| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Isabel Martinez-Pena y Valenzuela, Mohammed Akaaboun. Acetylcholinesterase mobility and stability at the neuromuscular junction of living mice. Molecular biology of the cell. vol 18. issue 8. 2007-10-17. PMID:17538015. |
acetylcholinesterase (ache) is an enzyme that terminates acetylcholine neurotransmitter function at the synaptic cleft of cholinergic synapses. |
2007-10-17 |
2023-08-12 |
mouse |
| Jin Kyung Oh, Yoon-Sang Kim, Hyun-Jung Park, Eun-Mee Lim, Kwang-Ho Pyun, Insop Shi. Antidepressant effects of Soyo-san on Immobilization stress in ovariectomized female rats. Biological & pharmaceutical bulletin. vol 30. issue 8. 2007-09-21. PMID:17666797. |
we assessed the changes in the reactivity of the cholinergic system by measuring the immunoreactive neurons of choline acetyltransferase (chat) and reactivity of acetylcholinesterase (ache) in the hippocampus, and the serum levels of corticosterone were assessed after behavioral testing. |
2007-09-21 |
2023-08-12 |
rat |
| Carlos H T P da Silva, Ivone Carvalho, C A Taf. Virtual screening, molecular interaction field, molecular dynamics, docking, density functional, and ADMET properties of novel AChE inhibitors in Alzheimer's disease. Journal of biomolecular structure & dynamics. vol 24. issue 6. 2007-09-18. PMID:17508773. |
many drugs currently used for the treatment of the ad are based on the improvement of cholinergic neurotransmission achieved by acetylcholinesterase (ache) inhibition, the enzyme responsible for acetylcholine hydrolysis. |
2007-09-18 |
2023-08-12 |
Not clear |
| Samira S Valvassori, Jucélia J Fortunato, Karin M Gomes, Gislaine Z Réus, Márcio R Martins, Elaine C Gavioli, Maria Rosa C Schetinger, Felipe Dal-Pizzol, João Queved. Acute and subacute exposure to malathion impairs aversive but not non-associative memory in rats. Neurotoxicity research. vol 12. issue 1. 2007-09-18. PMID:17513201. |
this pesticide affects the central nervous system by inhibiting acetylcholinesterase, leading to an increase of acetylcholine in the synaptic cleft, and subsequent activation of cholinergic muscarinic and nicotinic receptors. |
2007-09-18 |
2023-08-12 |
rat |
| Jerry J Buccafusco, James C Powers, Maria A Hernandez, Mark A Prendergast, Alvin V Terry, Ramamohana R Jonnal. MHP-133, a drug with multiple CNS targets: potential for neuroprotection and enhanced cognition. Neurochemical research. vol 32. issue 7. 2007-09-17. PMID:17404838. |
mhp-133 was shown to interact with subtypes of cholinergic, serotonergic, and imidazoline receptors and to weakly inhibit acetylcholinesterase activity. |
2007-09-17 |
2023-08-12 |
rat |
| Laure Ginestet, Juan E Ferrario, Rita Raisman-Vozari, Etienne C Hirsch, Thomas Debei. Donepezil induces a cholinergic sprouting in basocortical degeneration. Journal of neurochemistry. vol 102. issue 2. 2007-09-07. PMID:17394553. |
we investigated the effect of the acetylcholinesterase inhibitor donepezil administered subcutaneously in a rat model of partial unilateral cortical devascularization that induces a loss of the cortical cholinergic terminal network and a retrograde degeneration of the cholinergic projections that originate in the nucleus basalis. |
2007-09-07 |
2023-08-12 |
rat |
| R Ceravolo, D Volterrani, D Frosini, S Bernardini, C Rossi, C Logi, G Manca, L Kiferle, G Mariani, L Murri, U Bonuccell. Brain perfusion effects of cholinesterase inhibitors in Parkinson's disease with dementia. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 11. 2007-09-05. PMID:16758132. |
several evidences suggest that cholinergic deficits may significantly contribute to dementia in parkinson's disease (pdd) and acetylcholinesterase inhibitors (cheis) have been reported to improve cognitive symptoms in pdd, without worsening parkinsonism. |
2007-09-05 |
2023-08-12 |
Not clear |
| Hongjun Fu, Wenming Li, Yulin Liu, Yuanzhi Lao, Wei Liu, Cheng Chen, Hua Yu, Nelson T K Lee, Donald C Chang, Peng Li, Yuanping Pang, Karl W K Tsim, Mingtao Li, Yifan Ha. Mitochondrial proteomic analysis and characterization of the intracellular mechanisms of bis(7)-tacrine in protecting against glutamate-induced excitotoxicity in primary cultured neurons. Journal of proteome research. vol 6. issue 7. 2007-08-30. PMID:17530875. |
moreover, this reversal was independent of nmda antagonism, acetylcholinesterase inhibition, and cholinergic pathways. |
2007-08-30 |
2023-08-12 |
Not clear |
| b' Zbyn\\xc4\\x95k Svoboda, Jaroslav Kv\\xc4\\x95tina, Josef Herink, Jir\\xc3\\xad Bajgar, Lucie Bartosov\\xc3\\xa1, Vladim\\xc3\\xadr Palicka, Pavel Zivn\\xc3\\xb. Galantamine antiacetylcholinesterase activity in rat brain influenced by L-carnitine. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. vol 149. issue 2. 2007-08-28. PMID:16601783.' |
galantamine (gal) is a selective, competitive and reversible acetylcholinesterase (ache) inhibitor, which increases the activity of the cholinergic system and hence gives rise to an improvement of cognitive functions in patients suffering from dementia of alzheimer type. |
2007-08-28 |
2023-08-12 |
rat |
| Kamil Kuca, Jirí Cabal, Daniel Jun, Jirí Kassa, Lucie Bartosová, Gabriela Kunesová, Vlastimil Dohna. Strategy for the development of new acetylcholinesterase reactivators - antidotes used for treatment of nerve agent poisonings. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. vol 149. issue 2. 2007-08-28. PMID:16601804. |
the mechanism of intoxication with organophosphorus compounds, including highly toxic nerve agents, is based on the formation of irreversibly inhibited acetylcholinesterase (ache; ec 3.1.1.7) that could be followed by a generalized cholinergic crisis. |
2007-08-28 |
2023-08-12 |
Not clear |
| Stephen E Nadeau, Andrea L Behrman, Sandra E Davis, Kimberly Reid, Samuel S Wu, Brenda S Stidham, Karen M Helms, Leslie J Gonzalez Roth. Donepezil as an adjuvant to constraint-induced therapy for upper-limb dysfunction after stroke: an exploratory randomized clinical trial. Journal of rehabilitation research and development. vol 41. issue 4. 2007-08-21. PMID:15558381. |
donepezil, a primarily central acetylcholinesterase inhibitor, could potentiate learning in subjects with stroke by amplifying cholinergic input to the cerebral cortex from the nucleus basalis of meynert. |
2007-08-21 |
2023-08-12 |
human |
| M Perayre Badia, E Leiva Badosa, L Pastó Cardona, R Jódar Massané. [Intermediate syndrome after organophosphate poisoning despite continuous infusion of pralidoxime]. Anales de medicina interna (Madrid, Spain : 1984). vol 24. issue 3. 2007-08-21. PMID:17590134. |
acute organophosphate poisoning leads to a cholinergic crisis secondary to an acetylcholine rise, developed by an acetylcholinesterase inhibition. |
2007-08-21 |
2023-08-12 |
Not clear |
| Jean-Pierre Bellier, Hiroshi Kimur. Acetylcholine synthesis by choline acetyltransferase of a peripheral type as demonstrated in adult rat dorsal root ganglion. Journal of neurochemistry. vol 101. issue 6. 2007-08-16. PMID:17542812. |
our detailed analysis further showed that, despite low enzyme activities of both choline acetyltransferase and acetylcholinesterase, the level of acetylcholine in the ganglion was as high as to that in various brain regions receiving cholinergic innervation. |
2007-08-16 |
2023-08-12 |
rat |
| Md Badiul Bhuiyan, Ferid Murad, Michael E Fan. The placental cholinergic system: localization to the cytotrophoblast and modulation of nitric oxide. Cell communication and signaling : CCS. vol 4. 2007-08-01. PMID:16686954. |
the human placenta, a non-neuronal tissue, contains an active cholinergic system comprised of acetylcholine (ach), choline acetyltransferase (chat), acetylcholinesterase (ache), and high affinity muscarinic receptors. |
2007-08-01 |
2023-08-12 |
human |
| Naira Serobyan, Suchitra Jagannathan, Irina Orlovskaya, Ingrid Schraufstatter, Marina Skok, Jeanne Loring, Sophia Khaldoyanid. The cholinergic system is involved in regulation of the development of the hematopoietic system. Life sciences. vol 80. issue 24-25. 2007-08-01. PMID:17512954. |
gene expression profiling demonstrated that components of the cholinergic system, including choline acetyltransferase, acetylcholinesterase and nicotinic acetylcholine receptors (nachrs), are expressed in embryonic stem cells and differentiating embryoid bodies (ebs). |
2007-08-01 |
2023-08-12 |
Not clear |
| Wayne G Carter, Mabruka Tarhoni, Alexandra J Rathbone, David E Ra. Differential protein adduction by seven organophosphorus pesticides in both brain and thymus. Human & experimental toxicology. vol 26. issue 4. 2007-07-30. PMID:17615116. |
although the acute toxicity is largely explicable by acetylcholinesterase inhibition and the lasting effects of frank poisoning by direct excitotoxicity or indirect consequences of the cholinergic syndrome, effects at lower levels of exposure would not be predicted from these mechanisms. |
2007-07-30 |
2023-08-12 |
rat |
| Dayong Wang, Yukihiro Noda, Yuan Zhou, Akihiro Mouri, Hiroyuki Mizoguchi, Atsumi Nitta, Weiduo Chen, Toshitaka Nabeshim. The allosteric potentiation of nicotinic acetylcholine receptors by galantamine ameliorates the cognitive dysfunction in beta amyloid25-35 i.c.v.-injected mice: involvement of dopaminergic systems. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 6. 2007-07-27. PMID:17133263. |
galantamine, a drug for alzheimer's disease, is a novel cholinergic agent with a dual mode of action, which inhibits acetylcholinesterase and allosterically modulates nicotinic acetylcholine receptors (nachrs), as a result stimulates catecholamine neurotransmission. |
2007-07-27 |
2023-08-12 |
mouse |
| M E Selkirk, O Lazari, J B Matthew. Functional genomics of nematode acetylcholinesterases. Parasitology. vol 131 Suppl. 2007-07-17. PMID:16569291. |
acetylcholine is the major excitatory neurotransmitter controlling motor activities in nematodes, and the enzyme which hydrolyses and inactivates acetylcholine, acetylcholinesterase, is thus essential for regulation of cholinergic transmission. |
2007-07-17 |
2023-08-12 |
caenorhabditis_elegans |
| Adi Gilboa-Geffen, Paul P Lacoste, Lilach Soreq, Geraldine Cizeron-Clairac, Rozen Le Panse, Frederique Truffault, Iftach Shaked, Hermona Soreq, Sonia Berrih-Akni. The thymic theme of acetylcholinesterase splice variants in myasthenia gravis. Blood. vol 109. issue 10. 2007-07-12. PMID:17272501. |
cholinergic signaling and acetylcholinesterase (ache) influence immune response and inflammation. |
2007-07-12 |
2023-08-12 |
mouse |
| Isabel Cunha, Teresa Neuparth, Sandra Caeiro, Maria Helena Costa, Lúcia Guilhermin. Toxicity ranking of estuarine sediments on the basis of Sparus aurata biomarkers. Environmental toxicology and chemistry. vol 26. issue 3. 2007-05-30. PMID:17373507. |
no significant effects were observed on acetylcholinesterase activity, suggesting that cholinergic function of s. aurata is not affected by benzo[a]pyrene. |
2007-05-30 |
2023-08-12 |
Not clear |