal, Robert A Koeppe, Michael R Kilbourn, Sid Gilman, Roger L Albin, Kirk A Fre. Heterogeneity of cholinergic denervation in Parkinson's disease without dementia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 32. issue 8. 2012-10-15. PMID:22569194. |
cholinergic denervation is heterogeneous with reduced neocortical and/or thalamic acetylcholinesterase activity in 36% of nondemented pd subjects with corresponding clinical phenotypic variation. |
2012-10-15 |
2023-08-12 |
human |
| S A Jones, S A Greenfiel. Behavioural correlates of the release and subsequent action of acetylcholinesterase secreted in the substantia nigra. The European journal of neuroscience. vol 3. issue 3. 2012-10-02. PMID:12106207. |
acetylcholinesterase is secreted in the central nervous system (independently of cholinergic transmission) in a non-classic, non-enzymatic capacity. |
2012-10-02 |
2023-08-12 |
Not clear |
| D B Sattelle, Y W Ho, G D Crawford, P M Salvaterra, W T Maso. Immunocytochemical staining of central neurones in Periplaneta americana using monoclonal antibodies to choline acetyltransferase. Tissue & cell. vol 18. issue 1. 2012-10-02. PMID:18620156. |
for some unidentified neurones, 4d7 staining is associated with the presence of acetylcholinesterase indicating that this monoclonal antibody offers a probe for mapping cholinergic neurones in the cns of periplaneta americana. |
2012-10-02 |
2023-08-12 |
rat |
| F F Casanueva, L Villanueva, F Cordido, Y Diaz, J A Cabranes, R Spiegel, C Diegue. Differential effects of direct and indirectly acting cholinergic agonists on growth hormone release in man, and lack of effect on cortisol secretion. Journal of neuroendocrinology. vol 1. issue 5. 2012-10-02. PMID:19210431. |
the former acts by inhibiting acetylcholinesterase, thus being an indirect muscarinic agonist, while the latter is a muscarinic receptor agonist which binds directly to and stimulates cholinergic receptors. |
2012-10-02 |
2023-08-12 |
human |
| E K Perry, R H Perry, B E Tomlinso. Circadian variations in cholinergic enzymes and muscarinic receptor binding in human cerebral cortex. Neuroscience letters. vol 4. issue 3-4. 2012-10-02. PMID:19604942. |
the cholinergic enzymes, choline acetyltransferase and acetylcholinesterase, and the muscarinic cholinergic receptor binding, measured in autopsy human brain, undergo significant variations in activity which are related to the time of death. |
2012-10-02 |
2023-08-12 |
human |
| Lauren Meredith Willis, Barbara Shukitt-Hale, James A Josep. Dietary polyunsaturated fatty acids improve cholinergic transmission in the aged brain. Genes & nutrition. vol 4. issue 4. 2012-10-02. PMID:19727886. |
despite years of research, pharmacological interventions to treat or forestall the development of alzheimer's disease have primarily focused on enhancing cholinergic transmission, either through increasing acetylcholine (ach) synthesis or inhibition of the acetylcholinesterase enzyme responsible for ach hydrolysis. |
2012-10-02 |
2023-08-12 |
Not clear |
| H Bree. Characterization of synaptosomes from the central nervous system of insects. Neurochemistry international. vol 3. issue 2. 2012-10-02. PMID:20487820. |
cholinergic activities (choline acetyltransferase, acetylcholinesterase, acetylcholine receptors) were found to be concentrated in the synaptosomal fraction. |
2012-10-02 |
2023-08-12 |
Not clear |
| N Morel, P Dreyfu. Association of acetylcholinesterase with the external surface of the presynaptic plasma membrane in Torpedo electric organ. Neurochemistry international. vol 4. issue 4. 2012-10-02. PMID:20487879. |
a high acetylcholinesterase (ache) activity was found associated with pure cholinergic synaptosomes prepared from torpedo electric organ. |
2012-10-02 |
2023-08-12 |
Not clear |
| A Barat, J Gómez-Barriocanal, G Ramíre. Two classes of collagen-tailed, asymmetric molecular forms of acetylcholinesterase in skeletal muscle: differential effects of denervation. Neurochemistry international. vol 6. issue 3. 2012-10-02. PMID:20488062. |
skeletal muscles of different vertebrate species contain, as it is the case in other cholinergic tissues, two classes of collagen-tailed, asymmetric forms (a-forms) of acetylcholinesterase (ache). |
2012-10-02 |
2023-08-12 |
rat |
| D M Evans, P J Richardson, A Fine, W T Mason, J Oliver Doll. Relationship of acceptors for botulinum neurotoxins (types A and B) in rat CNS with the cholinergic marker, chol-I. Neurochemistry international. vol 13. issue 1. 2012-10-02. PMID:20501268. |
ibotenic acid lesions of the cortical cholinergic tract caused a small reduction in the content of high affinity binding sites for type a neurotoxin and a concomitant decrease in the activities of acetylcholinesterase and choline acetyltransferase. |
2012-10-02 |
2023-08-12 |
rat |
| B Earley, A Biegon, B E Leonar. Quantitative autoradiographic analysis of muscarinic receptors and quantitative histochemistry of acetylcholinesterase in the rat brain after trimethyltin intoxication. Neurochemistry international. vol 15. issue 4. 2012-10-02. PMID:20504522. |
the influence of trimethyl tin (tmt) intoxication on muscarinic cholinergic receptors and histochemistry of acetylcholinesterase (ache) in the rat brain 21 days after treatment was studied. |
2012-10-02 |
2023-08-12 |
rat |
| A Szabó, J Nemcsók, P Kása, K Guly. Muscarinic cholinergic components in the carp brain. Neurochemistry international. vol 15. issue 4. 2012-10-02. PMID:20504527. |
the activity of the muscarinic cholinergic system (acetylcholine, ach; acetylcholinesterase, ache; choline acetyltransferase, chat; muscarinic acetylcholine receptors) was studied in the carp brain. |
2012-10-02 |
2023-08-12 |
Not clear |
| A D Taranalli, T C Cheeramkuzh. Influence of clitoria ternatea extracts on memory and central cholinergic activity in rats. Pharmaceutical biology. vol 38. issue 1. 2012-10-02. PMID:21214440. |
in order to delineate the possible mechanism through which c. ternatea elicits the anti-amnesic effects, we studied its influence on central cholinergic activity by estimating the acetylcholine content of the whole brain and acetylcholinesterase activity at different regions of the rat brain, viz., cerebral cortex, midbrain, medulla oblongata and cerebellum. |
2012-10-02 |
2023-08-12 |
rat |
| M K Schulz, J A McNulty, T P Hogan, J Zimmer, A J Castr. Biochemical and anatomical analysis of cholinergic, noradrenergic and serotonergic innervation of fetal neocortical transplants placed in excitotoxin-induced neocortical lesions of adult rats. Restorative neurology and neuroscience. vol 7. issue 3. 2012-10-02. PMID:21551780. |
cholinergic fiber innervation was examined at 3 months post grafting by measuring acetylcholinesterase (ache) and choline acetyl-transferase (chat) enzyme activities within the grafts and within the corresponding host cortex by radiochemical enzyme assays as well as by ache histochemistry for the visualization of ache positive fibers. |
2012-10-02 |
2023-08-12 |
rat |
| C N Pope, J Li. Age-related differences in sensitivity to organophosphorus pesticides. Environmental toxicology and pharmacology. vol 4. issue 3-4. 2012-10-02. PMID:21781839. |
the primary mechanism of action for op insecticides is inhibition of acetylcholinesterase (ache), an enzyme dynamically involved in cholinergic neurotransmission. |
2012-10-02 |
2023-08-12 |
rat |
| V Paul, P Ekambaram, A R Jayakuma. Effects of sodium fluoride on locomotor behavior and a few biochemical parameters in rats. Environmental toxicology and pharmacology. vol 6. issue 3. 2012-10-02. PMID:21781893. |
a cholinergic mechanism through a change in the activity of acetylcholinesterase may not account for this effect, since sodium fluoride treatment did not alter the activity this enzyme in brain regions. |
2012-10-02 |
2023-08-12 |
rat |