| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| O Soukup, Z Kristofikova, J Proska, G Tobin, J Patocka, J Marek, D Jun, J Fusek, D Ripova, K Kuc. Novel acetylcholinesterase reactivator K112 and its cholinergic properties. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 64. issue 8. 2011-02-09. PMID:20634031. |
novel acetylcholinesterase reactivator k112 and its cholinergic properties. |
2011-02-09 |
2023-08-12 |
rat |
| Hajer Attig, Alessandro Dagnino, Alessandro Negri, Jamel Jebali, Hamadi Boussetta, Aldo Viarengo, Francesco Dondero, Mohamed Bann. Uptake and biochemical responses of mussels Mytilus galloprovincialis exposed to sublethal nickel concentrations. Ecotoxicology and environmental safety. vol 73. issue 7. 2011-01-24. PMID:20800282. |
the cholinergic system was evaluated using the acetylcholinesterase activity (ache). |
2011-01-24 |
2023-08-12 |
Not clear |
| Mohammad A Kamal, M Reale, Abdulaziz A Al-Jafar. Multiple approaches to analyse the data for rat brain acetylcholinesterase inhibition by cyclophosphamide. Neurochemical research. vol 35. issue 10. 2011-01-18. PMID:20652634. |
acetylcholinesterase (ache) is an externally oriented membrane-bound enzyme and its main physiological role is termination of chemical transmission at cholinergic synapses and secretory organs by rapid hydrolysis of the neurotransmitter acetylcholine (ach). |
2011-01-18 |
2023-08-12 |
rat |
| Jan Korabecny, Kamil Musilek, Ondrej Holas, Jiri Binder, Filip Zemek, Jan Marek, Miroslav Pohanka, Veronika Opletalova, Vlastimil Dohnal, Kamil Kuc. Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease. Bioorganic & medicinal chemistry letters. vol 20. issue 20. 2011-01-13. PMID:20817518. |
among them, acetylcholinesterase inhibitors (acheis) are used to increase the cholinergic activity. |
2011-01-13 |
2023-08-12 |
human |
| Zaineb Henderson, Nazia Matto, Danielle John, Natalia N Nalivaeva, Anthony J Turne. Co-localization of PRiMA with acetylcholinesterase in cholinergic neurons of rat brain: an immunocytochemical study. Brain research. vol 1344. 2011-01-10. PMID:20471375. |
co-localization of prima with acetylcholinesterase in cholinergic neurons of rat brain: an immunocytochemical study. |
2011-01-10 |
2023-08-12 |
rat |
| Nidhi Sharma, Rahul Deshmukh, K L Bed. SP600125, a competitive inhibitor of JNK attenuates streptozotocin induced neurocognitive deficit and oxidative stress in rats. Pharmacology, biochemistry, and behavior. vol 96. issue 4. 2010-12-23. PMID:20600246. |
in addition, significant increase in acetylcholinesterase activity and lactate dehydrogenase (ldh) levels was observed in the present model indicating cholinergic hypofunction and increase in neuronal cell damage. |
2010-12-23 |
2023-08-12 |
rat |
| Nidhi Sharma, Rahul Deshmukh, K L Bed. SP600125, a competitive inhibitor of JNK attenuates streptozotocin induced neurocognitive deficit and oxidative stress in rats. Pharmacology, biochemistry, and behavior. vol 96. issue 4. 2010-12-23. PMID:20600246. |
whereas, sp600125 treatment significantly restored acetylcholinesterase activity and reduced ldh levels indicating restorative capacity of sp600125 with respect to cholinergic functions and preventing the neuronal damage. |
2010-12-23 |
2023-08-12 |
rat |
| Alejandro Romero, Javier Egea, Antonio G García, Manuela G Lópe. Synergistic neuroprotective effect of combined low concentrations of galantamine and melatonin against oxidative stress in SH-SY5Y neuroblastoma cells. Journal of pineal research. vol 49. issue 2. 2010-12-17. PMID:20536682. |
on the other hand, galantamine is a cholinergic drug with antioxidant and neuroprotective properties linked to inhibition of acetylcholinesterase and allosteric modulation of nicotinic receptors. |
2010-12-17 |
2023-08-12 |
human |
| M Figueiró, J Ilha, D Pochmann, L O Porciúncula, L L Xavier, M Achaval, D S Nunes, E Elisabetsk. Acetylcholinesterase inhibition in cognition-relevant brain areas of mice treated with a nootropic Amazonian herbal (Marapuama). Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 17. issue 12. 2010-12-15. PMID:20833520. |
the goal of acetylcholinesterase inhibitors (acheis) used to treat alzheimer's patients is an improvement in cholinergic transmission. |
2010-12-15 |
2023-08-12 |
mouse |
| Douglas H Adams, Christian Sonne, Niladri Basu, Rune Dietz, Dong-Ha Nam, Pall S Leifsson, Asger L Jense. Mercury contamination in spotted seatrout, Cynoscion nebulosus: an assessment of liver, kidney, blood, and nervous system health. The Science of the total environment. vol 408. issue 23. 2010-12-13. PMID:20850170. |
neurochemical analyses showed that brain n-methyl-d-aspartic acid (nmda) receptors (but not those of muscarinic cholinergic receptors, monoamine oxidase, or acetylcholinesterase) were significantly less in fish from south florida than from indian river lagoon. |
2010-12-13 |
2023-08-12 |
Not clear |
| David M Pereira, Federico Ferreres, Jorge M A Oliveira, Luís Gaspar, Joana Faria, Patrícia Valentão, Mariana Sottomayor, Paula B Andrad. Pharmacological effects of Catharanthus roseus root alkaloids in acetylcholinesterase inhibition and cholinergic neurotransmission. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 17. issue 8-9. 2010-12-03. PMID:19962870. |
pharmacological effects of catharanthus roseus root alkaloids in acetylcholinesterase inhibition and cholinergic neurotransmission. |
2010-12-03 |
2023-08-12 |
rat |
| Yoshihiko Kakinuma, Mutsuo Furihata, Tsuyoshi Akiyama, Mikihiko Arikawa, Takemi Handa, Rajesh G Katare, Takayuki Sat. Donepezil, an acetylcholinesterase inhibitor against Alzheimer's dementia, promotes angiogenesis in an ischemic hindlimb model. Journal of molecular and cellular cardiology. vol 48. issue 4. 2010-11-16. PMID:19962381. |
therefore, we assessed the hypothesis that the cholinergic modulator donepezil, an acetylcholinesterase inhibitor utilized in alzheimer's disease, exhibits beneficial effects, especially on the acceleration of angiogenesis. |
2010-11-16 |
2023-08-12 |
mouse |
| Tatsuya Kikuchi, Toshimitsu Okamura, Kiyoshi Fukushi, Toshiaki Iri. Piperidine-4-methanthiol ester derivatives for a selective acetylcholinesterase assay. Biological & pharmaceutical bulletin. vol 33. issue 4. 2010-11-12. PMID:20410609. |
the activity of acetylcholinesterase (ache) is measured to obtain pathological information about the cholinergic system in various disease states and to assess the effect of ache inhibitors. |
2010-11-12 |
2023-08-12 |
human |
| Cyndya Shibao, Luis E Okamoto, Alfredo Gamboa, Chang Yu, Andre' Diedrich, Satish R Raj, David Robertson, Italo Biaggion. Comparative efficacy of yohimbine against pyridostigmine for the treatment of orthostatic hypotension in autonomic failure. Hypertension (Dallas, Tex. : 1979). vol 56. issue 5. 2010-11-10. PMID:20837887. |
alternatively, the acetylcholinesterase inhibitor, pyridostigmine, can increase sympathetic tone by improving ganglionic cholinergic neurotransmission. |
2010-11-10 |
2023-08-12 |
Not clear |
| Bombi Lee, Bong-Jun Sur, Jeong-Jun Han, Insop Shim, Song Her, Hye-Jung Lee, Dae-Hyun Hah. Krill phosphatidylserine improves learning and memory in Morris water maze in aged rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 34. issue 6. 2010-11-02. PMID:20677367. |
changes in the cholinergic system were examined by measuring choline acetyltransferase (chat) and acetylcholinesterase (ache) immunoreactivity in the hippocampus. |
2010-11-02 |
2023-08-12 |
rat |
| Yoshihiko Ito, Taketsugu Harada, Kasumi Fushimi, Yoshiyuki Kagawa, Hidenobu Oka, Hiroshi Nakazawa, Reiko Homma, Yoshihisa Kato, Shizuo Yamad. Pharmacokinetic and pharmacodynamic analysis of acetylcholinesterase inhibition by distigmine bromide in rats. Drug metabolism and pharmacokinetics. vol 25. issue 3. 2010-10-12. PMID:20610884. |
distigmine bromide (distigmine) is associated with a serious adverse reaction, cholinergic crisis, due to a marked decrease in serum acetylcholinesterase (ache) levels. |
2010-10-12 |
2023-08-12 |
rat |
| Chunyuan Luo, Carolyn Chambers, Nagarajan Pattabiraman, Min Tong, Prasanthi Tipparaju, Ashima Saxen. Y124 at the peripheral anionic site is important for the reactivation of nerve agent-inhibited acetylcholinesterase by H oximes. Biochemical pharmacology. vol 80. issue 9. 2010-10-06. PMID:20655881. |
the toxicity of organophosphorus (op) nerve agents is manifested through irreversible inhibition of acetylcholinesterase (ache) at the cholinergic synapses, which stops nerve signal transmission, resulting in a cholinergic crisis and eventually death of the poisoned person. |
2010-10-06 |
2023-08-12 |
human |
| Ethika Tyagi, Rahul Agrawal, Chandishwar Nath, Rakesh Shukl. Effect of melatonin on neuroinflammation and acetylcholinesterase activity induced by LPS in rat brain. European journal of pharmacology. vol 640. issue 1-3. 2010-10-04. PMID:20450904. |
to study the cholinergic intervention during neuroinflammatory conditions acetylcholinesterase (ache) enzyme activity was taken as marker of cholinergic activity. |
2010-10-04 |
2023-08-12 |
rat |
| Steeve Hervé Thany, Hélène Tricoire-Leignel, Bruno Lapie. Identification of cholinergic synaptic transmission in the insect nervous system. Advances in experimental medicine and biology. vol 683. 2010-09-30. PMID:20737784. |
a major criteria initially used to localize cholinergic neuronal elements in nervous systems tissues that involve acetylcholine (ach) as neurotransmitter is mainly based on immunochemical studies using choline acetyltransferase (chat), an enzyme which catalyzes ach biosynthesis and the ach degradative enzyme named acetylcholinesterase (ache). |
2010-09-30 |
2023-08-12 |
Not clear |
| Yanzi Zhou, Shenglong Wang, Yingkai Zhan. Catalytic reaction mechanism of acetylcholinesterase determined by Born-Oppenheimer ab initio QM/MM molecular dynamics simulations. The journal of physical chemistry. B. vol 114. issue 26. 2010-09-27. PMID:20550161. |
acetylcholinesterase (ache) is a remarkably efficient serine hydrolase responsible for the termination of impulse signaling at cholinergic synapses. |
2010-09-27 |
2023-08-12 |
Not clear |