| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christian Grasshoff, Horst Thiermann, Bernd Antkowia. Anaesthesia in patients suffering from organophosphorus intoxication--interactions between general anaesthetics and acetylcholine in cortical networks in vitro. Toxicology. vol 233. issue 1-3. 2007-05-29. PMID:17030394. |
organophosphate compounds produce excessive cholinergic overstimulation in the cns via blocking acetylcholinesterase activity. |
2007-05-29 |
2023-08-12 |
human |
| M H Bazalakova, R D Blakel. The high-affinity choline transporter: a critical protein for sustaining cholinergic signaling as revealed in studies of genetically altered mice. Handbook of experimental pharmacology. issue 175. 2007-05-23. PMID:16722248. |
studies in various mouse models of cholinergic dysfunction, including acetylcholinesterase (ache) transgenic and knockout mice, choline acetyltransferase (chat) heterozygote mice, muscarinic (machr) and nicotinic (machr) receptor knockout mice, as well as cht knockout and heterozygote mice, have revealed new information about the role of cht expression and regulation in response to long-term alterations in cholinergic neurotransmission. |
2007-05-23 |
2023-08-12 |
mouse |
| Sultan Darvesh, Ryan Walsh, Earl Marti. Homocysteine thiolactone and human cholinesterases. Cellular and molecular neurobiology. vol 27. issue 1. 2007-05-22. PMID:16955366. |
acetylcholinesterase (ache) and butyrylcholinesterase (buche) are serine hydrolase enzymes that catalyze the hydrolysis of the neurotransmitter acetylcholine, a key process in the regulation of the cholinergic system. |
2007-05-22 |
2023-08-12 |
human |
| M Dumont, R Lalonde, J-F Ghersi-Egea, K Fukuchi, C Straziell. Regional acetylcholinesterase activity and its correlation with behavioral performances in 15-month old transgenic mice expressing the human C99 fragment of APP. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 9. 2007-05-02. PMID:16362638. |
in the present investigation, the cholinergic innervation in forebrain regions of transgenic mice (tg13592) expressing the human betaapp c99 fragment was compared to that of non-transgenic controls by measuring the activity of the non-specific catabolic enzyme, acetylcholinesterase (ache). |
2007-05-02 |
2023-08-12 |
mouse |
| Ruth R Jameson, Frederic J Seidler, Theodore A Slotki. Nonenzymatic functions of acetylcholinesterase splice variants in the developmental neurotoxicity of organophosphates: chlorpyrifos, chlorpyrifos oxon, and diazinon. Environmental health perspectives. vol 115. issue 1. 2007-05-02. PMID:17366821. |
organophosphate pesticides affect mammalian brain development through mechanisms separable from the inhibition of acetylcholinesterase (ache) enzymatic activity and resultant cholinergic hyperstimulation. |
2007-05-02 |
2023-08-12 |
Not clear |
| J-P Colletier, M Wei. [Exploring the conformational energy landscape of acetylcholinesterase by kinetic crystallography]. Annales pharmaceutiques francaises. vol 65. issue 2. 2007-05-02. PMID:17404544. |
acetylcholinesterase is a very rapid enzyme, essential in the process of nerve impulse transmission at cholinergic synapses. |
2007-05-02 |
2023-08-12 |
Not clear |
| Minjeong Sun, C Justin Lee, Hee-Sup Shi. Reduced nicotinic receptor function in sympathetic ganglia is responsible for the hypothermia in the acetylcholinesterase knockout mouse. The Journal of physiology. vol 578. issue Pt 3. 2007-04-26. PMID:17038428. |
paradoxically, acetylcholinesterase (ache) inhibitors, which should enhance cholinergic signalling, induce hypothermia. |
2007-04-26 |
2023-08-12 |
mouse |
| Timothy C Marrs, Paul Rice, J Allister Val. The role of oximes in the treatment of nerve agent poisoning in civilian casualties. Toxicological reviews. vol 25. issue 4. 2007-04-17. PMID:17288500. |
nerve agents phosphonylate a serine hydroxyl group in the active site of the enzyme, acetylcholinesterase (ache), which results in accumulation of acetylcholine and, in turn, causes enhancement and prolongation of cholinergic effects and depolarisation blockade. |
2007-04-17 |
2023-08-12 |
Not clear |
| Joachim Hartmann, Cornelia Kiewert, Ellen G Duysen, Oksana Lockridge, Nigel H Greig, Jochen Klei. Excessive hippocampal acetylcholine levels in acetylcholinesterase-deficient mice are moderated by butyrylcholinesterase activity. Journal of neurochemistry. vol 100. issue 5. 2007-04-02. PMID:17212694. |
cholinergic dysfunction is treated with inhibitors of acetylcholinesterase (ache) while the role of butyrylcholinesterase (bche) for brain cholinergic function is unclear. |
2007-04-02 |
2023-08-12 |
mouse |
| Jonathan Newmar. Nerve agents. The neurologist. vol 13. issue 1. 2007-03-21. PMID:17215724. |
nerve agents, the deadliest of the classic chemical warfare agents, primarily function as acetylcholinesterase inhibitors and cause a rapidly progressive cholinergic crisis. |
2007-03-21 |
2023-08-12 |
Not clear |
| Osamu Yasuhara, Akinori Matsuo, Jean-Pierre Bellier, Yoshinari Aim. Demonstration of choline acetyltransferase of a peripheral type in the rat heart. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 55. issue 3. 2007-03-20. PMID:17142806. |
cholinergic innervation of the heart has been analyzed using cholinergic markers including acetylcholinesterase, choline acetyltransferase (chat), and vesicular acetylcholine transporter (vacht). |
2007-03-20 |
2023-08-12 |
rat |
| M Jamal, K Ameno, S Ameno, J Morishita, W Wang, M Kumihashi, U Ikuo, T Miki, I Ijir. Changes in cholinergic function in the frontal cortex and hippocampus of rat exposed to ethanol and acetaldehyde. Neuroscience. vol 144. issue 1. 2007-03-15. PMID:17045751. |
to better understand the mechanisms of etoh and ace's effects on the cholinergic system in the brain, choline acetyltransferase (chat) and acetylcholinesterase (ache) expression was examined at 40 and 240 min after a dose of etoh (1 g/kg) in the rat frontal cortex and hippocampus. |
2007-03-15 |
2023-08-12 |
rat |
| Silvia C Lenzken, Cristina Lanni, Stefano Govoni, Adele Lucchelli, Gennaro Schettini, Marco Racch. Nicotinic component of galantamine in the regulation of amyloid precursor protein processing. Chemico-biological interactions. vol 165. issue 2. 2007-03-13. PMID:17196952. |
current therapies for alzheimer's disease treatment rely mainly on acetylcholinesterase inhibitors, improving central cholinergic neurotransmission. |
2007-03-13 |
2023-08-12 |
Not clear |
| Silvia C Lenzken, Cristina Lanni, Stefano Govoni, Adele Lucchelli, Gennaro Schettini, Marco Racch. Nicotinic component of galantamine in the regulation of amyloid precursor protein processing. Chemico-biological interactions. vol 165. issue 2. 2007-03-13. PMID:17196952. |
among these molecules, galantamine (gal) has an interesting pharmacological profile as it is both a reversible acetylcholinesterase inhibitor and an allosteric potentiator of nicotinic cholinergic receptors. |
2007-03-13 |
2023-08-12 |
Not clear |
| J Y H Chan, S H H Chan, K Y Dai, H L Cheng, J L J Chou, A Y W Chan. Cholinergic-receptor-independent dysfunction of mitochondrial respiratory chain enzymes, reduced mitochondrial transmembrane potential and ATP depletion underlie necrotic cell death induced by the organophosphate poison mevinphos. Neuropharmacology. vol 51. issue 7-8. 2007-03-09. PMID:16984802. |
taking advantage of the absence in an in vitro system of acetylcholinesterase, the pharmacological target of organophosphate compounds, the present study evaluated the hypothesis that the repertoire of cholinergic receptor-independent cellular events that underlie fatal organophosphate poisoning entails induction of mitochondrial dysfunction, followed by bioenergetic failure that leads to necrotic cell death because of atp depletion. |
2007-03-09 |
2023-08-12 |
Not clear |
| Xilong Zhao, William Marszalec, Peter T Toth, Joseph Huang, Jay Z Yeh, Toshio Narahash. In vitro galantamine-memantine co-application: mechanism of beneficial action. Neuropharmacology. vol 51. issue 7-8. 2007-03-09. PMID:17011596. |
since alzheimer's disease is known to be associated with down-regulation of the cholinergic and n-methyl-d-aspartate (nmda) systems, most of these drugs inhibit acetylcholinesterase, potentiate the activity of nicotinic acetylcholine receptors (nachrs), or modulate nmda receptors. |
2007-03-09 |
2023-08-12 |
rat |
| Amir Dori, Hermona Sore. Neuromuscular therapeutics by RNA-targeted suppression of ACHE gene expression. Annals of the New York Academy of Sciences. vol 1082. 2007-03-05. PMID:17145929. |
here, we report the use of monarsen, a 20-mer acetylcholinesterase-targeted antisense agent with three 3'-2'o-methyl-protected nucleotides, for selectively attenuating the stress-induced accumulation of the normally rare, soluble "readthrough" acetylcholinesterase variant ache-r. acetylcholine hydrolysis by ache-r may cause muscle fatigue and moreover, limit the cholinergic anti-inflammatory blockade, yielding inflammation-associated pathology. |
2007-03-05 |
2023-08-12 |
human |
| Christian Grasshoff, Berthold Drexler, Bernd Antkowia. Effects of cholinergic overstimulation on isoflurane potency and efficacy in cortical and spinal networks. Toxicology. vol 229. issue 3. 2007-02-28. PMID:17141935. |
organophosphates block acetylcholinesterase activity, thereby inducing excessive cholinergic overstimulation in the central nervous system. |
2007-02-28 |
2023-08-12 |
human |
| Laura E Paraoanu, Gunnar Steinert, Janine Klaczinski, Michaela Becker-Röck, Afrim Bytyqi, Paul G Laye. On functions of cholinesterases during embryonic development. Journal of molecular neuroscience : MN. vol 30. issue 1-2. 2007-02-23. PMID:17192676. |
this means that che functioning during development fits into the classical cholinergic neurotransmitter system: acetylcholine (ach), as a signal, binds to ach receptors and then is degraded by acetylcholinesterase (ache) as the terminating enzyme. |
2007-02-23 |
2023-08-12 |
Not clear |
| Jean Massoulié, Suzanne Bo. The C-terminal T peptide of cholinesterases: structure, interactions, and influence on protein folding and secretion. Journal of molecular neuroscience : MN. vol 30. issue 1-2. 2007-02-23. PMID:17192683. |
mammalian cholinergic tissues mostly express the t splice variant of acetylcholinesterase, in which the catalytic domain is associated with a c-terminal peptide of 40 residues, called the t peptide (massoulié, 2002). |
2007-02-23 |
2023-08-12 |
caenorhabditis_elegans |