| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Talma Brenner, Eran Nizri, Michal Irony-Tur-Sinai, Yasmine Hamra-Amitay, Itzhak Wirgui. Acetylcholinesterase inhibitors and cholinergic modulation in Myasthenia Gravis and neuroinflammation. Journal of neuroimmunology. vol 201-202. 2008-12-23. PMID:18684515. |
in myasthenia gravis (mg), diagnosis and symptomatic therapy are based on cholinergic modulation by acetylcholinesterase inhibitors (achei). |
2008-12-23 |
2023-08-12 |
Not clear |
| Finla Chathu, Amee Krishnakumar, Cheramadathikudyil S Paulos. Acetylcholine esterase activity and behavioral response in hypoxia induced neonatal rats: effect of glucose, oxygen and epinephrine supplementation. Brain and cognition. vol 68. issue 1. 2008-12-22. PMID:18406032. |
in the present study, we assessed the changes in the cholinergic system by measuring the acetylcholinesterase (ache) activity and the behavioral responses shown by hypoxia induced neonatal rats and hypoxic rats supplemented with glucose, oxygen and epinephrine using elevated plus-maze and open-field test. |
2008-12-22 |
2023-08-12 |
rat |
| Sadaharu Kotani, Toshihiko Yamauchi, Tetsuyuki Teramoto, Hiroo Ogur. Donepezil, an acetylcholinesterase inhibitor, enhances adult hippocampal neurogenesis. Chemico-biological interactions. vol 175. issue 1-3. 2008-12-10. PMID:18501884. |
donepezil hydrochloride is a potent and selective acetylcholinesterase inhibitor and has been treated for alzheimer's disease, in which the cholinergic dysfunction is observed. |
2008-12-10 |
2023-08-12 |
rat |
| Roy C Y Choi, Mokka K W Mok, Anna W H Cheung, Nina L Siow, Heidi Q Xie, Karl W K Tsi. Regulation of PRiMA-linked G(4) AChE by a cAMP-dependent signaling pathway in cultured rat pheochromocyoma PC12 cells. Chemico-biological interactions. vol 175. issue 1-3. 2008-12-10. PMID:18514641. |
the catalytic subunit of acetylcholinesterase (ache(t)) interacts with proline-rich membrane anchor (prima) to form prima-linked g(4) ache on membrane surface for its cholinergic function. |
2008-12-10 |
2023-08-12 |
rat |
| Wei Su, Jun Wu, Wei-Yuan Ye, Xue-Jun Zhan. A monoclonal antibody against synaptic AChE: a useful tool for detecting apoptotic cells. Chemico-biological interactions. vol 175. issue 1-3. 2008-12-10. PMID:18538755. |
the classical function of acetylcholinesterase (ache) is to terminate synaptic transmission at cholinergic synapses by rapidly hydrolyzing the neurotransmitter acetylcholine (ach). |
2008-12-10 |
2023-08-12 |
Not clear |
| Jiri Bajgar, Josef Fusek, Jiri Kassa, Daniel Jun, Kamil Kuca, Petr Haje. An attempt to assess functionally minimal acetylcholinesterase activity necessary for survival of rats intoxicated with nerve agents. Chemico-biological interactions. vol 175. issue 1-3. 2008-12-10. PMID:18579126. |
acetylcholinesterase (ache, ec 3.1.1.7) is an important enzyme for cholinergic nerve transmission. |
2008-12-10 |
2023-08-12 |
rat |
| Israel Silman, Joel L Sussma. Acetylcholinesterase: how is structure related to function? Chemico-biological interactions. vol 175. issue 1-3. 2008-12-10. PMID:18586019. |
in accordance with its biological role, termination of neurotransmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter, acetylcholine, acetylcholinesterase is one of nature's most efficient enzymes. |
2008-12-10 |
2023-08-12 |
Not clear |
| Annemarie W Oldenbeuving, Paul L M de Kort, Ben P W Jansen, L Jaap Kappelle, Gerwin Rok. A pilot study of rivastigmine in the treatment of delirium after stroke: a safe alternative. BMC neurology. vol 8. 2008-12-02. PMID:18803862. |
given the presumed cholinergic deficiency in delirium, we tested treatment with the acetylcholinesterase inhibitor rivastigmine. |
2008-12-02 |
2023-08-12 |
Not clear |
| Nikita Mirajkar, Carey N Pop. In vitro sensitivity of cholinesterases and [3H]oxotremorine-M binding in heart and brain of adult and aging rats to organophosphorus anticholinesterases. Biochemical pharmacology. vol 76. issue 8. 2008-11-18. PMID:18761328. |
organophosphorus (op) insecticides elicit toxicity via acetylcholinesterase inhibition, allowing acetylcholine accumulation and excessive stimulation of cholinergic receptors. |
2008-11-18 |
2023-08-12 |
rat |
| Abraham Fishe. Cholinergic treatments with emphasis on m1 muscarinic agonists as potential disease-modifying agents for Alzheimer's disease. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 5. issue 3. 2008-11-05. PMID:18625455. |
such linkages may have therapeutic implications, and this review is an attempt to analyze these versus the advantages and drawbacks of some cholinergic compounds, such as acetylcholinesterase inhibitors, m1 muscarinic agonists, m2 antagonists, and nicotinic agonists. |
2008-11-05 |
2023-08-12 |
Not clear |
| Mohammad A Kamal, Xianqin Qu, Qian-Sheng Yu, David Tweedie, Harold W Holloway, Yazhou Li, Yi Tan, Nigel H Grei. Tetrahydrofurobenzofuran cymserine, a potent butyrylcholinesterase inhibitor and experimental Alzheimer drug candidate, enzyme kinetic analysis. Journal of neural transmission (Vienna, Austria : 1996). vol 115. issue 6. 2008-10-03. PMID:18235987. |
synaptic loss, particularly related to the forebrain cholinergic system, is considered to be an early event that leads to alzheimer's disease (ad) and has led to the development of acetylcholinesterase inhibitors (ache-is) as the mainstay of treatment for several degenerative disorders that culminate in dementia. |
2008-10-03 |
2023-08-12 |
human |
| Anurag Kuhad, Richa Sethi, Kanwaljit Chopr. Lycopene attenuates diabetes-associated cognitive decline in rats. Life sciences. vol 83. issue 3-4. 2008-09-23. PMID:18585396. |
acetylcholinesterase activity, a marker of cholinergic dysfunction, was increased by 1.8 fold in the cerebral cortex of diabetic rats. |
2008-09-23 |
2023-08-12 |
rat |
| Jacques-Philippe Colletier, Dominique Bourgeois, Benoît Sanson, Didier Fournier, Joel L Sussman, Israel Silman, Martin Wei. Shoot-and-Trap: use of specific x-ray damage to study structural protein dynamics by temperature-controlled cryo-crystallography. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 33. 2008-09-16. PMID:18701720. |
in particular, a nonhydrolyzable substrate analogue of acetylcholinesterase, the "off-switch" at cholinergic synapses, was radiocleaved within the buried enzymatic active site. |
2008-09-16 |
2023-08-12 |
Not clear |
| Michal Harel, Leilani K Sonoda, Israel Silman, Joel L Sussman, Terrone L Rosenberr. Crystal structure of thioflavin T bound to the peripheral site of Torpedo californica acetylcholinesterase reveals how thioflavin T acts as a sensitive fluorescent reporter of ligand binding to the acylation site. Journal of the American Chemical Society. vol 130. issue 25. 2008-09-15. PMID:18512913. |
acetylcholinesterase plays a key role in cholinergic synaptic transmission by hydrolyzing the neurotransmitter acetylcholine with one of the highest known catalytic rate constants. |
2008-09-15 |
2023-08-12 |
Not clear |
| Hung-Bun Lam, Ching-Hua Yeh, Kai-Chun Cheng, Chao-Tien Hsu, Juei-Tang Chen. Effect of cholinergic denervation on hepatic fibrosis induced by carbon tetrachloride in rats. Neuroscience letters. vol 438. issue 1. 2008-09-08. PMID:18472332. |
acetylcholinesterase (ache) staining showed the distribution of cholinergic nerve around fibrosis scaring septa. |
2008-09-08 |
2023-08-12 |
rat |
| Debby Van Dam, Katrien Coen, Peter Paul De Dey. Cognitive evaluation of disease-modifying efficacy of donepezil in the APP23 mouse model for Alzheimer's disease. Psychopharmacology. vol 197. issue 1. 2008-08-29. PMID:18008065. |
the interest for acetylcholinesterase inhibitors in the treatment of alzheimer's disease has been greatly renewed owing to the discovery of a broad range of additional cholinergic and non-cholinergic effects, exploitable to maximize the efficacy of these drugs beyond merely improving intellectual functions at the symptomatic level. |
2008-08-29 |
2023-08-12 |
mouse |
| Ilkay Orhan, Fatma Tosun, Bilge Sene. Coumarin, anthroquinone and stilbene derivatives with anticholinesterase activity. Zeitschrift fur Naturforschung. C, Journal of biosciences. vol 63. issue 5-6. 2008-08-26. PMID:18669022. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are the key enzymes in pathogenesis of alzheimer's disease (ad), which is characterized by a deficit in central cholinergic transmission. |
2008-08-26 |
2023-08-12 |
Not clear |
| Adhil Bhagwandin, Kjell Fuxe, Nigel C Bennett, Paul R Mange. Nuclear organization and morphology of cholinergic, putative catecholaminergic and serotonergic neurons in the brains of two species of African mole-rat. Journal of chemical neuroanatomy. vol 35. issue 4. 2008-08-21. PMID:18407460. |
the distribution, morphology and nuclear subdivisions of the cholinergic, putative catecholaminergic and serotonergic systems within the brains of two species of african mole-rat (cape dune mole-rat -bathyergus suillus; highveld mole-rat -cryptomys hottentotuspretoriae) were identified following immunohistochemistry for acetylcholinesterase, tyrosine hydroxylase and serotonin. |
2008-08-21 |
2023-08-12 |
rat |
| Mohammad A Kamal, Peter Klein, Weiming Luo, Yazhou Li, Harold W Holloway, David Tweedie, Nigel H Grei. Kinetics of human serum butyrylcholinesterase inhibition by a novel experimental Alzheimer therapeutic, dihydrobenzodioxepine cymserine. Neurochemical research. vol 33. issue 5. 2008-08-11. PMID:17985237. |
cholinergic loss is the single most replicated neurotransmitter deficiency in alzheimer's disease (ad) and has led to the use of acetylcholinesterase inhibitors (ache-is) and unselective cholinesterase inhibitors (che-is) as the mainstay of treatment. |
2008-08-11 |
2023-08-12 |
human |
| G I Nezhinskaia, A L Vladykin, N S Saprono. [Modulation of the cholinergic system during inflammation]. Eksperimental'naia i klinicheskaia farmakologiia. vol 71. issue 2. 2008-07-25. PMID:18488913. |
during the anaphylaxis, peripheral effects of the cholinergic system induced by blocking m-achr on the target cells (neuronal and non-neuronal lung cells) and acetylcholinesterase inhibition are related to suppression of the bronchoconstrictor response. |
2008-07-25 |
2023-08-12 |
Not clear |