| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Koichiro Kawashima, Takeshi Fuji. The lymphocytic cholinergic system and its contribution to the regulation of immune activity. Life sciences. vol 74. issue 6. 2004-02-11. PMID:14654162. |
lymphocytes express most of the cholinergic components found in the nervous system, including acetylcholine (ach), choline acetyltransferase (chat), high affinity choline transporter, muscarinic and nicotinic ach receptors (machrs and nachrs, respectively), and acetylcholinesterase. |
2004-02-11 |
2023-08-12 |
Not clear |
| Laura A Volpicelli-Daley, Anna Hrabovska, Ellen G Duysen, Shawn M Ferguson, Randy D Blakely, Oksana Lockridge, Allan I Leve. Altered striatal function and muscarinic cholinergic receptors in acetylcholinesterase knockout mice. Molecular pharmacology. vol 64. issue 6. 2004-01-16. PMID:14645660. |
altered striatal function and muscarinic cholinergic receptors in acetylcholinesterase knockout mice. |
2004-01-16 |
2023-08-12 |
mouse |
| Sebastian Lazareno, Angela Popham, Nigel J M Birdsal. Progress toward a high-affinity allosteric enhancer at muscarinic M1 receptors. Journal of molecular neuroscience : MN. vol 20. issue 3. 2003-12-23. PMID:14501021. |
however, acetylcholinesterase inhibitors, such as donepezil (aricept), which potentiate cholinergic neurotransmission, do have a therapeutic role in the management of ad and so the m1 receptor remains a viable therapeutic target. |
2003-12-23 |
2023-08-12 |
Not clear |
| Bin Li, Ellen G Duysen, Laura A Volpicelli-Daley, Allan I Levey, Oksana Lockridg. Regulation of muscarinic acetylcholine receptor function in acetylcholinesterase knockout mice. Pharmacology, biochemistry, and behavior. vol 74. issue 4. 2003-12-15. PMID:12667913. |
acetylcholinesterase (ache) hydrolyzes acetylcholine to terminate cholinergic neurotransmission. |
2003-12-15 |
2023-08-12 |
mouse |
| D O Kennedy, G Wake, S Savelev, N T J Tildesley, E K Perry, K A Wesnes, A B Schole. Modulation of mood and cognitive performance following acute administration of single doses of Melissa officinalis (Lemon balm) with human CNS nicotinic and muscarinic receptor-binding properties. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 10. 2003-12-05. PMID:12888775. |
the current study involved an initial screening of samples of m. officinalis for human acetylcholinesterase inhibition and cholinergic receptor-binding properties. |
2003-12-05 |
2023-08-12 |
human |
| Tsuyoshi Akiyama, Toji Yamazaki, Hidezo Mori, Kenji Sunagaw. Inhibition of cholinesterase elicits muscarinic receptor-mediated synaptic transmission in the rat adrenal medulla. Autonomic neuroscience : basic & clinical. vol 107. issue 2. 2003-11-19. PMID:12963416. |
to determine the role of acetylcholinesterase in cholinergic synaptic transmission in the adrenal medulla in vivo, we applied a dialysis technique to the adrenal medulla of anesthetized rats and examined the effect of acetylcholinesterase inhibitor on the contribution of nicotinic and muscarinic receptors to catecholamine release. |
2003-11-19 |
2023-08-12 |
rat |
| Tsuyoshi Akiyama, Toji Yamazaki, Hidezo Mori, Kenji Sunagaw. Inhibition of cholinesterase elicits muscarinic receptor-mediated synaptic transmission in the rat adrenal medulla. Autonomic neuroscience : basic & clinical. vol 107. issue 2. 2003-11-19. PMID:12963416. |
in the rat adrenal medulla, the inhibition of acetylcholinesterase not only enhanced cholinergic synaptic transmission but also elicited muscarinic receptor-mediated synaptic transmission for epinephrine release. |
2003-11-19 |
2023-08-12 |
rat |
| Maria Tomaszewicz, Steffen Rossner, Reinhard Schliebs, Justyna Cwikowska, Andrzej Szutowic. Changes in cortical acetyl-CoA metabolism after selective basal forebrain cholinergic degeneration by 192IgG-saporin. Journal of neurochemistry. vol 87. issue 2. 2003-11-06. PMID:14511109. |
cholinergic lesion produced 83%, 72% and 32% decreases in the activities of choline acetyltransferase, acetylcholinesterase and atp-citrate lyase in nerve terminals isolated from rat brain cortex, respectively, but no change in pyruvate dehydrogenase activity. |
2003-11-06 |
2023-08-12 |
rat |
| Christopher D Herzog, Kelly A Nowak, Martin Sarter, John P Brun. Microdialysis without acetylcholinesterase inhibition reveals an age-related attenuation in stimulated cortical acetylcholine release. Neurobiology of aging. vol 24. issue 6. 2003-10-29. PMID:12927768. |
aging-related differences in the ability of cortical cholinergic inputs to respond to local depolarization was assessed in young (3-6 months) and old (26-33 months) awake rats using in vivo microdialysis in the absence of an inhibitor of acetylcholinesterase. |
2003-10-29 |
2023-08-12 |
rat |
| Richard A Baine. Postsynaptic protein kinase A reduces neuronal excitability in response to increased synaptic excitation in the Drosophila CNS. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 25. 2003-10-14. PMID:14507965. |
synaptic excitation is increased in genetic backgrounds that lack either a camp-specific phosphodiesterase (ec:3.1.4, dunce) or acetylcholinesterase (ec:3.1.1.7, ace), the enzyme that terminates the endogenous cholinergic excitation of these motoneurons. |
2003-10-14 |
2023-08-12 |
drosophila_melanogaster |
| B P Kirby, J N P Rawlin. The role of the septo-hippocampal cholinergic projection in T-maze rewarded alternation. Behavioural brain research. vol 143. issue 1. 2003-09-09. PMID:12842294. |
administration of 192igg-saporin, a cholinergic neurotoxin, to the medial septum destroys the cell bodies from which the septo-hippocampal cholinergic projection originates, leading to reductions in both hippocampal acetylcholinesterase (ache) and choline acetyltransferase (chat). |
2003-09-09 |
2023-08-12 |
rat |
| Sultan Darvesh, David A Hopkin. Differential distribution of butyrylcholinesterase and acetylcholinesterase in the human thalamus. The Journal of comparative neurology. vol 463. issue 1. 2003-08-29. PMID:12811800. |
it has been hypothesized that acetylcholinesterase (ache) and butyrylcholinesterase (buche) are coregulators of the duration of action of acetylcholine in cholinergic neurotransmission, suggesting that buche may also have an important role in the brain. |
2003-08-29 |
2023-08-12 |
human |
| Birgit Zassler, Carla Weis, Christian Humpe. Tumor necrosis factor-alpha triggers cell death of sensitized potassium chloride-stimulated cholinergic neurons. Brain research. Molecular brain research. vol 113. issue 1-2. 2003-08-18. PMID:12750009. |
cholinergic neurons were visualized by immunohistochemistry for the enzyme choline acetyltransferase and nerve fibers by histochemistry for the enzyme acetylcholinesterase. |
2003-08-18 |
2023-08-12 |
rat |
| Véronique Bernard, Corinne Brana, Isabel Liste, Oksana Lockridge, Bertrand Bloc. Dramatic depletion of cell surface m2 muscarinic receptor due to limited delivery from intracytoplasmic stores in neurons of acetylcholinesterase-deficient mice. Molecular and cellular neurosciences. vol 23. issue 1. 2003-07-28. PMID:12799142. |
we have studied the consequences of the constitutive acetylcholinesterase (ache) deficiency in knockout mice for the ache gene on the subcellular localization of the m2 receptor (m2r) and the regulation of its intraneuronal compartmentalization by the cholinergic environment, using immunohistochemistry at light and electron microscopic levels. |
2003-07-28 |
2023-08-12 |
mouse |
| P C Miceli, K Jacobso. Cholinergic pathways modulate experimental dinitrobenzene sulfonic acid colitis in rats. Autonomic neuroscience : basic & clinical. vol 105. issue 1. 2003-07-24. PMID:12742187. |
in the current study, we examined the role of cholinergic pathways in modulating the severity of acute dinitrobenzene sulfonic acid colitis, using pharmacological agents to suppress acetylcholinesterase in sprague-dawley rats, and evaluating the colitis in the cholinergic hyperresponsive flinder's sensitive line rats and their control counterparts, the flinder's resistant line. |
2003-07-24 |
2023-08-12 |
rat |
| Laura A Volpicelli-Daley, Ellen G Duysen, Oksana Lockridge, Allan I Leve. Altered hippocampal muscarinic receptors in acetylcholinesterase-deficient mice. Annals of neurology. vol 53. issue 6. 2003-07-09. PMID:12783426. |
a primary therapeutic strategy for alzheimer's disease includes acetylcholinesterase (ache) inhibitors with the goal of enhancing cholinergic transmission. |
2003-07-09 |
2023-08-12 |
mouse |
| Gary L Wenk, Susanna Rosi, Kristin McGann, Beatrice Hauss-Wegrzynia. A nitric oxide-donating flurbiprofen derivative reduces neuroinflammation without interacting with galantamine in the rat. European journal of pharmacology. vol 453. issue 2-3. 2003-07-08. PMID:12398920. |
current therapies focus on enhancing cholinergic function by administrating acetylcholinesterase inhibitors, such as galantamine. |
2003-07-08 |
2023-08-12 |
rat |
| Brian D Ackley, Seong Hoon Kang, Jennifer R Crew, Chris Suh, Yishi Jin, James M Krame. The basement membrane components nidogen and type XVIII collagen regulate organization of neuromuscular junctions in Caenorhabditis elegans. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 9. 2003-06-19. PMID:12736328. |
the mutant animals exhibit mild movement defects and altered responses to an inhibitor of acetylcholinesterase and a cholinergic agonist, indicating altered synaptic function. |
2003-06-19 |
2023-08-12 |
caenorhabditis_elegans |
| H Shinotoh, K Fukushi, S Nagatsuka, N Tanaka, A Aotsuka, T Ota, H Namba, S Tanada, T Iri. The amygdala and Alzheimer's disease: positron emission tomographic study of the cholinergic system. Annals of the New York Academy of Sciences. vol 985. 2003-06-17. PMID:12724174. |
we measured brain acetylcholinesterase (ache) activity in 54 patients with ad and in 22 normal controls by positron emission tomography and n-[(11)c]methylpiperidin-4-yl acetate to characterize the cholinergic pathology in ad. |
2003-06-17 |
2023-08-12 |
Not clear |
| Iwona Kłoszewsk. [Acetylcholinesterase inhibitors--beyond Alzheimer's disease]. Psychiatria polska. vol 36. issue 6 Suppl. 2003-06-05. PMID:12647432. |
based on a literature review, the application of acetylcholinesterase inhibitors, iache (donepezil, rivastigmine, galantanine) in the treatment of various illnesses which have cholinergic system disability and dementia in their course--(dementia with lewy bodies, vascular dementia, parkinson's disease, multiple sclerosis, down syndrome), delirium symptoms (e.g. |
2003-06-05 |
2023-08-12 |
Not clear |