| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohammad-Reza Zarrindast, Ailar Sroushi, Maryam Bananej, Nasim Vousooghi, Shokouh Hamidkhanih. Involvement of the dopaminergic receptors of the rat basolateral amygdala in anxiolytic-like effects of the cholinergic system. European journal of pharmacology. vol 672. issue 1-3. 2012-03-07. PMID:21968140. |
we have studied the effect of cholinergic system activation in the basolateral amygdala on anxiety-related behaviors in adult male wistar rats using the acetylcholinesterase inhibitor physostigmine. |
2012-03-07 |
2023-08-12 |
rat |
| Hong-Jye Hong, Po-Yuan Chen, Tzu-Ching Shih, Che-Yen Ou, Mien-De Jhuo, Yen-Yu Huang, Chia-Hsing Cheng, Yu-Chi Wu, Jing-Gung Chun. Computational pharmaceutical analysis of anti-Alzheimer's Chinese medicine Coptidis Rhizoma alkaloids. Molecular medicine reports. vol 5. issue 1. 2012-02-27. PMID:22002431. |
most pharmacological research has focused on the ability of acetylcholinesterase to alleviate cholinergic deficit and improve neurotransmission. |
2012-02-27 |
2023-08-12 |
Not clear |
| I Erdogan Orhan, G Orhan, E Gurka. An overview on natural cholinesterase inhibitors--a multi-targeted drug class--and their mass production. Mini reviews in medicinal chemistry. vol 11. issue 10. 2012-02-15. PMID:21762104. |
cholinesterase enzyme family consisting of acetylcholinesterase (ache) and butrylcholinesterase (bche) is important in pathogenesis of alzheimer's disease (ad), explained by "cholinergic hypothesis". |
2012-02-15 |
2023-08-12 |
Not clear |
| Rita Romani, Roberta Galeazzi, Gabriella Rosi, Rosamaria Fiorini, Irene Pirisinu, Annarina Ambrosini, Giovanna Zoles. Anandamide and its congeners inhibit human plasma butyrylcholinesterase. Possible new roles for these endocannabinoids? Biochimie. vol 93. issue 9. 2012-02-03. PMID:21664223. |
butyrylcholinesterase (bche), a serine hydrolase biochemically related to the cholinergic enzyme acetylcholinesterase (ache), is found in many mammalian tissues, such as serum and central nervous system, but its physiological role is still unclear. |
2012-02-03 |
2023-08-12 |
human |
| M Sánchez-Guerra, N Pérez-Herrera, B Quintanilla-Veg. Organophosphorous pesticides research in Mexico: epidemiological and experimental approaches. Toxicology mechanisms and methods. vol 21. issue 9. 2012-01-30. PMID:22003926. |
studies in agricultural workers from several regions of the country reported moderate to severe cholinergic symptoms, including decreased acetylcholinesterase (ache) activity (the main acute op toxic effect that causes an over accumulation of the neurotransmitter acetylcholine), revealing the potential risk of intoxication of mexican farmers. |
2012-01-30 |
2023-08-12 |
human |
| Andrew T Allen, Kathryn N Maher, Khursheed A Wani, Katherine E Betts, Daniel L Chas. Coexpressed D1- and D2-like dopamine receptors antagonistically modulate acetylcholine release in Caenorhabditis elegans. Genetics. vol 188. issue 3. 2012-01-17. PMID:21515580. |
to investigate the interaction between the d1- and d2-like receptors specifically in these cholinergic motor neurons, we measured the sensitivity of dopamine-signaling mutants and transgenic animals to the acetylcholinesterase inhibitor aldicarb. |
2012-01-17 |
2023-08-12 |
caenorhabditis_elegans |
| Daniel P Holschneider, Yumei Guo, Margareth Roch, Keith M Norman, Oscar U Scremi. Acetylcholinesterase inhibition and locomotor function after motor-sensory cortex impact injury. Journal of neurotrauma. vol 28. issue 9. 2012-01-16. PMID:21787180. |
the hypothesis that enhancement of cholinergic function by inhibition of acetylcholinesterase (ache) improves locomotion following tbi was tested in sprague-dawley male rats after a unilateral controlled cortical impact (cci) injury of the motor-sensory cortex. |
2012-01-16 |
2023-08-12 |
rat |
| G RamaRao, B K Bhattacharya, Subodh Kumar, C K Waghmar. Gene expression and phosphoprotein profile of certain key neuronal signaling proteins following soman intoxication. Toxicology. vol 290. issue 2-3. 2012-01-12. PMID:21971501. |
nerve agents irreversibly inhibit acetylcholinesterase (ache), leading to cholinergic crisis and death at acute exposure levels. |
2012-01-12 |
2023-08-12 |
Not clear |
| Ben Avi Weissman, Lily Rave. Multifunctional drugs as novel antidotes for organophosphates' poisoning. Toxicology. vol 290. issue 2-3. 2012-01-12. PMID:21978866. |
indeed, therapy comprised of an acetylcholinesterase reactivator (i.e., oxime) and a cholinergic antagonist (e.g., atropine) is the accepted major paradigm for protection. |
2012-01-12 |
2023-08-12 |
Not clear |
| Raffaele Nardone, Stefan Golaszewski, Gunther Ladurner, Frediano Tezzon, Eugen Trink. A review of transcranial magnetic stimulation in the in vivo functional evaluation of central cholinergic circuits in dementia. Dementia and geriatric cognitive disorders. vol 32. issue 1. 2012-01-11. PMID:21822020. |
since sai can be increased by acetylcholinesterase inhibitors, tms may help in identifying the patients who would be suitable for long-term treatment with cholinergic agents. |
2012-01-11 |
2023-08-12 |
human |
| Mikihiko Arikawa, Yoshihiko Kakinuma, Takemi Handa, Fumiyasu Yamasaki, Takayuki Sat. Donepezil, anti-Alzheimer's disease drug, prevents cardiac rupture during acute phase of myocardial infarction in mice. PloS one. vol 6. issue 7. 2011-12-27. PMID:21750701. |
we have previously demonstrated that the chronic intervention in the cholinergic system by donepezil, an acetylcholinesterase inhibitor, plays a beneficial role in suppressing long-term cardiac remodeling after myocardial infarction (mi). |
2011-12-27 |
2023-08-12 |
mouse |
| Joaquim Cerejeira, Pedro Batista, Vasco Nogueira, Horácio Firmino, Adriano Vaz-Serra, Elizabeta B Mukaetova-Ladinsk. Low preoperative plasma cholinesterase activity as a risk marker of postoperative delirium in elderly patients. Age and ageing. vol 40. issue 5. 2011-12-09. PMID:21576115. |
cholinergic dysfunction has been implicated in delirium pathophysiology and plasmatic acetylcholinesterase (ache) and butyrylcholinesterase (buche) activities are suppressed in patients with delirium. |
2011-12-09 |
2023-08-12 |
Not clear |
| Bombi Lee, Insop Shim, Hyejung Lee, Dae-Hyun Hah. Rehmannia glutinosa ameliorates scopolamine-induced learning and memory impairment in rats. Journal of microbiology and biotechnology. vol 21. issue 8. 2011-12-05. PMID:21876380. |
changes in cholinergic system reactivity were also examined by measuring the immunoreactive neurons of choline acetyltransferase (chat) and the reactivity of acetylcholinesterase (ache) in the hippocampus. |
2011-12-05 |
2023-08-12 |
rat |
| Songmi Kim, Yuno Lee, Prettina Lazar, Minky Son, Ayoung Baek, Sundarapandian Thangapandian, Na Young Jeong, Young Hyun Yoo, Keun Woo Le. Binding conformation prediction between human acetylcholinesterase and cytochrome c using molecular modeling methods. Journal of molecular graphics & modelling. vol 29. issue 8. 2011-12-01. PMID:21570330. |
the acetylcholinesterase (ache) is important to terminate acetylcholine-mediated neurotransmission at cholinergic synapses. |
2011-12-01 |
2023-08-12 |
human |
| Michael Adler, Richard E Sweeney, Tracey A Hamilton, Oksana Lockridge, Ellen G Duysen, Angela L Purcell, Sharad S Deshpand. Role of acetylcholinesterase on the structure and function of cholinergic synapses: insights gained from studies on knockout mice. Cellular and molecular neurobiology. vol 31. issue 6. 2011-11-30. PMID:21538119. |
role of acetylcholinesterase on the structure and function of cholinergic synapses: insights gained from studies on knockout mice. |
2011-11-30 |
2023-08-12 |
mouse |
| Sture Forsgren, Håkan Alfredson, Dennis Bjur, Solbritt Rantapää-Dahlqvist, Orjan Norrgård, Tore Dalén, Patrik Danielso. Novel information on the non-neuronal cholinergic system in orthopedics provides new possible treatment strategies for inflammatory and degenerative diseases. Orthopedic reviews. vol 1. issue 1. 2011-11-10. PMID:21808665. |
therapy regimens aimed at up-regulating cholinergic functions, such as treatment with acetylcholinesterase inhibitors, are also currently prescribed. |
2011-11-10 |
2023-08-12 |
Not clear |
| M Kox, J C Pompe, E Peters, M Vaneker, J W van der Laak, J G van der Hoeven, G J Scheffer, C W Hoedemaekers, P Pickker. α7 nicotinic acetylcholine receptor agonist GTS-21 attenuates ventilator-induced tumour necrosis factor-α production and lung injury. British journal of anaesthesia. vol 107. issue 4. 2011-10-31. PMID:21771746. |
furthermore, we investigated whether altering endogenous cholinergic signalling, by administration of the non-specific nachr antagonist mecamylamine and the peripherally acting acetylcholinesterase inhibitor neostigmine, modulates the mv-induced inflammatory response. |
2011-10-31 |
2023-08-12 |
Not clear |
| Renato Scacchi, Maria Ruggeri, Rosa Maria Corb. Variation of the butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) genes in coronary artery disease. Clinica chimica acta; international journal of clinical chemistry. vol 412. issue 15-16. 2011-09-30. PMID:21473860. |
butyrylcholinesterase (bche) and acetylcholinesterase (ache) are two enzymes of the cholinergic system putatively involved in coronary artery disease (cad). |
2011-09-30 |
2023-08-12 |
human |
| Yukio Ago, Ken Koda, Kazuhiro Takuma, Toshio Matsud. Pharmacological aspects of the acetylcholinesterase inhibitor galantamine. Journal of pharmacological sciences. vol 116. issue 1. 2011-09-22. PMID:21498956. |
since galantamine is a rather weak acetylcholinesterase inhibitor, but has additional allosteric potentiating effects at nicotinic receptors, it affects not only cholinergic transmission but also other neurotransmitter systems such as monoamines, glutamate, and γ-aminobutyric acid (gaba) through its allosteric mechanism. |
2011-09-22 |
2023-08-12 |
Not clear |
| Sergio Zarazúa, Susanne Bürger, Juan M Delgado, Maria E Jiménez-Capdeville, Reinhard Schlieb. Arsenic affects expression and processing of amyloid precursor protein (APP) in primary neuronal cells overexpressing the Swedish mutation of human APP. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 29. issue 4. 2011-09-13. PMID:21440049. |
exposure of cholinergic sn56.b5.g4 cells with either sodium arsenite or dma decreased cell viability in a concentration- and exposure-time dependent manner, and affected the activities of the cholinergic enzymes acetylcholinesterase and choline acetyltransferase. |
2011-09-13 |
2023-08-12 |
mouse |