| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| V N Tales. Acetylcholinesterase in Alzheimer's disease. Mechanisms of ageing and development. vol 122. issue 16. 2001-12-31. PMID:11589914. |
since the discovery of the cholinergic deficit in alzheimer disease (ad), acetylcholinesterase (ache) has been widely investigated in tissues involved in the disease. |
2001-12-31 |
2023-08-12 |
Not clear |
| E C Smith, B Padnos, C J Cordo. Peripheral versus central muscarinic effects on blood pressure, cardiac contractility, heart rate, and body temperature in the rat monitored by radiotelemetry. Pharmacology & toxicology. vol 89. issue 1. 2001-12-18. PMID:11484908. |
since organophosphate pesticides inhibit acetylcholinesterase activity and cause cholinergic stimulation in the central nervous system and peripheral tissues, we suspect that the hypertensive response from chlorpyrifos is elicited by activation of pressor areas in the brain stem, specifically muscarinic receptors which are known to mediate hypertensive responses. |
2001-12-18 |
2023-08-12 |
rat |
| H M Dodds, L P Rivor. Comment on a published paper. The adverse cholinergic effects of the chemotherapeutic agent irinotecan (CPT-11) were unlikely to be mediated by the inhibition of acetylcholinesterase (AChE). British journal of pharmacology. vol 134. issue 2. 2001-12-04. PMID:11564665. |
the adverse cholinergic effects of the chemotherapeutic agent irinotecan (cpt-11) were unlikely to be mediated by the inhibition of acetylcholinesterase (ache). |
2001-12-04 |
2023-08-12 |
Not clear |
| M U Delmonte Corrado, H Politi, M Ognibene, C Angelini, F Trielli, P Ballarini, C Falug. Synthesis of the signal molecule acetylcholine during the developmental cycle of Paramecium primaurelia (Protista, Ciliophora) and its possible function in conjugation. The Journal of experimental biology. vol 204. issue Pt 11. 2001-09-27. PMID:11441032. |
we recently discovered, in mating-competent paramecium primaurelia, the presence of functionally related molecules of the cholinergic system: the neurotransmitter acetylcholine (ach), both its nicotinic and muscarinic receptors and its lytic enzyme acetylcholinesterase (ache). |
2001-09-27 |
2023-08-12 |
Not clear |
| J Villalobos, O Rios, M Barbos. Postnatal development of cholinergic system in mouse basal forebrain: acetylcholinesterase histochemistry and choline-acetyltransferase immunoreactivity. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 19. issue 5. 2001-09-20. PMID:11470379. |
postnatal development of cholinergic system in mouse basal forebrain: acetylcholinesterase histochemistry and choline-acetyltransferase immunoreactivity. |
2001-09-20 |
2023-08-12 |
mouse |
| J Villalobos, O Rios, M Barbos. Postnatal development of cholinergic system in mouse basal forebrain: acetylcholinesterase histochemistry and choline-acetyltransferase immunoreactivity. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 19. issue 5. 2001-09-20. PMID:11470379. |
these results seem to indicate that the acetylcholinesterase could have a non-classic cholinergic role in the first stages of postnatal development, acting as a growth and cellular differentiation factor. |
2001-09-20 |
2023-08-12 |
mouse |
| B Platt, G Fiddler, G Riedel, Z Henderso. Aluminium toxicity in the rat brain: histochemical and immunocytochemical evidence. Brain research bulletin. vol 55. issue 2. 2001-09-06. PMID:11470325. |
damage of the cingulate bundle in al-treated animals led to a severe anterograde degeneration of cholinergic terminals in cortex and hippocampus, as indicated by acetylcholinesterase labelling. |
2001-09-06 |
2023-08-12 |
rat |
| K Sinha, H K Dannelly, S K Ghos. Effects of T-lymphocyte-dependent and -independent immunity on cholinergic enzyme activity in mouse lacrimal gland. Experimental physiology. vol 86. issue 2. 2001-08-23. PMID:11429631. |
to delineate the effects that immunogenic differences might have on the activities of the cholinergic enzymes, choline acetyl-transferase (chat) and acetylcholinesterase (ache) were assayed using radiolabelled substrates and measuring labelled products. |
2001-08-23 |
2023-08-12 |
mouse |
| M Mihovilovic, J Butterworth-Robinett. Thymic epithelial cell line expresses transcripts encoding alpha-3, alpha-5 and beta-4 subunits of acetylcholine receptors, responds to cholinergic agents and expresses choline acetyl transferase. An in vitro system to investigate thymic cholinergic mechanisms. Journal of neuroimmunology. vol 117. issue 1-2. 2001-08-23. PMID:11431005. |
strengthening the hypothesis that cholinergic receptors mediate the effects of physostigmine, acetylcholinesterase (acchase) activity is not detected in te750 cells. |
2001-08-23 |
2023-08-12 |
Not clear |
| B Lockhart, M Closier, K Howard, C Steward, P Lestag. Differential inhibition of [3H]-oxotremorine-M and [3H]-quinuclinidyl benzilate binding to muscarinic receptors in rat brain membranes with acetylcholinesterase inhibitors. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 4. 2001-08-16. PMID:11330337. |
the potential interaction of acetylcholinesterase inhibitors with cholinergic receptors may play a significant role in the therapeutic and/or side-effects associated with this class of compound. |
2001-08-16 |
2023-08-12 |
rat |
| G Ferreira, M Meurisse, Y Tillet, F Lév. Distribution and co-localization of choline acetyltransferase and p75 neurotrophin receptors in the sheep basal forebrain: implications for the use of a specific cholinergic immunotoxin. Neuroscience. vol 104. issue 2. 2001-08-16. PMID:11377845. |
the loss of basal forebrain cholinergic neurons and acetylcholinesterase fibers in basal forebrain projection areas was assessed in ewes that had received intracerebroventricular injections of the immunotoxin (50, 100 or 150 microg) alone, as well as, in some of the ewes treated with the highest dose, with bilateral immunotoxin injections in the nucleus basalis (11 microg/side). |
2001-08-16 |
2023-08-12 |
Not clear |
| E W Cheon, O Kuwata, T Sait. Muscarinic acetylcholine receptors in the normal, developing and regenerating newt retinas. Brain research. Developmental brain research. vol 127. issue 1. 2001-07-12. PMID:11287060. |
like acetylcholinesterase (ache), the m2 was first detected in somata located at the most proximal level of the retina well before chat-ir cholinergic neurons appeared, while the m4 was detected at the time of appearance of chat, in both developing and regenerating retinas. |
2001-07-12 |
2023-08-12 |
Not clear |
| R Makuch, J Baratta, L D Karaelias, J C Lauterborn, C M Gall, J Yu, R T Robertso. Arrival of afferents and the differentiation of target neurons: studies of developing cholinergic projections to the dentate gyrus. Neuroscience. vol 104. issue 1. 2001-07-12. PMID:11311533. |
acetylcholinesterase histochemistry was used to identify septal cholinergic afferents to the dentate gyrus; parallel studies used anterograde movement of a carbocyanine dye to label the septal projections. |
2001-07-12 |
2023-08-12 |
rat |
| O A Timofeeva, C J Gordo. Changes in EEG power spectra and behavioral states in rats exposed to the acetylcholinesterase inhibitor chlorpyrifos and muscarinic agonist oxotremorine. Brain research. vol 893. issue 1-2. 2001-06-21. PMID:11223004. |
organophosphates (ops) inhibit acetylcholinesterase (ache) activity causing cholinergic stimulation in the central nervous system (cns). |
2001-06-21 |
2023-08-12 |
rat |
| M H Aziz, A K Agrawal, V M Adhami, Y Shukla, P K Set. Neurodevelopmental consequences of gestational exposure (GD14-GD20) to low dose deltamethrin in rats. Neuroscience letters. vol 300. issue 3. 2001-06-14. PMID:11226636. |
the significant increase in acetylcholinesterase activity and decrease in (3)h-quinuclidinyl benzilate binding in the hippocampal region of dt exposed animals, suggesting impairment in cholinergic (muscarinic) receptors. |
2001-06-14 |
2023-08-12 |
rat |
| N D Volkow, Y S Ding, J S Fowler, S J Gatle. Imaging brain cholinergic activity with positron emission tomography: its role in the evaluation of cholinergic treatments in Alzheimer's dementia. Biological psychiatry. vol 49. issue 3. 2001-06-07. PMID:11230872. |
positron emission tomography is a medical imaging method that can be used to measure the concentration, kinetics, and distribution of cholinergic-enhancing drugs directly in the human brain and assess the effects of the drugs at markers of cholinergic cell viability (vesicular transporters, acetylcholinesterase), at muscarininc and nicotinic receptors, at extracellular acetylcholine, at markers of brain function (glucose metabolism and blood flow), and on amyloid plaque burden in vivo in the brains of patients with alzheimer's disease. |
2001-06-07 |
2023-08-12 |
human |
| A B Belousov, B F O'Hara, J V Denisov. Acetylcholine becomes the major excitatory neurotransmitter in the hypothalamus in vitro in the absence of glutamate excitation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 6. 2001-06-07. PMID:11245685. |
this activity was suppressed with acetylcholine (ach) receptor antagonists and was potentiated by eserine, an inhibitor of acetylcholinesterase, suggesting its cholinergic nature. |
2001-06-07 |
2023-08-12 |
Not clear |
| M E Rhodes, S M O'Toole, S L Wright, R K Czambel, R T Rubi. Sexual diergism in rat hypothalamic-pituitary-adrenal axis responses to cholinergic stimulation and antagonism. Brain research bulletin. vol 54. issue 1. 2001-05-17. PMID:11226719. |
in the present study we investigated muscarinic and nicotinic cholinergic influences on hpa axis activity in male and female rats by pretreatment with selective cholinergic receptor antagonists followed by stimulation with physostigmine (physo), an acetylcholinesterase inhibitor. |
2001-05-17 |
2023-08-12 |
rat |
| C Erb, J Troost, S Kopf, U Schmitt, K Löffelholz, H Soreq, J Klei. Compensatory mechanisms enhance hippocampal acetylcholine release in transgenic mice expressing human acetylcholinesterase. Journal of neurochemistry. vol 77. issue 2. 2001-05-17. PMID:11299326. |
central cholinergic neurotransmission was studied in learning-impaired transgenic mice expressing human acetylcholinesterase (hache-tg). |
2001-05-17 |
2023-08-12 |
mouse |
| b' J Patocka, A Struneck\\xc3\\xa1, D R\\xc3\\xadpov\\xc3\\xa. [Cholinesterases and their importance in the etiology, diagnosis and therapy of Alzheimer\'s disease]. Ceskoslovenska fysiologie. vol 50. issue 1. 2001-05-03. PMID:11268561.' |
acetylcholinesterase (ache) plays the key role in cholinergic neurotransmission, whereas the function of butyrylcholinesterase (buche) is still unrevealed. |
2001-05-03 |
2023-08-12 |
Not clear |