| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Natalia Wszelaki, Agnieszka Kuciun, Anna Karolina Kis. Screening of traditional European herbal medicines for acetylcholinesterase and butyrylcholinesterase inhibitory activity. Acta pharmaceutica (Zagreb, Croatia). vol 60. issue 1. 2010-09-23. PMID:20228046. |
acetylcholinesterase (ache) inhibitors are widely used for the symptomatic treatment of alzheimer's disease (ad) to enhance central cholinergic transmission. |
2010-09-23 |
2023-08-12 |
Not clear |
| K Matsueda, M Hongo, J Tack, H Aoki, Y Saito, H Kat. Clinical trial: dose-dependent therapeutic efficacy of acotiamide hydrochloride (Z-338) in patients with functional dyspepsia - 100 mg t.i.d. is an optimal dosage. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 22. issue 6. 2010-09-16. PMID:20059698. |
acotiamide is a selective acetylcholinesterase inhibitor and enhances the actions of cholinergic neurons localized in the stomach. |
2010-09-16 |
2023-08-12 |
Not clear |
| Peter Eyer, Franz Worek, Horst Thiermann, Michael Eddlesto. Paradox findings may challenge orthodox reasoning in acute organophosphate poisoning. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:19883634. |
it is generally accepted that inhibition of acetylcholinesterase (ache) is the most important acute toxic action of organophosphorus compounds, leading to accumulation of acetylcholine followed by a dysfunction of cholinergic signaling. |
2010-09-01 |
2023-08-12 |
mouse |
| Horst Thiermann, Thomas Seeger, Sascha Gonder, Nadja Herkert, Bernd Antkowiak, Thomas Zilker, Florian Eyer, Franz Wore. Assessment of neuromuscular dysfunction during poisoning by organophosphorus compounds. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:20036651. |
it is both of central and peripheral origin due to impaired cholinergic signalling upon inhibition of acetylcholinesterase (ache). |
2010-09-01 |
2023-08-12 |
human |
| Hay Dvir, Israel Silman, Michal Harel, Terrone L Rosenberry, Joel L Sussma. Acetylcholinesterase: from 3D structure to function. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:20138030. |
by rapid hydrolysis of the neurotransmitter, acetylcholine, acetylcholinesterase terminates neurotransmission at cholinergic synapses. |
2010-09-01 |
2023-08-12 |
human |
| Julian R Haigh, Michael Adler, James P Apland, Sharad S Deshpande, Charles B Barham, Patrick Desmond, Irwin Koplovitz, David E Lenz, Richard K Gordo. Protection by pyridostigmine bromide of marmoset hemi-diaphragm acetylcholinesterase activity after soman exposure. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:20144889. |
organophosphate (op) chemical warfare agents such as gd exert their toxic effects by inhibiting acetylcholinesterase (ache) from terminating the action of acetylcholine at postsynaptic sites in cholinergic nerve terminals (including crucial peripheral muscle such as diaphragm). |
2010-09-01 |
2023-08-12 |
marmoset |
| Heidi Q Xie, K Wing Leung, Vicky P Chen, Gallant K L Chan, Sherry L Xu, Ava J Y Guo, Kevin Y Zhu, Ken Y Z Zheng, Cathy W Bi, Janis Y X Zhan, Wallace K P Chan, Roy C Y Choi, Karl W K Tsi. PRiMA directs a restricted localization of tetrameric AChE at synapses. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:20178777. |
acetylcholinesterase (ache), a highly polymorphic enzyme with various splicing variants and molecular isoforms, plays an essential role in the cholinergic neurotransmission by hydrolyzing acetylcholine into choline and acetate. |
2010-09-01 |
2023-08-12 |
Not clear |
| Katarina Pegan, Urska Matkovic, Tomaz Mars, Katarina Mis, Sergej Pirkmajer, Janez Brecelj, Zoran Grubi. Acetylcholinesterase is involved in apoptosis in the precursors of human muscle regeneration. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:20338155. |
the best established role of acetylcholinesterase (ec 3.1.1.7, ache) is termination of neurotransmission at cholinergic synapses. |
2010-09-01 |
2023-08-12 |
human |
| M G Aluigi, C Guida, C Falug. Apoptosis as a specific biomarker of diazinon toxicity in NTera2-D1 cells. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:20338157. |
its property to express a whole set of molecules related to the cholinergic neurotransmission system, including active acetylcholinesterase (ache, ec 3.1.1.7) makes it a good alternative model for testing the effects of neurotoxic compounds, such as organophosphorus (op) insecticides, whose primary target is the inhibition of ache activity. |
2010-09-01 |
2023-08-12 |
human |
| Zaheer-ul-Haq, Sobia Ahsan Halim, Reaz Uddin, Jeffry D Madur. Benchmarking docking and scoring protocol for the identification of potential acetylcholinesterase inhibitors. Journal of molecular graphics & modelling. vol 28. issue 8. 2010-08-12. PMID:20447848. |
acetylcholinesterase (ache) plays a crucial role in nerve impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter acetylcholine (ach). |
2010-08-12 |
2023-08-12 |
Not clear |
| Harald John, Michael Eddleston, R Eddie Clutton, Franz Worek, Horst Thierman. Simultaneous quantification of the organophosphorus pesticides dimethoate and omethoate in porcine plasma and urine by LC-ESI-MS/MS and flow-injection-ESI-MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 878. issue 17-18. 2010-08-10. PMID:20106727. |
it also exhibits toxic activity towards mammalian organism provoked by catalytic desulfuration in the liver producing its oxon-derivative omethoate thus inhibiting acetylcholinesterase, initiating cholinergic crisis and ultimately leading to death by respiratory paralysis and cardiovascular collapse. |
2010-08-10 |
2023-08-12 |
Not clear |
| Sherri Young, Karine Fabio, Christophe Guillon, Pramod Mohanta, Timothy A Halton, Diane E Heck, Robert A Flowers, Jeffrey D Laskin, Ned D Heinde. Peripheral site acetylcholinesterase inhibitors targeting both inflammation and cholinergic dysfunction. Bioorganic & medicinal chemistry letters. vol 20. issue 9. 2010-07-27. PMID:20347302. |
peripheral site acetylcholinesterase inhibitors targeting both inflammation and cholinergic dysfunction. |
2010-07-27 |
2023-08-12 |
Not clear |
| Sang-Hoon Lee, Jin-Sook Park, Se-Kwon Kim, Chang-Bum Ahn, Jae-Young J. Chitooligosaccharides suppress the level of protein expression and acetylcholinesterase activity induced by Abeta25-35 in PC12 cells. Bioorganic & medicinal chemistry letters. vol 19. issue 3. 2010-07-06. PMID:19097785. |
clinical applications of acetylcholinesterase (ache) inhibitors are widespread in alzheimer's sufferers in order to activate central cholinergic system and alleviate cognitive deficits by inhibiting the hydrolysis of acetylcholine. |
2010-07-06 |
2023-08-12 |
Not clear |
| Gracielle Alves-Amaral, Marcelo Pires-Oliveira, Ana Luiza Andrade-Lopes, Tiago Chiavegatti, Rosely Oliveira Godinh. Gender-related differences in circadian rhythm of rat plasma acetyl- and butyrylcholinesterase: effects of sex hormone withdrawal. Chemico-biological interactions. vol 186. issue 1. 2010-07-01. PMID:20399201. |
the role of acetylcholinesterase (ache) in the termination of the cholinergic response through acetylcholine (ach) hydrolysis and the involvement of plasma butyrylcholinesterase (buche), mainly of hepatic origin, in the metabolism of xenobiotics with ester bonds is well known. |
2010-07-01 |
2023-08-12 |
rat |
| Jean Marc Miezan Ezoulin, Bi-Yun Shao, Zheng Xia, Qiong Xie, Juan Li, Yong-Yao Cui, Hao Wang, Chang-Zhi Dong, Yan-Xing Zhao, France Massicot, Zhui-Bai Qiu, Françoise Heymans, Hong-Zhuan Che. Novel piperazine derivative PMS1339 exhibits tri-functional properties and cognitive improvement in mice. The international journal of neuropsychopharmacology. vol 12. issue 10. 2010-06-29. PMID:19460190. |
the acetylcholinesterase (ache) inhibitors are the first class of drugs used to enhance surviving cholinergic activities. |
2010-06-29 |
2023-08-12 |
mouse |
| Philippe Anglade, Yamina Larabi-Godino. Historical landmarks in the histochemistry of the cholinergic synapse: Perspectives for future researches. Biomedical research (Tokyo, Japan). vol 31. issue 1. 2010-06-22. PMID:20203414. |
this report presents historical landmarks in the histochemistry of major cholinergic agents (acetylcholinesterase, nicotinic acetylcholine receptor, choline acetyltransferase, and ach), a domain which has greatly contributed to the knowledge of the nerve system. |
2010-06-22 |
2023-08-12 |
Not clear |
| Yvonne Rook, Kai-Uwe Schmidtke, Friedemann Gaube, Dirk Schepmann, Bernhard Wünsch, Jörg Heilmann, Jochen Lehmann, Thomas Winckle. Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents. Journal of medicinal chemistry. vol 53. issue 9. 2010-06-11. PMID:20361801. |
inhibitors of acetylcholinesterase (ache) and butyrylcholinesterase (bche) improve cholinergic signaling in the central nervous system and thus ache inhibitors are well established in the therapy of ad to improve memory disturbances and other cognitive symptoms. |
2010-06-11 |
2023-08-12 |
Not clear |
| Picheng Zhao, Kun Yan Zhu, Haobo Jian. Heterologous expression, purification, and biochemical characterization of a greenbug (Schizaphis graminum) acetylcholinesterase encoded by a paralogous gene (ace-1). Journal of biochemical and molecular toxicology. vol 24. issue 1. 2010-05-13. PMID:20146377. |
acetylcholinesterase is a critical enzyme in the regulation of cholinergic neurotransmission in insects. |
2010-05-13 |
2023-08-12 |
Not clear |
| Denis V Abramochkin, Leniz F Nurullin, Anastasia A Borodinova, Nadezhda V Tarasova, Galina S Sukhova, Eugen E Nikolsky, Leonid V Rosenshtrauk. Non-quantal release of acetylcholine from parasympathetic nerve terminals in the right atrium of rats. Experimental physiology. vol 95. issue 2. 2010-05-06. PMID:19767403. |
acetylcholinesterase (ache) inhibitors provoke typical cholinergic effects in the isolated right atrium of the rat due to the accumulation of acetylcholine (ach). |
2010-05-06 |
2023-08-12 |
rat |
| Chiara Scanarotti, Anna Maria Bassi, Mariafrancesca Catalano, Chiara Guida, Rosella Coradeghini, Carla Falugi, Mariagrazia Aluigi, Pierluigi Santi, Edoardo Raposi. Neurogenic-committed human pre-adipocytes express CYP1A isoforms. Chemico-biological interactions. vol 184. issue 3. 2010-05-04. PMID:20080079. |
to evaluate neurogenic differentiation, we analysed expression of cholinergic system and acetylcholinesterase immunoreactivity. |
2010-05-04 |
2023-08-12 |
human |