| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| María Isabel Fernández-Bachiller, Concepción Pérez, Nuria Eugenia Campillo, Juan Antonio Páez, Gema Cristina González-Muñoz, Paola Usán, Esther García-Palomero, Manuela G López, Mercedes Villarroya, Antonio G García, Ana Martínez, María Isabel Rodríguez-Franc. Tacrine-melatonin hybrids as multifunctional agents for Alzheimer's disease, with cholinergic, antioxidant, and neuroprotective properties. ChemMedChem. vol 4. issue 5. 2009-07-27. PMID:19308922. |
they show improved cholinergic and antioxidant properties, and are more potent and selective inhibitors of human acetylcholinesterase (hache) than tacrine. |
2009-07-27 |
2023-08-12 |
human |
| Andrea R Stapleton, Victor T Cha. Subtoxic chlorpyrifos treatment resulted in differential expression of genes implicated in neurological functions and development. Archives of toxicology. vol 83. issue 4. 2009-06-04. PMID:18668222. |
chlorpyrifos (cpf), a commonly used organophosphorus insecticide, induces acetylcholinesterase inhibition and cholinergic toxicity. |
2009-06-04 |
2023-08-12 |
rat |
| M L Bolognesi, M Rosini, V Andrisano, M Bartolini, A Minarini, V Tumiatti, C Melchiorr. MTDL design strategy in the context of Alzheimer's disease: from lipocrine to memoquin and beyond. Current pharmaceutical design. vol 15. issue 6. 2009-05-12. PMID:19199985. |
our first rationally designed mtdl was the polyamine caproctamine (1), which provided a synergistic cholinergic action against ad by antagonizing muscarinic m(2) autoreceptors and inhibiting acetylcholinesterase (ache). |
2009-05-12 |
2023-08-12 |
Not clear |
| Ying Y Jean, Lauren D Lercher, Cheryl F Dreyfu. Glutamate elicits release of BDNF from basal forebrain astrocytes in a process dependent on metabotropic receptors and the PLC pathway. Neuron glia biology. vol 4. issue 1. 2009-04-17. PMID:19267952. |
in initial work bdnf derived from bf-astrocyte-conditioned medium (acm) was found to increase both numbers of bf acetylcholinesterase (ache+) cholinergic neurons and the cholinergic synthetic enzyme choline acetyltransferase (chat). |
2009-04-17 |
2023-08-12 |
Not clear |
| Shahin Akhondzadeh, Maryam Gerami, Maryam Noroozian, Narges Karamghadiri, Aboulfazl Ghoreishi, Seyed-Hesameddin Abbasi, Sams-Ali Rezazade. A 12-week, double-blind, placebo-controlled trial of donepezil adjunctive treatment to risperidone in chronic and stable schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry. vol 32. issue 8. 2009-04-15. PMID:18727948. |
one of the theoretically promising novel treatment candidates is acetylcholinesterase inhibitors that increase the synaptic levels of cholinergic, nicotinic, and muscarinic receptor activity. |
2009-04-15 |
2023-08-12 |
human |
| B P Paudya. Organophosphorus poisoning. JNMA; journal of the Nepal Medical Association. vol 47. issue 172. 2009-04-14. PMID:19079407. |
the toxicity of these op pesticides is due to the irreversible inhibition of acetylcholinesterase (ache) enzyme leading to accumulation of acetylcholine and subsequent over-activation of cholinergic receptors in various parts of the body. |
2009-04-14 |
2023-08-12 |
Not clear |
| Anuradha Nallapaneni, Jing Liu, Subramanya Karanth, Carey Pop. Pharmacological enhancement of endocannabinoid signaling reduces the cholinergic toxicity of diisopropylfluorophosphate. Neurotoxicology. vol 29. issue 6. 2009-03-26. PMID:18765251. |
diisopropylfluorophosphate (dfp) elicits cholinergic toxicity by inhibiting acetylcholinesterase, leading to accumulation of the neurotransmitter acetylcholine and excessive stimulation of cholinergic receptors throughout the body. |
2009-03-26 |
2023-08-12 |
rat |
| Ethika Tyagi, Rahul Agrawal, Chandishwar Nath, Rakesh Shukl. Influence of LPS-induced neuroinflammation on acetylcholinesterase activity in rat brain. Journal of neuroimmunology. vol 205. issue 1-2. 2009-03-19. PMID:18838174. |
proinflammatory cytokines (tnf-alpha and il-1beta), acetylcholinesterase (ache) activity, malondialdehyde (mda) and reduced glutathione (gsh) were studied as markers for neuroinflammation, cholinergic activity and oxidative stress respectively in different brain regions at different time points after lps injection. |
2009-03-19 |
2023-08-12 |
rat |
| R Jazi, R Lalonde, S Qian, C Straziell. Regional brain evaluation of acetylcholinesterase activity in PS1/A246E transgenic mice. Neuroscience research. vol 63. issue 2. 2009-03-17. PMID:19056437. |
forebrain cholinergic innervation was estimated in transgenic mice with the a246e mutation by measuring the activity of the non-specific catabolic enzyme, acetylcholinesterase (ache). |
2009-03-17 |
2023-08-12 |
mouse |
| Cemil Kavalci, Polat Durukan, Mehmet Ozer, Yunsur Cevik, Gülsüm Kavalc. Organophosphate poisoning due to a wheat bagel. Internal medicine (Tokyo, Japan). vol 48. issue 2. 2009-03-09. PMID:19145051. |
organophosphate compounds cause poisoning, inhibiting acetylcholinesterase at the cholinergic synapses. |
2009-03-09 |
2023-08-12 |
Not clear |
| F Nardi, B Barazzuoli, S Ciolfi, A Carapelli, R Dallai, F Frat. Acetylcholinesterase genes in the basal Hexapod Orchesella villosa. Insect molecular biology. vol 18. issue 1. 2009-03-04. PMID:19016914. |
acetylcholinesterase (ache) is a key enzyme of the cholinergic nerve system. |
2009-03-04 |
2023-08-12 |
Not clear |
| Mylène Fréchette, Kerry Rennie, Bruce A Pappa. Developmental forebrain cholinergic lesion and environmental enrichment: behaviour, CA1 cytoarchitecture and neurogenesis. Brain research. vol 1252. 2009-02-27. PMID:19084506. |
intraventricular injections of 192 igg saporin in 7-day-old rat severely reduced hippocampal cholinergic innervation as reflected by both decreased acetylcholinesterase staining and immunoreactivity for the p75 neurotrophin receptor. |
2009-02-27 |
2023-08-12 |
rat |
| Philip J Welsby, Michael J Rowan, Roger Anwy. Intracellular mechanisms underlying the nicotinic enhancement of LTP in the rat dentate gyrus. The European journal of neuroscience. vol 29. issue 1. 2009-02-19. PMID:19077124. |
in particular, the involvement of activation of intracellular kinases was examined using selective kinase antagonists, and the effects of enhancing cholinergic function with positive allosteric modulators of the alpha7 nachr and with acetylcholinesterase (ache) inhibitors were also investigated. |
2009-02-19 |
2023-08-12 |
rat |
| S K Tayebati, M A Di Tullio, F Ament. Vesicular acetylcholine transporter (VAChT) in the brain of spontaneously hypertensive rats (SHR): effect of treatment with an acetylcholinesterase inhibitor. Clinical and experimental hypertension (New York, N.Y. : 1993). vol 30. issue 8. 2009-02-06. PMID:19021024. |
the sensitivity of manipulation of cholinergic system on vacht was assessed in rats treated for four weeks with the acetylcholinesterase (ache) inhibitor galantamine (3 mg/kg/day). |
2009-02-06 |
2023-08-12 |
rat |
| Valentin A Pavlov, William R Parrish, Mauricio Rosas-Ballina, Mahendar Ochani, Margot Puerta, Kanta Ochani, Sangeeta Chavan, Yousef Al-Abed, Kevin J Trace. Brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway. Brain, behavior, and immunity. vol 23. issue 1. 2009-02-03. PMID:18639629. |
brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway. |
2009-02-03 |
2023-08-12 |
mouse |
| Eran Nizri, Michal Irony-Tur-Sinai, Nabil Faranesh, Iris Lavon, Ehud Lavi, Marta Weinstock, Talma Brenne. Suppression of neuroinflammation and immunomodulation by the acetylcholinesterase inhibitor rivastigmine. Journal of neuroimmunology. vol 203. issue 1. 2009-02-02. PMID:18692909. |
in this study we determined the influence of cholinergic up-regulation by rivastigmine, an acetylcholinesterase inhibitor, on central nervous system inflammation. |
2009-02-02 |
2023-08-12 |
Not clear |
| Guojun Chen, Paul Chen, Huibing Tan, Da Ma, Fei Dou, Jian Feng, Zhen Ya. Regulation of the NMDA receptor-mediated synaptic response by acetylcholinesterase inhibitors and its impairment in an animal model of Alzheimer's disease. Neurobiology of aging. vol 29. issue 12. 2009-01-23. PMID:17555845. |
inhibitors of acetylcholinesterase (ache), which act to enhance cholinergic function by prolonging the action of endogenously released ach, have been used as the major therapy of ad. |
2009-01-23 |
2023-08-12 |
mouse |
| O V Zaĭtseva, T V Kuznetsov. [Distribution of acetylcholinesterase activity in the digestive system of the gastropod molluscs Littorina littorea and Achatina fulica]. Morfologiia (Saint Petersburg, Russia). vol 133. issue 1. 2009-01-13. PMID:19069417. |
with the use of the histochemical procedure for the demonstration of acetylcholinesterase (ache) activity, the distribution cholinergic regulatory elements was studied in the esophagus, the pharynx, the stomach, the liver (the digestive gland) and the intestine in sea and terrestrial gastropod molluscs that differed in their general organization level, lifestyle, habitat and feeding type. |
2009-01-13 |
2023-08-12 |
Not clear |
| Sukhdev Singh Kamboj, Kanwaljit Chopra, Rajat Sandhi. Neuroprotective effect of N-acetylcysteine in the development of diabetic encephalopathy in streptozotocin-induced diabetes. Metabolic brain disease. vol 23. issue 4. 2009-01-09. PMID:18802743. |
acetylcholinesterase activity, a marker of cholinergic function, was decreased by 15.6% in the cerebral cortex, 20.9% in cerebellum and 14.9% in brain stem of diabetic rats compared to control rats. |
2009-01-09 |
2023-08-12 |
rat |
| Talma Brenner, Eran Nizri, Michal Irony-Tur-Sinai, Yasmine Hamra-Amitay, Itzhak Wirgui. Acetylcholinesterase inhibitors and cholinergic modulation in Myasthenia Gravis and neuroinflammation. Journal of neuroimmunology. vol 201-202. 2008-12-23. PMID:18684515. |
acetylcholinesterase inhibitors and cholinergic modulation in myasthenia gravis and neuroinflammation. |
2008-12-23 |
2023-08-12 |
Not clear |