| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lucie Bartosova, Kamil Kuca, Daniel Jun, Gabriela Kunesov. Bispyridinium oximes as antidotal treatment of cyclosarin poisoning-in vitro and in vivo testing. International journal of toxicology. vol 24. issue 6. 2006-03-15. PMID:16393932. |
the mechanism of intoxication with organophosphorus compounds, including highly toxic nerve agents and less toxic pesticides, is based on the formation of irreversibly inhibited acetylcholinesterase, which causes cumulation of neuromediator acetylcholine in synaptic clefts and subsequent overstimulation of cholinergic receptors, that is followed by a generalized cholinergic crisis. |
2006-03-15 |
2023-08-12 |
mouse |
| J M Rollinger, P Mocka, C Zidorn, E P Ellmerer, T Langer, H Stuppne. Application of the in combo screening approach for the discovery of non-alkaloid acetylcholinesterase inhibitors from Cichorium intybus. Current drug discovery technologies. vol 2. issue 3. 2006-03-10. PMID:16472227. |
because of the direct correlation of cholinergic deficit and the severity of dementia, alzheimer's disease is preferentially treated with acetylcholinesterase (ache) inhibitors to supplement the acetylcholine level. |
2006-03-10 |
2023-08-12 |
Not clear |
| Cecilio J Vida. Expression of cholinesterases in brain and non-brain tumours. Chemico-biological interactions. vol 157-158. 2006-02-24. PMID:16256970. |
although the involvement of cholinesterases (ches) in the removal of acetylcholine (ach) at cholinergic synapses is firmly established, there is evidence to suggest that acetylcholinesterase (ache) and butyrylcholinesterase (buche) take part in several cellular processes. |
2006-02-24 |
2023-08-12 |
Not clear |
| Jean Massoulié, Suzanne Bon, Noël Perrier, Cinzia Falasc. The C-terminal peptides of acetylcholinesterase: cellular trafficking, oligomerization and functional anchoring. Chemico-biological interactions. vol 157-158. 2006-02-24. PMID:16257397. |
the "tailed" (t) variant exists in all vertebrate cholinesterases and their c-terminal t peptides are strongly conserved; in mammals, ache(t) subunits represent the major type of acetylcholinesterase in cholinergic tissues. |
2006-02-24 |
2023-08-12 |
mouse |
| Paul T Franci. The interplay of neurotransmitters in Alzheimer's disease. CNS spectrums. vol 10. issue 11 Suppl 18. 2006-02-24. PMID:16273023. |
this deficit and other presynaptic cholinergic deficits, including loss of cholinergic neurons and decreased acetylcholinesterase activity, underscore the cholinergic hypothesis of alzheimer's disease. |
2006-02-24 |
2023-08-12 |
Not clear |
| Maxine Lintern, Chris Taylor, Janet Wetherell, Margaret E Smit. Attenuation of the effects of physostigmine by hyoscine in guinea-pig brain cholinergic enzymes: acetylcholinesterase. Chemico-biological interactions. vol 157-158. 2006-02-24. PMID:16289415. |
attenuation of the effects of physostigmine by hyoscine in guinea-pig brain cholinergic enzymes: acetylcholinesterase. |
2006-02-24 |
2023-08-12 |
Not clear |
| Susan Greenfiel. A peptide derived from acetylcholinesterase is a pivotal signalling molecule in neurodegeneration. Chemico-biological interactions. vol 157-158. 2006-02-24. PMID:16297900. |
it is now widely accepted that acetylcholinesterase (ache) also displays non-cholinergic functions, completely independent of cholinergic transmission. |
2006-02-24 |
2023-08-12 |
Not clear |
| Mrinalini Muralidharan, Hermona Soreq, Tsafrir S Mo. Characterizing pea acetylcholinesterase. Chemico-biological interactions. vol 157-158. 2006-02-24. PMID:16429548. |
although the best-defined role of acetylcholinesterase (ache) is to terminate cholinergic transmission signals, the presence of the enzyme and its substrate is not limited to the metazoan nervous system. |
2006-02-24 |
2023-08-12 |
Not clear |
| G Grön, I Brandenburg, A P Wunderlich, M W Riep. Inhibition of hippocampal function in mild cognitive impairment: targeting the cholinergic hypothesis. Neurobiology of aging. vol 27. issue 1. 2006-02-14. PMID:16298243. |
we hypothesized that cholinergic malfunction may underlie memory impairment in these subjects and applied a low dosage of an acetylcholinesterase inhibitor and modulator of nicotinic acetylcholine receptors, galantamine (4 mg bid), for 7 days. |
2006-02-14 |
2023-08-12 |
human |
| G Grön, I Brandenburg, A P Wunderlich, M W Riep. Inhibition of hippocampal function in mild cognitive impairment: targeting the cholinergic hypothesis. Neurobiology of aging. vol 27. issue 1. 2006-02-14. PMID:16298243. |
malfunction of the cholinergic system may be tackled pharmacologically via the inhibition of acetylcholinesterase even when the impairment is slight. |
2006-02-14 |
2023-08-12 |
human |
| Ora Kofman, Guy Ben-Basha. Diisopropylfluorophosphate administration in the pre-weanling period induces long-term changes in anxiety behavior and passive avoidance in adult mice. Psychopharmacology. vol 183. issue 4. 2006-01-31. PMID:16283257. |
the developing brain may be particularly vulnerable to exposure to acetylcholinesterase (ache) inhibitors because of the role of ache on neuronal development and the effects of cholinergic pathways in mediating behavioral and hormonal responses to stress. |
2006-01-31 |
2023-08-12 |
mouse |
| Debra Toiber, Hermona Sore. Cellular stress reactions as putative cholinergic links in Alzheimer's disease. Neurochemical research. vol 30. issue 6-7. 2006-01-30. PMID:16187225. |
here, we present evidence to the fact that these two distinct phenomena both associate with specific changes in acetylcholinesterase (ache) gene expression within cholinergic neurons. |
2006-01-30 |
2023-08-12 |
Not clear |
| Cindy K J Lieben, Arjan Blokland, Ayhan Sik, Eric Sung, Petra van Nieuwenhuizen, Rudy Schreibe. The selective 5-HT6 receptor antagonist Ro4368554 restores memory performance in cholinergic and serotonergic models of memory deficiency in the rat. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 30. issue 12. 2006-01-24. PMID:15957009. |
the present study sought to characterize the cognitive-enhancing effects of the 5-ht(6) antagonist ro4368554 (3-benzenesulfonyl-7-(4-methyl-piperazin-1-yl)1h-indole) in a rat object recognition task employing a cholinergic (scopolamine pretreatment) and a serotonergic- (tryptophan (trp) depletion) deficient model, and compared its pattern of action with that of the acetylcholinesterase inhibitor metrifonate. |
2006-01-24 |
2023-08-12 |
rat |
| Yehudit Hasin, Nili Avidan, Dani Bercovich, Amos D Korczyn, Israel Silman, Jacques S Beckmann, Joel L Sussma. Analysis of genetic polymorphisms in acetylcholinesterase as reflected in different populations. Current Alzheimer research. vol 2. issue 2. 2006-01-18. PMID:15974920. |
acetylcholinesterase (ache) plays a crucial physiological role in termination of impulse transmission at cholinergic synapses through rapid hydrolysis of acetylcholine. |
2006-01-18 |
2023-08-12 |
human |
| Nigel H Greig, Tadanobu Utsuki, Donald K Ingram, Yue Wang, Giancarlo Pepeu, Carla Scali, Qian-Sheng Yu, Jacek Mamczarz, Harold W Holloway, Tony Giordano, DeMao Chen, Katsutoshi Furukawa, Kumar Sambamurti, Arnold Brossi, Debomoy K Lahir. Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 47. 2006-01-12. PMID:16275899. |
like acetylcholinesterase, butyrylcholinesterase (bche) inactivates the neurotransmitter acetylcholine (ach) and is hence a viable therapeutic target in alzheimer's disease, which is characterized by a cholinergic deficit. |
2006-01-12 |
2023-08-12 |
mouse |
| S Kleinschmidt, S Ziegeler, C Baue. [Cholinesterase inhibitors. Importance in anaesthesia, intensive care medicine, emergency medicine and pain therapy]. Der Anaesthesist. vol 54. issue 8. 2005-11-30. PMID:15933880. |
many drugs currently used in anaesthesia practice modify cholinergic transmission, therefore, acetylcholinesterase inhibitors are a part of anaesthetic pharmacology. |
2005-11-30 |
2023-08-12 |
Not clear |
| P U Onganer, M B A Djamgo. Small-cell lung cancer (human): potentiation of endocytic membrane activity by voltage-gated Na(+) channel expression in vitro. The Journal of membrane biology. vol 204. issue 2. 2005-10-13. PMID:16151702. |
the possibility that the endocytic activity in the h510 sclc cells involved an endogenous cholinergic system was investigated by testing the effects of carbachol (a cholinergic receptor agonist) and eserine (an inhibitor of acetylcholinesterase). |
2005-10-13 |
2023-08-12 |
human |
| José Correa-Basurto, Iván Vázquez Alcántara, L Michel Espinoza-Fonseca, José G Trujillo-Ferrar. p-Aminobenzoic acid derivatives as acetylcholinesterase inhibitors. European journal of medicinal chemistry. vol 40. issue 7. 2005-10-07. PMID:15935907. |
because alzheimer's disease (ad) is a medical problem characterized by progressive loss of memory and cognition that is associated with a deficient cholinergic system, this work aims to evaluate some p-aminobenzoic acid (paba) derivatives as acetylcholinesterase inhibitors in vitro, in continuation with our last studies. |
2005-10-07 |
2023-08-12 |
Not clear |
| Edward G Smith, Christopher J Gordo. The effects of chlorpyrifos on blood pressure and temperature regulation in spontaneously hypertensive rats. Basic & clinical pharmacology & toxicology. vol 96. issue 6. 2005-09-16. PMID:15910416. |
chlorpyrifos inhibits acetylcholinesterase activity, resulting in central and peripheral stimulation of central cholinergic pathways involved in blood pressure regulation. |
2005-09-16 |
2023-08-12 |
rat |
| Israel Silman, Joel L Sussma. Acetylcholinesterase: 'classical' and 'non-classical' functions and pharmacology. Current opinion in pharmacology. vol 5. issue 3. 2005-09-08. PMID:15907917. |
the synaptic enzyme acetylcholinesterase (ache) terminates transmission at cholinergic synapses by rapidly hydrolysing acetylcholine. |
2005-09-08 |
2023-08-12 |
Not clear |