| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kenichi Mishima, Nobuaki Egashira, Yoshiaki Matsumoto, Katsunori Iwasaki, Michihiro Fujiwar. Involvement of reduced acetylcholine release in Delta9-tetrahydrocannabinol-induced impairment of spatial memory in the 8-arm radial maze. Life sciences. vol 72. issue 4-5. 2003-01-27. PMID:12467880. |
to clarify the mechanism by which delta9-tetrahydrocannabinol, a major psychoactive component of marijuana, impairs spatial memory in the 8-arm radial maze in rats via the cholinergic system, we used two acetylcholinesterase inhibitors, physostigmine and tetrahydroaminoacridine. |
2003-01-27 |
2023-08-12 |
rat |
| Rita Moretti, Paola Torre, Rodolfo M Antonello, Giuseppe Cazzato, Antonio Bav. Rivastigmine in subcortical vascular dementia: an open 22-month study. Journal of the neurological sciences. vol 203-204. 2003-01-23. PMID:12417373. |
further to recent data indicating that patients with vascular dementia (vad) show a cholinergic deficit, we aimed to determine whether rivastigmine, a dual inhibitor of acetylcholinesterase (ache) and butyrylcholinesterase (buche), has any effects on the symptoms of vad. |
2003-01-23 |
2023-08-12 |
Not clear |
| Richard B Rosse, Stephen I Deutsc. Adjuvant galantamine administration improves negative symptoms in a patient with treatment-refractory schizophrenia. Clinical neuropharmacology. vol 25. issue 5. 2003-01-13. PMID:12410061. |
galantamine is an inhibitor of acetylcholinesterase and a positive allosteric modulator of nicotinic cholinergic receptors (with a fda-approved indication for the treatment of patients with mild to moderate alzheimer disease (ad) under the trade name reminyl). |
2003-01-13 |
2023-08-12 |
Not clear |
| C Flores-Flores, A Nissim, S Shochat, H Sore. Development of human antibody fragments directed towards synaptic acetylcholinesterase using a semi-synthetic phage display library. Journal of neural transmission. Supplementum. issue 62. 2003-01-10. PMID:12456061. |
current alzheimer's disease therapies suppress acetylcholine hydrolysis by inhibiting acetylcholinesterase (ache) at cholinergic synapses. |
2003-01-10 |
2023-08-12 |
human |
| Mohamed B Abou-Donia, Anjelika M Dechkovskaia, Larry B Goldstein, Deepti U Shah, Sarah L Bullman, Wasiuddin A Kha. Uranyl acetate-induced sensorimotor deficit and increased nitric oxide generation in the central nervous system in rats. Pharmacology, biochemistry, and behavior. vol 72. issue 4. 2003-01-08. PMID:12062578. |
the levels of nitric oxide as marker for increased oxidative stress, and the integrity of the cholinergic system as reflected in acetylcholinesterase (ache) activity and m2 muscarinic acetylcholine receptors ligand binding, were determined. |
2003-01-08 |
2023-08-12 |
rat |
| R A Giniatullin, L G Magazani. [Desensitisation of postsynaptic membrane in the neuro-muscular junction due to an increase in spontaneous quantal release of a mediator]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 83. issue 3. 2003-01-06. PMID:12436684. |
a sharp increase of mepc frequency (not less than approximately 50 per sec) was followed by an obvious fall in both their amplitude and acceleration of decay only in the presence of 3 microm prostigmine (acetylcholinesterase inhibitor) and 5 microm proadiphene, these agents promoting a desensitization of cholinergic postsynaptic membrane. |
2003-01-06 |
2023-08-12 |
Not clear |
| John R Fawcett, Elizabeth Z Bordayo, Kathy Jackson, Howard Liu, Jennifer Peterson, Aleta Svitak, William H Fre. Inactivation of the human brain muscarinic acetylcholine receptor by oxidative damage catalyzed by a low molecular weight endogenous inhibitor from Alzheimer's brain is prevented by pyrophosphate analogs, bioflavonoids and other antioxidants. Brain research. vol 950. issue 1-2. 2002-12-23. PMID:12231224. |
natural antioxidants and pyrophosphate analogs may improve the effectiveness of acetylcholinesterase inhibitors and prove useful in the treatment and prevention of alzheimer's disease since the muscarinic acetylcholine receptor is required for memory, and decreased cholinergic function is a critical deficit in alzheimer's disease. |
2002-12-23 |
2023-08-12 |
human |
| L Jaganathan, R Boopath. A direct method to visualise the aryl acylamidase activity on cholinesterases in polyacrylamide gels. BMC biochemistry. vol 1. 2002-12-18. PMID:11231883. |
the function of acetylcholinesterase is to hydrolyse acetylcholine, thereby terminating the neurotransmission at cholinergic synapse, while the precise physiological function of butyrylcholinesterase has not been identified. |
2002-12-18 |
2023-08-12 |
Not clear |
| M Ballmaier, F Casamenti, C Scali, R Mazzoncini, M Zoli, G Pepeu, P F Span. Rivastigmine antagonizes deficits in prepulse inhibition induced by selective immunolesioning of cholinergic neurons in nucleus basalis magnocellularis. Neuroscience. vol 114. issue 1. 2002-11-26. PMID:12207957. |
in addition, our findings strongly indicate that even after dramatic decrease of cholinergic neurons, inhibition of acetylcholinesterase restores the cholinergic synaptic function to a point approaching normalization of experimentally induced psychopathology. |
2002-11-26 |
2023-08-12 |
rat |
| Satoshi Ikemoto, Roy A Wis. Rewarding effects of the cholinergic agents carbachol and neostigmine in the posterior ventral tegmental area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 22. 2002-11-18. PMID:12427846. |
rats learned to lever-press for microinjections of the cholinergic agonist carbachol (30-500 pmol per infusion) or the acetylcholinesterase inhibitor neostigmine (7.5-75 pmol per infusion) into the posterior ventral tegmental area (vta) of the brain. |
2002-11-18 |
2023-08-12 |
rat |
| Filippo Drago, Silvia Macauda, Soudabeh Saleh. Small doses of melatonin increase intestinal motility in rats. Digestive diseases and sciences. vol 47. issue 9. 2002-10-23. PMID:12353839. |
injection of the reversible acetylcholinesterase inhibitor and cholinergic agent, neostigmine, accelerated intestinal transit but failed to influence melatonin effect on this parameter. |
2002-10-23 |
2023-08-12 |
rat |
| K Oravecz, D Kalka, F Jeney, M Cantz, I Zs-Nag. Hydroxyl free radicals induce cell differentiation in SK-N-MC neuroblastoma cells. Tissue & cell. vol 34. issue 1. 2002-10-16. PMID:11989968. |
microscopic morphological signs, as well as the acetylcholinesterase and ganglioside sialidase activities were considered as markers of neuronal differentiation of this cholinergic neuroblastoma cell line. |
2002-10-16 |
2023-08-12 |
Not clear |
| Ho-Jin Heo, Seong-Chan Hong, Hong-Yon Cho, Bumshik Hong, Hye-Kyung Kim, Eun-Ki Kim, Dong-Hoon Shi. Inhibitory effect of zeatin, isolated from Fiatoua villosa, on acetylcholinesterase activity from PC12 cells. Molecules and cells. vol 13. issue 1. 2002-10-10. PMID:11911460. |
acetylcholinesterase (ache) inhibitors, which enhance cholinergic transmission by reducing the enzymatic degradation of acetylcholine, are the only source of the compound that is currently approved for the treatment of alzheimer's disease (ad). |
2002-10-10 |
2023-08-12 |
Not clear |
| P Tario. Current status and new developments with galantamine in the treatment of Alzheimer's disease. Expert opinion on pharmacotherapy. vol 2. issue 12. 2002-09-26. PMID:11825333. |
galantamine is a newly available cholinergic drug that offsets reductions in central cholinergic neurotransmission in alzheimer's disease (ad) by specifically and reversibly inhibiting acetylcholinesterase (ache) and by allosterically modulating nicotinic cholinergic receptors. |
2002-09-26 |
2023-08-12 |
Not clear |
| Sławomir Gralewicz, Piotr Lutz, Tadeusz Toma. Behavioural responsiveness to amphetamine or scopolamine following repeated exposure to chlorphenvinphos in rats. Acta neurobiologiae experimentalis. vol 62. issue 2. 2002-09-12. PMID:12201035. |
a number of reports indicate that exposure to organophosphates (ops), inhibitors of acetylcholinesterase (ache), may result in long-lasting neurobehavioural alterations suggestive of an increased cholinergic tone. |
2002-09-12 |
2023-08-12 |
rat |
| S D Skaper, G L Adelson, J E Seegmille. Metabolism of biogenic amines in neuroblastoma and glioma cells in culture. Journal of neurochemistry. vol 27. issue 5. 2002-08-27. PMID:12170589. |
these results suggest that in neurons neither mao nor comt plays a major role in the type of transmitter inactivation that is analogous to that of acetylcholinesterase in cholinergic synapses. |
2002-08-27 |
2023-08-12 |
mouse |
| S Roman, N M Vivas, A Badia, M V Clo. Interaction of a new potent anticholinesterasic compound (+/-)huprine X with muscarinic receptors in rat brain. Neuroscience letters. vol 325. issue 2. 2002-08-06. PMID:12044632. |
the present results demonstrate that this acetylcholinesterase inhibitor has an ample cholinergic profile, which suggests a potential source of interest of (+/-)huprine x in alzheimer's disease therapy. |
2002-08-06 |
2023-08-12 |
rat |
| U Freo, G Pizzolato, M Dam, C Ori, L Battisti. A short review of cognitive and functional neuroimaging studies of cholinergic drugs: implications for therapeutic potentials. Journal of neural transmission (Vienna, Austria : 1996). vol 109. issue 5-6. 2002-08-06. PMID:12111473. |
acetylcholine precursors, cholinergic agonists and acetylcholinesterase inhibitors) enhance attention and memory in experiment animals, healthy human subjects and alzheimer disease patients. |
2002-08-06 |
2023-08-12 |
human |
| Ronald A Greenfield, Brent R Brown, James B Hutchins, John J Iandolo, Rhett Jackson, Leonard N Slater, Michael S Bronz. Microbiological, biological, and chemical weapons of warfare and terrorism. The American journal of the medical sciences. vol 323. issue 6. 2002-07-10. PMID:12074487. |
nerve agents inhibit acetylcholinesterase and thus produce symptoms of increased cholinergic activity. |
2002-07-10 |
2023-08-12 |
Not clear |
| M-M Mesulam, A Guillozet, P Shaw, A Levey, E G Duysen, O Lockridg. Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholine. Neuroscience. vol 110. issue 4. 2002-06-12. PMID:11934471. |
acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholine. |
2002-06-12 |
2023-08-12 |
mouse |