| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paul A Dabisch, David C Burnett, Dennis B Miller, Edward M Jakubowski, William T Muse, Jeffry S Forster, Jacqueline A Scotto, Jill R Jarvis, Emily A Davis, Stanley W Hulet, Sharon A Reutter, Robert J Mioduszewski, Sandra A Thomso. Tolerance to the miotic effect of sarin vapor in rats after multiple low-level exposures. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. vol 21. issue 3. 2005-08-26. PMID:15969635. |
inhibition of acetylcholinesterase (ache) by the organophosphorous compound sarin (gb) results in the accumulation of acetylcholine and excessive cholinergic stimulation. |
2005-08-26 |
2023-08-12 |
rat |
| Marcella Reale, Carla Iarlori, Francesco Gambi, Isabella Lucci, Mirella Salvatore, Domenico Gamb. Acetylcholinesterase inhibitors effects on oncostatin-M, interleukin-1 beta and interleukin-6 release from lymphocytes of Alzheimer's disease patients. Experimental gerontology. vol 40. issue 3. 2005-08-25. PMID:15763393. |
one strategy for treatment of ad has been to use acetylcholinesterase (ache) inhibitors to increase the levels of acetylcholine and enhancing cholinergic activity in the affected regions of the brain. |
2005-08-25 |
2023-08-12 |
Not clear |
| Kathleen M Guthrie, Amy Tran, Janie Baratta, Jen Yu, Richard T Robertso. Patterns of afferent projections to the dentate gyrus studied in organotypic co-cultures. Brain research. Developmental brain research. vol 157. issue 2. 2005-08-24. PMID:15882910. |
acetylcholinesterase (ache) histochemistry demonstrated that cholinergic axons from septum, substantia innominata, and striatum all consistently targeted the inner molecular layer of the dentate gyrus. |
2005-08-24 |
2023-08-12 |
Not clear |
| Peter J Houghton, Melanie-Jayne Howe. Natural products and derivatives affecting neurotransmission relevant to Alzheimer's and Parkinson's disease. Neuro-Signals. vol 14. issue 1-2. 2005-08-18. PMID:15956811. |
the major advances in the treatment of ad have been the use of acetylcholinesterase inhibitors such as galantamine, huperzine a, physostigmine and its derivatives to increase the levels of ach rather than the use of cholinergic compounds, although compounds with nicotinic properties have attracted some interest. |
2005-08-18 |
2023-08-12 |
Not clear |
| Muhammad Mubarak Hossain, Tadahiko Suzuki, Itaru Sato, Tadashi Takewaki, Koichi Suzuki, Haruo Kobayash. Neuromechanical effects of pyrethroids, allethrin, cyhalothrin and deltamethrin on the cholinergic processes in rat brain. Life sciences. vol 77. issue 7. 2005-08-08. PMID:15936353. |
to better understand the mechanisms of their modulatory effects and also other effects on the cholinergic system in the brain, the activities of ach hydrolyzing enzyme acetylcholinesterase (ache), ach synthesizing enzyme choline acetyltransferase (chat) and ach synthesizing rate-limiting step, high-affinity choline uptake (hacu) were examined in the present study. |
2005-08-08 |
2023-08-12 |
rat |
| C Unger, M M Svedberg, M Schutte, I Bednar, A Nordber. Effect of memantine on the alpha 7 neuronal nicotinic receptors, synaptophysin- and low molecular weight MAP-2 levels in the brain of transgenic mice over-expressing human acetylcholinesterase. Journal of neural transmission (Vienna, Austria : 1996). vol 112. issue 2. 2005-07-29. PMID:15372325. |
transgenic mice over-expressing human acetylcholinesterase (hache-tg) display memory impairments, cholinergic deficits and reduced dendritic branching. |
2005-07-29 |
2023-08-12 |
mouse |
| Yehudit Hasin, Nili Avidan, Dani Bercovich, Amos Korczyn, Israel Silman, Jacques S Beckmann, Joel L Sussma. A paradigm for single nucleotide polymorphism analysis: the case of the acetylcholinesterase gene. Human mutation. vol 24. issue 5. 2005-07-29. PMID:15459952. |
acetylcholinesterase (ache) plays a crucial physiological role in termination of impulse transmission at cholinergic synapses through rapid hydrolysis of acetylcholine. |
2005-07-29 |
2023-08-12 |
human |
| Michal Harel, Janice L Hyatt, Boris Brumshtein, Christopher L Morton, Kyoung Jin P Yoon, Randy M Wadkins, Israel Silman, Joel L Sussman, Philip M Potte. The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action. Molecular pharmacology. vol 67. issue 6. 2005-07-14. PMID:15772291. |
the crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (cpt-11) with torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action. |
2005-07-14 |
2023-08-12 |
Not clear |
| Sabine Traver, Bénédicte Salthun-Lassalle, Marc Marien, Etienne C Hirsch, Francis Colpaert, Patrick P Miche. The neurotransmitter noradrenaline rescues septal cholinergic neurons in culture from degeneration caused by low-level oxidative stress. Molecular pharmacology. vol 67. issue 6. 2005-07-14. PMID:15784847. |
in this study, we showed that cholinergic neurons identified by acetylcholinesterase cytochemistry or choline acetyl transferase immunocytochemistry are rescued efficiently by the neurotransmitter noradrenaline (na). |
2005-07-14 |
2023-08-12 |
rat |
| Yehuda Pollak, Adi Gilboa, Ofra Ben-Menachem, Tamir Ben-Hur, Hermona Soreq, Raz Yirmiy. Acetylcholinesterase inhibitors reduce brain and blood interleukin-1beta production. Annals of neurology. vol 57. issue 5. 2005-06-24. PMID:15852394. |
these findings demonstrate that cholinergic enhancement produces central and peripheral antiinflammatory effects and suggest a novel therapeutic mechanism for acetylcholinesterase inhibitors. |
2005-06-24 |
2023-08-12 |
mouse |
| Joseph A Araujo, Christa M Studzinski, Norton W Milgra. Further evidence for the cholinergic hypothesis of aging and dementia from the canine model of aging. Progress in neuro-psychopharmacology & biological psychiatry. vol 29. issue 3. 2005-06-17. PMID:15795050. |
this paper reviews recent evidence suggesting cholinergic involvement in canine cognitive aging based on studies with the anti-cholinergic drug, scopolamine, and a novel acetylcholinesterase inhibitor, phenserine. |
2005-06-17 |
2023-08-12 |
human |
| G C Romá. Vascular dementia. Advances in nosology, diagnosis, treatment and prevention. Panminerva medica. vol 46. issue 4. 2005-06-13. PMID:15876977. |
this condition responds to acetylcholinesterase inhibitors, confirming the central role of cholinergic deficit in its pathogenesis. |
2005-06-13 |
2023-08-12 |
Not clear |
| Debby Van Dam, Bart Marescau, Sebastiaan Engelborghs, Thomas Cremers, Jan Mulder, Matthias Staufenbiel, Peter Paul De Dey. Analysis of cholinergic markers, biogenic amines, and amino acids in the CNS of two APP overexpression mouse models. Neurochemistry international. vol 46. issue 5. 2005-06-10. PMID:15737439. |
impairment of cholinergic transmission, the prominent neurochemical deficit in alzheimer brain, was examined; acetylcholinesterase and choline acetyltransferase activity levels were determined as markers of the cholinergic system. |
2005-06-10 |
2023-08-12 |
mouse |
| Changiz Geula, Sultan Darves. Butyrylcholinesterase, cholinergic neurotransmission and the pathology of Alzheimer's disease. Drugs of today (Barcelona, Spain : 1998). vol 40. issue 8. 2005-06-07. PMID:15510242. |
butyrylcholinesterase is a serine hydrolase biochemically related to the cholinergic enzyme acetylcholinesterase. |
2005-06-07 |
2023-08-12 |
Not clear |
| Changiz Geula, Sultan Darves. Butyrylcholinesterase, cholinergic neurotransmission and the pathology of Alzheimer's disease. Drugs of today (Barcelona, Spain : 1998). vol 40. issue 8. 2005-06-07. PMID:15510242. |
in particular, recent evidence indicates that along with acetylcholinesterase, butyrylcholinesterase catalyzes the hydrolysis of acetylcholine, and thus serves as a co-regulator of cholinergic transmission. |
2005-06-07 |
2023-08-12 |
Not clear |
| K Sembulingam, Prema Sembulingam, A Namasivaya. Effect of Ocimum sanctum Linn on the changes in central cholinergic system induced by acute noise stress. Journal of ethnopharmacology. vol 96. issue 3. 2005-05-24. PMID:15619567. |
the ethanolic extract from the leaves of ocimum sanctum linn was screened for its effects on the noise induced changes in the central cholinergic system of albino rats by investigating the acetylcholine content and acetylcholinesterase activity in discrete areas of brain. |
2005-05-24 |
2023-08-12 |
rat |
| Xavier Cousin, Uwe Strähle, Arnaud Chatonne. Are there non-catalytic functions of acetylcholinesterases? Lessons from mutant animal models. BioEssays : news and reviews in molecular, cellular and developmental biology. vol 27. issue 2. 2005-05-16. PMID:15666354. |
acetylcholinesterase (ache) hydrolyses acetylcholine (ach) ensuring the fast clearance of released neurotransmitter at cholinergic synapses. |
2005-05-16 |
2023-08-12 |
Not clear |
| Lynnette J Cook, Luk W Ho, Lin Wang, Edith Terrenoire, Carol Brayne, John Grimley Evans, John Xuereb, Nigel J Cairns, Dragana Turic, Paul Hollingworth, Pamela J Moore, Luke Jehu, Nicola Archer, Sarah Walter, Catherine Foy, Amanda Edmondson, John Powell, Simon Lovestone, Julie Williams, David C Rubinsztei. Candidate gene association studies of genes involved in neuronal cholinergic transmission in Alzheimer's disease suggests choline acetyltransferase as a candidate deserving further study. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 132B. issue 1. 2005-05-12. PMID:15690550. |
consistent deficits in the cholinergic system are evident in the brains of alzheimer's disease (ad) patients, including reductions in the activities of acetylcholine, acetylcholinesterase (ache), and choline acetyltransferase (chat), increased butyrylcholinesterase (bche) activity, and a selective loss of nicotinic acetylcholine receptors (nachrs). |
2005-05-12 |
2023-08-12 |
Not clear |
| Marco Battaglia, Anna Ogliar. Anxiety and panic: from human studies to animal research and back. Neuroscience and biobehavioral reviews. vol 29. issue 1. 2005-04-25. PMID:15652264. |
the overproduction of the acetylcholinesterase readthrough splice variant after minor stress can promote passive avoidance and learning through action at the level of the corticolimbic circuitries, as well as heightened sensitivity to suffocative stimuli by action upon the cholinergic components of chemoception. |
2005-04-25 |
2023-08-12 |
human |
| Françoise Boman, Laurent Corsois, François Para. [Hirschsprung's disease: practical considerations]. Annales de pathologie. vol 24. issue 6. 2005-04-21. PMID:15785397. |
acetylcholinesterase staining is performed on a frozen fragment to demonstrate the hyperplasia of cholinergic fibers that is very suggestive of hirschsprung's disease. |
2005-04-21 |
2023-08-12 |
Not clear |